{"id":"https://openalex.org/W7128733360","doi":"https://doi.org/10.7554/elife.94514.3","title":"Sperm motility in mice with oligo-astheno-teratozoospermia restored by in vivo injection and electroporation of naked mRNA","display_name":"Sperm motility in mice with oligo-astheno-teratozoospermia restored by in vivo injection and electroporation of naked mRNA","publication_year":2026,"publication_date":"2026-02-12","ids":{"openalex":"https://openalex.org/W7128733360","doi":"https://doi.org/10.7554/elife.94514.3"},"language":"en","primary_location":{"id":"doi:10.7554/elife.94514.3","doi":"https://doi.org/10.7554/elife.94514.3","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.94514.3","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.94514.3","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045899899","display_name":"Charline Vilpreux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210160510","display_name":"Institut pour l'avanc\u00e9e des biosciences","ror":"https://ror.org/05kwbf598","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I4210128919","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210160510","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Charline Vilpreux","raw_affiliation_strings":["Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210160510","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114551565","display_name":"Paul Fourquin","orcid":"https://orcid.org/0009-0001-2561-3837","observed_orcids":["https://orcid.org/0009-0001-2561-3837"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210160510","display_name":"Institut pour l'avanc\u00e9e des biosciences","ror":"https://ror.org/05kwbf598","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I4210128919","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210160510","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Paul Fourquin","raw_affiliation_strings":["Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences"],"raw_orcid":"https://orcid.org/0009-0001-2561-3837","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210160510","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036547398","display_name":"Guillaume Martinez","orcid":"https://orcid.org/0000-0002-7572-9096","observed_orcids":["https://orcid.org/0000-0002-7572-9096"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210091189","display_name":"H\u00f4pital Couple Enfant","ror":"https://ror.org/00dxw4v18","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I2800555055","https://openalex.org/I4210091189"]},{"id":"https://openalex.org/I4210160510","display_name":"Institut pour l'avanc\u00e9e des biosciences","ror":"https://ror.org/05kwbf598","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I4210128919","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210160510","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Guillaume Martinez","raw_affiliation_strings":["UM de G\u00e9n\u00e9tique Chromosomique, H\u00f4pital Couple-Enfant, CHU Grenoble Alpes","Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences"],"raw_orcid":"https://orcid.org/0000-0002-7572-9096","affiliations":[{"raw_affiliation_string":"UM de G\u00e9n\u00e9tique Chromosomique, H\u00f4pital Couple-Enfant, CHU Grenoble Alpes","institution_ids":["https://openalex.org/I4210091189"]},{"raw_affiliation_string":"Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210160510","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011694011","display_name":"Magali Court","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210160510","display_name":"Institut pour l'avanc\u00e9e des biosciences","ror":"https://ror.org/05kwbf598","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I4210128919","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210160510","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Magali Court","raw_affiliation_strings":["Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210160510","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068489758","display_name":"Florence Appaix","orcid":"https://orcid.org/0000-0002-0278-0675","observed_orcids":["https://orcid.org/0000-0002-0278-0675"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210160510","display_name":"Institut pour l'avanc\u00e9e des biosciences","ror":"https://ror.org/05kwbf598","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I4210128919","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210160510","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Florence Appaix","raw_affiliation_strings":["University Grenoble Alpes, INSERM U1209, CNRS UMR5309, Optical microscopy and cell imaging (MicroCell) facility, Institute for Advanced Biosciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Grenoble Alpes, INSERM U1209, CNRS UMR5309, Optical microscopy and cell imaging (MicroCell) facility, Institute for Advanced Biosciences","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210160510","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011042715","display_name":"Jean-Luc