{"id":"https://openalex.org/W7128375290","doi":"https://doi.org/10.1158/1078-0432.ccr-25-3557","title":"Proactive Brain Screening Using Contrast-Enhanced Brain CT Scans in HER2+ Metastatic Breast Cancer","display_name":"Proactive Brain Screening Using Contrast-Enhanced Brain CT Scans in HER2+ Metastatic Breast Cancer","publication_year":2026,"publication_date":"2026-02-09","ids":{"openalex":"https://openalex.org/W7128375290","doi":"https://doi.org/10.1158/1078-0432.ccr-25-3557","pmid":"https://pubmed.ncbi.nlm.nih.gov/41661219"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-25-3557","doi":"https://doi.org/10.1158/1078-0432.ccr-25-3557","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-25-3557","pdf_url":"https://aacrjournals.org/clincancerres/article-pdf/doi/10.1158/1078-0432.CCR-25-3557/3736351/ccr-25-3557.pdf","source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://aacrjournals.org/clincancerres/article-pdf/doi/10.1158/1078-0432.CCR-25-3557/3736351/ccr-25-3557.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085165482","display_name":"Gaia Griguolo","orcid":"https://orcid.org/0000-0002-8782-4509","observed_orcids":["https://orcid.org/0000-0002-8782-4509"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]},{"id":"https://openalex.org/I4210109345","display_name":"Istituto Oncologico Veneto","ror":"https://ror.org/01xcjmy57","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109345","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gaia Griguolo","raw_affiliation_strings":["Istituto Oncologico Veneto 2 Division of Oncology 2, IRCCS, Padova, Italy","University of Padova 1 Department of Surgery, Oncology and Gastroenterology, , Padova, Italy"],"raw_orcid":"https://orcid.org/0000-0002-8782-4509","affiliations":[{"raw_affiliation_string":"Istituto Oncologico Veneto 2 Division of Oncology 2, IRCCS, Padova, Italy","institution_ids":["https://openalex.org/I4210109345"]},{"raw_affiliation_string":"University of Padova 1 Department of Surgery, Oncology and Gastroenterology, , Padova, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000380796","display_name":"M. Bottosso","orcid":"https://orcid.org/0000-0002-8098-1819","observed_orcids":["https://orcid.org/0000-0002-8098-1819"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]},{"id":"https://openalex.org/I4210109345","display_name":"Istituto Oncologico Veneto","ror":"https://ror.org/01xcjmy57","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109345","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michele Bottosso","raw_affiliation_strings":["Istituto Oncologico Veneto 2 Division of Oncology 2, IRCCS, Padova, Italy","University of Padova 1 Department of Surgery, Oncology and Gastroenterology, , Padova, Italy"],"raw_orcid":"https://orcid.org/0000-0002-8098-1819","affiliations":[{"raw_affiliation_string":"Istituto Oncologico Veneto 2 Division of Oncology 2, IRCCS, Padova, Italy","institution_ids":["https://openalex.org/I4210109345"]},{"raw_affiliation_string":"University of Padova 1 Department of Surgery, Oncology and Gastroenterology, , Padova, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122854764","display_name":"Giusy Landa","orcid":"https://orcid.org/0009-0001-4303-2462","observed_orcids":["https://orcid.org/0009-0001-4303-2462"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]},{"id":"https://openalex.org/I4210109345","display_name":"Istituto Oncologico Veneto","ror":"https://ror.org/01xcjmy57","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109345","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giusy Landa","raw_affiliation_strings":["Istituto Oncologico Veneto 2 Division of Oncology 2, IRCCS, Padova, Italy","University of Padova 1 Department of Surgery, Oncology and Gastroenterology, , Padova, Italy"],"raw_orcid":"https://orcid.org/0009-0001-4303-2462","affiliations":[{"raw_affiliation_string":"Istituto Oncologico Veneto 2 Division of Oncology 2, IRCCS, Padova, Italy","institution_ids":["https://openalex.org/I4210109345"]},{"raw_affiliation_string":"University of Padova 1 Department of Surgery, Oncology and Gastroenterology, , Padova, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081899865","display_name":"Giorgio Bonomi","orcid":"https://orcid.org/0009-0005-8085-3170","observed_orcids":["https://orcid.org/0009-0005-8085-3170"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]},{"id":"https://openalex.org/I4210109345","display_name":"Istituto Oncologico Veneto","ror":"https://ror.org/01xcjmy57","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109345","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giorgio