{"id":"https://openalex.org/W7128380343","doi":"https://doi.org/10.17116/jnevro202612601182","title":"Fortelyzin for acute ischaemic stroke treatment in an extended (4.5 to 24 hours from the onset of symptoms) time window: data from the observational study FORPI registry","display_name":"Fortelyzin for acute ischaemic stroke treatment in an extended (4.5 to 24 hours from the onset of symptoms) time window: data from the observational study FORPI registry","publication_year":2026,"publication_date":"2026-02-09","ids":{"openalex":"https://openalex.org/W7128380343","doi":"https://doi.org/10.17116/jnevro202612601182","pmid":"https://pubmed.ncbi.nlm.nih.gov/41661014"},"language":"en","primary_location":{"id":"doi:10.17116/jnevro202612601182","doi":"https://doi.org/10.17116/jnevro202612601182","is_oa":false,"landing_page_url":"https://doi.org/10.17116/jnevro202612601182","pdf_url":null,"source":{"id":"https://openalex.org/S949205458","display_name":"S S Korsakov Journal of Neurology and Psychiatry","issn_l":"1997-7298","issn":["1997-7298","2309-4729"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4322616688","host_organization_name":"Media Sphera Publishing Group","host_organization_lineage":["https://openalex.org/P4322616688"],"host_organization_lineage_names":["Media Sphera Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"S.S. Korsakov Journal of Neurology and Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038391709","display_name":"Nikolay A Shamalov","orcid":"https://orcid.org/0000-0001-6250-0762","observed_orcids":["https://orcid.org/0000-0001-6250-0762"]},"institutions":[{"id":"https://openalex.org/I337778094","display_name":"Pirogov Russian National Research Medical University","ror":"https://ror.org/018159086","country_code":"RU","type":"education","lineage":["https://openalex.org/I337778094","https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4387153610","display_name":"Federal Center of Brain Research and Neurotechnologies","ror":"https://ror.org/03583sy04","country_code":null,"type":"government","lineage":["https://openalex.org/I4387153610","https://openalex.org/I64264942"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"N.A. Shamalov","raw_affiliation_strings":["Federal Center for Brain and Neurotechnology","Pirogov Russian National Research Medical University"],"raw_orcid":"https://orcid.org/0000-0001-6250-0762","affiliations":[{"raw_affiliation_string":"Federal Center for Brain and Neurotechnology","institution_ids":["https://openalex.org/I4387153610"]},{"raw_affiliation_string":"Pirogov Russian National Research Medical University","institution_ids":["https://openalex.org/I337778094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080466779","display_name":"M. Yu. Martynov","orcid":"https://orcid.org/0000-0003-2797-7877","observed_orcids":["https://orcid.org/0000-0003-2797-7877"]},"institutions":[{"id":"https://openalex.org/I337778094","display_name":"Pirogov Russian National Research Medical University","ror":"https://ror.org/018159086","country_code":"RU","type":"education","lineage":["https://openalex.org/I337778094","https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4387153610","display_name":"Federal Center of Brain Research and Neurotechnologies","ror":"https://ror.org/03583sy04","country_code":null,"type":"government","lineage":["https://openalex.org/I4387153610","https://openalex.org/I64264942"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"M.Yu. Martynov","raw_affiliation_strings":["Federal Center for Brain and Neurotechnology","Pirogov Russian National Research Medical University"],"raw_orcid":"https://orcid.org/0000-0003-2797-7877","affiliations":[{"raw_affiliation_string":"Federal Center for Brain and Neurotechnology","institution_ids":["https://openalex.org/I4387153610"]},{"raw_affiliation_string":"Pirogov Russian National Research Medical University","institution_ids":["https://openalex.org/I337778094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071024717","display_name":"E. Y. Gusev","orcid":"https://orcid.org/0000-0003-0742-6875","observed_orcids":["https://orcid.org/0000-0003-0742-6875","https://orcid.org/0000-0002-7145-2376"]},"institutions":[{"id":"https://openalex.org/I337778094","display_name":"Pirogov Russian National Research Medical University","ror":"https://ror.org/018159086","country_code":"RU","type":"education","lineage":["https://openalex.org/I337778094","https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4387153610","display_name":"Federal Center of Brain Research and Neurotechnologies","ror":"https://ror.org/03583sy04","country_code":null,"type":"government","lineage":["https://openalex.org/I4387153610","https://openalex.org/I64264942"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E.I. Gusev","raw_affiliation_strings":["Federal