{"id":"https://openalex.org/W7128535552","doi":"https://doi.org/10.3389/fendo.2026.1750308","title":"Comparative effectiveness of pemafibrate versus bezafibrate on hepatic and vascular endothelial function in patients with coronary artery disease and metabolic dysfunction-associated steatotic liver disease","display_name":"Comparative effectiveness of pemafibrate versus bezafibrate on hepatic and vascular endothelial function in patients with coronary artery disease and metabolic dysfunction-associated steatotic liver disease","publication_year":2026,"publication_date":"2026-02-11","ids":{"openalex":"https://openalex.org/W7128535552","doi":"https://doi.org/10.3389/fendo.2026.1750308","pmid":"https://pubmed.ncbi.nlm.nih.gov/41757235","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12932250"},"language":"en","primary_location":{"id":"doi:10.3389/fendo.2026.1750308","doi":"https://doi.org/10.3389/fendo.2026.1750308","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2026.1750308","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2026.1750308/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://public-pages-files-2025.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2026.1750308/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5123204425","display_name":"Akihiro Nakamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090926","display_name":"Iwate Prefectural Central Hospital","ror":"https://ror.org/00g916n77","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210090926"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Akihiro Nakamura","raw_affiliation_strings":["Department of Cardiology, Iwate Prefectural Central Hospital, Morioka,\u00a0Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Iwate Prefectural Central Hospital, Morioka,\u00a0Japan","institution_ids":["https://openalex.org/I4210090926"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112874128","display_name":"Yuta Kagaya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090926","display_name":"Iwate Prefectural Central Hospital","ror":"https://ror.org/00g916n77","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210090926"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuta Kagaya","raw_affiliation_strings":["Department of Cardiology, Iwate Prefectural Central Hospital, Morioka,\u00a0Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Iwate Prefectural Central Hospital, Morioka,\u00a0Japan","institution_ids":["https://openalex.org/I4210090926"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071547043","display_name":"Hiroki Saito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090926","display_name":"Iwate Prefectural Central Hospital","ror":"https://ror.org/00g916n77","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210090926"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroki Saito","raw_affiliation_strings":["Department of Cardiology, Iwate Prefectural Central Hospital, Morioka,\u00a0Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Iwate Prefectural Central Hospital, Morioka,\u00a0Japan","institution_ids":["https://openalex.org/I4210090926"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053639040","display_name":"Masanori Kanazawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090926","display_name":"Iwate Prefectural Central Hospital","ror":"https://ror.org/00g916n77","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210090926"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masanori Kanazawa","raw_affiliation_strings":["Department of Cardiology, Iwate Prefectural Central Hospital, Morioka,\u00a0Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Iwate Prefectural Central Hospital, Morioka,\u00a0Japan","institution_ids":["https://openalex.org/I4210090926"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103859351","display_name":"Masanobu Miura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090926","display_name":"Iwate Prefectural Central Hospital","ror":"https://ror.org/00g916n77","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210090926"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masanobu Miura","raw_affiliation_strings":["Department of Cardiology, Iwate Prefectural Central Hospital, Morioka,\u00a0Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Iwate Prefectural Central Hospital, Morioka,\u00a0Japan","institution_ids":["https://openalex.org/I4210090926"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113167934","display_name":"Masateru Kondo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090926","display_name":"Iwate Prefectural Central Hospital","ror":"https://ror.org/00g916n77","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210090926"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masateru Kondo","raw_affiliation_strings":["Department of Cardiology, Iwate Prefectural Central Hospital, Morioka,\u00a0Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Iwate Prefectural Central Hospital, Morioka,\u00a0Japan","institution_ids":["https://openalex.org/I4210090926"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101509308","display_name":"Hideaki Endo","orcid":"https://orcid.org/0000-0002-9936-3447","observed_orcids":["https://orcid.org/0000-0002-9936-3447"]},"institutions":[{"id":"https://openalex.org/I4210090926","display_name":"Iwate