{"id":"https://openalex.org/W7128730786","doi":"https://doi.org/10.3324/haematol.2025.288286","title":"High-cholesterol diet fuels myeloma progression, dysregulates adipokine expression in vivo, and impairs treatment response ex vivo","display_name":"High-cholesterol diet fuels myeloma progression, dysregulates adipokine expression in vivo, and impairs treatment response ex vivo","publication_year":2026,"publication_date":"2026-02-12","ids":{"openalex":"https://openalex.org/W7128730786","doi":"https://doi.org/10.3324/haematol.2025.288286","pmid":"https://pubmed.ncbi.nlm.nih.gov/41676897"},"language":"en","primary_location":{"id":"doi:10.3324/haematol.2025.288286","doi":"https://doi.org/10.3324/haematol.2025.288286","is_oa":true,"landing_page_url":"https://doi.org/10.3324/haematol.2025.288286","pdf_url":null,"source":{"id":"https://openalex.org/S2752781272","display_name":"Haematologica","issn_l":"0390-6078","issn":["0390-6078","1592-8721"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310317774","host_organization_name":"Ferrata Storti Foundation","host_organization_lineage":["https://openalex.org/P4310317774"],"host_organization_lineage_names":["Ferrata Storti Foundation"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3324/haematol.2025.288286","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112282196","display_name":"Beatriz G\u00e1mez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Beatriz G\u00e1mez","raw_affiliation_strings":["Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK; Oxford Translational Myeloma Centre, University of Oxford, Oxford"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK; Oxford Translational Myeloma Centre, University of Oxford, Oxford","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015888147","display_name":"Danielle Whipp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Danielle J. Whipp","raw_affiliation_strings":["Nuffield Department of Surgical Sciences, University of Oxford, Oxford"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Surgical Sciences, University of Oxford, Oxford","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050706438","display_name":"Srinivasa R. Rao","orcid":"https://orcid.org/0000-0003-1889-6530","observed_orcids":["https://orcid.org/0000-0003-1889-6530"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Srinivasa R. Rao","raw_affiliation_strings":["Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK; Oxford Translational Myeloma Centre, University of Oxford, Oxford"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK; Oxford Translational Myeloma Centre, University of Oxford, Oxford","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034982360","display_name":"Emma V. Morris","orcid":"https://orcid.org/0000-0003-1230-2586","observed_orcids":["https://orcid.org/0000-0003-1230-2586"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Emma V. Morris","raw_affiliation_strings":["Nuffield Department of Surgical Sciences, University of Oxford, Oxford"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Surgical Sciences, University of Oxford, Oxford","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125691735","display_name":"Young Eun Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Young Eun Park","raw_affiliation_strings":["Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK; Oxford Translational Myeloma Centre, University of Oxford, Oxford"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK; Oxford Translational Myeloma Centre, University of Oxford, Oxford","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007653648","display_name":"Zeynep Kaya","orcid":"https://orcid.org/0000-0002-5626-262X","observed_orcids":["https://orcid.org/0000-0002-5626-262X"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Zeynep Kaya","raw_affiliation_strings":["Nuffield Department of Surgical Sciences, University of Oxford, Oxford"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Surgical Sciences, University of Oxford, Oxford","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018583564","display_name":"Claire M. Edwards","orcid":"https://orcid.org/0000-0002-1257-5659","observed_orcids":["https://orcid.org/0000-0002-1257-5659"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Claire M. Edwards","raw_affiliation_strings":["Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK; Oxford Translational Myeloma Centre, University of Oxford, Oxford, UK; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford. claire.edwards@ndorms.ox.ac.uk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK; Oxford Translational Myeloma Centre, University of Oxford, Oxford, UK; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford. claire.edwards@ndorms.ox.ac.uk","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I40120149"],"apc_list":{"value":2000,"currency":"EUR","value_usd":2157},"apc_paid":{"value":2000,"currency":"EUR","value_usd":2157},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10240663,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"111","issue":"8","first_page":"2750","last_page":"2756"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-cholesterol-diet","display_name":"high-cholesterol diet","score":0.9279999732971191},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9229999780654907},{"id":"https://openalex.org/keywords/myeloma-progression","display_name":"myeloma progression","score":0.9390000104904175},{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.968999981880188},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.8190000057220459},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.5490000247955322},{"id":"https://openalex.org/keywords/diet-and-cancer","display_name":"diet and cancer","score":0.4869999885559082}],"concepts":[{"id":"https://openalex.org/C194832188","wikidata":"https://www.wikidata.org/wiki/Q2638593","display_name":"Adipokine","level":4,"score":0.8471999764442444},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5913000106811523},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5662999749183655},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5649999976158142},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.5123999714851379},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.35440000891685486},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.31029999256134033},{"id":"https://openalex.org/C2776782570","wikidata":"https://www.wikidata.org/wiki/Q357439","display_name":"Adiponectin","level":4,"score":0.3073999881744385},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.30399999022483826},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3027999997138977},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2971000075340271},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.2865000069141388}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3324/haematol.2025.288286","doi":"https://doi.org/10.3324/haematol.2025.288286","is_oa":true,"landing_page_url":"https://doi.org/10.3324/haematol.2025.288286","pdf_url":null,"source":{"id":"https://openalex.org/S2752781272","display_name":"Haematologica","issn_l":"0390-6078","issn":["0390-6078","1592-8721"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310317774","host_organization_name":"Ferrata Storti Foundation","host_organization_lineage":["https://openalex.org/P4310317774"],"host_organization_lineage_names":["Ferrata Storti Foundation"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"journal-article"},{"id":"pmid:41676897","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41676897","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13482217","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13482217/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13482217/pdf/1112750.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Haematologica","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:ca11abf9184b42ee85712d81c0666b93","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ca11abf9184b42ee85712d81c0666b93","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Haematologica, Vol 999, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3324/haematol.2025.288286","doi":"https://doi.org/10.3324/haematol.2025.288286","is_oa":true,"landing_page_url":"https://doi.org/10.3324/haematol.2025.288286","pdf_url":null,"source":{"id":"https://openalex.org/S2752781272","display_name":"Haematologica","issn_l":"0390-6078","issn":["0390-6078","1592-8721"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310317774","host_organization_name":"Ferrata Storti Foundation","host_organization_lineage":["https://openalex.org/P4310317774"],"host_organization_lineage_names":["Ferrata Storti Foundation"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.4312458038330078,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2434519682","display_name":null,"funder_award_id":"20004","funder_id":"https://openalex.org/F4320329013","funder_display_name":"Blood Cancer UK"},{"id":"https://openalex.org/G3906557818","display_name":null,"funder_award_id":"15026","funder_id":"https://openalex.org/F4320329013","funder_display_name":"Blood Cancer UK"}],"funders":[{"id":"https://openalex.org/F4320306439","display_name":"Multiple Myeloma Research Foundation","ror":"https://ror.org/03ww1bx13"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320290","display_name":"University of Oxford","ror":"https://ror.org/052gg0110"},{"id":"https://openalex.org/F4320320320","display_name":"Rosetrees Trust","ror":"https://ror.org/04e3zg361"},{"id":"https://openalex.org/F4320329013","display_name":"Blood Cancer UK","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Not":[0],"available.":[1]},"counts_by_year":[],"updated_date":"2026-10-02T10:15:12.560889","created_date":"2026-02-13T00:00:00"}