{"id":"https://openalex.org/W7128529819","doi":"https://doi.org/10.1093/nar/gkag851","title":"Loss of SUMOylation drives aberrant PRC1 clustering and 3D genome rewiring independent of H3K27me3","display_name":"Loss of SUMOylation drives aberrant PRC1 clustering and 3D genome rewiring independent of H3K27me3","publication_year":2026,"publication_date":"2026-08-23","ids":{"openalex":"https://openalex.org/W7128529819","doi":"https://doi.org/10.1093/nar/gkag851","pmid":"https://pubmed.ncbi.nlm.nih.gov/42708413","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13551046"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkag851","doi":"https://doi.org/10.1093/nar/gkag851","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkag851","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/nar/gkag851","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037102742","display_name":"Nazli Akilli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210163339","display_name":"Institut de G\u00e9n\u00e9tique Humaine","ror":"https://ror.org/05ee10k25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210163339"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nazli Akilli","raw_affiliation_strings":["Institute of Human Genetics, UMR9002, Univ Montpellier, CNRS , 34396 Cedex 5,Montpellier ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human Genetics, UMR9002, Univ Montpellier, CNRS , 34396 Cedex 5,Montpellier ,","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210163339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125476612","display_name":"Paul-Swann Puel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210100775","display_name":"Laboratoire de Biologie et Mod\u00e9lisation de la Cellule","ror":"https://ror.org/01bj4fd12","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I4210100775"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Paul-Swann Puel","raw_affiliation_strings":["Laboratoire de Biologie et Mod\u00e9lisation de la Cellule, \u00c9cole Normale Sup\u00e9rieure de Lyon, CNRS, UMR5239, Inserm U1293, Universit\u00e9 Claude Bernard Lyon 1, 69364 Cedex 07,Lyon,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Biologie et Mod\u00e9lisation de la Cellule, \u00c9cole Normale Sup\u00e9rieure de Lyon, CNRS, UMR5239, Inserm U1293, Universit\u00e9 Claude Bernard Lyon 1, 69364 Cedex 07,Lyon,","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210100775"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090755680","display_name":"Marco Di Stefano","orcid":"https://orcid.org/0000-0001-6195-4754","observed_orcids":["https://orcid.org/0000-0001-6195-4754"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210163339","display_name":"Institut de G\u00e9n\u00e9tique Humaine","ror":"https://ror.org/05ee10k25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210163339"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marco Di Stefano","raw_affiliation_strings":["Institute of Human Genetics, UMR9002, Univ Montpellier, CNRS , 34396 Cedex 5,Montpellier ,"],"raw_orcid":"https://orcid.org/0000-0001-6195-4754","affiliations":[{"raw_affiliation_string":"Institute of Human Genetics, UMR9002, Univ Montpellier, CNRS , 34396 Cedex 5,Montpellier ,","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210163339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011894011","display_name":"Fernando Muzzopappa","orcid":"https://orcid.org/0000-0001-6420-828X","observed_orcids":["https://orcid.org/0000-0001-6420-828X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4405266242","display_name":"Centre de Biologie Int\u00e9grative de Toulouse","ror":"https://ror.org/01f4pb571","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4405258862","https://openalex.org/I4405266242"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fernando Muzzopappa","raw_affiliation_strings":["MCD, Center for Integrative Biology (CBI), University of Toulouse, CNRS , 31400,Toulouse ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MCD, Center for Integrative Biology (CBI), University of Toulouse, CNRS , 31400,Toulouse ,","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4405258862","https://openalex.org/I4405266242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040335455","display_name":"Lauriane Fritsch","orcid":"https://orcid.org/0009-0008-7769-1184","observed_orcids":["https://orcid.org/0009-0008-7769-1184"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210163339","display_name":"Institut de G\u00e9n\u00e9tique Humaine","ror":"https://ror.org/05ee10k25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210163339"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lauriane Fritsch","raw_affiliation_strings":["Institute of Human Genetics, UMR9002, Univ Montpellier, CNRS , 34396 Cedex 5,Montpellier ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human Genetics, UMR9002, Univ Montpellier, CNRS , 34396 Cedex 5,Montpellier ,","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210163339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085223649","display_name":"Fabian Erdel","orcid":"https://orcid.org/0000-0003-2888-7777","observed_orcids":["https://orcid.org/0000-0003-2888-7777"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4405266242","display_name":"Centre de Biologie Int\u00e9grative de Toulouse","ror":"https://ror.org/01f4pb571","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4405258862","https://openalex.org/I4405266242"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fabian Erdel","raw_affiliation_strings":["MCD, Center for Integrative Biology (CBI), University of