{"id":"https://openalex.org/W7128548909","doi":"https://doi.org/10.2139/ssrn.6201847","title":"Fine-Tuning Viral Adaptation through Genomic Contraction: Insights from Mpox Outbreaks in South Korea","display_name":"Fine-Tuning Viral Adaptation through Genomic Contraction: Insights from Mpox Outbreaks in South Korea","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7128548909","doi":"https://doi.org/10.2139/ssrn.6201847"},"language":"en","primary_location":{"id":"doi:10.2139/ssrn.6201847","doi":"https://doi.org/10.2139/ssrn.6201847","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.6201847","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.2139/ssrn.6201847","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100747576","display_name":"Minji Lee","orcid":"https://orcid.org/0000-0003-4356-0051","observed_orcids":["https://orcid.org/0000-0003-4356-0051","https://orcid.org/0000-0003-3466-5257"]},"institutions":[{"id":"https://openalex.org/I2801339556","display_name":"Government of the Republic of Korea","ror":"https://ror.org/019xm3p48","country_code":"KR","type":"government","lineage":["https://openalex.org/I2801339556"]},{"id":"https://openalex.org/I4210148299","display_name":"Korea Disease Control and Prevention Agency","ror":"https://ror.org/04jgeq066","country_code":"KR","type":"government","lineage":["https://openalex.org/I4210148299"]},{"id":"https://openalex.org/I4210161077","display_name":"Korea Center for Disease Control and Prevention","ror":"https://ror.org/056za9j29","country_code":"KR","type":"government","lineage":["https://openalex.org/I4210161077"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Minji Lee","raw_affiliation_strings":["Government of the Republic of Korea - Korea Centers for Disease Control and Prevention (KCDC)","Government of the Republic of Korea - Korea Centers for Disease Control and Prevention (KCDC), Osong, Korea, Republic of (South Korea)"],"raw_orcid":"https://orcid.org/0000-0003-4356-0051","affiliations":[{"raw_affiliation_string":"Government of the Republic of Korea - Korea Centers for Disease Control and Prevention (KCDC)","institution_ids":["https://openalex.org/I4210148299","https://openalex.org/I4210161077"]},{"raw_affiliation_string":"Government of the Republic of Korea - Korea Centers for Disease Control and Prevention (KCDC), Osong, Korea, Republic of (South Korea)","institution_ids":["https://openalex.org/I2801339556","https://openalex.org/I4210148299","https://openalex.org/I4210161077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102762083","display_name":"Chi\u2010Hwan Choi","orcid":"https://orcid.org/0000-0002-8560-5230","observed_orcids":["https://orcid.org/0000-0002-8560-5230"]},"institutions":[{"id":"https://openalex.org/I4210148299","display_name":"Korea Disease Control and Prevention Agency","ror":"https://ror.org/04jgeq066","country_code":"KR","type":"government","lineage":["https://openalex.org/I4210148299"]},{"id":"https://openalex.org/I4210161077","display_name":"Korea Center for Disease Control and Prevention","ror":"https://ror.org/056za9j29","country_code":"KR","type":"government","lineage":["https://openalex.org/I4210161077"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chi-Hwan Choi","raw_affiliation_strings":["Government of the Republic of Korea - Korea Centers for Disease Control and Prevention (KCDC)"],"raw_orcid":"https://orcid.org/0000-0002-8560-5230","affiliations":[{"raw_affiliation_string":"Government of the Republic of Korea - Korea Centers for Disease Control and Prevention (KCDC)","institution_ids":["https://openalex.org/I4210148299","https://openalex.org/I4210161077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064892729","display_name":"Jin\u2010Won Kim","orcid":"https://orcid.org/0000-0002-2374-1077","observed_orcids":["https://orcid.org/0000-0002-2374-1077"]},"institutions":[{"id":"https://openalex.org/I4210148299","display_name":"Korea Disease Control and Prevention Agency","ror":"https://ror.org/04jgeq066","country_code":"KR","type":"government","lineage":["https://openalex.org/I4210148299"]},{"id":"https://openalex.org/I4210161077","display_name":"Korea Center for Disease Control and Prevention","ror":"https://ror.org/056za9j29","country_code":"KR","type":"government","lineage":["https://openalex.org/I4210161077"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jin-Won