Prefectural Central Hospital","ror":"https://ror.org/00g916n77","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210090926"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideaki Endo","raw_affiliation_strings":["Department of Cardiology, Iwate Prefectural Central Hospital, Morioka,\u00a0Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Iwate Prefectural Central Hospital, Morioka,\u00a0Japan","institution_ids":["https://openalex.org/I4210090926"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5123204425"],"corresponding_institution_ids":["https://openalex.org/I4210090926"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":2.7324,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.84868352,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"17","issue":null,"first_page":"1750308","last_page":"1750308"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pemafibrate","display_name":"pemafibrate","score":1.0},{"id":"https://openalex.org/keywords/bezafibrate","display_name":"bezafibrate","score":1.0},{"id":"https://openalex.org/keywords/ppar-agonists","display_name":"PPAR agonists","score":0.7889999747276306},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9900000095367432},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.9409999847412109},{"id":"https://openalex.org/keywords/hypertriglyceridemia","display_name":"hypertriglyceridemia","score":0.968999981880188},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"alanine aminotransferase","score":0.9459999799728394},{"id":"https://openalex.org/keywords/endothelial-function","display_name":"endothelial function","score":0.8149999976158142},{"id":"https://openalex.org/keywords/flow-mediated-dilation","display_name":"flow-mediated dilation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.953000009059906},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.8999999761581421},{"id":"https://openalex.org/keywords/fatty-liver-index","display_name":"fatty liver index","score":0.8009999990463257},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C2776362216","wikidata":"https://www.wikidata.org/wiki/Q577387","display_name":"Bezafibrate","level":2,"score":0.9387000203132629},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8585000038146973},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6980000138282776},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.6568999886512756},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.6539000272750854},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.531000018119812},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.47679999470710754},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.46799999475479126},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4131999909877777},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.39959999918937683},{"id":"https://openalex.org/C2992208098","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver function","level":2,"score":0.3815000057220459},{"id":"https://openalex.org/C2991848491","wikidata":"https://www.wikidata.org/wiki/Q2351083","display_name":"Metabolic disease","level":2,"score":0.3675999939441681},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3659999966621399},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.3650999963283539},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3522000014781952},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.35010001063346863},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.3059999942779541},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.2874999940395355},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.28380000591278076},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.2700999975204468},{"id":"https://openalex.org/C512861765","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver function tests","level":2,"score":0.2612000107765198},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.26100000739097595},{"id":"https://openalex.org/C194832188","wikidata":"https://www.wikidata.org/wiki/Q2638593","display_name":"Adipokine","level":4,"score":0.2538999915122986}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000410","descriptor_name":"Alanine Transaminase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000960","descriptor_name":"Hypolipidemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001583","descriptor_name":"Benzoxazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001629","descriptor_name":"Bezafibrate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002087","descriptor_name":"Butyrates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047493","descriptor_name":"PPAR alpha","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3389/fendo.2026.1750308","doi":"https://doi.org/10.3389/fendo.2026.1750308","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2026.1750308","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2026.1750308/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},{"id":"pmid:41757235","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41757235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12932250","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12932250/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Endocrinol (Lausanne)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:ba09d7de25c945ad915d5017af3a5ad7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ba09d7de25c945ad915d5017af3a5ad7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Endocrinology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fendo.2026.1750308","doi":"https://doi.org/10.3389/fendo.2026.1750308","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2026.1750308","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2026.1750308/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7128535552.pdf","grobid_xml":"https://content.openalex.org/works/W7128535552.