Toulouse, CNRS , 31400,Toulouse ,"],"raw_orcid":"https://orcid.org/0000-0003-2888-7777","affiliations":[{"raw_affiliation_string":"MCD, Center for Integrative Biology (CBI), University of Toulouse, CNRS , 31400,Toulouse ,","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4405258862","https://openalex.org/I4405266242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090174880","display_name":"Daniel Jost","orcid":"https://orcid.org/0000-0002-9877-6864","observed_orcids":["https://orcid.org/0000-0002-9877-6864","https://orcid.org/0000-0001-7327-7789"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210100775","display_name":"Laboratoire de Biologie et Mod\u00e9lisation de la Cellule","ror":"https://ror.org/01bj4fd12","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I4210100775"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Daniel Jost","raw_affiliation_strings":["Laboratoire de Biologie et Mod\u00e9lisation de la Cellule, \u00c9cole Normale Sup\u00e9rieure de Lyon, CNRS, UMR5239, Inserm U1293, Universit\u00e9 Claude Bernard Lyon 1, 69364 Cedex 07,Lyon,"],"raw_orcid":"https://orcid.org/0000-0002-9877-6864","affiliations":[{"raw_affiliation_string":"Laboratoire de Biologie et Mod\u00e9lisation de la Cellule, \u00c9cole Normale Sup\u00e9rieure de Lyon, CNRS, UMR5239, Inserm U1293, Universit\u00e9 Claude Bernard Lyon 1, 69364 Cedex 07,Lyon,","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210100775"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037109213","display_name":"Thierry Cheutin","orcid":"https://orcid.org/0000-0002-7051-6219","observed_orcids":["https://orcid.org/0000-0002-7051-6219"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210163339","display_name":"Institut de G\u00e9n\u00e9tique Humaine","ror":"https://ror.org/05ee10k25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210163339"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thierry Cheutin","raw_affiliation_strings":["Institute of Human Genetics, UMR9002, Univ Montpellier, CNRS , 34396 Cedex 5,Montpellier ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human Genetics, UMR9002, Univ Montpellier, CNRS , 34396 Cedex 5,Montpellier ,","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210163339"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087766645","display_name":"Giacomo Cavalli","orcid":"https://orcid.org/0000-0003-3709-3469","observed_orcids":["https://orcid.org/0000-0003-3709-3469"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210163339","display_name":"Institut de G\u00e9n\u00e9tique Humaine","ror":"https://ror.org/05ee10k25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210163339"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Giacomo Cavalli","raw_affiliation_strings":["Institute of Human Genetics, UMR9002, Univ Montpellier, CNRS , 34396 Cedex 5,Montpellier ,"],"raw_orcid":"https://orcid.org/0000-0003-3709-3469","affiliations":[{"raw_affiliation_string":"Institute of Human Genetics, UMR9002, Univ Montpellier, CNRS , 34396 Cedex 5,Montpellier ,","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210163339"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5087766645"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210163339"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":{"value":3992,"currency":"USD","value_usd":3992},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05787344,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"54","issue":"17","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0333000011742115,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sumoylation","display_name":"SUMOylation","score":0.9739999771118164},{"id":"https://openalex.org/keywords/polycomb-repressive-complex-1","display_name":"PRC1","score":0.9390000104904175},{"id":"https://openalex.org/keywords/biomolecular-condensation","display_name":"biomolecular condensation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/3d-genome-organization","display_name":"3D genome organization","score":0.9670000076293945},{"id":"https://openalex.org/keywords/topologically-associated-domains","display_name":"topologically associating domains","score":0.9850000143051147},{"id":"https://openalex.org/keywords/h3k27me3","display_name":"H3K27me3","score":0.9290000200271606},{"id":"https://openalex.org/keywords/chromatin-organization","display_name":"chromatin organization","score":0.5839999914169312},{"id":"https://openalex.org/keywords/gene-expression-dysregulation","display_name":"gene expression dysregulation","score":0.8629999756813049},{"id":"https://openalex.org/keywords/drosophila-wing-imaginal-disc","display_name":"Drosophila wing imaginal disc","score":0.902999997138977},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.7089999914169312},{"id":"https://openalex.org/keywords/chromatin-interactions","display_name":"chromatin interactions","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.7685999870300293},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.6449999809265137},{"id":"https://openalex.org/C171350616","wikidata":"https://www.wikidata.org/wiki/Q61506","display_name":"SUMO protein","level":4,"score":0.5726000070571899},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5554999709129333},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5044999718666077},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.47859999537467957},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.4602999985218048},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.45660001039505005},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3874000012874603},{"id":"https://openalex.org/C22322919","wikidata":"https://www.wikidata.org/wiki/Q5533501","display_name":"Genomic