Duteyrat","orcid":"https://orcid.org/0000-0002-7126-8798","observed_orcids":["https://orcid.org/0000-0002-7126-8798"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405253049","display_name":"Structure F\u00e9d\u00e9rative de Recherche Biosciences","ror":"https://ror.org/008e8k888","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4405253049"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Luc Duteyrat","raw_affiliation_strings":["Universit\u00e9 Claude Bernard Lyon 1, CNRS UAR3444, Inserm US8, ENS de Lyon, SFR Biosciences"],"raw_orcid":"https://orcid.org/0000-0002-7126-8798","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Claude Bernard Lyon 1, CNRS UAR3444, Inserm US8, ENS de Lyon, SFR Biosciences","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4405253049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011278252","display_name":"Maxime Henry","orcid":"https://orcid.org/0000-0002-8009-3205","observed_orcids":["https://orcid.org/0000-0002-8009-3205"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210160510","display_name":"Institut pour l'avanc\u00e9e des biosciences","ror":"https://ror.org/05kwbf598","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I4210128919","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210160510","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Maxime Henry","raw_affiliation_strings":["Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, plateforme Optimal, Institute for Advanced Biosciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, plateforme Optimal, Institute for Advanced Biosciences","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210160510","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052495432","display_name":"Julien Vollaire","orcid":"https://orcid.org/0000-0001-7001-4190","observed_orcids":["https://orcid.org/0000-0001-7001-4190"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210160510","display_name":"Institut pour l'avanc\u00e9e des biosciences","ror":"https://ror.org/05kwbf598","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I4210128919","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210160510","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Julien Vollaire","raw_affiliation_strings":["Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, plateforme Optimal, Institute for Advanced Biosciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, plateforme Optimal, Institute for Advanced Biosciences","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210160510","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078376336","display_name":"Camille Ayad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210087293","display_name":"Institut de Biologie et de Chimie des Prot\u00e9ines","ror":"https://ror.org/0019x5d05","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I4210087293","https://openalex.org/I4210096427"]},{"id":"https://openalex.org/I4210156542","display_name":"Laboratoire de Biologie Tissulaire et d'Ing\u00e9nierie Th\u00e9rapeutique","ror":"https://ror.org/04fqvqs63","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I4210096427","https://openalex.org/I4210156542"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Camille Ayad","raw_affiliation_strings":["Universit\u00e9 Claude Bernard Lyon 1 - Laboratoire de Biologie Tissulaire et d\u2019Ing\u00e9nierie Th\u00e9rapeutique, UMR 5305, Universit\u00e9 Lyon 1, CNRS, IBCP"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Claude Bernard Lyon 1 - Laboratoire de Biologie Tissulaire et d\u2019Ing\u00e9nierie Th\u00e9rapeutique, UMR 5305, Universit\u00e9 Lyon 1, CNRS, IBCP","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I4210087293","https://openalex.org/I4210156542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062472837","display_name":"Altan Yavuz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210087293","display_name":"Institut de Biologie et de Chimie des Prot\u00e9ines","ror":"https://ror.org/0019x5d05","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I4210087293","https://openalex.org/I4210096427"]},{"id":"https://openalex.org/I4210156542","display_name":"Laboratoire de Biologie Tissulaire et d'Ing\u00e9nierie Th\u00e9rapeutique","ror":"https://ror.org/04fqvqs63","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I4210096427","https://openalex.org/I4210156542"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Altan Yavuz","raw_affiliation_strings":["Universit\u00e9 Claude Bernard Lyon 1 - Laboratoire de Biologie Tissulaire et d\u2019Ing\u00e9nierie Th\u00e9rapeutique, UMR 5305, Universit\u00e9 Lyon 1, CNRS, IBCP"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Claude Bernard Lyon 1 - Laboratoire de Biologie Tissulaire et d\u2019Ing\u00e9nierie Th\u00e9rapeutique, UMR 5305, Universit\u00e9 Lyon 1, CNRS, IBCP","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I4210087293","https://openalex.org/I4210156542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108140010","display_name":"Genevi\u00e8ve