{"id":"https://openalex.org/W7128819873","doi":"https://doi.org/10.59295/spd2025e.36","title":"Regulation of immune system homeostasis by free amino acids depending on diet and the functioning of certain body systems","display_name":"Regulation of immune system homeostasis by free amino acids depending on diet and the functioning of certain body systems","publication_year":2026,"publication_date":"2026-02-01","ids":{"openalex":"https://openalex.org/W7128819873","doi":"https://doi.org/10.59295/spd2025e.36"},"language":"en","primary_location":{"id":"doi:10.59295/spd2025e.36","doi":"https://doi.org/10.59295/spd2025e.36","is_oa":false,"landing_page_url":"https://doi.org/10.59295/spd2025e.36","pdf_url":null,"source":{"id":"https://openalex.org/S7407096253","display_name":"Integrare prin cercetare \u0219i inovare. \u0218tiin\u021be exacte \u0219i ale naturii","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310321163","host_organization_name":"Moldova State University","host_organization_lineage":["https://openalex.org/P4310321163"],"host_organization_lineage_names":["Moldova State University"],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Integrare prin cercetare \u0219i inovare. \u0218tiin\u021be exacte \u0219i ale naturii","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065281581","display_name":"\u0421\u0432\u0435\u0442\u043b\u0430\u043d\u0430 \u0413\u0430\u0440\u0430\u0435\u0432\u0430","orcid":"https://orcid.org/0000-0002-9257-5818","observed_orcids":["https://orcid.org/0000-0002-9257-5818"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Svetlana Garaeva","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9257-5818","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047245900","display_name":"Lilia Poleacova","orcid":"https://orcid.org/0000-0001-8212-096X","observed_orcids":["https://orcid.org/0000-0001-8212-096X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lilia Poleacova","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8212-096X","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5051300702","display_name":"\u0413\u0430\u043b\u0438\u043d\u0430 \u041f\u043e\u0441\u0442\u043e\u043b\u0430\u0442\u0438","orcid":"https://orcid.org/0009-0009-0439-8929","observed_orcids":["https://orcid.org/0009-0009-0439-8929"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Galina Postolati","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8634-4856","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"264","last_page":"271"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.5776000022888184,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.5776000022888184,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.13680000603199005,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10152","display_name":"Animal Nutrition and Physiology","score":0.08410000056028366,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-homeostasis","display_name":"immune homeostasis","score":0.8529999852180481},{"id":"https://openalex.org/keywords/free-amino-acids","display_name":"free amino acids","score":0.8740000128746033},{"id":"https://openalex.org/keywords/dietary-amino-acids","display_name":"dietary amino acids","score":0.8080000281333923},{"id":"https://openalex.org/keywords/glutamine","display_name":"glutamine","score":0.9819999933242798},{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/branched-chain-amino-acids","display_name":"branched-chain amino acids","score":1.0},{"id":"https://openalex.org/keywords/lymphocyte-activation","display_name":"lymphocyte activation","score":0.9110000133514404},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.996999979019165},{"id":"https://openalex.org/keywords/intestinal-barrier","display_name":"intestinal barrier","score":0.8629999756813049},{"id":"https://openalex.org/keywords/nutrition-and-immunity","display_name":"nutrition and immunity","score":0.777999997138977},{"id":"https://openalex.org/keywords/neuroimmune-interactions","display_name":"neuroimmune interactions","score":0.8309999704360962},{"id":"https://openalex.org/keywords/immune-endocrine-interaction","display_name":"endocrine-immune interaction","score":0.7990000247955322},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"personalized