Kim","raw_affiliation_strings":["Government of the Republic of Korea - Korea Centers for Disease Control and Prevention (KCDC)"],"raw_orcid":"https://orcid.org/0000-0002-2374-1077","affiliations":[{"raw_affiliation_string":"Government of the Republic of Korea - Korea Centers for Disease Control and Prevention (KCDC)","institution_ids":["https://openalex.org/I4210148299","https://openalex.org/I4210161077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018715837","display_name":"SangEun Lee","orcid":"https://orcid.org/0000-0002-0635-151X","observed_orcids":["https://orcid.org/0000-0002-0635-151X"]},"institutions":[{"id":"https://openalex.org/I2801339556","display_name":"Government of the Republic of Korea","ror":"https://ror.org/019xm3p48","country_code":"KR","type":"government","lineage":["https://openalex.org/I2801339556"]},{"id":"https://openalex.org/I4210148299","display_name":"Korea Disease Control and Prevention Agency","ror":"https://ror.org/04jgeq066","country_code":"KR","type":"government","lineage":["https://openalex.org/I4210148299"]},{"id":"https://openalex.org/I4210161077","display_name":"Korea Center for Disease Control and Prevention","ror":"https://ror.org/056za9j29","country_code":"KR","type":"government","lineage":["https://openalex.org/I4210161077"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"SangEun Lee","raw_affiliation_strings":["Government of the Republic of Korea - Korea Centers for Disease Control and Prevention (KCDC)","Government of the Republic of Korea - Korea Centers for Disease Control and Prevention (KCDC), Osong, Korea, Republic of (South Korea)"],"raw_orcid":"https://orcid.org/0000-0002-0635-151X","affiliations":[{"raw_affiliation_string":"Government of the Republic of Korea - Korea Centers for Disease Control and Prevention (KCDC)","institution_ids":["https://openalex.org/I4210148299","https://openalex.org/I4210161077"]},{"raw_affiliation_string":"Government of the Republic of Korea - Korea Centers for Disease Control and Prevention (KCDC), Osong, Korea, Republic of (South Korea)","institution_ids":["https://openalex.org/I2801339556","https://openalex.org/I4210148299","https://openalex.org/I4210161077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094128742","display_name":"Gyuri Sim","orcid":"https://orcid.org/0009-0004-9131-065X","observed_orcids":["https://orcid.org/0009-0004-9131-065X"]},"institutions":[{"id":"https://openalex.org/I2801339556","display_name":"Government of the Republic of Korea","ror":"https://ror.org/019xm3p48","country_code":"KR","type":"government","lineage":["https://openalex.org/I2801339556"]},{"id":"https://openalex.org/I4210148299","display_name":"Korea Disease Control and Prevention Agency","ror":"https://ror.org/04jgeq066","country_code":"KR","type":"government","lineage":["https://openalex.org/I4210148299"]},{"id":"https://openalex.org/I4210161077","display_name":"Korea Center for Disease Control and Prevention","ror":"https://ror.org/056za9j29","country_code":"KR","type":"government","lineage":["https://openalex.org/I4210161077"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Gyuri Sim","raw_affiliation_strings":["Government of the Republic of Korea - Korea Centers for Disease Control and Prevention (KCDC)","Government of the Republic of Korea - Korea Centers for Disease Control and Prevention (KCDC), Osong, Korea, Republic of (South Korea)"],"raw_orcid":"https://orcid.org/0009-0004-9131-065X","affiliations":[{"raw_affiliation_string":"Government of the Republic of Korea - Korea Centers for Disease Control and Prevention (KCDC)","institution_ids":["https://openalex.org/I4210148299","https://openalex.org/I4210161077"]},{"raw_affiliation_string":"Government of the Republic of Korea - Korea Centers for Disease Control and Prevention (KCDC), Osong, Korea, Republic of (South Korea)","institution_ids":["https://openalex.org/I2801339556","https://openalex.org/I4210148299","https://openalex.org/I4210161077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021823162","display_name":"Hwajung Yi","orcid":"https://orcid.org/0000-0001-9381-0616","observed_orcids":["https://orcid.org/0000-0001-9381-0616"]},"institutions":[{"id":"https://openalex.org/I2801339556","display_name":"Government