organization","level":4,"score":0.36820000410079956},{"id":"https://openalex.org/C2776745794","wikidata":"https://www.wikidata.org/wiki/Q24777451","display_name":"Histone H3","level":4,"score":0.3352999985218048},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.3336000144481659},{"id":"https://openalex.org/C2777116130","wikidata":"https://www.wikidata.org/wiki/Q4082046","display_name":"Polycomb-group proteins","level":5,"score":0.32710000872612},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.31209999322891235},{"id":"https://openalex.org/C2776915012","wikidata":"https://www.wikidata.org/wiki/Q17125871","display_name":"PRC2","level":5,"score":0.3052999973297119},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.295199990272522},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.2922999858856201},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.275299996137619},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.26989999413490295},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.26579999923706055},{"id":"https://openalex.org/C56428682","wikidata":"https://www.wikidata.org/wiki/Q24785535","display_name":"Histone H2A","level":4,"score":0.2603999972343445},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.2563000023365021}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014921","descriptor_name":"Wings, Animal","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D014921","descriptor_name":"Wings, Animal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025841","descriptor_name":"Small Ubiquitin-Related Modifier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025841","descriptor_name":"Small Ubiquitin-Related Modifier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058207","descriptor_name":"Sumoylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060227","descriptor_name":"Imaginal Discs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D063150","descriptor_name":"Polycomb Repressive Complex 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D063150","descriptor_name":"Polycomb Repressive Complex 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D063150","descriptor_name":"Polycomb Repressive Complex 1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1093/nar/gkag851","doi":"https://doi.org/10.1093/nar/gkag851","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkag851","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"doi:10.64898/2026.02.05.704038","doi":"https://doi.org/10.64898/2026.02.05.704038","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.02.05.704038","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/02/06/2026.02.05.704038.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42708413","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42708413","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13551046","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13551046/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-05761104v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.umontpellier.fr/hal-05761104","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Research, 2026, 54 (17), ⟨10.1093/nar/gkag851⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/nar/gkag851","doi":"https://doi.org/10.1093/nar/gkag851","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkag851","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1190173965","display_name":null,"funder_award_id":"France2030","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G1332878132","display_name":"Role of Rad51 filament structure and dynamics in homology search in living cells","funder_award_id":"ANR-23-CE12-0014","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G1699713809","display_name":"Optogenetic probing of the 4D genome","funder_award_id":"ANR-23-CE12-0039","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G1793803902","display_name":"Understanding how condensin folds chromatinized genomes into loops","funder_award_id":"ANR-22-CE12-0035","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G1851896201","display_name":"Chromatin control of sperm nuclear compaction and shaping","funder_award_id":"ANR-21-CE13-0037","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G2231653517","display_name":"Pilotage et gouvernance du programme Cell ID","funder_award_id":"ANR-24-EXCI-0001","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G2762060436","display_name":"Accessing individual Cell Identity in their native spatial context: The revolution of single cell and spatially resolved multi-omics.","funder_award_id":"ANR-24-EXCI-0002","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G323482957","display_name":"Training and career development & Innovation","funder_award_id":"ANR-24-EXCI-0005","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G6299852252","display_name":null,"funder_award_id":"101141930","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"},{"id":"https://openalex.org/G6372570281","display_name":null,"funder_award_id":"EQU202303016280","funder_id":"https://openalex.org/F4320321589","funder_display_name":"Fondation pour la Recherche M\u00e9dicale"},{"id":"https://openalex.org/G6821970025","display_name":"LivChrom: The Living Chromatin framework to investigate the functional compartmentalization of the genome","funder_award_id":"ANR-21-CE45-0011","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G7389996359","display_name":"Data Integration and Medical