{"id":"https://openalex.org/W7128380564","doi":"https://doi.org/10.6084/m9.figshare.31290847","title":"Interest of biochemical monitoring of liver function for patients under anti-tuberculosis treatment","display_name":"Interest of biochemical monitoring of liver function for patients under anti-tuberculosis treatment","publication_year":2026,"publication_date":"2026-02-09","ids":{"openalex":"https://openalex.org/W7128380564","doi":"https://doi.org/10.6084/m9.figshare.31290847"},"language":"en","primary_location":{"id":"doi:10.6084/m9.figshare.31290847","doi":"https://doi.org/10.6084/m9.figshare.31290847","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.31290847","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.6084/m9.figshare.31290847","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021736097","display_name":"Alsayed Ahmad Dana","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alsayed Ahmad Dana","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125413686","display_name":"Chikhi Aicha","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chikhi Aicha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125401855","display_name":"Sai Touba","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sai Touba","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125393773","display_name":"Benzitouni Aicha","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benzitouni Aicha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125377581","display_name":"Aoues Khadidja","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aoues Khadidja","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5082953227","display_name":"Abderrezak Khelfi","orcid":"https://orcid.org/0000-0002-8522-7647","observed_orcids":["https://orcid.org/0000-0002-8522-7647"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Khelfi Abderrezak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-induced-liver-injury","display_name":"drug-induced liver injury","score":0.9639999866485596},{"id":"https://openalex.org/keywords/antituberculosis-drugs","display_name":"antitubercular agents","score":0.9909999966621399},{"id":"https://openalex.org/keywords/liver-function-tests","display_name":"liver function tests","score":0.9470000267028809},{"id":"https://openalex.org/keywords/biochemical-monitoring","display_name":"biochemical monitoring","score":0.7599999904632568},{"id":"https://openalex.org/keywords/liver-enzymes","display_name":"liver enzymes","score":0.46399998664855957},{"id":"https://openalex.org/keywords/aspartate-aminotransferase","display_name":"aspartate aminotransferase","score":0.902999997138977},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"alanine aminotransferase","score":1.0},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.9900000095367432},{"id":"https://openalex.org/keywords/bilirubin","display_name":"bilirubin","score":0.8939999938011169},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.8999999761581421},{"id":"https://openalex.org/keywords/tuberculosis-treatment","display_name":"tuberculosis treatment","score":0.8019999861717224},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.8429999947547913}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.857200026512146},{"id":"https://openalex.org/C2777513400","wikidata":"https://www.wikidata.org/wiki/Q104219","display_name":"Bilirubin","level":2,"score":0.8547000288963318},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.7799999713897705},{"id":"https://openalex.org/C512861765","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver function tests","level":2,"score":0.7387999892234802},{"id":"https://openalex.org/C2992208098","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver function","level":2,"score":0.7064999938011169},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.696399986743927},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6780999898910522},{"id":"https://openalex.org/C2909331925","wikidata":"https://www.wikidata.org/wiki/Q104219","display_name":"Direct bilirubin","level":4,"score":0.6761000156402588},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6335999965667725},{"id":"https://openalex.org/C2992872382","wikidata":"https://www.wikidata.org/wiki/Q305481","display_name":"Alanine aminotransferase","level":2,"score":0.5684999823570251},{"id":"https://openalex.org/C2778606649","wikidata":"https://www.wikidata.org/wiki/Q305481","display_name":"Alanine transaminase","level":2,"score":0.3977000117301941},{"id":"https://openalex.org/C2994203108","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Hepatic function","level":2,"score":0.3935999870300293},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3910999894142151},{"id":"https://openalex.org/C3020359197","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver enzyme","level":2,"score":0.3763999938964844},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.37439998984336853},{"id":"https://openalex.org/C2777969384","wikidata":"https://www.wikidata.org/wiki/Q17011974","display_name":"Elevated alkaline phosphatase","level":4,"score":0.32199999690055847},{"id":"https://openalex.org/C2993709057","wikidata":"https://www.wikidata.org/wiki/Q1349821","display_name":"Liver toxicity","level":3,"score":0.3158999979496002},{"id":"https://openalex.org/C2991928575","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver dysfunction","level":2,"score":0.30489999055862427},{"id":"https://openalex.org/C2993432071","wikidata":"https://www.wikidata.org/wiki/Q45959","display_name":"Drug reaction","level":3,"score":0.29899999499320984},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2888000011444092},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.28790000081062317},{"id":"https://openalex.org/C2780542314","wikidata":"https://www.wikidata.org/wiki/Q45959","display_name":"Adverse drug reaction","level":3,"score":0.2784000039100647},{"id":"https://openalex.org/C2986900798","wikidata":"https://www.wikidata.org/wiki/Q5308926","display_name":"Drug treatment","level":2,"score":0.2615000009536743}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.6084/m9.figshare.31290847","doi":"https://doi.org/10.6084/m9.figshare.31290847","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.31290847","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.6084/m9.figshare.31290847.v1","doi":"https://doi.org/10.6084/m9.figshare.31290847.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.31290847.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.6084/m9.figshare.31290847","doi":"https://doi.org/10.6084/m9.figshare.31290847","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.31290847","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7212078427","https://openalex.org/W4206691195","https://openalex.org/W4386363353","https://openalex.org/W2942781324","https://openalex.org/W4391948472","https://openalex.org/W2347776225","https://openalex.org/W6930864247","https://openalex.org/W2119488948","https://openalex.org/W4405927465","https://openalex.org/W3213720063"],"abstract_inverted_index":{"Drug-induced":[0],"hepatotoxicity":[1],"(DIH)":[2],"is":[3,246],"an":[4],"adverse":[5,92],"reaction":[6],"secondary":[7],"to":[8,17,238,243],"the":[9,19,30,47,63,106,172,181,196,230,249],"administration":[10],"of":[11,21,105,113,144,158,169,191,195,221,227,236,252],"anti-tuberculosis":[12],"(anti-TB)":[13],"drugs.":[14,99],"We":[15],"aimed":[16],"evaluate":[18],"importance":[20],"implementing":[22],"periodic":[23],"liver":[24,222],"function":[25,35,223],"tests":[26,36],"before":[27],"and":[28,44,55,78,90,130,141,166,188,211],"throughout":[29,46,229],"anti-TB":[31,48,98,231],"treatment":[32,49,88,145,232,245],"course.":[33,233],"Liver":[34],"were":[37,60,84,160,177],"performed":[38],"on":[39],"recruited":[40],"patients":[41,83],"at":[42,175],"baseline":[43,176],"periodically":[45],"course":[50,89],"(10":[51],"days,":[52],"3":[53,140,167,189],"months,":[54],"6":[56,142],"months).":[57],"Test":[58],"results":[59],"collected":[61],"for":[62,103,147,193,248],"predictive":[64,219],"biomarkers:":[65],"aspartate":[66],"amino-transferase":[67,70],"(AST),":[68],"alanine":[69],"(ALT),":[71],"alkaline":[72],"phosphatase":[73],"(ALP),":[74],"total":[75],"bilirubin":[76,80],"(TBil),":[77],"conjugated":[79],"(BC).":[81],"Some":[82],"surveyed":[85],"about":[86],"their":[87],"any":[91],"drug":[93],"reactions":[94],"(ADRs)":[95],"caused":[96],"by":[97,110,139],"The":[100,154,234],"mean":[101,155,173,182],"values":[102],"each":[104,194],"following":[107,197],"markers":[108],"spiked":[109],"10":[111,164,186],"days":[112,165,187],"treatment:":[114],"AST":[115,199],"(73.235":[116],"\u00b1":[117,122,127,133],"77.632":[118],"IU/L),":[119,124],"ALT":[120,203],"(77.537":[121],"95.737":[123],"TBil":[125,207],"(9.460":[126],"8.254":[128],"mg/L),":[129,135],"BC":[131,148,212],"(1.476":[132],"0.730":[134],"then":[136],"gradually":[137,161],"stabilized":[138],"months":[143,168,190],"(except":[146],"levels,":[149],"which":[150],"showed":[151],"slight":[152],"fluctuations).":[153],"concentration":[156],"levels":[157,174,183],"ALP":[159],"increasing":[162],"after":[163],"treatment.":[170],"Furthermore,":[171],"significantly":[178],"different":[179],"from":[180],"in":[184],"both":[185],"treatment,":[192],"markers:":[198],"(p":[200,204,208,213],"<":[201,205,209,214],"0.01),":[202,206],"0.05),":[210],"0.05).":[215],"In":[216],"this":[217],"study,":[218],"biomarkers":[220],"witnessed":[224],"varying":[225],"patterns":[226],"fluctuation":[228],"adherence":[235],"practitioners":[237],"a":[239],"more":[240],"standardized":[241],"approach":[242],"TB":[244],"vital":[247],"early":[250],"management":[251],"DIH.":[253]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-02-10T00:00:00"}