Chevalier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210160510","display_name":"Institut pour l'avanc\u00e9e des biosciences","ror":"https://ror.org/05kwbf598","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I4210128919","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210160510","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Genevi\u00e8ve Chevalier","raw_affiliation_strings":["Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210160510","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071368118","display_name":"Lisa De Macedo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210160510","display_name":"Institut pour l'avanc\u00e9e des biosciences","ror":"https://ror.org/05kwbf598","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I4210128919","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210160510","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lisa De Macedo","raw_affiliation_strings":["Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210160510","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146702468","display_name":"Sofia Andrade Rebelo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210160510","display_name":"Institut pour l'avanc\u00e9e des biosciences","ror":"https://ror.org/05kwbf598","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I4210128919","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210160510","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sofia Andrade Rebelo","raw_affiliation_strings":["Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210160510","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021703311","display_name":"Edgar Del Llano","orcid":"https://orcid.org/0000-0001-8585-1581","observed_orcids":["https://orcid.org/0000-0001-8585-1581"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210160510","display_name":"Institut pour l'avanc\u00e9e des biosciences","ror":"https://ror.org/05kwbf598","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I4210128919","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210160510","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Edgar Del Llano","raw_affiliation_strings":["Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences"],"raw_orcid":"https://orcid.org/0000-0001-8585-1581","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210160510","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099990609","display_name":"C\u00e9lia Tebbakh","orcid":"https://orcid.org/0009-0008-0026-9479","observed_orcids":["https://orcid.org/0009-0008-0026-9479"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210091189","display_name":"H\u00f4pital Couple Enfant","ror":"https://ror.org/00dxw4v18","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I2800555055","https://openalex.org/I4210091189"]},{"id":"https://openalex.org/I4210160510","display_name":"Institut pour l'avanc\u00e9e des biosciences","ror":"https://ror.org/05kwbf598","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I4210128919","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210160510","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C\u00e9lia Tebbakh","raw_affiliation_strings":["UM de G\u00e9n\u00e9tique Chromosomique, H\u00f4pital Couple-Enfant, CHU Grenoble Alpes","Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UM de G\u00e9n\u00e9tique Chromosomique, H\u00f4pital Couple-Enfant, CHU Grenoble Alpes","institution_ids":["https://openalex.org/I4210091189"]},{"raw_affiliation_string":"Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210160510","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069757119","display_name":"Zine\u2010Eddine Kherraf","orcid":"https://orcid.org/0000-0003-0351-6689","observed_orcids":["https://orcid.org/0000-0003-0351-6689"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210091189","display_name":"H\u00f4pital Couple Enfant","ror":"https://ror.org/00dxw4v18","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I2800555055","https://openalex.org/I4210091189"]},{"id":"https://openalex.org/I4210160510","display_name":"Institut pour l'avanc\u00e9e des biosciences","ror":"https://ror.org/05kwbf598","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I4210128919","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210160510","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Zine-Eddine Kherraf","raw_affiliation_strings":["UM de G\u00e9n\u00e9tique Chromosomique, H\u00f4pital Couple-Enfant, CHU Grenoble Alpes","Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UM de G\u00e9n\u00e9tique Chromosomique, H\u00f4pital Couple-Enfant, CHU Grenoble Alpes","institution_ids":["https://openalex.org/I4210091189"]},{"raw_affiliation_string":"Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210160510","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081084146","display_name":"Emeline Lambert","orcid":"https://orcid.org/0009-0005-6909-5831","observed_orcids":["https://orcid.org/0009-0005-6909-5831"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210160510","display_name":"Institut