Center for Brain and Neurotechnology","Pirogov Russian National Research Medical University"],"raw_orcid":"https://orcid.org/0000-0003-0742-6875","affiliations":[{"raw_affiliation_string":"Federal Center for Brain and Neurotechnology","institution_ids":["https://openalex.org/I4387153610"]},{"raw_affiliation_string":"Pirogov Russian National Research Medical University","institution_ids":["https://openalex.org/I337778094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002359043","display_name":"N. A. Marskaya","orcid":"https://orcid.org/0000-0002-0789-4823","observed_orcids":["https://orcid.org/0000-0002-0789-4823"]},"institutions":[{"id":"https://openalex.org/I4387153610","display_name":"Federal Center of Brain Research and Neurotechnologies","ror":"https://ror.org/03583sy04","country_code":null,"type":"government","lineage":["https://openalex.org/I4387153610","https://openalex.org/I64264942"]}],"countries":[],"is_corresponding":false,"raw_author_name":"N.A. Marskaya","raw_affiliation_strings":["Federal Center for Brain and Neurotechnology"],"raw_orcid":"https://orcid.org/0000-0002-0789-4823","affiliations":[{"raw_affiliation_string":"Federal Center for Brain and Neurotechnology","institution_ids":["https://openalex.org/I4387153610"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035490283","display_name":"Dina Rustemovna Khasanova","orcid":"https://orcid.org/0000-0002-8825-2346","observed_orcids":["https://orcid.org/0000-0002-8825-2346"]},"institutions":[{"id":"https://openalex.org/I186356647","display_name":"Kazan State Medical University","ror":"https://ror.org/013pk4y14","country_code":"RU","type":"education","lineage":["https://openalex.org/I186356647"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"D.R. Khasanova","raw_affiliation_strings":["Kazan State Medical University"],"raw_orcid":"https://orcid.org/0000-0002-8825-2346","affiliations":[{"raw_affiliation_string":"Kazan State Medical University","institution_ids":["https://openalex.org/I186356647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071070670","display_name":"Elena Borisovna Yarovaya","orcid":"https://orcid.org/0000-0002-6615-4315","observed_orcids":["https://orcid.org/0000-0002-6615-4315"]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E.B. Yarovaya","raw_affiliation_strings":["Lomonosov Moscow State University"],"raw_orcid":"https://orcid.org/0000-0002-6615-4315","affiliations":[{"raw_affiliation_string":"Lomonosov Moscow State University","institution_ids":["https://openalex.org/I19880235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049417211","display_name":"Zh. Yu. Chefranova","orcid":"https://orcid.org/0000-0002-2106-7461","observed_orcids":["https://orcid.org/0000-0002-2106-7461"]},"institutions":[{"id":"https://openalex.org/I120938084","display_name":"Belgorod National Research University","ror":"https://ror.org/044cm3z84","country_code":"RU","type":"education","lineage":["https://openalex.org/I120938084"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Z.Yu. Chefranova","raw_affiliation_strings":["Belgorod State National Research University"],"raw_orcid":"https://orcid.org/0000-0002-2106-7461","affiliations":[{"raw_affiliation_string":"Belgorod State National Research University","institution_ids":["https://openalex.org/I120938084"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033532321","display_name":"I.A. Voznyuk","orcid":"https://orcid.org/0000-0001-7192-0961","observed_orcids":["https://orcid.org/0000-0001-7192-0961"]},"institutions":[{"id":"https://openalex.org/I2799540354","display_name":"First Pavlov State Medical University of St. Petersburg","ror":"https://ror.org/04g525b43","country_code":"RU","type":"education","lineage":["https://openalex.org/I2799540354"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"I.A. Voznuk","raw_affiliation_strings":["I.P. Pavlov First State Medical University"],"raw_orcid":"https://orcid.org/0000-0002-4292-4258","affiliations":[{"raw_affiliation_string":"I.P. Pavlov First State Medical University","institution_ids":["https://openalex.org/I2799540354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022347684","display_name":"Andrey Marisovich Alasheev","orcid":"https://orcid.org/0000-0003-1610-2127","observed_orcids":["https://orcid.org/0000-0003-1610-2127"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A.M. Alasheev","raw_affiliation_strings":["Sverdlovsk Regional Clinical Hospital No. 1"],"raw_orcid":"https://orcid.org/0000-0003-1610-2127","affiliations":[{"raw_affiliation_string":"Sverdlovsk Regional Clinical Hospital No. 