of the Republic of Korea","ror":"https://ror.org/019xm3p48","country_code":"KR","type":"government","lineage":["https://openalex.org/I2801339556"]},{"id":"https://openalex.org/I4210148299","display_name":"Korea Disease Control and Prevention Agency","ror":"https://ror.org/04jgeq066","country_code":"KR","type":"government","lineage":["https://openalex.org/I4210148299"]},{"id":"https://openalex.org/I4210161077","display_name":"Korea Center for Disease Control and Prevention","ror":"https://ror.org/056za9j29","country_code":"KR","type":"government","lineage":["https://openalex.org/I4210161077"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hwajung Yi","raw_affiliation_strings":["Government of the Republic of Korea - Korea Centers for Disease Control and Prevention (KCDC)","Government of the Republic of Korea - Korea Centers for Disease Control and Prevention (KCDC), Osong, Korea, Republic of (South Korea)"],"raw_orcid":"https://orcid.org/0000-0001-9381-0616","affiliations":[{"raw_affiliation_string":"Government of the Republic of Korea - Korea Centers for Disease Control and Prevention (KCDC)","institution_ids":["https://openalex.org/I4210148299","https://openalex.org/I4210161077"]},{"raw_affiliation_string":"Government of the Republic of Korea - Korea Centers for Disease Control and Prevention (KCDC), Osong, Korea, Republic of (South Korea)","institution_ids":["https://openalex.org/I2801339556","https://openalex.org/I4210148299","https://openalex.org/I4210161077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125500299","display_name":"Jee-Woong Kim","orcid":"https://orcid.org/0000-0003-4164-1886","observed_orcids":["https://orcid.org/0000-0003-4164-1886"]},"institutions":[{"id":"https://openalex.org/I4210148299","display_name":"Korea Disease Control and Prevention Agency","ror":"https://ror.org/04jgeq066","country_code":"KR","type":"government","lineage":["https://openalex.org/I4210148299"]},{"id":"https://openalex.org/I4210161077","display_name":"Korea Center for Disease Control and Prevention","ror":"https://ror.org/056za9j29","country_code":"KR","type":"government","lineage":["https://openalex.org/I4210161077"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jee-Woong Kim","raw_affiliation_strings":["Government of the Republic of Korea - Korea Centers for Disease Control and Prevention (KCDC)"],"raw_orcid":"https://orcid.org/0000-0003-4164-1886","affiliations":[{"raw_affiliation_string":"Government of the Republic of Korea - Korea Centers for Disease Control and Prevention (KCDC)","institution_ids":["https://openalex.org/I4210148299","https://openalex.org/I4210161077"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011932716","display_name":"Yoon\u2010Seok Chung","orcid":"https://orcid.org/0000-0003-4562-5533","observed_orcids":["https://orcid.org/0000-0003-4562-5533"]},"institutions":[{"id":"https://openalex.org/I4210148299","display_name":"Korea Disease Control and Prevention Agency","ror":"https://ror.org/04jgeq066","country_code":"KR","type":"government","lineage":["https://openalex.org/I4210148299"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Yoon-Seok Chung","raw_affiliation_strings":["Korea Disease Control and Prevention Agency - Division of Infectious Disease Response"],"raw_orcid":"https://orcid.org/0000-0003-4562-5533","affiliations":[{"raw_affiliation_string":"Korea Disease Control and Prevention Agency - Division of Infectious Disease Response","institution_ids":["https://openalex.org/I4210148299"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5011932716"],"corresponding_institution_ids":["https://openalex.org/I4210148299"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11767","display_name":"Poxvirus research and outbreaks","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11767","display_name":"Poxvirus research and outbreaks","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mpox","display_name":"monkeypox","score":0.8320000171661377},{"id":"https://openalex.org/keywords/monkeypox-virus","display_name":"monkeypox virus","score":0.8159999847412109},{"id":"https://openalex.org/keywords/large-genomic-deletions","display_name":"large genomic deletions","score":0.8759999871253967},{"id":"https://openalex.org/keywords/virus-adaptation","display_name":"viral