Bonomi","raw_affiliation_strings":["Istituto Oncologico Veneto 2 Division of Oncology 2, IRCCS, Padova, Italy","University of Padova 1 Department of Surgery, Oncology and Gastroenterology, , Padova, Italy"],"raw_orcid":"https://orcid.org/0009-0005-8085-3170","affiliations":[{"raw_affiliation_string":"Istituto Oncologico Veneto 2 Division of Oncology 2, IRCCS, Padova, Italy","institution_ids":["https://openalex.org/I4210109345"]},{"raw_affiliation_string":"University of Padova 1 Department of Surgery, Oncology and Gastroenterology, , Padova, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013497028","display_name":"Federica Miglietta","orcid":"https://orcid.org/0000-0001-6203-874X","observed_orcids":["https://orcid.org/0000-0001-6203-874X"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]},{"id":"https://openalex.org/I4210109345","display_name":"Istituto Oncologico Veneto","ror":"https://ror.org/01xcjmy57","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109345","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Federica Miglietta","raw_affiliation_strings":["Istituto Oncologico Veneto 2 Division of Oncology 2, IRCCS, Padova, Italy","University of Padova 1 Department of Surgery, Oncology and Gastroenterology, , Padova, Italy"],"raw_orcid":"https://orcid.org/0000-0001-6203-874X","affiliations":[{"raw_affiliation_string":"Istituto Oncologico Veneto 2 Division of Oncology 2, IRCCS, Padova, Italy","institution_ids":["https://openalex.org/I4210109345"]},{"raw_affiliation_string":"University of Padova 1 Department of Surgery, Oncology and Gastroenterology, , Padova, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061815984","display_name":"Maria Cristina Guarascio","orcid":"https://orcid.org/0000-0002-6007-6061","observed_orcids":["https://orcid.org/0000-0002-6007-6061"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]},{"id":"https://openalex.org/I4210109345","display_name":"Istituto Oncologico Veneto","ror":"https://ror.org/01xcjmy57","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109345","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Cristina Guarascio","raw_affiliation_strings":["Istituto Oncologico Veneto 2 Division of Oncology 2, IRCCS, Padova, Italy","University of Padova 1 Department of Surgery, Oncology and Gastroenterology, , Padova, Italy"],"raw_orcid":"https://orcid.org/0000-0002-6007-6061","affiliations":[{"raw_affiliation_string":"Istituto Oncologico Veneto 2 Division of Oncology 2, IRCCS, Padova, Italy","institution_ids":["https://openalex.org/I4210109345"]},{"raw_affiliation_string":"University of Padova 1 Department of Surgery, Oncology and Gastroenterology, , Padova, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033452099","display_name":"Marina La Commare","orcid":"https://orcid.org/0009-0002-8412-4926","observed_orcids":["https://orcid.org/0009-0002-8412-4926"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]},{"id":"https://openalex.org/I4210109345","display_name":"Istituto Oncologico Veneto","ror":"https://ror.org/01xcjmy57","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109345","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marina La Commare","raw_affiliation_strings":["Istituto Oncologico Veneto 2 Division of Oncology 2, IRCCS, Padova, Italy","University of Padova 1 Department of Surgery, Oncology and Gastroenterology, , Padova, Italy"],"raw_orcid":"https://orcid.org/0009-0002-8412-4926","affiliations":[{"raw_affiliation_string":"Istituto Oncologico Veneto 2 Division of Oncology 2, IRCCS, Padova, Italy","institution_ids":["https://openalex.org/I4210109345"]},{"raw_affiliation_string":"University of Padova 1 Department of Surgery, Oncology and Gastroenterology, , Padova, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092203352","display_name":"Francesca Zanghi","orcid":"https://orcid.org/0009-0001-8295-0725","observed_orcids":["https://orcid.org/0009-0001-8295-0725","https://orcid.org/0009-0003-0249-8527"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]},{"id":"https://openalex.org/I4210109345","display_name":"Istituto Oncologico Veneto","ror":"https://ror.org/01xcjmy57","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109345","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Zangh\u00ec","raw_affiliation_strings":["Istituto Oncologico Veneto 2 Division of Oncology 2, IRCCS, Padova, Italy","University of Padova 1 Department of Surgery, Oncology and Gastroenterology, , Padova, Italy"],"raw_orcid":"https://orcid.org/0009-0001-8295-0725","affiliations":[{"raw_affiliation_string":"Istituto