pour l'avanc\u00e9e des biosciences","ror":"https://ror.org/05kwbf598","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I4210128919","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210160510","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Emeline Lambert","raw_affiliation_strings":["Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210160510","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113129256","display_name":"Sekou Ahmed Conte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210160510","display_name":"Institut pour l'avanc\u00e9e des biosciences","ror":"https://ror.org/05kwbf598","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I4210128919","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210160510","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sekou Ahmed Conte","raw_affiliation_strings":["Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210160510","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013993651","display_name":"Zeina Wehbe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210091189","display_name":"H\u00f4pital Couple Enfant","ror":"https://ror.org/00dxw4v18","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I2800555055","https://openalex.org/I4210091189"]},{"id":"https://openalex.org/I4210160510","display_name":"Institut pour l'avanc\u00e9e des biosciences","ror":"https://ror.org/05kwbf598","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I4210128919","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210160510","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Zeina Wehbe","raw_affiliation_strings":["UM de G\u00e9n\u00e9tique Chromosomique, H\u00f4pital Couple-Enfant, CHU Grenoble Alpes","Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UM de G\u00e9n\u00e9tique Chromosomique, H\u00f4pital Couple-Enfant, CHU Grenoble Alpes","institution_ids":["https://openalex.org/I4210091189"]},{"raw_affiliation_string":"Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210160510","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025829932","display_name":"Elsa Giordani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210160510","display_name":"Institut pour l'avanc\u00e9e des biosciences","ror":"https://ror.org/05kwbf598","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I4210128919","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210160510","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Elsa Giordani","raw_affiliation_strings":["Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210160510","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072017923","display_name":"V\u00e9ronique Josserand","orcid":"https://orcid.org/0000-0001-6733-3801","observed_orcids":["https://orcid.org/0000-0001-6733-3801"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210160510","display_name":"Institut pour l'avanc\u00e9e des biosciences","ror":"https://ror.org/05kwbf598","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I4210128919","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210160510","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"V\u00e9ronique Josserand","raw_affiliation_strings":["Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, plateforme Optimal, Institute for Advanced Biosciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, plateforme Optimal, Institute for Advanced Biosciences","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210160510","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024885373","display_name":"Jacques S. Brocard","orcid":"https://orcid.org/0000-0002-0752-5737","observed_orcids":["https://orcid.org/0000-0002-0752-5737"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405253049","display_name":"Structure F\u00e9d\u00e9rative de Recherche Biosciences","ror":"https://ror.org/008e8k888","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4405253049"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jacques Brocard","raw_affiliation_strings":["Universit\u00e9 Claude Bernard Lyon 1, CNRS UAR3444, Inserm US8, ENS de Lyon, SFR Biosciences"],"raw_orcid":"https://orcid.org/0000-0002-0752-5737","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Claude Bernard Lyon 1, CNRS UAR3444, Inserm US8, ENS de Lyon, SFR Biosciences","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4405253049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042241430","display_name":"Charles Coutton","orcid":"https://orcid.org/0000-0002-8873-8098","observed_orcids":["https://orcid.org/0000-0002-8873-8098"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210091189","display_name":"H\u00f4pital Couple Enfant","ror":"https://ror.org/00dxw4v18","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I2800555055","https://openalex.org/I4210091189"]},{"id":"https://openalex.org/I4210160510","display_name":"Institut pour l'avanc\u00e9e des