Applications","funder_award_id":"ANR-24-EXCI-0004","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G8863144185","display_name":"dedicated experimental systems","funder_award_id":"ANR-24-EXCI-0003","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320321589","display_name":"Fondation pour la Recherche M\u00e9dicale","ror":"https://ror.org/04w6kn183"},{"id":"https://openalex.org/F4320322361","display_name":"Fondation ARC pour la Recherche sur le Cancer","ror":"https://ror.org/0489qz649"},{"id":"https://openalex.org/F4320322363","display_name":"Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"},{"id":"https://openalex.org/F4320324952","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72"},{"id":"https://openalex.org/F4320328356","display_name":"R\u00e9gion Occitanie Pyr\u00e9n\u00e9es-M\u00e9diterran\u00e9e","ror":"https://ror.org/05mzwwx48"},{"id":"https://openalex.org/F4320329934","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18"},{"id":"https://openalex.org/F4320330081","display_name":"Laboratoire d'Excellence EpiGenMed","ror":null},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7128529819.pdf","grobid_xml":"https://content.openalex.org/works/W7128529819.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W95252060","https://openalex.org/W1975678442","https://openalex.org/W1985020668","https://openalex.org/W2017524293","https://openalex.org/W2022508345","https://openalex.org/W2039811720","https://openalex.org/W2077561581","https://openalex.org/W2081646275","https://openalex.org/W2087090187","https://openalex.org/W2087172939","https://openalex.org/W2095002834","https://openalex.org/W2098500735","https://openalex.org/W2113702322","https://openalex.org/W2148914950","https://openalex.org/W2169456326","https://openalex.org/W2179438025","https://openalex.org/W2227178360","https://openalex.org/W2425405879","https://openalex.org/W2694038906","https://openalex.org/W2760742318","https://openalex.org/W2768013244","https://openalex.org/W2792357206","https://openalex.org/W2885330316","https://openalex.org/W2891043781","https://openalex.org/W2902114405","https://openalex.org/W2937408164","https://openalex.org/W2946162145","https://openalex.org/W2950464315","https://openalex.org/W2951871954","https://openalex.org/W2953728710","https://openalex.org/W2960979937","https://openalex.org/W2981259033","https://openalex.org/W3014809609","https://openalex.org/W3095847053","https://openalex.org/W3095917659","https://openalex.org/W3203089164","https://openalex.org/W4200184903","https://openalex.org/W4281688348","https://openalex.org/W4311693703","https://openalex.org/W4313640723","https://openalex.org/W4366609963","https://openalex.org/W4385230320","https://openalex.org/W4385618227","https://openalex.org/W4391281145","https://openalex.org/W4391529719","https://openalex.org/W4392877779","https://openalex.org/W4393098347","https://openalex.org/W4396597684","https://openalex.org/W4396667339","https://openalex.org/W4402419188","https://openalex.org/W4406401365","https://openalex.org/W4410816879"],"related_works":["https://openalex.org/W4385230320","https://openalex.org/W3027849952","https://openalex.org/W1985020668","https://openalex.org/W3024885938","https://openalex.org/W4408119551","https://openalex.org/W4389461521","https://openalex.org/W7167517819","https://openalex.org/W2039811720","https://openalex.org/W4393098347","https://openalex.org/W4377020062"],"abstract_inverted_index":{"Polycomb":[0,126],"repressive":[1],"complex":[2],"1":[3],"(PRC1)":[4],"forms":[5],"nuclear":[6],"condensates":[7,46,71],"that":[8,32,57,141],"organize":[9],"target":[10],"chromatin":[11],"domains.":[12],"SUMOylation":[13,132],"modulates":[14,147],"PRC1":[15,45,61,70,138],"clustering,":[16],"but":[17],"its":[18],"impact":[19],"on":[20],"condensate":[21],"properties":[22],"and":[23,151],"3D":[24,148],"genome":[25,149],"architecture":[26,150],"remains":[27],"unclear.":[28],"Here,":[29],"we":[30],"show":[31],"depletion":[33],"of":[34,68,84,93,123,137,144],"small":[35],"ubiquitin-like":[36],"modifier":[37],"(SUMO)":[38],"in":[39,60,125],"Drosophila":[40],"wing":[41],"imaginal":[42],"discs":[43],"transforms":[44],"into":[47],"large":[48,69],"structures":[49],"with":[50,105,112,119],"reduced":[51],"molecular":[52],"dynamics.":[53],"Biophysical":[54],"modeling":[55],"suggests":[56],"the":[58,66,85],"changes":[59,124],"self-interactions":[62],"are":[63],"responsible":[64],"for":[65],"formation":[67],"when":[72],"SUMO":[73],"is":[74],"depleted.":[75],"Interestingly,":[76],"this":[77],"biophysical":[78],"reorganization":[79],"occurs":[80],"without":[81],"global":[82],"loss":[83],"H3K27me3":[86],"mark.":[87],"Instead,":[88],"Hi-C":[89],"reveals":[90],"widespread":[91],"rewiring":[92],"topologically":[94],"associating":[95],"domain":[96],"(TAD)":[97],"interactions.":[98],"PRC1-bound":[99],"TADs":[100],"lose":[101],"specific":[102],"long-range":[103],"contacts":[104],"each":[106],"other":[107],"while":[108],"gaining":[109],"ectopic":[110],"interactions":[111],"active":[113],"chromatin.":[114],"These":[115],"topological":[116],"shifts":[117],"correlate":[118],"gene":[120],"misregulation":[121],"independently":[122],"histone":[127,158],"modifications.":[128],"Our":[129],"results":[130],"establish":[131],"as":[133],"a":[134],"critical":[135],"regulator":[136],"condensates,":[139],"demonstrating":[140],"post-translational":[142],"control":[143],"biomolecular":[145],"condensation":[146],"transcriptional":[152],"output":[153],"through":[154],"mechanisms":[155],"separable":[156],"from":[157],"mark":[159],"deposition.":[160]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-02-11T00:00:00"}