Oncologico Veneto 2 Division of Oncology 2, IRCCS, Padova, Italy","institution_ids":["https://openalex.org/I4210109345"]},{"raw_affiliation_string":"University of Padova 1 Department of Surgery, Oncology and Gastroenterology, , Padova, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125415466","display_name":"Terlisa Sheppard","orcid":"https://orcid.org/0009-0008-4844-0888","observed_orcids":["https://orcid.org/0009-0008-4844-0888"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Terlisa Sheppard","raw_affiliation_strings":["3Patient Advocate, Orlando, Florida"],"raw_orcid":"https://orcid.org/0009-0008-4844-0888","affiliations":[{"raw_affiliation_string":"3Patient Advocate, Orlando, Florida","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083670600","display_name":"Carlo Alberto Giorgi","orcid":"https://orcid.org/0000-0001-5406-0357","observed_orcids":["https://orcid.org/0000-0001-5406-0357","https://orcid.org/0000-0002-2571-6828"]},"institutions":[{"id":"https://openalex.org/I4210109345","display_name":"Istituto Oncologico Veneto","ror":"https://ror.org/01xcjmy57","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109345","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carlo Alberto Giorgi","raw_affiliation_strings":["Istituto Oncologico Veneto 2 Division of Oncology 2, IRCCS, Padova, Italy"],"raw_orcid":"https://orcid.org/0000-0001-5406-0357","affiliations":[{"raw_affiliation_string":"Istituto Oncologico Veneto 2 Division of Oncology 2, IRCCS, Padova, Italy","institution_ids":["https://openalex.org/I4210109345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105206726","display_name":"Cristina Falci","orcid":"https://orcid.org/0000-0003-4595-1937","observed_orcids":["https://orcid.org/0000-0003-4595-1937"]},"institutions":[{"id":"https://openalex.org/I4210109345","display_name":"Istituto Oncologico Veneto","ror":"https://ror.org/01xcjmy57","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109345","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cristina Falci","raw_affiliation_strings":["Istituto Oncologico Veneto 2 Division of Oncology 2, IRCCS, Padova, Italy"],"raw_orcid":"https://orcid.org/0000-0003-4595-1937","affiliations":[{"raw_affiliation_string":"Istituto Oncologico Veneto 2 Division of Oncology 2, IRCCS, Padova, Italy","institution_ids":["https://openalex.org/I4210109345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068478901","display_name":"Christine Hodgdon","orcid":"https://orcid.org/0009-0006-1905-115X","observed_orcids":["https://orcid.org/0009-0006-1905-115X"]},"institutions":[{"id":"https://openalex.org/I4210099632","display_name":"Global and Regional Asperger Syndrome Partnership","ror":"https://ror.org/00zzgy689","country_code":"US","type":"other","lineage":["https://openalex.org/I4210099632"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine Hodgdon","raw_affiliation_strings":["4GRASP, Baltimore, Maryland"],"raw_orcid":"https://orcid.org/0009-0006-1905-115X","affiliations":[{"raw_affiliation_string":"4GRASP, Baltimore, Maryland","institution_ids":["https://openalex.org/I4210099632"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019458294","display_name":"Francesca Caumo","orcid":"https://orcid.org/0000-0002-9457-5176","observed_orcids":["https://orcid.org/0000-0002-9457-5176"]},"institutions":[{"id":"https://openalex.org/I4210109345","display_name":"Istituto Oncologico Veneto","ror":"https://ror.org/01xcjmy57","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109345","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Caumo","raw_affiliation_strings":["Istituto Oncologico Veneto 5 Radiology Unit, IRCCS, Padova, Italy"],"raw_orcid":"https://orcid.org/0000-0002-9457-5176","affiliations":[{"raw_affiliation_string":"Istituto Oncologico Veneto 5 Radiology Unit, IRCCS, Padova, Italy","institution_ids":["https://openalex.org/I4210109345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081552375","display_name":"Maria Vittoria Dieci","orcid":"https://orcid.org/0000-0002-3967-9861","observed_orcids":["https://orcid.org/0000-0002-3967-9861"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]},{"id":"https://openalex.org/I4210109345","display_name":"Istituto Oncologico Veneto","ror":"https://ror.org/01xcjmy57","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109345","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Vittoria Dieci","raw_affiliation_strings":["Istituto Oncologico Veneto 2 Division of Oncology 2, IRCCS, Padova, Italy","University of Padova 