1","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5095959708","display_name":"M. V. Sutormin","orcid":"https://orcid.org/0009-0004-8742-6182","observed_orcids":["https://orcid.org/0009-0004-8742-6182","https://orcid.org/0009-0001-5563-0363"]},"institutions":[{"id":"https://openalex.org/I4210115129","display_name":"Moscow Regional Scientific Research Clinical Institute. MF Vladimirsky","ror":"https://ror.org/0233m9s16","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210115129"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"M.V. Sutormin","raw_affiliation_strings":["M.F. Vladimirsky Moscow Regional Research Clinical Institute"],"raw_orcid":"https://orcid.org/0009-0004-8742-6182","affiliations":[{"raw_affiliation_string":"M.F. Vladimirsky Moscow Regional Research Clinical Institute","institution_ids":["https://openalex.org/I4210115129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089916084","display_name":"Natalya V. Khalo","orcid":"https://orcid.org/0000-0001-5603-6318","observed_orcids":["https://orcid.org/0000-0001-5603-6318"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N.V. Khalo","raw_affiliation_strings":["I.S. Berzon Krasnoyarsk Interdistrict Clinical Hospital No. 20"],"raw_orcid":"https://orcid.org/0000-0001-5603-6318","affiliations":[{"raw_affiliation_string":"I.S. Berzon Krasnoyarsk Interdistrict Clinical Hospital No. 20","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031193015","display_name":"Madina Bogatyreva","orcid":"https://orcid.org/0000-0002-8838-5958","observed_orcids":["https://orcid.org/0000-0002-8838-5958","https://orcid.org/0000-0002-8753-6611"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M.D. Bogatyreva","raw_affiliation_strings":["Stavropol Regional Clinical Hospital"],"raw_orcid":"https://orcid.org/0000-0002-8838-5958","affiliations":[{"raw_affiliation_string":"Stavropol Regional Clinical Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056442387","display_name":"Dmitry S. Khan","orcid":"https://orcid.org/0000-0002-7179-1917","observed_orcids":["https://orcid.org/0000-0002-7179-1917","https://orcid.org/0000-0002-3621-3003"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D.S. Khan","raw_affiliation_strings":["Primorsky Regional Clinical Hospital No. 1"],"raw_orcid":"https://orcid.org/0000-0002-7179-1917","affiliations":[{"raw_affiliation_string":"Primorsky Regional Clinical Hospital No. 1","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001152769","display_name":"L L Korsunskaya","orcid":"https://orcid.org/0000-0003-0958-130X","observed_orcids":["https://orcid.org/0000-0003-0958-130X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L.L. Korsunskaya","raw_affiliation_strings":["Simferopol City Clinical Hospital No. 7"],"raw_orcid":"https://orcid.org/0000-0003-0958-130X","affiliations":[{"raw_affiliation_string":"Simferopol City Clinical Hospital No. 7","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082791136","display_name":"Tatiana V. Kharitonova","orcid":"https://orcid.org/0000-0003-4021-9421","observed_orcids":["https://orcid.org/0000-0003-4021-9421"]},"institutions":[{"id":"https://openalex.org/I4210105794","display_name":"Research Institute of Emergency Care","ror":"https://ror.org/01j9c2p04","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210105794"]},{"id":"https://openalex.org/I4210131285","display_name":"Saint-Petersburg I. I. Dzhanelidze Research Institute of Emergency Medicine","ror":"https://ror.org/03awxm844","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210131285"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"T.V. Kharitonova","raw_affiliation_strings":["I.I. Dzhanelidze Research Institute of Emergency Care"],"raw_orcid":"https://orcid.org/0000-0003-4021-9421","affiliations":[{"raw_affiliation_string":"I.I. Dzhanelidze Research Institute of Emergency Care","institution_ids":["https://openalex.org/I4210105794","https://openalex.org/I4210131285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045989117","display_name":"Ksenia V Choroshavina","orcid":"https://orcid.org/0000-0001-7165-6793","observed_orcids":["https://orcid.org/0000-0001-7165-6793"]},"institutions":[{"id":"https://openalex.org/I4210100112","display_name":"Tver State Medical University","ror":"https://ror.org/013cc5h66","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210100112"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"K.V. Khoroshavina","raw_affiliation_strings":["Tver Regional Clinical Hospital"],"raw_orcid":"https://orcid.org/0000-0001-7165-6793","affiliations":[{"raw_affiliation_string":"Tver Regional Clinical Hospital","institution_ids":["https://openalex.org/I4210100112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085001033","display_name":"\u0422\u0438\u043c\u0447\u0435\u043d\u043a\u043e \u041b\u044e\u0434\u043c\u0438\u043b\u0430 \u0412\u0438\u043a\u0442\u043e\u0440\u043e\u0432\u043d\u0430","orcid":"https://orcid.org/0000-0001-6341-0101","observed_orcids":["https://orcid.org/0000-0001-6341-0101"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L.V. Timchenko","raw_affiliation_strings":["S.V. Ochapovsky Research Institute \u2014 Regional Clinical Hospital No. 1"],"raw_orcid":"https://orcid.org/0000-0001-6341-0101","affiliations":[{"raw_affiliation_string":"S.V. Ochapovsky Research Institute \u2014 Regional Clinical Hospital No. 1","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068880870","display_name":"V. N. Nesterova","orcid":"https://orcid.org/0000-0002-2456-7971","observed_orcids":["https://orcid.org/0000-0002-2456-7971"]},"institutions":[{"id":"https://openalex.org/I4210090862","display_name":"Nizhny Novgorod Regional Clinical Hospital named after Semashko","ror":"https://ror.org/009w6v212","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210090862"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"V.N. Nesterova","raw_affiliation_strings":["N.A. Semashko Nizhny Novgorod Regional Clinical Hospital"],"raw_orcid":"https://orcid.org/0000-0002-2456-7971","affiliations":[{"raw_affiliation_string":"N.A. Semashko Nizhny Novgorod Regional Clinical Hospital","institution_ids":["https://openalex.org/I4210090862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038641053","display_name":"Aleksey A. Kulesh","orcid":"https://orcid.org/0000-0001-6061-8118","observed_orcids":["https://orcid.org/0000-0001-6061-8118"]},"institutions":[{"id":"https://openalex.org/I4210088483","display_name":"Perm State Medical Academy","ror":"https://ror.org/003a79y48","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210088483"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A.A. Kulesh","raw_affiliation_strings":["City Clinical Hospital No. 4","E.A. Wagner Perm State Medical University"],"raw_orcid":"https://orcid.org/0000-0001-6061-8118","affiliations":[{"raw_affiliation_string":"City Clinical Hospital No. 4","institution_ids":[]},{"raw_affiliation_string":"E.A. Wagner Perm State Medical University","institution_ids":["https://openalex.org/I4210088483"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091778007","display_name":"Natalya V Zhukovskaya","orcid":"https://orcid.org/0000-0002-7434-3044","observed_orcids":["https://orcid.org/0000-0002-7434-3044"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N.V. Zhukovskaya","raw_affiliation_strings":["Leningrad Regional Clinical Hospital"],"raw_orcid":"https://orcid.org/0000-0002-7434-3044","affiliations":[{"raw_affiliation_string":"Leningrad Regional Clinical Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073887999","display_name":"O V Androfagina","orcid":"https://orcid.org/0000-0002-4217-1989","observed_orcids":["https://orcid.org/0000-0002-4217-1989"]},"institutions":[{"id":"https://openalex.org/I4210151766","display_name":"Samara Regional Clinical Hospital named after V.D. Seredavina","ror":"https://ror.org/04rwzz867","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210151766"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"O.V. Androphagina","raw_affiliation_strings":["V.D. Seredavin Samara Regional Clinical Hospital"],"raw_orcid":"https://orcid.org/0000-0002-4217-1989","affiliations":[{"raw_affiliation_string":"V.D. Seredavin Samara Regional Clinical Hospital","institution_ids":["https://openalex.org/I4210151766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049933446","display_name":"Vladimir Aleksandrovich Kutsenko","orcid":"https://orcid.org/0000-0001-9844-3122","observed_orcids":["https://orcid.org/0000-0001-9844-3122"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V.A. Kutsenko","raw_affiliation_strings":["National Medical Research Center for Therapy and Preventive Medicine"],"raw_orcid":"https://orcid.org/0000-0001-9844-3122","affiliations":[{"raw_affiliation_string":"National Medical Research Center for Therapy and Preventive Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"O.E. Ivlev","orcid":"https://orcid.org/0000-0002-3663-6305","observed_orcids":["https://orcid.org/0000-0002-3663-6305"]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"O.E. Ivlev","raw_affiliation_strings":["Lomonosov Moscow State University","National Medical Research Center for Therapy and Preventive Medicine"],"raw_orcid":"https://orcid.org/0000-0002-3663-6305","affiliations":[{"raw_affiliation_string":"Lomonosov Moscow State University","institution_ids":["https://openalex.org/I19880235"]},{"raw_affiliation_string":"National Medical Research Center for Therapy and Preventive Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023559865","display_name":"Anna