{"id":"https://openalex.org/W7128738457","doi":"https://doi.org/10.1152/ajpgi.00349.2025","title":"WNT3a induces external anal sphincter fibrosis and dysfunction in rabbits","display_name":"WNT3a induces external anal sphincter fibrosis and dysfunction in rabbits","publication_year":2026,"publication_date":"2026-02-12","ids":{"openalex":"https://openalex.org/W7128738457","doi":"https://doi.org/10.1152/ajpgi.00349.2025","pmid":"https://pubmed.ncbi.nlm.nih.gov/41677453"},"language":"en","primary_location":{"id":"doi:10.1152/ajpgi.00349.2025","doi":"https://doi.org/10.1152/ajpgi.00349.2025","is_oa":true,"landing_page_url":"https://doi.org/10.1152/ajpgi.00349.2025","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1152/ajpgi.00349.2025","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5118809075","display_name":"Jagadeesh Thippeswamy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jagadeesh Thippeswamy","raw_affiliation_strings":["San Diego VA Health Care System","University of California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Diego VA Health Care System","institution_ids":["https://openalex.org/I4210099595"]},{"raw_affiliation_string":"University of California","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025442540","display_name":"Merlin Mamachan","orcid":"https://orcid.org/0009-0002-5861-1878","observed_orcids":["https://orcid.org/0009-0002-5861-1878"]},"institutions":[{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Merlin Mamachan","raw_affiliation_strings":["San Diego VA Health Care System","University of California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Diego VA Health Care System","institution_ids":["https://openalex.org/I4210099595"]},{"raw_affiliation_string":"University of California","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125686447","display_name":"Jennifer Shin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Shin","raw_affiliation_strings":["San Diego VA Health Care System"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Diego VA Health Care System","institution_ids":["https://openalex.org/I4210099595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117179403","display_name":"Sushma Halekote Rudramurthy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sushma Halekote Rudramurthy","raw_affiliation_strings":["University of Illinois Urbana-Champaign"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Illinois Urbana-Champaign","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079922220","display_name":"Manesh Kumar Panner Selvam","orcid":"https://orcid.org/0000-0002-9120-2278","observed_orcids":["https://orcid.org/0000-0002-9120-2278"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manesh Kumar Panner Selvam","raw_affiliation_strings":["Tulane University School of Medicine"],"raw_orcid":"https://orcid.org/0000-0002-9120-2278","affiliations":[{"raw_affiliation_string":"Tulane University School of Medicine","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125689889","display_name":"Mahadevan Rajasekaran","orcid":"https://orcid.org/0000-0003-4188-1628","observed_orcids":["https://orcid.org/0000-0003-4188-1628"]},"institutions":[{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahadevan Rajasekaran","raw_affiliation_strings":["San Diego VA Health Care System","University of California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Diego VA Health Care System","institution_ids":["https://openalex.org/I4210099595"]},{"raw_affiliation_string":"University of California","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5144250418","display_name":"Ravinder K. Mittal","orcid":"https://orcid.org/0000-0001-5228-9617","observed_orcids":["https://orcid.org/0000-0001-5228-9617"]},"institutions":[{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravinder K. Mittal","raw_affiliation_strings":["San Diego VA Health Care System","University of California"],"raw_orcid":"https://orcid.org/0000-0001-5228-9617","affiliations":[{"raw_affiliation_string":"San Diego VA Health Care System","institution_ids":["https://openalex.org/I4210099595"]},{"raw_affiliation_string":"University of California","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08019526,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"330","issue":"3","first_page":"G349","last_page":"G360"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.34200000762939453,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.34200000762939453,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10418","display_name":"Pelvic floor disorders treatments","score":0.1793999969959259,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.1534000039100647,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wnt3a","display_name":"Wnt3a","score":0.9449999928474426},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.8650000095367432},{"id":"https://openalex.org/keywords/external-anal-sphincter","display_name":"external anal sphincter","score":0.9890000224113464},{"id":"https://openalex.org/keywords/anal-sphincter-dysfunction","display_name":"anal sphincter dysfunction","score":0.9039999842643738},{"id":"https://openalex.org/keywords/local-injection","display_name":"local injection","score":0.6309999823570251},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.7799999713897705}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7293999791145325},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.6417999863624573},{"id":"https://openalex.org/C2777399655","wikidata":"https://www.wikidata.org/wiki/Q2379958","display_name":"External