biosciences","ror":"https://ror.org/05kwbf598","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I4210128919","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210160510","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Coutton Charles","raw_affiliation_strings":["UM de G\u00e9n\u00e9tique Chromosomique, H\u00f4pital Couple-Enfant, CHU Grenoble Alpes","Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences"],"raw_orcid":"https://orcid.org/0000-0002-8873-8098","affiliations":[{"raw_affiliation_string":"UM de G\u00e9n\u00e9tique Chromosomique, H\u00f4pital Couple-Enfant, CHU Grenoble Alpes","institution_ids":["https://openalex.org/I4210091189"]},{"raw_affiliation_string":"Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210160510","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064631913","display_name":"Bernard Verrier","orcid":"https://orcid.org/0000-0002-8478-7095","observed_orcids":["https://orcid.org/0000-0002-8478-7095"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210087293","display_name":"Institut de Biologie et de Chimie des Prot\u00e9ines","ror":"https://ror.org/0019x5d05","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I4210087293","https://openalex.org/I4210096427"]},{"id":"https://openalex.org/I4210156542","display_name":"Laboratoire de Biologie Tissulaire et d'Ing\u00e9nierie Th\u00e9rapeutique","ror":"https://ror.org/04fqvqs63","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I4210096427","https://openalex.org/I4210156542"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bernard Verrier","raw_affiliation_strings":["Universit\u00e9 Claude Bernard Lyon 1 - Laboratoire de Biologie Tissulaire et d\u2019Ing\u00e9nierie Th\u00e9rapeutique, UMR 5305, Universit\u00e9 Lyon 1, CNRS, IBCP"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Claude Bernard Lyon 1 - Laboratoire de Biologie Tissulaire et d\u2019Ing\u00e9nierie Th\u00e9rapeutique, UMR 5305, Universit\u00e9 Lyon 1, CNRS, IBCP","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I4210087293","https://openalex.org/I4210156542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001457323","display_name":"Pierre F. Ray","orcid":"https://orcid.org/0000-0003-1544-7449","observed_orcids":["https://orcid.org/0000-0003-1544-7449"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2800555055","display_name":"Centre Hospitalier Universitaire de Grenoble","ror":"https://ror.org/041rhpw39","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I2800555055"]},{"id":"https://openalex.org/I4210160510","display_name":"Institut pour l'avanc\u00e9e des biosciences","ror":"https://ror.org/05kwbf598","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I4210128919","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210160510","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre F Ray","raw_affiliation_strings":["UM GI-DPI, CHU Grenoble Alpes","Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences"],"raw_orcid":"https://orcid.org/0000-0003-1544-7449","affiliations":[{"raw_affiliation_string":"UM GI-DPI, CHU Grenoble Alpes","institution_ids":["https://openalex.org/I2800555055","https://openalex.org/I899635006"]},{"raw_affiliation_string":"Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210160510","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089610922","display_name":"Corinne Loeuillet","orcid":"https://orcid.org/0000-0001-6474-4453","observed_orcids":["https://orcid.org/0000-0001-6474-4453"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210160510","display_name":"Institut pour l'avanc\u00e9e des biosciences","ror":"https://ror.org/05kwbf598","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I4210128919","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210160510","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Corinne Loeuillet","raw_affiliation_strings":["Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210160510","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064642133","display_name":"Christophe Arnoult","orcid":"https://orcid.org/0000-0002-3753-5901","observed_orcids":["https://orcid.org/0000-0002-3753-5901","https://orcid.org/0000-0003-3255-5214"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210160510","display_name":"Institut pour l'avanc\u00e9e des biosciences","ror":"https://ror.org/05kwbf598","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I4210128919","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210160510","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christophe Arnoult","raw_affiliation_strings":["Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences"],"raw_orcid":"https://orcid.org/0000-0002-3753-5901","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210160510","https://openalex.org/I899635006"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075089476","display_name":"Jessica Escoffier","orcid":"https://orcid.org/0000-0001-8166-5845","observed_orcids":["https://orcid.org/0000-0001-8166-5845"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210160510","display_name":"Institut pour l'avanc\u00e9e des