{"id":"https://openalex.org/W7128540599","doi":"https://doi.org/10.1016/j.ijbiomac.2026.150821","title":"Structural reprogramming of irradiated ellagic acid suppresses cell cycle regulators and modulates cytokines via activation of the p53/BAX-CASP3/Bcl-2-cyclin D1 pathway: Validation studies across breast cancer cell lines","display_name":"Structural reprogramming of irradiated ellagic acid suppresses cell cycle regulators and modulates cytokines via activation of the p53/BAX-CASP3/Bcl-2-cyclin D1 pathway: Validation studies across breast cancer cell lines","publication_year":2026,"publication_date":"2026-02-11","ids":{"openalex":"https://openalex.org/W7128540599","doi":"https://doi.org/10.1016/j.ijbiomac.2026.150821","pmid":"https://pubmed.ncbi.nlm.nih.gov/41679479"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijbiomac.2026.150821","doi":"https://doi.org/10.1016/j.ijbiomac.2026.150821","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijbiomac.2026.150821","pdf_url":null,"source":{"id":"https://openalex.org/S83853393","display_name":"International Journal of Biological Macromolecules","issn_l":"0141-8130","issn":["0141-8130","1879-0003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Macromolecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5125526209","display_name":"Hager M. Eldairy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Hager M. Eldairy","raw_affiliation_strings":["Zoology Department, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zoology Department, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypt","institution_ids":["https://openalex.org/I107720978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068148760","display_name":"Sahar Abd El-Razik Mosallam","orcid":"https://orcid.org/0000-0002-3392-7772","observed_orcids":["https://orcid.org/0000-0002-3392-7772"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Sahar Abd El-Razik Mosallam","raw_affiliation_strings":["Zoology Department, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zoology Department, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypt","institution_ids":["https://openalex.org/I107720978"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029378502","display_name":"Alaa Elmetwalli","orcid":"https://orcid.org/0000-0001-5372-4297","observed_orcids":["https://orcid.org/0000-0001-5372-4297"]},"institutions":[{"id":"https://openalex.org/I72264486","display_name":"University of Tabuk","ror":"https://ror.org/04yej8x59","country_code":"SA","type":"education","lineage":["https://openalex.org/I72264486"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Alaa Elmetwalli","raw_affiliation_strings":["Prince Fahad bin Sultan Chair for Biomedical Research, University of Tabuk, Tabuk, Saudi Arabia. Electronic address: aelmetwalli@ut.edu.sa"],"raw_orcid":"https://orcid.org/0000-0001-5372-4297","affiliations":[{"raw_affiliation_string":"Prince Fahad bin Sultan Chair for Biomedical Research, University of Tabuk, Tabuk, Saudi Arabia. Electronic address: aelmetwalli@ut.edu.sa","institution_ids":["https://openalex.org/I72264486"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5029378502"],"corresponding_institution_ids":["https://openalex.org/I72264486"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":3.3722,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.84581601,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"349","issue":null,"first_page":"150821","last_page":"150821"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12638","display_name":"Pomegranate: compositions and health benefits","score":0.9057999849319458,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12638","display_name":"Pomegranate: compositions and health benefits","score":0.9057999849319458,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.031599998474121094,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ellagic-acid","display_name":"ellagic acid","score":0.9929999709129333},{"id":"https://openalex.org/keywords/gamma-irradiation","display_name":"gamma irradiation","score":0.7390000224113464},{"id":"https://openalex.org/keywords/ellagic-acid-derivatives","display_name":"ellagic acid derivatives","score":0.5139999985694885},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.6359999775886536},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8849999904632568},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9300000071525574},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.9120000004768372},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9779999852180481},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.8389999866485596},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.7419999837875366},{"id":"https://openalex.org/keywords/selective-cytotoxicity","display_name":"selective cytotoxicity","score":0.6700000166893005},{"id":"https://openalex.org/keywords/particle-size-and-morphology","display_name":"particle size and morphology","score":0.6050000190734863},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.8109999895095825},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.8659999966621399},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.9950000047683716}],"concepts":[{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.6881999969482422},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6489999890327454},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.5997999906539917},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5724999904632568},{"id":"https://openalex.org/C2781464872","wikidata":"https://www.wikidata.org/wiki/Q422044","display_name":"Ellagic