anal sphincter","level":4,"score":0.6013000011444092},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5060999989509583},{"id":"https://openalex.org/C2780035688","wikidata":"https://www.wikidata.org/wiki/Q2465231","display_name":"Anal canal","level":3,"score":0.5005000233650208},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.43630000948905945},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.42160001397132874},{"id":"https://openalex.org/C518705261","wikidata":"https://www.wikidata.org/wiki/Q25615","display_name":"Connective tissue","level":2,"score":0.41290000081062317},{"id":"https://openalex.org/C2778236600","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Immunofluorescence","level":3,"score":0.4113999903202057},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.3921999931335449},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.36719998717308044},{"id":"https://openalex.org/C2781102422","wikidata":"https://www.wikidata.org/wiki/Q2601133","display_name":"Internal anal sphincter","level":4,"score":0.34940001368522644},{"id":"https://openalex.org/C2776813522","wikidata":"https://www.wikidata.org/wiki/Q1147182","display_name":"Fecal incontinence","level":2,"score":0.34779998660087585},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3310000002384186},{"id":"https://openalex.org/C2779072444","wikidata":"https://www.wikidata.org/wiki/Q425146","display_name":"Desmin","level":4,"score":0.32330000400543213},{"id":"https://openalex.org/C88537330","wikidata":"https://www.wikidata.org/wiki/Q1424728","display_name":"Urethral sphincter","level":3,"score":0.32179999351501465},{"id":"https://openalex.org/C2777310793","wikidata":"https://www.wikidata.org/wiki/Q1725675","display_name":"Lamina propria","level":3,"score":0.3183000087738037},{"id":"https://openalex.org/C2779794767","wikidata":"https://www.wikidata.org/wiki/Q18248676","display_name":"Decorin","level":4,"score":0.3057999908924103},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.30489999055862427},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.29339998960494995},{"id":"https://openalex.org/C2779131293","wikidata":"https://www.wikidata.org/wiki/Q18048098","display_name":"WNT3A","level":4,"score":0.2824999988079071},{"id":"https://openalex.org/C2993285706","wikidata":"https://www.wikidata.org/wiki/Q4751007","display_name":"Anal sphincter","level":2,"score":0.27090001106262207},{"id":"https://openalex.org/C2778514504","wikidata":"https://www.wikidata.org/wiki/Q797559","display_name":"Muscle tissue","level":2,"score":0.27070000767707825},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.26649999618530273},{"id":"https://openalex.org/C147447768","wikidata":"https://www.wikidata.org/wiki/Q411624","display_name":"Vimentin","level":3,"score":0.266400009393692},{"id":"https://openalex.org/C2780105995","wikidata":"https://www.wikidata.org/wiki/Q232358","display_name":"Tendon","level":2,"score":0.2590999901294708},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.25}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001003","descriptor_name":"Anal Canal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001003","descriptor_name":"Anal Canal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001003","descriptor_name":"Anal Canal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001003","descriptor_name":"Anal Canal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001003","descriptor_name":"Anal Canal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001003","descriptor_name":"Anal Canal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001003","descriptor_name":"Anal Canal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001003","descriptor_name":"Anal Canal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001003","descriptor_name":"Anal Canal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001003","descriptor_name":"Anal Canal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001003","descriptor_name":"Anal Canal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001003","descriptor_name":"Anal Canal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001003","descriptor_name":"Anal Canal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001003","descriptor_name":"Anal Canal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001003","descriptor_name":"Anal Canal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001003","descriptor_name":"Anal Canal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001003","descriptor_name":"Anal Canal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001003","descriptor_name":"Anal Canal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001003","descriptor_name":"Anal Canal","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001003","descriptor_name":"Anal Canal","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001003","descriptor_name":"Anal Canal","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001003","descriptor_name":"Anal Canal","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001003","descriptor_name":"Anal Canal","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001003","descriptor_name":"Anal Canal","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001003","descriptor_name":"Anal