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1555489744","https://openalex.org/W1968375269","https://openalex.org/W2001454915","https://openalex.org/W2004880409","https://openalex.org/W2020262245","https://openalex.org/W2022879391","https://openalex.org/W2047257800","https://openalex.org/W2054727930","https://openalex.org/W2064387090","https://openalex.org/W2086022508","https://openalex.org/W2110733021","https://openalex.org/W2110875907","https://openalex.org/W2111946630","https://openalex.org/W2114611332","https://openalex.org/W2124402648","https://openalex.org/W2130906973","https://openalex.org/W2132205261","https://openalex.org/W2136057321","https://openalex.org/W2138223428","https://openalex.org/W2152189242","https://openalex.org/W2156696514","https://openalex.org/W2164247714","https://openalex.org/W2334832052","https://openalex.org/W2400712338","https://openalex.org/W2443825963","https://openalex.org/W2596624061","https://openalex.org/W2796005123","https://openalex.org/W2965329631","https://openalex.org/W3002287592","https://openalex.org/W3015579983","https://openalex.org/W3123910101","https://openalex.org/W3147476766","https://openalex.org/W3154897461","https://openalex.org/W3181107254","https://openalex.org/W3201123873","https://openalex.org/W3216379705","https://openalex.org/W4244656864","https://openalex.org/W4283743604","https://openalex.org/W4308367139","https://openalex.org/W4312123975","https://openalex.org/W4313304103","https://openalex.org/W4319216443","https://openalex.org/W4390063472","https://openalex.org/W4399725448"],"related_works":["https://openalex.org/W4388595827","https://openalex.org/W4393410386","https://openalex.org/W4306320078","https://openalex.org/W4414146661","https://openalex.org/W4392095488","https://openalex.org/W4415571484","https://openalex.org/W4407081563","https://openalex.org/W7220725480","https://openalex.org/W4414290442","https://openalex.org/W4416257012"],"abstract_inverted_index":{"Background:":[0],"Peroxisome":[1],"proliferator-activated":[2],"receptor":[3],"(PPAR)":[4],"agonists":[5],"are":[6],"promising":[7],"therapeutic":[8],"agents":[9],"for":[10,35,42],"metabolic":[11],"dysfunction-associated":[12],"steatotic":[13],"liver":[14,58],"disease":[15],"(MASLD),":[16],"which":[17],"increases":[18],"cardiovascular":[19],"risk.":[20],"Methods:":[21],"analysis":[22],"of":[23,99,144,163],"a":[24,40],"randomized,":[25],"crossover":[26,41],"study":[27],"that":[28],"treated":[29],"hypertriglyceridemia":[30],"with":[31,119,123,138,157,222],"pemafibrate":[32,120],"or":[33],"bezafibrate":[34,124,203],"24":[36,44],"weeks,":[37],"followed":[38],"by":[39],"another":[43],"weeks.":[45],"Of":[46],"the":[47,92,142,145,161,187,192],"60":[48,62],"enrolled":[49],"patients,":[50],"21":[51],"were":[52,75,89],"identified":[53],"as":[54,70,105],"having":[55],"MASLD":[56],"(fatty":[57],"index":[59,66],"[FLI]":[60],"\u2265":[61,68],"and":[63,83,94,175,216],"hepatic":[64],"steatosis":[65],"[HSI]":[67],"36":[69],"indicators).":[71],"The":[72,110],"primary":[73],"outcomes":[74,88],"changes":[76,90],"in":[77,91,113,135,141,154,160,178,219],"serum":[78],"alanine":[79],"aminotransferase":[80],"(ALT)":[81],"levels":[82,115,207],"flow-mediated":[84],"dilation":[85],"(FMD).":[86],"Secondary":[87],"FLI":[93,151],"HSI.":[95],"Homeostasis":[96],"model":[97],"assessment":[98],"insulin":[100,214],"resistance":[101,215],"(HOMA-IR)":[102],"was":[103,116,170,189],"assessed":[104],"an":[106],"exploratory":[107],"outcome.":[108],"Results:":[109],"percentage":[111,146],"reduction":[112],"ALT":[114,206],"significantly":[117,133,152,172,183],"greater":[118],"treatment":[121,125,177],"than":[122,202],"(-23.1%":[126],"vs.":[127],"-9.2%,":[128],"P":[129],"=":[130,149,166,195],"0.035).":[131],"FMD":[132],"increased":[134],"both":[136,155],"groups,":[137],"no":[139,158],"difference":[140,159],"magnitude":[143,162],"change":[147,164],"(P":[148,165,194],"0.267).":[150],"decreased":[153],"groups":[156,193],"0.983),":[167],"while":[168,208],"HSI":[169],"not":[171],"different":[173],"before":[174],"after":[176],"either":[179],"group.":[180],"Both":[181],"treatments":[182],"lowered":[184],"HOMA-IR;":[185],"however,":[186],"decrease":[188],"similar":[190,210],"between":[191],"0.724).":[196],"Conclusions:":[197],"Pemafibrate":[198],"is":[199],"more":[200],"effective":[201],"at":[204],"reducing":[205],"offering":[209],"beneficial":[211],"effects":[212],"on":[213],"endothelial":[217],"function":[218],"CAD":[220],"patients":[221],"MASLD.":[223]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-02-11T00:00:00"}