G. Soplenkova","orcid":"https://orcid.org/0000-0003-0703-146X","observed_orcids":["https://orcid.org/0000-0003-0703-146X"]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A.G. Soplenkova","raw_affiliation_strings":["Lomonosov Moscow State University","National Medical Research Center for Therapy and Preventive Medicine"],"raw_orcid":"https://orcid.org/0000-0003-0703-146X","affiliations":[{"raw_affiliation_string":"Lomonosov Moscow State University","institution_ids":["https://openalex.org/I19880235"]},{"raw_affiliation_string":"National Medical Research Center for Therapy and Preventive Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032283387","display_name":"M. K. Guseva","orcid":"https://orcid.org/0000-0002-5576-6164","observed_orcids":["https://orcid.org/0000-0002-5576-6164"]},"institutions":[{"id":"https://openalex.org/I4210152028","display_name":"Institute of Biomedical Chemistry","ror":"https://ror.org/040wrkp27","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210152028"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"M.K. Guseva","raw_affiliation_strings":["Institute of Biomedical Chemistry"],"raw_orcid":"https://orcid.org/0000-0002-5576-6164","affiliations":[{"raw_affiliation_string":"Institute of Biomedical Chemistry","institution_ids":["https://openalex.org/I4210152028"]}]},{"author_position":"middle","author":{"id":null,"display_name":"E.A. Karpova","orcid":"https://orcid.org/0000-0003-1291-3838","observed_orcids":["https://orcid.org/0000-0003-1291-3838"]},"institutions":[{"id":"https://openalex.org/I4210152028","display_name":"Institute of Biomedical Chemistry","ror":"https://ror.org/040wrkp27","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210152028"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E.A. Karpova","raw_affiliation_strings":["Institute of Biomedical Chemistry"],"raw_orcid":"https://orcid.org/0000-0003-1291-3838","affiliations":[{"raw_affiliation_string":"Institute of Biomedical Chemistry","institution_ids":["https://openalex.org/I4210152028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126571016","display_name":"A. M. Semenov","orcid":"https://orcid.org/0000-0003-1247-4978","observed_orcids":["https://orcid.org/0000-0003-1247-4978"]},"institutions":[{"id":"https://openalex.org/I4210149223","display_name":"SuperGen (United States)","ror":"https://ror.org/049922318","country_code":"US","type":"company","lineage":["https://openalex.org/I114030911","https://openalex.org/I4210149223","https://openalex.org/I4387155454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A.M. Semenov","raw_affiliation_strings":["SuperGene LLC"],"raw_orcid":"https://orcid.org/0000-0003-1247-4978","affiliations":[{"raw_affiliation_string":"SuperGene LLC","institution_ids":["https://openalex.org/I4210149223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078442412","display_name":"M. P. Semenov","orcid":"https://orcid.org/0000-0002-6877-4817","observed_orcids":["https://orcid.org/0000-0002-6877-4817"]},"institutions":[{"id":"https://openalex.org/I4210149223","display_name":"SuperGen (United States)","ror":"https://ror.org/049922318","country_code":"US","type":"company","lineage":["https://openalex.org/I114030911","https://openalex.org/I4210149223","https://openalex.org/I4387155454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.P. Semenov","raw_affiliation_strings":["SuperGene LLC"],"raw_orcid":"https://orcid.org/0000-0002-6877-4817","affiliations":[{"raw_affiliation_string":"SuperGene LLC","institution_ids":["https://openalex.org/I4210149223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134523565","display_name":"S. V. Ivanov","orcid":"https://orcid.org/0000-0003-0438-9108","observed_orcids":["https://orcid.org/0000-0003-0438-9108"]},"institutions":[{"id":"https://openalex.org/I4210149223","display_name":"SuperGen (United States)","ror":"https://ror.org/049922318","country_code":"US","type":"company","lineage":["https://openalex.org/I114030911","https://openalex.org/I4210149223","https://openalex.org/I4387155454"]},{"id":"https://openalex.org/I4210152028","display_name":"Institute of Biomedical Chemistry","ror":"https://ror.org/040wrkp27","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210152028"]}],"countries":["RU","US"],"is_corresponding":false,"raw_author_name":"S.V. Ivanov","raw_affiliation_strings":["Institute of Biomedical Chemistry","SuperGene LLC"],"raw_orcid":"https://orcid.org/0000-0003-0438-9108","affiliations":[{"raw_affiliation_string":"Institute of Biomedical Chemistry","institution_ids":["https://openalex.org/I4210152028"]},{"raw_affiliation_string":"SuperGene LLC","institution_ids":["https://openalex.org/I4210149223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028557946","display_name":"Yulia