adaptation","score":0.5540000200271606},{"id":"https://openalex.org/keywords/positive-selection","display_name":"positive selection","score":0.9620000123977661},{"id":"https://openalex.org/keywords/host-range","display_name":"host range","score":0.550000011920929},{"id":"https://openalex.org/keywords/virulence","display_name":"virulence","score":0.7570000290870667},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.7519999742507935},{"id":"https://openalex.org/keywords/human-to-human-transmission","display_name":"human-to-human transmission","score":0.9509999752044678},{"id":"https://openalex.org/keywords/genomic-surveillance","display_name":"genomic surveillance","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8197000026702881},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.628000020980835},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6165000200271606},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5131999850273132},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.45969998836517334},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4178999960422516},{"id":"https://openalex.org/C2776914050","wikidata":"https://www.wikidata.org/wiki/Q19597524","display_name":"Host adaptation","level":4,"score":0.3962000012397766},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3898000121116638},{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.38769999146461487},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.3853999972343445},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.375},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.3529999852180481},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3490000069141388},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.33570000529289246},{"id":"https://openalex.org/C2910240311","wikidata":"https://www.wikidata.org/wiki/Q5418641","display_name":"Mutation Accumulation","level":4,"score":0.31779998540878296},{"id":"https://openalex.org/C24432333","wikidata":"https://www.wikidata.org/wiki/Q2068526","display_name":"Whole genome sequencing","level":4,"score":0.3176000118255615},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.31369999051094055},{"id":"https://openalex.org/C22322919","wikidata":"https://www.wikidata.org/wiki/Q5533501","display_name":"Genomic organization","level":4,"score":0.31220000982284546},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3098999857902527},{"id":"https://openalex.org/C167683757","wikidata":"https://www.wikidata.org/wiki/Q5937774","display_name":"Human evolutionary genetics","level":4,"score":0.3059000074863434},{"id":"https://openalex.org/C2994067223","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"Genomic sequencing","level":4,"score":0.3046000003814697},{"id":"https://openalex.org/C171578705","wikidata":"https://www.wikidata.org/wiki/Q5418700","display_name":"Evolutionary dynamics","level":3,"score":0.2994000017642975},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.29490000009536743},{"id":"https://openalex.org/C44465124","wikidata":"https://www.wikidata.org/wiki/Q713623","display_name":"Clade","level":4,"score":0.29350000619888306},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2906000018119812},{"id":"https://openalex.org/C8769409","wikidata":"https://www.wikidata.org/wiki/Q2066554","display_name":"Viral evolution","level":4,"score":0.2662000060081482},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.265500009059906}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2139/ssrn.6201847","doi":"https://doi.org/10.2139/ssrn.6201847","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.6201847","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.2139/ssrn.6201847","doi":"https://doi.org/10.2139/ssrn.6201847","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.6201847","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7220866959","https://openalex.org/W4414931826","https://openalex.org/W7126115821","https://openalex.org/W7169613035","https://openalex.org/W4412483701","https://openalex.org/W7165116919","https://openalex.org/W4414018432","https://openalex.org/W4378783127","https://openalex.org/W4402847571","https://openalex.org/W4283360071"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-02-11T00:00:00"}