{"id":"https://openalex.org/W7128407614","doi":"https://doi.org/10.56238/medcientifica-073","title":"RISCOS CARDIOVASCULARES ASSOCIADOS AO USO SIST\u00caMICO DE NAFAZOLINA: UMA REVIS\u00c3O INTEGRATIVA","display_name":"RISCOS CARDIOVASCULARES ASSOCIADOS AO USO SIST\u00caMICO DE NAFAZOLINA: UMA REVIS\u00c3O INTEGRATIVA","publication_year":2026,"publication_date":"2026-02-08","ids":{"openalex":"https://openalex.org/W7128407614","doi":"https://doi.org/10.56238/medcientifica-073"},"language":"pt","primary_location":{"id":"doi:10.56238/medcientifica-073","doi":"https://doi.org/10.56238/medcientifica-073","is_oa":true,"landing_page_url":"https://doi.org/10.56238/medcientifica-073","pdf_url":"https://anaiseventosbr.com/ae/article/download/242/244","source":{"id":"https://openalex.org/S7407096526","display_name":"Congresso Nacional de Medicina","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Congresso Nacional de Medicina","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://anaiseventosbr.com/ae/article/download/242/244","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5125403394","display_name":"Jo\u00e3o Pedro Martins Napi Correa","orcid":"https://orcid.org/0009-0003-9375-2067","observed_orcids":["https://orcid.org/0009-0003-9375-2067"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jo\u00e3o Pedro Martins Napi Correa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088582672","display_name":"Raynara Brito Silva","orcid":"https://orcid.org/0000-0002-8002-6192","observed_orcids":["https://orcid.org/0000-0002-8002-6192"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raynara Brito Silva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125376168","display_name":"Dayana Assun\u00e7\u00e3o Nascimento","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156655148","display_name":"Universidade Municipal de S\u00e3o Caetano do Sul","ror":"https://ror.org/00gby0d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I156655148"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Dayana Assun\u00e7\u00e3o Nascimento","raw_affiliation_strings":["M\u00e9dica Institui\u00e7\u00e3o : Universidade Municipal de S\u00e3o Caetano do Sul (USCS)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M\u00e9dica Institui\u00e7\u00e3o : Universidade Municipal de S\u00e3o Caetano do Sul (USCS)","institution_ids":["https://openalex.org/I156655148"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125424131","display_name":"Pedro Costa Lima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pedro Costa Lima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074346595","display_name":"Rafaella Abrantes e Silva","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rafaella Abrantes e Silva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057930485","display_name":"Carlos Arthur Marinho da Silva Beltr\u00e3o","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlos Arthur Marinho da Silva Beltr\u00e3o","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113274775","display_name":"Luma Moreira Soares de Andrade","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luma Moreira Soares de Andrade","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125430348","display_name":"Adriane Brasileiro Mazocoli Silva","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adriane Brasileiro Mazocoli Silva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125421611","display_name":"Andr\u00e9 Junior Lopez Lima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Junior Lopez Lima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120793556","display_name":"Hanna Fauzi Abdul Rahim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hanna Fauzi Abdul Rahim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003818053","display_name":"Marcos Phellype de Souza Kussler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marcos Phellype de Souza Kussler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120793555","display_name":"Adrieli Tavares Polate","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adrieli Tavares Polate","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120793554","display_name":"Ana Clara Cavalaro Zamboni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ana Clara Cavalaro Zamboni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125412954","display_name":"Jos\u00e9 Iracy Mac\u00e1rio Barros J\u00fanior","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Iracy Mac\u00e1rio Barros J\u00fanior","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121033150","display_name":"Wesley C\u00e1ssio de Souza Silva","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wesley C\u00e1ssio de Souza Silva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125406057","display_name":"Andr\u00e9 Gustavo Sampaio Costa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Gustavo Sampaio Costa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116672928","display_name":"Wendel Marcelo Quaresma