A. Romashova","orcid":"https://orcid.org/0000-0001-9580-0251","observed_orcids":["https://orcid.org/0000-0001-9580-0251"]},"institutions":[{"id":"https://openalex.org/I4210152028","display_name":"Institute of Biomedical Chemistry","ror":"https://ror.org/040wrkp27","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210152028"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Yu.A. Romashova","raw_affiliation_strings":["Institute of Biomedical Chemistry"],"raw_orcid":"https://orcid.org/0000-0001-9580-0251","affiliations":[{"raw_affiliation_string":"Institute of Biomedical Chemistry","institution_ids":["https://openalex.org/I4210152028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071641104","display_name":"Valery V. Beregovykh","orcid":"https://orcid.org/0000-0002-0210-4570","observed_orcids":["https://orcid.org/0000-0002-0210-4570"]},"institutions":[{"id":"https://openalex.org/I4210152028","display_name":"Institute of Biomedical Chemistry","ror":"https://ror.org/040wrkp27","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210152028"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"V.V. Beregovykh","raw_affiliation_strings":["Institute of Biomedical Chemistry"],"raw_orcid":"https://orcid.org/0000-0002-0210-4570","affiliations":[{"raw_affiliation_string":"Institute of Biomedical Chemistry","institution_ids":["https://openalex.org/I4210152028"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058426137","display_name":"Sergey S. Markin","orcid":"https://orcid.org/0000-0002-0242-0282","observed_orcids":["https://orcid.org/0000-0002-0242-0282"]},"institutions":[{"id":"https://openalex.org/I4210149223","display_name":"SuperGen (United States)","ror":"https://ror.org/049922318","country_code":"US","type":"company","lineage":["https://openalex.org/I114030911","https://openalex.org/I4210149223","https://openalex.org/I4387155454"]},{"id":"https://openalex.org/I4210152028","display_name":"Institute of Biomedical Chemistry","ror":"https://ror.org/040wrkp27","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210152028"]}],"countries":["RU","US"],"is_corresponding":false,"raw_author_name":"S.S. Markin","raw_affiliation_strings":["Institute of Biomedical Chemistry","SuperGene LLC"],"raw_orcid":"https://orcid.org/0000-0002-0242-0282","affiliations":[{"raw_affiliation_string":"Institute of Biomedical Chemistry","institution_ids":["https://openalex.org/I4210152028"]},{"raw_affiliation_string":"SuperGene LLC","institution_ids":["https://openalex.org/I4210149223"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":15,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":17.1014,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.98987798,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"126","issue":"1","first_page":"82","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/staphylokinase","display_name":"staphylokinase","score":0.9580000042915344},{"id":"https://openalex.org/keywords/acute-ischemic-stroke","display_name":"acute ischemic stroke","score":0.972000002861023},{"id":"https://openalex.org/keywords/thrombolysis","display_name":"thrombolysis","score":0.890999972820282},{"id":"https://openalex.org/keywords/extended-time-window","display_name":"extended time window","score":0.8029999732971191},{"id":"https://openalex.org/keywords/symptomatic-intracranial-hemorrhage","display_name":"symptomatic intracranial hemorrhage","score":0.8489999771118164},{"id":"https://openalex.org/keywords/functional-recovery","display_name":"functional recovery","score":0.7409999966621399},{"id":"https://openalex.org/keywords/modified-rankin-scale","display_name":"modified Rankin Scale","score":0.9559999704360962},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.8519999980926514},{"id":"https://openalex.org/keywords/real-world-clinical-practice","display_name":"real-world clinical practice","score":0.6259999871253967},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.5580000281333923},{"id":"https://openalex.org/keywords/stroke-treatment-outcomes","display_name":"stroke treatment outcomes","score":0.3440000116825104},{"id":"https://openalex.org/keywords/alteplase","display_name":"alteplase","score":0.37700000405311584}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8575000166893005},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.695900022983551},{"id":"https://openalex.org/C3018755981","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischaemic