{"id":"https://openalex.org/W7129002003","doi":"https://doi.org/10.65735/ajhs.2025.41.01.12","title":"Relationship between protamine dosage for reversing heparin effects in cardiopulmonary bypass surgery and hemostatic and metabolic outcomes","display_name":"Relationship between protamine dosage for reversing heparin effects in cardiopulmonary bypass surgery and hemostatic and metabolic outcomes","publication_year":2026,"publication_date":"2026-02-09","ids":{"openalex":"https://openalex.org/W7129002003","doi":"https://doi.org/10.65735/ajhs.2025.41.01.12"},"language":"en","primary_location":{"id":"doi:10.65735/ajhs.2025.41.01.12","doi":"https://doi.org/10.65735/ajhs.2025.41.01.12","is_oa":true,"landing_page_url":"https://doi.org/10.65735/ajhs.2025.41.01.12","pdf_url":null,"source":{"id":"https://openalex.org/S5407055811","display_name":"Academic Journal of Health Sciences","issn_l":"2255-0569","issn":["2255-0569"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Academic Journal of Health Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.65735/ajhs.2025.41.01.12","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022701681","display_name":"Bi\u015far Ama\u00e7","orcid":"https://orcid.org/0000-0003-0320-4239","observed_orcids":["https://orcid.org/0000-0003-0320-4239"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bi\u015far Ama\u00e7","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0320-4239","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066850357","display_name":"Mustafa Abanoz","orcid":"https://orcid.org/0000-0003-1821-1706","observed_orcids":["https://orcid.org/0000-0003-1821-1706"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mustafa Abanoz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1821-1706","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126072984","display_name":"Alaa Hijazi","orcid":"https://orcid.org/0009-0001-5400-4168","observed_orcids":["https://orcid.org/0009-0001-5400-4168"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alaa Hijazi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-5400-4168","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004924252","display_name":"Mesut Engin","orcid":"https://orcid.org/0000-0003-2418-5823","observed_orcids":["https://orcid.org/0000-0003-2418-5823"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mesut Engin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2418-5823","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5042702977","display_name":"\u00d6mer G\u00f6\u00e7","orcid":"https://orcid.org/0000-0002-3047-6232","observed_orcids":["https://orcid.org/0000-0002-3047-6232"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u00d6mer G\u00f6\u00e7","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3047-6232","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07990883,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":"1","first_page":"76","last_page":"86"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.04179999977350235,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protamine","display_name":"protamine","score":0.8500000238418579},{"id":"https://openalex.org/keywords/heparin-reversal","display_name":"heparin reversal","score":0.9660000205039978},{"id":"https://openalex.org/keywords/cardiopulmonary-bypass","display_name":"cardiopulmonary bypass","score":0.9020000100135803},{"id":"https://openalex.org/keywords/cardiac-surgery","display_name":"cardiac surgery","score":0.7580000162124634},{"id":"https://openalex.org/keywords/postoperative-bleeding","display_name":"postoperative bleeding","score":0.652999997138977},{"id":"https://openalex.org/keywords/blood-transfusion","display_name":"blood transfusion","score":0.9210000038146973},{"id":"https://openalex.org/keywords/length-of-hospital-stay","display_name":"length of hospital stay","score":0.9769999980926514},{"id":"https://openalex.org/keywords/postoperative-lactate","display_name":"postoperative lactate","score":0.8140000104904175},{"id":"https://openalex.org/keywords/systemic-anticoagulation","display_name":"systemic anticoagulation","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C2780835560","wikidata":"https://www.wikidata.org/wiki/Q5449573","display_name":"Protamine","level":3,"score":0.9228000044822693},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9182000160217285},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.8255000114440918},{"id":"https://openalex.org/C2778881276","wikidata":"https://www.wikidata.org/wiki/Q552304","display_name":"Cardiopulmonary bypass","level":2,"score":0.7954000234603882},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5357999801635742},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.42399999499320984},{"id":"https://openalex.org/C2778789114","wikidata":"https://www.wikidata.org/wiki/Q235007","display_name":"Cardiac