Canal","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D060508","descriptor_name":"Wnt3 Protein","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D060508","descriptor_name":"Wnt3 Protein","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D060508","descriptor_name":"Wnt3 Protein","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D060509","descriptor_name":"Wnt3A Protein","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D060509","descriptor_name":"Wnt3A Protein","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D060509","descriptor_name":"Wnt3A Protein","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D060509","descriptor_name":"Wnt3A Protein","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajpgi.00349.2025","doi":"https://doi.org/10.1152/ajpgi.00349.2025","is_oa":true,"landing_page_url":"https://doi.org/10.1152/ajpgi.00349.2025","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},{"id":"pmid:41677453","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41677453","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Gastrointestinal and liver physiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13023414","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13023414/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13023414/pdf/nihms-2150722.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Am J Physiol Gastrointest Liver Physiol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1152/ajpgi.00349.2025","doi":"https://doi.org/10.1152/ajpgi.00349.2025","is_oa":true,"landing_page_url":"https://doi.org/10.1152/ajpgi.00349.2025","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.6124774813652039,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G693698866","display_name":null,"funder_award_id":"5IO1BX006370","funder_id":"https://openalex.org/F4320332757","funder_display_name":"Veterans Affairs San Diego Healthcare System"}],"funders":[{"id":"https://openalex.org/F4320332603","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48"},{"id":"https://openalex.org/F4320332757","display_name":"Veterans Affairs San Diego Healthcare System","ror":"https://ror.org/00znqwq11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W1599405881","https://openalex.org/W1895601060","https://openalex.org/W1909516796","https://openalex.org/W1914659192","https://openalex.org/W1965727304","https://openalex.org/W1987483436","https://openalex.org/W1993600822","https://openalex.org/W1994928797","https://openalex.org/W1998417945","https://openalex.org/W2000870077","https://openalex.org/W2003123091","https://openalex.org/W2010199370","https://openalex.org/W2028385156","https://openalex.org/W2039378503","https://openalex.org/W2039510005","https://openalex.org/W2045142779","https://openalex.org/W2051437976","https://openalex.org/W2057281874","https://openalex.org/W2063457741","https://openalex.org/W2064590658","https://openalex.org/W2064600258","https://openalex.org/W2065056367","https://openalex.org/W2068483959","https://openalex.org/W2074663067","https://openalex.org/W2079019573","https://openalex.org/W2080347068","https://openalex.org/W2080778311","https://openalex.org/W2102018988","https://openalex.org/W2112119237","https://openalex.org/W2124153237","https://openalex.org/W2124841074","https://openalex.org/W2133208956","https://openalex.org/W2133485412","https://openalex.org/W2145280913","https://openalex.org/W2148558651","https://openalex.org/W2153217835","https://openalex.org/W2155061406","https://openalex.org/W2158021558","https://openalex.org/W2158025124","https://openalex.org/W2163170981","https://openalex.org/W2169453638","https://openalex.org/W2276707926","https://openalex.org/W2325413783","https://openalex.org/W2332840599","https://openalex.org/W2344324270","https://openalex.org/W2402253336","https://openalex.org/W2403112374","https://openalex.org/W2410344578","https://openalex.org/W2439973029","https://openalex.org/W2472899497","https://openalex.org/W2592331564","https://openalex.org/W2601343417","https://openalex.org/W2606605021","https://openalex.org/W2745317455","https://openalex.org/W2766378797","https://openalex.org/W2766965802","https://openalex.org/W2794059153","https://openalex.org/W2885074747","https://openalex.org/W2898290288","https://openalex.org/W2945866401","https://openalex.org/W3003440392","https://openalex.org/W3026647502","https://openalex.org/W3080482452","https://openalex.org/W3124246878","https://openalex.org/W3199998437","https://openalex.org/W4221127182","https://openalex.org/W4386527281","https://openalex.org/W4388774816","https://openalex.org/W4402338923"],"related_works":[],"abstract_inverted_index":{"In":[0],"the":[1,5,10,20,31,52,61],"current":[2],"study,":[3],"for":[4],"first":[6],"time":[7],"we":[8],"investigated":[9],"effects":[11],"of":[12,16,19,33,47],"a":[13],"local":[14],"injection":[15,39],"Wnt3a-an":[17],"agonist":[18],"WNT":[21,35],"signaling":[22,36,54],"pathway-on":[23],"EAS":[24,43],"function,":[25],"muscle":[26,48],"replacement":[27,46],"by":[28],"fibrosis,":[29],"and":[30,45],"activation":[32],"downstream":[34,53],"pathways.":[37],"Wnt3a":[38,62],"resulted":[40],"in":[41],"impaired":[42],"function":[44],"with":[49],"fibrosis.":[50],"Notably,":[51],"remained":[55],"active":[56],"even":[57],"8":[58],"wk":[59],"after":[60],"injection.":[63]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2026-02-13T00:00:00"}