acid","level":4,"score":0.5691999793052673},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5375000238418579},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5343000292778015},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.47850000858306885},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4690000116825104},{"id":"https://openalex.org/C109541995","wikidata":"https://www.wikidata.org/wiki/Q1881253","display_name":"MCF-7","level":5,"score":0.4465000033378601},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43380001187324524},{"id":"https://openalex.org/C2994372470","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell lines","level":4,"score":0.4323999881744385},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41909998655319214},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3995000123977661},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3434999883174896},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.3154999911785126},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30970001220703125},{"id":"https://openalex.org/C118792377","wikidata":"https://www.wikidata.org/wiki/Q108584245","display_name":"Selectivity","level":3,"score":0.30250000953674316},{"id":"https://openalex.org/C2994037739","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle progression","level":4,"score":0.2784999907016754},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.26969999074935913},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26510000228881836},{"id":"https://openalex.org/C2994423619","wikidata":"https://www.wikidata.org/wiki/Q9103","display_name":"Human breast","level":4,"score":0.2574000060558319},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.2540000081062317}],"mesh":[{"descriptor_ui":"D000092302","descriptor_name":"MDA-MB-231 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004610","descriptor_name":"Ellagic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004610","descriptor_name":"Ellagic Acid","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D004610","descriptor_name":"Ellagic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005720","descriptor_name":"Gamma Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ijbiomac.2026.150821","doi":"https://doi.org/10.1016/j.ijbiomac.2026.150821","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijbiomac.2026.150821","pdf_url":null,"source":{"id":"https://openalex.org/S83853393","display_name":"International Journal of Biological Macromolecules","issn_l":"0141-8130","issn":["0141-8130","1879-0003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Macromolecules","raw_type":"journal-article"},{"id":"pmid:41679479","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41679479","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of biological macromolecules","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W1969310555","https://openalex.org/W2005993590","https://openalex.org/W2038189029","https://openalex.org/W2046451859","https://openalex.org/W2059588013","https://openalex.org/W2076734290","https://openalex.org/W2111369086","https://openalex.org/W2113123048","https://openalex.org/W2118280582","https://openalex.org/W2164110088","https://openalex.org/W2294923227","https://openalex.org/W2527438532","https://openalex.org/W2593653900","https://openalex.org/W2604294853","https://openalex.org/W2708077475","https://openalex.org/W2738276698","https://openalex.org/W2751615548","https://openalex.org/W2755778068","https://openalex.org/W2766400948","https://openalex.org/W2793019915","https://openalex.org/W2806655963","https://openalex.org/W2888797821","https://openalex.org/W2901601146","https://openalex.org/W2973530780","https://openalex.org/W2986572941","https://openalex.org/W3015453285","https://openalex.org/W3023150306","https://openalex.org/W3024561493","https://openalex.org/W3045062935","https://openalex.org/W3045938749","https://openalex.org/W3130954936","https://openalex.org/W3133578393","https://openalex.org/W3158220003","https://openalex.org/W3190048637","https://openalex.org/W3191372987","https://openalex.org/W3206597254","https://openalex.org/W3212877681","https://openalex.org/W3216655385","https://openalex.org/W4200250025","https://openalex.org/W4210466682","https://openalex.org/W4210596392","https://openalex.org/W4220742838","https://openalex.org/W4223559953","https://openalex.org/W4281491687","https://openalex.org/W4283368799","https://openalex.org/W4283826714","https://openalex.org/W4285393804","https://openalex.org/W4294189863","https://openalex.org/W4310490305","https://openalex.org/W4312103116","https://openalex.org/W4312116229","https://openalex.org/W4313890260","https://openalex.org/W4314945982","https://openalex.org/W4320496288","https://openalex.org/W4321092565","https://openalex.org/W4376122096","https://openalex.org/W4382402644","https://openalex.org/W4382457033","https://openalex.org/W4383505997","https://openalex.org/W4386846524","https://openalex.org/W4386859627","https://openalex.org/W4387580807","https://openalex.org/W4388699626","https://openalex.org/W4390400049","https://openalex.org/W4393930056","https://openalex.org/W4396613261","https://openalex.org/W4396686080","https://openalex.org/W4399301412","https://openalex.org/W4402131485","https://openalex.org/W4402703237","https://openalex.org/W4403867224","https://openalex.org/W4404043097","https://openalex.org/W4404784294","https://openalex.org/W4405040782","https://openalex.org/W4405671774","https://openalex.org/W4406117207","https://openalex.org/W4408503205","https://openalex.org/W4411864111","https://openalex.org/W4412481476"],"related_works":["https://openalex.org/W4415721327","https://openalex.org/W2738276698","https://openalex.org/W1998074620","https://openalex.org/W2939175897","https://openalex.org/W2766400948","https://openalex.org/W2789470176","https://openalex.org/W2620076354","https://openalex.org/W2570637323","https://openalex.org/W2034299050","https://openalex.org/W3160813681"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-02-11T00:00:00"}