stroke","level":3,"score":0.5138999819755554},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.4918000102043152},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.4004000127315521},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37630000710487366},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.33149999380111694},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3221000134944916},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.29350000619888306},{"id":"https://openalex.org/C545542383","wikidata":"https://www.wikidata.org/wiki/Q2751242","display_name":"Medical emergency","level":1,"score":0.2888000011444092},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.28839999437332153},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.2883000075817108},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.2533999979496002},{"id":"https://openalex.org/C3019871722","wikidata":"https://www.wikidata.org/wiki/Q718944","display_name":"Hospital admission","level":2,"score":0.2531999945640564},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2502000033855438}],"mesh":[{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000096182","descriptor_name":"Treatment Delay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000096182","descriptor_name":"Treatment Delay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000096182","descriptor_name":"Treatment Delay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000096182","descriptor_name":"Treatment Delay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000096182","descriptor_name":"Treatment Delay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012042","descriptor_name":"Registries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012042","descriptor_name":"Registries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012042","descriptor_name":"Registries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012042","descriptor_name":"Registries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012042","descriptor_name":"Registries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012042","descriptor_name":"Registries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012042","descriptor_name":"Registries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015912","descriptor_name":"Thrombolytic Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D015912","descriptor_name":"Thrombolytic Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D015912","descriptor_name":"Thrombolytic Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D015912","descriptor_name":"Thrombolytic Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D015912","descriptor_name":"Thrombolytic Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D015912","descriptor_name":"Thrombolytic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015912","descriptor_name":"Thrombolytic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020300","descriptor_name":"Intracranial Hemorrhages","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D020300","descriptor_name":"Intracranial Hemorrhages","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D020300","descriptor_name":"Intracranial Hemorrhages","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D020300","descriptor_name":"Intracranial Hemorrhages","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D020300","descriptor_name":"Intracranial Hemorrhages","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D020300","descriptor_name":"Intracranial Hemorrhages","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D020300","descriptor_name":"Intracranial Hemorrhages","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D020300","descriptor_name":"Intracranial Hemorrhages","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D020300","descriptor_name":"Intracranial Hemorrhages","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D061665","descriptor_name":"Time-to-Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D061665","descriptor_name":"Time-to-Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.17116/jnevro202612601182","doi":"https://doi.org/10.17116/jnevro202612601182","is_oa":false,"landing_page_url":"https://doi.org/10.17116/jnevro202612601182","pdf_url":null,"source":{"id":"https://openalex.org/S949205458","display_name":"S S Korsakov Journal of Neurology and Psychiatry","issn_l":"1997-7298","issn":["1997-7298","2309-4729"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4322616688","host_organization_name":"Media Sphera Publishing Group","host_organization_lineage":["https://openalex.org/P4322616688"],"host_organization_lineage_names":["Media Sphera Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"S.S. Korsakov Journal of Neurology and