medicine","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.8648999929428101},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.6152999997138977},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.5848000049591064},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5508000254631042},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5475999712944031},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.513700008392334},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.4246000051498413},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4081000089645386},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.39820000529289246},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.3785000145435333},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.31929999589920044},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.310699999332428},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.28790000081062317},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2827000021934509},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.267300009727478},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2662000060081482},{"id":"https://openalex.org/C103395026","wikidata":"https://www.wikidata.org/wiki/Q5380231","display_name":"Enteroendocrine cell","level":4,"score":0.2621999979019165},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.25600001215934753},{"id":"https://openalex.org/C2776533406","wikidata":"https://www.wikidata.org/wiki/Q187215","display_name":"Sympathetic nervous system","level":3,"score":0.2533999979496002},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25130000710487366},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2506999969482422}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.59295/spd2025e.36","doi":"https://doi.org/10.59295/spd2025e.36","is_oa":false,"landing_page_url":"https://doi.org/10.59295/spd2025e.36","pdf_url":null,"source":{"id":"https://openalex.org/S7407096253","display_name":"Integrare prin cercetare \u0219i inovare. \u0218tiin\u021be exacte \u0219i ale naturii","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310321163","host_organization_name":"Moldova State University","host_organization_lineage":["https://openalex.org/P4310321163"],"host_organization_lineage_names":["Moldova State University"],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Integrare prin cercetare \u0219i inovare. \u0218tiin\u021be exacte \u0219i ale naturii","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1975202380","https://openalex.org/W1975358903","https://openalex.org/W1990452634","https://openalex.org/W2011814478","https://openalex.org/W2049099916","https://openalex.org/W2055712486","https://openalex.org/W2093381843","https://openalex.org/W2149154883","https://openalex.org/W2160700926","https://openalex.org/W2272263214","https://openalex.org/W2754803308","https://openalex.org/W2939767734","https://openalex.org/W2951879720","https://openalex.org/W3019532495","https://openalex.org/W3040970001","https://openalex.org/W3048561769","https://openalex.org/W3131883664","https://openalex.org/W3176551662","https://openalex.org/W4205564634","https://openalex.org/W4411098116"],"related_works":["https://openalex.org/W7216184793","https://openalex.org/W2144507395","https://openalex.org/W2565642272","https://openalex.org/W2011814478","https://openalex.org/W2472071085","https://openalex.org/W4404512833","https://openalex.org/W4411152814","https://openalex.org/W2126638072","https://openalex.org/W85147734","https://openalex.org/W4409373551"],"abstract_inverted_index":{"The":[0,71,87],"immune":[1,42,88],"system":[2,89],"is":[3],"essential":[4],"for":[5],"maintaining":[6],"homeostasis,":[7],"and":[8,14,20,30,53,64,77,84,95,100],"its":[9],"dysfunctions":[10],"influence":[11],"the":[12,26,31,65,68,93],"onset":[13],"progression":[15],"of":[16,28,33,67,73],"infectious,":[17],"autoimmune,":[18],"oncological,":[19],"allergic":[21],"diseases,":[22],"as":[23,25,50],"well":[24],"efficacy":[27],"treatment":[29],"risk":[32],"complications.":[34],"Nutrition":[35],"plays":[36],"a":[37],"fundamental":[38],"role":[39],"in":[40],"modulating":[41],"responses,":[43],"particularly":[44],"through":[45,98],"specific":[46],"amino":[47,55,75],"acids":[48,76],"such":[49],"glutamine,":[51],"arginine,":[52],"branched-chain":[54],"acids,":[56],"which":[57],"directly":[58],"stimulate":[59],"lymphocyte":[60,78],"activation,":[61],"cytokine":[62],"production,":[63],"integrity":[66],"intestinal":[69],"barrier.":[70],"analysis":[72],"immunoactive":[74],"metabolic":[79,101],"parameters":[80],"offers":[81],"promising":[82],"diagnostic":[83],"therapeutic":[85],"tools.":[86],"interacts":[90],"dynamically":[91],"with":[92],"nervous":[94],"endocrine":[96],"systems":[97],"neuroimmune":[99],"pathways,":[102],"supporting":[103],"personalized":[104],"medical":[105],"strategies.":[106]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-02-14T00:00:00"}