biosciences","ror":"https://ror.org/05kwbf598","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I4210128919","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210160510","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jessica Escoffier","raw_affiliation_strings":["Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences"],"raw_orcid":"https://orcid.org/0000-0001-8166-5845","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team Genetic, Epigenetic and Therapies of infertility, Institute for Advanced Biosciences","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210160510","https://openalex.org/I899635006"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.5541999936103821,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.5541999936103821,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.3529999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.07599999755620956,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/male-infertility","display_name":"male infertility","score":0.7940000295639038},{"id":"https://openalex.org/keywords/sperm-motility","display_name":"sperm motility","score":0.8949999809265137},{"id":"https://openalex.org/keywords/mrna-electroporation","display_name":"mRNA electroporation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/spermatogenesis","display_name":"spermatogenesis","score":0.7390000224113464},{"id":"https://openalex.org/keywords/in-vitro-fertilization","display_name":"in vitro fertilization","score":0.3790000081062317},{"id":"https://openalex.org/keywords/intracytoplasmic-sperm-injection","display_name":"intracytoplasmic sperm injection","score":0.8140000104904175},{"id":"https://openalex.org/keywords/fertility-restoration","display_name":"fertility restoration","score":0.4180000126361847},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.3109999895095825}],"concepts":[{"id":"https://openalex.org/C186852380","wikidata":"https://www.wikidata.org/wiki/Q1142521","display_name":"Electroporation","level":3,"score":0.8098000288009644},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7117999792098999},{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.6620000004768372},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6172999739646912},{"id":"https://openalex.org/C2777632594","wikidata":"https://www.wikidata.org/wiki/Q27116486","display_name":"Sperm motility","level":3,"score":0.5963000059127808},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.5906999707221985},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.5514000058174133},{"id":"https://openalex.org/C123765429","wikidata":"https://www.wikidata.org/wiki/Q36961","display_name":"Spermatogenesis","level":2,"score":0.5285999774932861},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.4871000051498413},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.48559999465942383},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.44429999589920044},{"id":"https://openalex.org/C2777338322","wikidata":"https://www.wikidata.org/wiki/Q280156","display_name":"Male infertility","level":4,"score":0.4413999915122986},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4404999911785126},{"id":"https://openalex.org/C2778278907","wikidata":"https://www.wikidata.org/wiki/Q28700","display_name":"Intracytoplasmic sperm injection","level":4,"score":0.36660000681877136},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33169999718666077},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3305000066757202},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.32600000500679016},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.2500999867916107}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.7554/elife.94514.3","doi":"https://doi.org/10.7554/elife.94514.3","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.94514.3","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.7554/elife.94514.3","doi":"https://doi.org/10.7554/elife.94514.3","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.94514.3","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G381665449","display_name":null,"funder_award_id":"ANR\u201010_INBS\u201004","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G3891843390","display_name":null,"funder_award_id":"ECO202006011669","funder_id":"https://openalex.org/F4320321589","funder_display_name":"Fondation pour la Recherche M\u00e9dicale"},{"id":"https://openalex.org/G4711226058","display_name":"Restoration of a functional spermatogenesis in infertile mice by in vivo therapy.","funder_award_id":"ANR-20-CE18-0007","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320321589","display_name":"Fondation pour la Recherche