surgery","level":2,"score":0.42250001430511475},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.3767000138759613},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3499999940395355},{"id":"https://openalex.org/C2779354726","wikidata":"https://www.wikidata.org/wiki/Q22075855","display_name":"Protamine sulfate","level":4,"score":0.30169999599456787},{"id":"https://openalex.org/C3018023364","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Significant difference","level":2,"score":0.2953999936580658},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.2915000021457672},{"id":"https://openalex.org/C2780365088","wikidata":"https://www.wikidata.org/wiki/Q48318","display_name":"Urea","level":2,"score":0.2903999984264374},{"id":"https://openalex.org/C66112548","wikidata":"https://www.wikidata.org/wiki/Q1225698","display_name":"Fresh frozen plasma","level":3,"score":0.27559998631477356},{"id":"https://openalex.org/C2778205648","wikidata":"https://www.wikidata.org/wiki/Q215118","display_name":"Anticoagulant","level":2,"score":0.2743000090122223},{"id":"https://openalex.org/C2778589496","wikidata":"https://www.wikidata.org/wiki/Q487937","display_name":"Hemostasis","level":2,"score":0.26919999718666077},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26499998569488525},{"id":"https://openalex.org/C2778176769","wikidata":"https://www.wikidata.org/wiki/Q764079","display_name":"Blood urea nitrogen","level":3,"score":0.2612999975681305}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.65735/ajhs.2025.41.01.12","doi":"https://doi.org/10.65735/ajhs.2025.41.01.12","is_oa":true,"landing_page_url":"https://doi.org/10.65735/ajhs.2025.41.01.12","pdf_url":null,"source":{"id":"https://openalex.org/S5407055811","display_name":"Academic Journal of Health Sciences","issn_l":"2255-0569","issn":["2255-0569"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Academic Journal of Health Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.65735/ajhs.2025.41.01.12","doi":"https://doi.org/10.65735/ajhs.2025.41.01.12","is_oa":true,"landing_page_url":"https://doi.org/10.65735/ajhs.2025.41.01.12","pdf_url":null,"source":{"id":"https://openalex.org/S5407055811","display_name":"Academic Journal of Health Sciences","issn_l":"2255-0569","issn":["2255-0569"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Academic Journal of Health Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7150382968","https://openalex.org/W7118127845","https://openalex.org/W4383645668","https://openalex.org/W2082826915","https://openalex.org/W2408254737","https://openalex.org/W7171703389","https://openalex.org/W2890973958","https://openalex.org/W4403319131","https://openalex.org/W4385510648","https://openalex.org/W7213233049"],"abstract_inverted_index":{"Introduction:":[0],"Systemic":[1],"anticoagulation":[2],"during":[3],"CPB":[4],"is":[5],"achieved":[6],"with":[7,11,45,155,175],"heparin":[8,59,77,179],"and":[9,41,65,86,96,123,132,138,158,184],"reversed":[10],"protamine,":[12],"though":[13],"practices":[14],"vary.":[15],"This":[16,30],"study":[17,32],"examined":[18],"the":[19,38,90,112,144,165,173,176],"impact":[20],"of":[21,58,76,89,114,167],"two":[22],"protamine":[23,53,71],"dosing":[24],"strategies":[25],"on":[26],"clinical":[27,139],"outcomes.":[28],"Methods:":[29],"retrospective":[31],"included":[33],"653":[34],"patients":[35,66,91],"who":[36,49,67],"met":[37],"inclusion":[39],"criteria":[40],"underwent":[42],"cardiac":[43],"surgery":[44],"cardiopulmonary":[46],"bypass.":[47],"Patients":[48],"received":[50,68],"0.6":[51,177],"mg":[52,70],"for":[54,72],"every":[55,73],"100":[56,74],"units":[57,75],"were":[60,78,92,99,126,147,153,187],"defined":[61,79],"as":[62,80],"Group":[63,81],"1,":[64],"1.2":[69],"2.":[82],"Descriptive":[83],"data,":[84],"preoperative":[85],"postoperative":[87,182],"variables":[88],"evaluated.":[93],"Results:":[94],"Demographic":[95],"descriptive":[97],"data":[98,119,140],"similar":[100,148],"between":[101,109],"groups":[102,110],"(p>0.05).":[103,149],"The":[104],"only":[105],"clinically":[106],"significant":[107],"difference":[108],"was":[111,170],"length":[113,166],"hospital":[115,168],"stay":[116,169],"(p=0.003).":[117],"Metabolic":[118],"showed":[120],"that":[121],"urea":[122,183],"lactate":[124,185],"levels":[125,186],"higher":[127,190],"in":[128,162,172,191],"group":[129,174],"1":[130],"(p=0.012":[131],"p<0.001,":[133],"respectively).":[134],"Other":[135],"haematological,":[136],"metabolomic,":[137],"potentially":[141],"related":[142],"to":[143],"protamine/heparin":[145],"ratio":[146],"Conclusion:":[150],"Both":[151],"doses":[152],"associated":[154],"comparable":[156],"bleeding":[157],"transfusion":[159],"requirements.":[160],"However,":[161],"our":[163],"study,":[164],"longer":[171],"mg/100IU":[178],"ratio.":[180],"Additionally,":[181],"also":[188],"significantly":[189],"this":[192],"group.":[193]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-02-17T00:00:00"}