1 Department of Surgery, Oncology and Gastroenterology, , Padova, Italy"],"raw_orcid":"https://orcid.org/0000-0002-3967-9861","affiliations":[{"raw_affiliation_string":"Istituto Oncologico Veneto 2 Division of Oncology 2, IRCCS, Padova, Italy","institution_ids":["https://openalex.org/I4210109345"]},{"raw_affiliation_string":"University of Padova 1 Department of Surgery, Oncology and Gastroenterology, , Padova, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034632931","display_name":"Valentina Guarneri","orcid":"https://orcid.org/0000-0002-2375-8397","observed_orcids":["https://orcid.org/0000-0002-2375-8397"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]},{"id":"https://openalex.org/I4210109345","display_name":"Istituto Oncologico Veneto","ror":"https://ror.org/01xcjmy57","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109345","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valentina Guarneri","raw_affiliation_strings":["Istituto Oncologico Veneto 2 Division of Oncology 2, IRCCS, Padova, Italy","University of Padova 1 Department of Surgery, Oncology and Gastroenterology, , Padova, Italy"],"raw_orcid":"https://orcid.org/0000-0002-2375-8397","affiliations":[{"raw_affiliation_string":"Istituto Oncologico Veneto 2 Division of Oncology 2, IRCCS, Padova, Italy","institution_ids":["https://openalex.org/I4210109345"]},{"raw_affiliation_string":"University of Padova 1 Department of Surgery, Oncology and Gastroenterology, , Padova, Italy","institution_ids":["https://openalex.org/I138689650"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.9265,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.96616607,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"32","issue":"9","first_page":"1790","last_page":"1798"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13077","display_name":"Cancer-related cognitive impairment studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/her2-positive-metastatic-breast-cancer","display_name":"HER2-positive metastatic breast cancer","score":0.9800000190734863},{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.8610000014305115},{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.7559999823570251},{"id":"https://openalex.org/keywords/pertuzumab","display_name":"pertuzumab","score":0.9959999918937683},{"id":"https://openalex.org/keywords/taxane-based-chemotherapy","display_name":"taxane-based chemotherapy","score":0.6800000071525574},{"id":"https://openalex.org/keywords/whole-brain-radiotherapy","display_name":"whole brain radiotherapy","score":0.843999981880188},{"id":"https://openalex.org/keywords/performance-status","display_name":"performance status","score":0.8289999961853027},{"id":"https://openalex.org/keywords/asymptomatic-patients","display_name":"asymptomatic patients","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8704000115394592},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.6827999949455261},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.5264999866485596},{"id":"https://openalex.org/C2778164965","wikidata":"https://www.wikidata.org/wiki/Q1620196","display_name":"Brain metastasis","level":4,"score":0.4650999903678894},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.45649999380111694},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.43860000371932983},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4178999960422516},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3898000121116638},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3752000033855438},{"id":"https://openalex.org/C544519230","wikidata":"https://www.wikidata.org/wiki/Q32566","display_name":"Computed tomography","level":2,"score":0.364300012588501},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30469998717308044},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.3037000000476837},{"id":"https://openalex.org/C2779281540","wikidata":"https://www.wikidata.org/wiki/Q5062122","display_name":"Central nervous system disease","level":2,"score":0.2973000109195709},{"id":"https://openalex.org/C2994463257","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain cancer","level":3,"score":0.2766000032424927},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.26460000872612},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.263700008392334}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1158/1078-0432.ccr-25-3557","doi":"https://doi.org/10.1158/1078-0432.ccr-25-3557","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-25-3557","pdf_url":"https://aacrjournals.org/clincancerres/article-pdf/doi/10.1158/1078-0432.CCR-25-3557/3736351/ccr-25-3557.pdf","source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:41661219","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41661219","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13133600","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13133600/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clin