Ribeiro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wendel Marcelo Quaresma Ribeiro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125393365","display_name":"Hyury Cesar Barros de Oliveira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144834","display_name":"Universidade Federal de Roraima","ror":"https://ror.org/03ehp1h78","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210144834"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Hyury Cesar Barros de Oliveira","raw_affiliation_strings":["Universidade Federal de Roraima (UFRR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de Roraima (UFRR","institution_ids":["https://openalex.org/I4210144834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120793558","display_name":"Neuci Alves dos Santos Prata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neuci Alves dos Santos Prata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125386666","display_name":"L\u00edgia Brambilla Costa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089278","display_name":"Universidade do Oeste Paulista","ror":"https://ror.org/00ccec020","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210089278"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"L\u00edgia Brambilla Costa","raw_affiliation_strings":["Medicina Institui\u00e7\u00e3o : Universidade do Oeste Paulista"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicina Institui\u00e7\u00e3o : Universidade do Oeste Paulista","institution_ids":["https://openalex.org/I4210089278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067200723","display_name":"Nathalia Leite Lara Nunes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nathalia Leite Lara Nunes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122905065","display_name":"Angelo Coutinho Mazolini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Angelo Coutinho Mazolini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019841564","display_name":"Heloisa Maffioletti Ferrari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heloisa Maffioletti Ferrari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123234835","display_name":"Marcos Ant\u00f4nio Forte J\u00fanior","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marcos Ant\u00f4nio Forte J\u00fanior","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5001062929","display_name":"Lucas Cardeal Sim\u00e3o Ribeiro","orcid":"https://orcid.org/0000-0003-2995-5241","observed_orcids":["https://orcid.org/0000-0003-2995-5241"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lucas Cardeal Sim\u00e3o Ribeiro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.7109000086784363,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.7109000086784363,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.0551999993622303,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12082","display_name":"Takotsubo Cardiomyopathy and Associated Phenomena","score":0.024000000208616257,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adverse-cardiovascular-events","display_name":"cardiovascular adverse events","score":0.9330000281333923},{"id":"https://openalex.org/keywords/systemic-absorption","display_name":"systemic absorption","score":0.8190000057220459},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.6520000100135803},{"id":"https://openalex.org/keywords/reflex-bradycardia","display_name":"reflex bradycardia","score":0.9649999737739563},{"id":"https://openalex.org/keywords/cardiac-arrhythmia","display_name":"cardiac arrhythmias","score":0.8640000224113464},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nasal-decongestants","display_name":"nasal decongestants","score":0.8899999856948853},{"id":"https://openalex.org/keywords/self-medication","display_name":"self-medication","score":0.8989999890327454},{"id":"https://openalex.org/keywords/drug-abuse","display_name":"drug abuse","score":0.5389999747276306},{"id":"https://openalex.org/keywords/pharmacovigilance","display_name":"pharmacovigilance","score":0.8379999995231628},{"id":"https://openalex.org/keywords/rational-drug-use","display_name":"rational drug use","score":0.4860000014305115}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.680400013923645},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.35370001196861267},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.30630001425743103},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.24079999327659607},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.22100000083446503},{"id":"https://openalex.org/C2779962280","wikidata":"https://www.wikidata.org/wiki/Q7433389","display_name":"SciELO","level":3,"score":0.21359999477863312},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.19329999387264252},{"id":"https://openalex.org/C2987404301","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care","level":2,"score":0.1738000065088272},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.16300000250339508},{"id":"https://openalex.org/C2780081974","wikidata":"https://www.wikidata.org/wiki/Q415051","display_name":"Midodrine","level":4,"score":0.15039999783039093}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.56238/medcientifica-073","doi":"https://doi.org/10.56238/medcientifica-073","is_oa":true,"landing_page_url":"https://doi.org/10.56238/medcientifica-073","pdf_url":"https://anaiseventosbr.com/ae/article/download/242/244","source":{"id":"https://openalex.org/S7407096526","display_name":"Congresso