Psychiatry","raw_type":"journal-article"},{"id":"pmid:41661014","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41661014","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8062580823898315,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W2071680707","https://openalex.org/W2133514192","https://openalex.org/W2159233098","https://openalex.org/W2164763924","https://openalex.org/W2944491145","https://openalex.org/W3193313959","https://openalex.org/W4288776194","https://openalex.org/W4367298580","https://openalex.org/W4385246478","https://openalex.org/W4386083880","https://openalex.org/W4399710327","https://openalex.org/W4405042842","https://openalex.org/W4405471465","https://openalex.org/W4405996882","https://openalex.org/W4406994894","https://openalex.org/W4412398457","https://openalex.org/W4413902833","https://openalex.org/W4414642306","https://openalex.org/W4414668744","https://openalex.org/W4416361902","https://openalex.org/W4416687892","https://openalex.org/W7122820566"],"related_works":[],"abstract_inverted_index":{"Objective.":[0],"To":[1],"evaluate":[2],"the":[3,33,42,63,68,77,138,155,207,230,238,269,283,327,336,340,362,391],"safety":[4,124,152,392],"and":[5,37,41,71,125,145,166,214,257,393,406],"efficacy":[6,126,178,394],"of":[7,44,87,97,111,123,132,157,191,232,240,271,285,303,359,373,395],"Fortelyzin":[8,112,398],"thrombolytic":[9,48],"drug":[10],"(non-immunogenic":[11],"staphylokinase)":[12],"in":[13,16,113,116,130,137,206,237,282,326,339,357,361,399],"AIS":[14,114,400],"patients":[15,88,115,133,202,216,233,286,360,374,401],"an":[17,105],"\u00abextended\u00bb":[18],"therapeutic":[19],"window":[20,224,294,319,382],"from":[21,26,32,81,410],"4.5":[22,79,140,147,209,221,274,291,308,316,368,379,404,408],"to":[23,58,163,226],"24":[24,227],"h":[25,80,141,148,210,222,292,309,317,342,380],"symptoms\u2019":[27,82,411],"onset":[28,144,213],"based":[29],"on":[30,62,390],"data":[31,389],"FORPI":[34,102,385],"registry.":[35],"Material":[36],"methods.":[38],"Functional":[39],"outcomes":[40,127],"risk":[43],"intracranial":[45,159],"hemorrhage":[46,160],"after":[47,142,211],"therapy":[49],"(TLT)":[50],"for":[51,74],"acute":[52],"ischemic":[53],"stroke":[54],"(AIS)":[55],"are":[56,89],"known":[57],"be":[59],"directly":[60],"dependent":[61],"treatment":[64],"time":[65,73,93,149,223,293,318,381],"initiation.":[66],"Although":[67],"most":[69],"safe":[70],"effective":[72],"TLT":[75,136,204,218,235,272,288,366,377,396],"is":[76,100,104,333],"first":[78,139,208],"onset,":[83],"a":[84,186,258],"significant":[85],"proportion":[86],"hospitalized":[90],"beyond":[91,146,220,290,315,378,407],"this":[92,98],"window.":[94,150],"The":[95,101,151,177,198,276,301],"objective":[96],"study":[99,110],"registry":[103,386],"open-label,":[106],"prospective,":[107],"non-interventional":[108],"observational":[109],"real-world":[117],"clinical":[118],"practice.":[119],"A":[120],"comparative":[121],"analysis":[122,199],"was":[128,180,279,310,330,355],"conducted":[129],"groups":[131],"who":[134,364,375],"received":[135,365,376],"symptom":[143,212],"endpoints":[153],"were":[154,244],"rate":[156,338],"symptomatic":[158],"(sICH)":[161],"according":[162],"ECASS":[164],"III":[165],"SITS-MOST":[167],"criteria,":[168],"as":[169,171],"well":[170],"all-cause":[172],"mortality":[173,322,337],"at":[174,194,323,352],"day":[175,195,353],"90.":[176,196],"endpoint":[179],"good":[181],"functional":[182,348],"recovery,":[183],"defined":[184],"by":[185],"modified":[187],"Rankin":[188],"Scale":[189],"(mRS)":[190],"0\u20142":[192],"score":[193],"Results.":[197],"included":[200],"17.636":[201],"with":[203,217,234,268,287,313,335,371,397],"performed":[205,219,236,289],"358":[215],"(up":[225],"hours).":[228],"In":[229],"group":[231,270,284,343,363],"interval":[239],"4.5\u201424":[241,341],"hours,":[242],"there":[243],"statistically":[245],"significantly":[246],"fewer":[247],"people":[248],"over":[249],"80":[250],"years":[251],"old":[252],"(8%":[253],"vs":[254,263,297],"16%,":[255],"p=0.001),":[256],"lower":[259],"median":[260,278],"age":[261],"(66":[262],"68":[264],"years,":[265],"p=0.002)":[266],"compared":[267,312,370],"within":[273,307,367,403],"hours.":[275],"NIHSS":[277],"slightly":[280],"higher":[281],"(11":[295],"(8\u201416)":[296],"11":[298],"(8\u201415),":[299],"p=0.036).":[300],"incidence":[302],"sICH":[304],"(ECASS":[305],"III)":[306],"2%":[311],"2.5%":[314],"(p=0.454).":[320],"All-cause":[321],"90":[324,354],"days":[325],"main":[328],"population":[329],"9%,":[331],"which":[332],"comparable":[334],"\u2014":[344],"7%":[345],"(p=0.160).":[346],"Good":[347],"recovery":[349],"(mSR":[350],"0\u20142)":[351],"achieved":[356],"61%":[358],"h,":[369],"65%":[372],"(p=0.227).":[383],"Conclusion.":[384],"demonstrates":[387],"similar":[388],"both":[402],"hours":[405,409],"onset.":[412]},"counts_by_year":[{"year":2026,"cited_by_count":4}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-02-10T00:00:00"}