Cancer Res","raw_type":"Text"},{"id":"pmh:oai:www.research.unipd.it:11577/3587618","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11577/3587618","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.ccr-25-3557","doi":"https://doi.org/10.1158/1078-0432.ccr-25-3557","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-25-3557","pdf_url":"https://aacrjournals.org/clincancerres/article-pdf/doi/10.1158/1078-0432.CCR-25-3557/3736351/ccr-25-3557.pdf","source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7296854853630066,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G920323487","display_name":null,"funder_award_id":"2023-2024","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G952189410","display_name":null,"funder_award_id":"DOR_2023","funder_id":"https://openalex.org/F4320321966","funder_display_name":"Universit\u00e0 degli Studi di Padova"}],"funders":[{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"},{"id":"https://openalex.org/F4320321966","display_name":"Universit\u00e0 degli Studi di Padova","ror":"https://ror.org/00240q980"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7128375290.pdf","grobid_xml":"https://content.openalex.org/works/W7128375290.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"PURPOSE:":[0],"According":[1],"to":[2,268],"recent":[3],"EANO-ESMO":[4],"guidelines,":[5],"proactive":[6,259],"brain":[7,27,48,82,104,115,142,151,170,195,207,215,248,255],"imaging":[8,31,260,273],"can":[9],"be":[10],"considered":[11],"in":[12,50,131,157,175,227,261],"asymptomatic":[13],"patients":[14,51,58,140,158,176],"with":[15,52,61,65,240,245],"HER2+":[16,53,62,262],"metastatic":[17],"breast":[18],"cancer":[19],"(mBC)":[20],"because":[21],"of":[22,25,42,113],"high":[23],"risk":[24],"developing":[26],"metastases.":[28],"However,":[29],"optimal":[30,270],"modality":[32],"and":[33,106,127,134,201,250,272],"timing":[34,271],"remain":[35],"unclear.":[36],"We":[37],"retrospectively":[38,71],"assessed":[39],"the":[40,91,119,132,145,228],"impact":[41],"contrast-enhanced":[43,81],"CT":[44,83,116,241],"screening":[45,74,105,133,160,178,188,229,239],"on":[46],"symptomatic":[47,169,247],"metastases":[49,143,171,208,249],"mBC.":[54,263],"EXPERIMENTAL":[55],"DESIGN:":[56],"Consecutive":[57],"newly":[59],"diagnosed":[60],"mBC":[63],"treated":[64],"trastuzumab-pertuzumab":[66],"plus":[67],"taxane":[68],"(2014-2024)":[69],"were":[70,172,218],"identified.":[72],"Brain":[73,238],"was":[75,123,154,223,243],"defined":[76],"as":[77],"at":[78,194,254],"least":[79],"one":[80],"scan":[84],"per":[85],"year":[86],"without":[87],"neurologic":[88],"symptoms":[89],"during":[90,118,144],"first":[92,120,146],"2":[93,121,147],"years":[94,122],"after":[95,214],"diagnosis.":[96],"RESULTS:":[97],"Among":[98],"148":[99],"identified":[100],"patients,":[101],"73":[102],"underwent":[103],"75":[107],"did":[108],"not.":[109],"The":[110,149],"median":[111],"number":[112],"annual":[114],"scans":[117,242],"2.0":[124],"(IQR,":[125,129],"1.2-2.5)":[126],"0.0":[128],"0-0.5)":[130],"nonscreening":[135],"groups,":[136],"respectively.":[137],"Thirty":[138],"(20.3%)":[139],"developed":[141],"years.":[148],"cumulative":[150],"metastasis":[152,196,216,256],"incidence":[153],"significantly":[155,173],"higher":[156],"undergoing":[159,177,187],"(30.6%":[161],"vs.":[162,180,232],"12.3%,":[163],"Gray's":[164,182],"P":[165,183,234],"=":[166,184,199,210,235],"0.004),":[167],"but":[168],"lower":[174],"(0%":[179],"9.5%,":[181],"0.012).":[185],"Patients":[186],"had":[189],"better":[190,251],"preserved":[191],"performance":[192,252],"status":[193,253],"diagnosis":[197,217],"(P":[198,209],"0.002)":[200],"a":[202],"numerical":[203],"trend":[204],"toward":[205],"fewer":[206,246],"0.057).":[211],"Treatment":[212],"patterns":[213],"similar,":[219],"although":[220],"whole-brain":[221],"radiotherapy":[222],"used":[224],"less":[225],"often":[226],"group":[230],"(14.3%":[231],"44.4%,":[233],"0.073).":[236],"CONCLUSIONS:":[237],"associated":[244],"diagnosis,":[257],"supporting":[258],"Prospective":[264],"studies":[265],"are":[266],"warranted":[267],"define":[269],"modalities.":[274]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2026-02-10T00:00:00"}