{"id":"https://openalex.org/W7128399727","doi":"https://doi.org/10.1021/acs.analchem.5c07190","title":"FAP\u03b1-Activated NIR-I Fluorescent Probe with Improved Water Solubility for Tumor Imaging","display_name":"FAP\u03b1-Activated NIR-I Fluorescent Probe with Improved Water Solubility for Tumor Imaging","publication_year":2026,"publication_date":"2026-02-09","ids":{"openalex":"https://openalex.org/W7128399727","doi":"https://doi.org/10.1021/acs.analchem.5c07190","pmid":"https://pubmed.ncbi.nlm.nih.gov/41657104"},"language":"en","primary_location":{"id":"doi:10.1021/acs.analchem.5c07190","doi":"https://doi.org/10.1021/acs.analchem.5c07190","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.analchem.5c07190","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101236151","display_name":"Cheng Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]},{"id":"https://openalex.org/I4391767752","display_name":"State Key Laboratory of Chemobiosensing and Chemometrics","ror":"https://ror.org/05vg20182","country_code":"CN","type":"facility","lineage":["https://openalex.org/I16609230","https://openalex.org/I4391767752"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng Xie","raw_affiliation_strings":["Hunan University","Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan University","institution_ids":["https://openalex.org/I16609230"]},{"raw_affiliation_string":"Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine","institution_ids":["https://openalex.org/I4391767752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124583206","display_name":"J. C. Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]},{"id":"https://openalex.org/I4391767752","display_name":"State Key Laboratory of Chemobiosensing and Chemometrics","ror":"https://ror.org/05vg20182","country_code":"CN","type":"facility","lineage":["https://openalex.org/I16609230","https://openalex.org/I4391767752"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing-Jie Wu","raw_affiliation_strings":["Hunan University","Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan University","institution_ids":["https://openalex.org/I16609230"]},{"raw_affiliation_string":"Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine","institution_ids":["https://openalex.org/I4391767752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101350295","display_name":"Yurong Feng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]},{"id":"https://openalex.org/I4391767752","display_name":"State Key Laboratory of Chemobiosensing and Chemometrics","ror":"https://ror.org/05vg20182","country_code":"CN","type":"facility","lineage":["https://openalex.org/I16609230","https://openalex.org/I4391767752"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yurong Feng","raw_affiliation_strings":["Hunan University","Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan University","institution_ids":["https://openalex.org/I16609230"]},{"raw_affiliation_string":"Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine","institution_ids":["https://openalex.org/I4391767752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069802666","display_name":"Tian\u2010Bing Ren","orcid":"https://orcid.org/0000-0002-5774-8306","observed_orcids":["https://orcid.org/0000-0002-5774-8306"]},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]},{"id":"https://openalex.org/I4391767752","display_name":"State Key Laboratory of Chemobiosensing and Chemometrics","ror":"https://ror.org/05vg20182","country_code":"CN","type":"facility","lineage":["https://openalex.org/I16609230","https://openalex.org/I4391767752"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Tian-Bing Ren","raw_affiliation_strings":["Hunan University","Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine"],"raw_orcid":"https://orcid.org/0000-0002-5774-8306","affiliations":[{"raw_affiliation_string":"Hunan University","institution_ids":["https://openalex.org/I16609230"]},{"raw_affiliation_string":"Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine","institution_ids":["https://openalex.org/I4391767752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123407562","display_name":"Lin Yuan","orcid":"https://orcid.org/0000-0002-1015-5319","observed_orcids":["https://orcid.org/0000-0002-1015-5319"]},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]},{"id":"https://openalex.org/I4391767752","display_name":"State Key Laboratory of Chemobiosensing and Chemometrics","ror":"https://ror.org/05vg20182","country_code":"CN","type":"facility","lineage":["https://openalex.org/I16609230","https://openalex.org/I4391767752"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Yuan","raw_affiliation_strings":["Hunan University","Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine"],"raw_orcid":"https://orcid.org/0000-0002-1015-5319","affiliations":[{"raw_affiliation_string":"Hunan University","institution_ids":["https://openalex.org/I16609230"]},{"raw_affiliation_string":"Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine","institution_ids":["https://openalex.org/I4391767752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014460203","display_name":"Huan Shuang-yan","orcid":"https://orcid.org/0000-0001-5751-1889","observed_orcids":["https://orcid.org/0000-0001-5751-1889"]},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]},{"id":"https://openalex.org/I4391767752","display_name":"State Key Laboratory of Chemobiosensing and Chemometrics","ror":"https://ror.org/05vg20182","country_code":"CN","type":"facility","lineage":["https://openalex.org/I16609230","https://openalex.org/I4391767752"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shuang-Yan Huan","raw_affiliation_strings":["Hunan University","Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine"],"raw_orcid":"https://orcid.org/0000-0001-5751-1889","affiliations":[{"raw_affiliation_string":"Hunan