Nacional de Medicina","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Congresso Nacional de Medicina","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.56238/medcientifica-073","doi":"https://doi.org/10.56238/medcientifica-073","is_oa":true,"landing_page_url":"https://doi.org/10.56238/medcientifica-073","pdf_url":"https://anaiseventosbr.com/ae/article/download/242/244","source":{"id":"https://openalex.org/S7407096526","display_name":"Congresso Nacional de Medicina","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Congresso Nacional de Medicina","raw_type":"proceedings-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7128407614.pdf","grobid_xml":"https://content.openalex.org/works/W7128407614.grobid-xml"},"referenced_works_count":4,"referenced_works":["https://openalex.org/W205310263","https://openalex.org/W1483665481","https://openalex.org/W2113373290","https://openalex.org/W3118615836"],"related_works":["https://openalex.org/W7115931778","https://openalex.org/W3110805144","https://openalex.org/W3212286251","https://openalex.org/W2999023585","https://openalex.org/W4385228675","https://openalex.org/W4393356503","https://openalex.org/W4396967868","https://openalex.org/W4361000322","https://openalex.org/W4406200694","https://openalex.org/W7157510807"],"abstract_inverted_index":{"A":[0,54],"nafazolina,":[1,179],"uma":[2],"amina":[3],"simpaticomim\u00e9tica":[4],"de":[5,17,22,52,62,88,109,161,174,187,206,217],"a\u00e7\u00e3o":[6],"alfa-adren\u00e9rgica":[7],"amplamente":[8],"utilizada":[9],"em":[10,90,143,211],"descongestionantes":[11],"nasais":[12],"e":[13,40,60,68,77,86,122,129,151,163,170,202,209],"col\u00edrios,":[14],"apresenta":[15,185],"potencial":[16,186],"absor\u00e7\u00e3o":[18,118],"sist\u00eamica":[19,119],"com":[20],"risco":[21],"efeitos":[23,79,97],"cardiovasculares":[24,45],"adversos.":[25],"O":[26,132],"objetivo":[27],"desta":[28],"revis\u00e3o":[29,195],"integrativa":[30],"foi":[31,56],"analisar":[32],"criticamente":[33],"as":[34],"evid\u00eancias":[35],"cient\u00edficas":[36],"publicadas":[37],"entre":[38,58,116],"2015":[39],"2025":[41,63],"sobre":[42],"os":[43],"riscos":[44],"associados":[46],"ao":[47,214],"uso":[48,164,215],"sist\u00eamico":[49],"ou":[50,93,99],"abusivo":[51],"nafazolina.":[53],"pesquisa":[55],"conduzida":[57],"novembro":[59],"dezembro":[61],"nas":[64],"bases":[65],"PubMed/MEDLINE,":[66],"SciELO":[67],"Scopus,":[69],"utilizando":[70],"descritores":[71],"controlados":[72],"(DeCS/MeSH)":[73],"relacionados":[74],"\u00e0":[75],"nafazolina":[76,121],"seus":[78],"cardiovasculares.":[80],"Foram":[81],"inclu\u00eddos":[82],"estudos":[83],"cl\u00ednicos,":[84],"revis\u00f5es":[85],"relatos":[87],"caso":[89],"portugu\u00eas,":[91],"ingl\u00eas":[92],"espanhol":[94],"que":[95,105,177],"abordassem":[96],"sist\u00eamicos":[98],"eventos":[100,123],"cardiovasculares,":[101],"totalizando":[102],"14":[103],"artigos":[104],"atenderam":[106],"aos":[107],"crit\u00e9rios":[108],"inclus\u00e3o.":[110],"Os":[111],"achados":[112],"indicam":[113],"associa\u00e7\u00e3o":[114],"consistente":[115],"a":[117,137,178,204],"da":[120,147,200],"como":[124,182],"hipertens\u00e3o,":[125],"bradicardia":[126],"reflexa,":[127],"arritmias":[128],"isquemia":[130],"mioc\u00e1rdica.":[131],"principal":[133],"mecanismo":[134],"fisiopatol\u00f3gico":[135],"envolve":[136],"hiperestimula\u00e7\u00e3o":[138],"dos":[139],"receptores":[140],"alfa-adren\u00e9rgicos,":[141],"resultando":[142],"vasoconstri\u00e7\u00e3o":[144],"intensa,":[145],"aumento":[146],"resist\u00eancia":[148],"vascular":[149],"perif\u00e9rica":[150],"redu\u00e7\u00e3o":[152],"do":[153],"fluxo":[154],"coronariano.":[155],"Verificou-se":[156],"ainda":[157],"um":[158],"padr\u00e3o":[159],"recorrente":[160],"automedica\u00e7\u00e3o":[162],"prolongado,":[165],"favorecido":[166],"pela":[167,171],"venda":[168],"livre":[169],"percep\u00e7\u00e3o":[172],"equivocada":[173],"seguran\u00e7a.":[175],"Conclui-se":[176],"embora":[180],"eficaz":[181],"vasoconstritor":[183],"t\u00f3pico,":[184],"toxicidade":[188],"cardiovascular":[189],"relevante":[190],"quando":[191],"absorvida":[192],"sistemicamente.":[193],"Esta":[194],"contribui":[196],"para":[197],"o":[198],"fortalecimento":[199],"farmacovigil\u00e2ncia":[201],"destaca":[203],"necessidade":[205],"regula\u00e7\u00e3o":[207],"sanit\u00e1ria":[208],"educa\u00e7\u00e3o":[210],"sa\u00fade":[212],"voltadas":[213],"racional":[216],"descongestionantes.":[218]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-02-10T00:00:00"}