M\u00e9dicale","ror":"https://ror.org/04w6kn183"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1973687790","https://openalex.org/W1977955083","https://openalex.org/W1992578490","https://openalex.org/W1996182513","https://openalex.org/W1996671888","https://openalex.org/W2012820889","https://openalex.org/W2013321787","https://openalex.org/W2018682662","https://openalex.org/W2020721543","https://openalex.org/W2023363789","https://openalex.org/W2039354851","https://openalex.org/W2050578621","https://openalex.org/W2052548422","https://openalex.org/W2058647478","https://openalex.org/W2066312343","https://openalex.org/W2078968652","https://openalex.org/W2095950646","https://openalex.org/W2097044563","https://openalex.org/W2097939257","https://openalex.org/W2103759659","https://openalex.org/W2124608202","https://openalex.org/W2126503856","https://openalex.org/W2127619452","https://openalex.org/W2167279371","https://openalex.org/W2177607972","https://openalex.org/W2274492987","https://openalex.org/W2297953774","https://openalex.org/W2340179598","https://openalex.org/W2561575207","https://openalex.org/W2741302213","https://openalex.org/W2769907781","https://openalex.org/W2782708334","https://openalex.org/W2885277203","https://openalex.org/W2900354600","https://openalex.org/W2905714288","https://openalex.org/W2914909947","https://openalex.org/W2940525406","https://openalex.org/W3028173135","https://openalex.org/W3031814626","https://openalex.org/W3093949211","https://openalex.org/W3119364115","https://openalex.org/W3148255637","https://openalex.org/W3155194971","https://openalex.org/W3204927686","https://openalex.org/W4207032181","https://openalex.org/W4229029512","https://openalex.org/W4234730888","https://openalex.org/W4285391574","https://openalex.org/W4285801246","https://openalex.org/W4308741812","https://openalex.org/W4319334267","https://openalex.org/W4392564463","https://openalex.org/W4401502292"],"related_works":["https://openalex.org/W4407233529","https://openalex.org/W7133961206","https://openalex.org/W4415123204","https://openalex.org/W4308741812","https://openalex.org/W7169759172","https://openalex.org/W7128598802","https://openalex.org/W7167099661","https://openalex.org/W7221546829","https://openalex.org/W2914909947","https://openalex.org/W4415623523"],"abstract_inverted_index":{"Oligo-astheno-teratozoospermia":[0],"(OAT),":[1],"a":[2,16,30,42,47,60,67,91,108,178,253],"recurent":[3],"cause":[4],"of":[5,13,44,93,99,130,164,198,204,214,262],"male":[6,263,270],"infertility,":[7],"is":[8,55,64,105],"the":[9,26,125,128,162,202,212,220,238],"most":[10],"frequent":[11],"disorder":[12],"spermatogenesis":[14],"with":[15,66,174,177],"probable":[17],"genetic":[18],"cause.":[19],"Patients":[20],"and":[21,34,41,97,101,124,127,137,141,188,196,209,216,232,248,265],"mice":[22],"bearing":[23],"mutations":[24],"in":[25,70,73,94,114,135,138,158,191,219],"ARMC2":[27],"gene":[28],"have":[29],"decreased":[31],"sperm":[32,36,52,218,224,246],"concentration,":[33],"individual":[35],"show":[37,146,211],"multiple":[38],"morphological":[39],"defects":[40,72],"lack":[43],"motility":[45,247],"\u2013":[46],"canonical":[48],"OAT":[49],"phenotype.":[50],"Intracytoplasmic":[51],"injection":[53,96,195],"(ICSI)":[54],"required":[56],"to":[57,75,87,110,155,167,227,258],"treat":[58,111,168],"such":[59],"condition":[61],"but":[62],"it":[63],"associated":[65],"small":[68],"increase":[69],"birth":[71],"comparison":[74],"pregnancies":[76],"not":[77],"involving":[78],"assisted":[79],"conception.":[80],"Consequently,":[81,194],"new":[82,267],"targeted":[83],"treatments":[84],"are":[85,122,132,151],"needed":[86],"restore":[88,245],"fertility.":[89],"Here,":[90],"combination":[92],"vivo":[95,136],"electroporation":[98,197,243],"capped":[100],"poly-A-tailed":[102],"naked":[103,199],"mRNA":[104,165,242],"tested":[106,123],"as":[107],"strategy":[109],"ARMC2-related":[112],"infertility":[113,264,271],"mouse.":[115],"mRNAs":[116],"coding":[117],"for":[118,153,237,255,269],"several":[119],"reporter":[120,149],"genes":[121],"efficiency":[126],"kinetic":[129],"expression":[131,190],"assessed":[133],"using":[134],"vitro":[139],"2D":[140],"3D":[142],"imaging":[143],"experiments.":[144],"We":[145,170],"that":[147,241],"mRNA-coded":[148],"proteins":[150],"detected":[152],"up":[154],"3":[156],"weeks":[157],"germ":[159],"cells,":[160],"making":[161],"use":[163],"possible":[166],"infertility.":[169],"compare":[171],"these":[172],"results":[173],"those":[175],"obtained":[176],"non-integrative":[179],"plasmid":[180],"Enhanced":[181],"Episomal":[182],"Vector":[183],"(EEV),":[184],"which":[185],"induces":[186],"low":[187],"transient":[189],"spermatogenic":[192],"cells.":[193],"mRNA-Armc2":[200],"into":[201],"testes":[203],"Armc2-deficient":[205],"males":[206],"were":[207,225],"performed":[208],"we":[210],"presence":[213],"normal":[215],"motile":[217,223],"epididymis.":[221],"These":[222],"able":[226],"produce":[228],"embryos":[229],"by":[230],"IVF":[231],"ICSI.":[233],"This":[234],"study":[235],"demonstrates,":[236],"first":[239],"time,":[240],"can":[244],"partially":[249],"fertilizing":[250],"ability,":[251],"providing":[252],"proof-of-concept":[254],"mRNA-based":[256],"strategies":[257],"correct":[259],"monogenic":[260],"causes":[261],"opening":[266],"avenues":[268],"treatment.":[272]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-02-13T00:00:00"}