University","institution_ids":["https://openalex.org/I16609230"]},{"raw_affiliation_string":"Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine","institution_ids":["https://openalex.org/I4391767752"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5125379239","display_name":"Xiao-Bing Zhang","orcid":"https://orcid.org/0000-0002-4010-0028","observed_orcids":["https://orcid.org/0000-0002-4010-0028"]},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]},{"id":"https://openalex.org/I4391767752","display_name":"State Key Laboratory of Chemobiosensing and Chemometrics","ror":"https://ror.org/05vg20182","country_code":"CN","type":"facility","lineage":["https://openalex.org/I16609230","https://openalex.org/I4391767752"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Bing Zhang","raw_affiliation_strings":["Hunan University","Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine"],"raw_orcid":"https://orcid.org/0000-0002-4010-0028","affiliations":[{"raw_affiliation_string":"Hunan University","institution_ids":["https://openalex.org/I16609230"]},{"raw_affiliation_string":"Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine","institution_ids":["https://openalex.org/I4391767752"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5014460203","https://openalex.org/A5069802666","https://openalex.org/A5101350295"],"corresponding_institution_ids":["https://openalex.org/I16609230","https://openalex.org/I4391767752"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":6.4051,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.96720458,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"98","issue":"6","first_page":"4940","last_page":"4949"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10532","display_name":"Molecular Sensors and Ion Detection","score":0.9189000129699707,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10532","display_name":"Molecular Sensors and Ion Detection","score":0.9189000129699707,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.052299998700618744,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11240","display_name":"Luminescence and Fluorescent Materials","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fibroblast-activation-protein","display_name":"fibroblast activation protein","score":0.8600000143051147},{"id":"https://openalex.org/keywords/water-soluble-fluorophores","display_name":"water-soluble fluorophores","score":0.8029999732971191},{"id":"https://openalex.org/keywords/tumor-imaging","display_name":"tumor imaging","score":0.8330000042915344},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"biocompatibility","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9433000087738037},{"id":"https://openalex.org/C2778617687","wikidata":"https://www.wikidata.org/wiki/Q2448456","display_name":"Fluorophore","level":3,"score":0.8245000243186951},{"id":"https://openalex.org/C2777324032","wikidata":"https://www.wikidata.org/wiki/Q412922","display_name":"Cyanine","level":3,"score":0.7980999946594238},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.7239999771118164},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7114999890327454},{"id":"https://openalex.org/C29331040","wikidata":"https://www.wikidata.org/wiki/Q7239554","display_name":"Preclinical imaging","level":3,"score":0.45350000262260437},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4180999994277954},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.4178999960422516},{"id":"https://openalex.org/C57477423","wikidata":"https://www.wikidata.org/wiki/Q1434196","display_name":"Fluorescence-lifetime imaging microscopy","level":3,"score":0.38760000467300415},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.36579999327659607},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.34769999980926514},{"id":"https://openalex.org/C2780557392","wikidata":"https://www.wikidata.org/wiki/Q523796","display_name":"Linker","level":2,"score":0.33390000462532043},{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.32749998569488525},{"id":"https://openalex.org/C145169222","wikidata":"https://www.wikidata.org/wiki/Q9339485","display_name":"Molecular probe","level":3,"score":0.31679999828338623},{"id":"https://openalex.org/C136339569","wikidata":"https://www.wikidata.org/wiki/Q1142297","display_name":"Molecular imaging","level":3,"score":0.29679998755455017},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.29330000281333923},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.2712000012397766}],"mesh":[{"descriptor_ui":"D000098984","descriptor_name":"Fluorescent Chemosensor Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098984","descriptor_name":"Fluorescent Chemosensor Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098984","descriptor_name":"Fluorescent Chemosensor Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099167","descriptor_name":"Fibroblast Activation Protein Alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099167","descriptor_name":"Fibroblast Activation Protein Alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099167","descriptor_name":"Fibroblast Activation Protein Alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007259","descriptor_name":"Infrared Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007259","descriptor_name":"Infrared Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018093","descriptor_name":"Gelatinases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D018093","descriptor_name":"Gelatinases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D018093","descriptor_name":"Gelatinases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D018093","descriptor_name":"Gelatinases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D018093","descriptor_name":"Gelatinases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D018093","descriptor_name":"Gelatinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018093","descriptor_name":"Gelatinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018093","descriptor_name":"Gelatinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018093","descriptor_name":"Gelatinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018093","descriptor_name":"Gelatinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061848","descriptor_name":"Optical Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D061848","descriptor_name":"Optical Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D061848","descriptor_name":"Optical Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D061848","descriptor_name":"Optical Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D061848","descriptor_name":"Optical Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.analchem.5c07190","doi":"https://doi.org/10.1021/acs.analchem.5c07190","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.analchem.5c07190","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"pmid:41657104","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41657104","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","score":0.6543648838996887,"display_name":"Clean water and sanitation"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2444369858","display_name":null,"funder_award_id":"22374040","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2655830792","display_name":null,"funder_award_id":"2023YFA0915400","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G4157519479","display_name":null,"funder_award_id":"22374039","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G704268664","display_name":null,"funder_award_id":"2024RC3100","funder_id":"https://openalex.org/F4320330206","funder_display_name":"Science and Technology Program of Hunan Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320330206","display_name":"Science and Technology Program of Hunan Province","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1518396628","https://openalex.org/W1964818072","https://openalex.org/W1980724829","https://openalex.org/W1981328412","https://openalex.org/W1992592944","https://openalex.org/W2026428302","https://openalex.org/W2038527313","https://openalex.org/W2045727281","https://openalex.org/W2077759978","https://openalex.org/W2087766713","https://openalex.org/W2125071971","https://openalex.org/W2141067132","https://openalex.org/W2480450738","https://openalex.org/W2518811950","https://openalex.org/W2760901191","https://openalex.org/W2783678270","https://openalex.org/W2784923486","https://openalex.org/W2982342070","https://openalex.org/W2995745139","https://openalex.org/W3038979222","https://openalex.org/W3154095152","https://openalex.org/W3180659190","https://openalex.org/W3214155548","https://openalex.org/W4211064536","https://openalex.org/W4283012302","https://openalex.org/W4285178122","https://openalex.org/W4295049453","https://openalex.org/W4323294337","https://openalex.org/W4360606031","https://openalex.org/W4366742548","https://openalex.org/W4367308276","https://openalex.org/W4376617203","https://openalex.org/W4385685046","https://openalex.org/W4391044425","https://openalex.org/W4391257143","https://openalex.org/W4392196219","https://openalex.org/W4395004761","https://openalex.org/W4398250879","https://openalex.org/W4400012893","https://openalex.org/W4403532755","https://openalex.org/W4406059633","https://openalex.org/W4406514009","https://openalex.org/W4406913932","https://openalex.org/W4406915796","https://openalex.org/W4408333286","https://openalex.org/W4408392440","https://openalex.org/W4409094272","https://openalex.org/W4411458915","https://openalex.org/W4412177745","https://openalex.org/W4412384252","https://openalex.org/W4412695629","https://openalex.org/W4412792235","https://openalex.org/W4413286007","https://openalex.org/W4413787563"],"related_works":[],"abstract_inverted_index":{"Fibroblast":[0],"activation":[1],"protein-\u03b1":[2],"(FAP\u03b1),":[3],"with":[4,57],"restricted":[5],"biological":[6],"distribution":[7],"and":[8,16,21,44,55,79,109,125,146],"cleavage":[9],"site":[10],"specificity,":[11],"is":[12],"an":[13],"attractive":[14],"biomarker":[15],"target":[17],"for":[18,24,30,139],"diseases":[19],"diagnosis":[20],"therapy,":[22],"especially":[23],"cancers.":[25],"However,":[26],"effective":[27],"analytical":[28],"tools":[29],"in":[31,118,140],"vivo":[32,141],"FAP\u03b1":[33,82,117],"detection":[34,103],"are":[35],"lacking.":[36],"In":[37],"this":[38,114],"work,":[39],"based":[40],"on":[41],"classic":[42],"hemicyanine":[43],"cyanine":[45],"fluorophores,":[46],"we":[47],"developed":[48],"two":[49],"novel":[50],"FAP\u03b1-activated":[51],"fluorescent":[52],"probes,":[53],"Sulfo-OHDF":[54],"Sulfo-FQCy7,":[56],"improved":[58,110],"water":[59],"solubility":[60],"by":[61],"introducing":[62],"a":[63,136],"sulfonic":[64],"acid":[65],"group":[66],"into":[67],"the":[68,84,122],"fluorophore":[69],"scaffold.":[70],"Consequently,":[71],"these":[72],"probes":[73],"exhibited":[74],"much":[75],"higher":[76],"signal-to-noise":[77],"ratios":[78],"sensitivity":[80,100],"toward":[81,107],"than":[83],"control":[85],"probes.":[86],"Among":[87],"them,":[88],"Sulfo-OHDF,":[89],"featuring":[90],"near":[91],"infrared":[92],"exciation/emssion,":[93],"displayed":[94],"superior":[95],"fluorescence":[96],"enhancement":[97],"(113.2-fold),":[98],"excellent":[99],"(limit":[101],"of":[102,104,143],"1.59":[105],"ng/mL)":[106],"FAP\u03b1,":[108],"biocompatibility.":[111],"Furthermore,":[112],"using":[113],"probe,":[115],"overexpressed":[116],"cells,":[119],"tumor":[120],"tissues,":[121],"wound-healing":[123],"process,":[124],"tumor-bearing":[126],"mice":[127],"was":[128],"successfully":[129],"detected.":[130],"Overall,":[131],"our":[132],"work":[133],"may":[134],"provide":[135],"powerful":[137],"tool":[138],"imaging":[142],"FAP\u03b1-relevant":[144],"physiological":[145],"pathological":[147],"processes.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":4}],"updated_date":"2026-10-02T10:15:12.560889","created_date":"2026-02-10T00:00:00"}
