{"id":"https://openalex.org/W7128370872","doi":"https://doi.org/10.1021/jacs.5c21708","title":"Conditional Localization Pharmacology Manipulates the Cell Cycle with Spatiotemporal Precision","display_name":"Conditional Localization Pharmacology Manipulates the Cell Cycle with Spatiotemporal Precision","publication_year":2026,"publication_date":"2026-02-09","ids":{"openalex":"https://openalex.org/W7128370872","doi":"https://doi.org/10.1021/jacs.5c21708","pmid":"https://pubmed.ncbi.nlm.nih.gov/39314350"},"language":"en","primary_location":{"id":"doi:10.1021/jacs.5c21708","doi":"https://doi.org/10.1021/jacs.5c21708","is_oa":true,"landing_page_url":"https://doi.org/10.1021/jacs.5c21708","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1021/jacs.5c21708","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064402859","display_name":"Changfeng Deng","orcid":"https://orcid.org/0000-0001-9138-0851","observed_orcids":["https://orcid.org/0000-0001-9138-0851"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Changfeng Deng","raw_affiliation_strings":["Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113394118","display_name":"Yung-Chi Lan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yung-Chi Lan","raw_affiliation_strings":["Department of Biology, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021061515","display_name":"Geng-Yuan Chen","orcid":"https://orcid.org/0000-0002-0103-4494","observed_orcids":["https://orcid.org/0000-0002-0103-4494"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Geng-Yuan Chen","raw_affiliation_strings":["Department of Biology, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107473171","display_name":"Chigozie S. Ekeabu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chigozie S. Ekeabu","raw_affiliation_strings":["Department of Biology, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125382637","display_name":"Quoc Doan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Quoc Doan","raw_affiliation_strings":["Department of Biology, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108899791","display_name":"Megan Chung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan Chung","raw_affiliation_strings":["Department of Biology, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029345218","display_name":"Michael A. Lampson","orcid":"https://orcid.org/0000-0002-2825-1894","observed_orcids":["https://orcid.org/0000-0002-2825-1894"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael A. Lampson","raw_affiliation_strings":["Department of Biology, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000210369","display_name":"David M. Chenoweth","orcid":"https://orcid.org/0000-0002-0819-4669","observed_orcids":["https://orcid.org/0000-0002-0819-4669"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David M. Chenoweth","raw_affiliation_strings":["Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104, United States"],"raw_orcid":"https://orcid.org/0000-0002-0819-4669","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104, United States","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000210369","https://openalex.org/A5029345218"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":3.0625,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.85671313,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"148","issue":"7","first_page":"6793","last_page":"6797"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.5990999937057495,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.5990999937057495,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.06830000132322311,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11708","display_name":"Photochromic and Fluorescence Chemistry","score":0.047200001776218414,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mps1-kinase","display_name":"Mps1 kinase","score":0.7319999933242798},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.6740000247955322},{"id":"https://openalex.org/keywords/spindle-assembly-checkpoint","display_name":"spindle assembly checkpoint","score":0.777999997138977},{"id":"https://openalex.org/keywords/mitotic-exit","display_name":"mitotic exit","score":0.9620000123977661},{"id":"https://openalex.org/keywords/live-cell-imaging","display_name":"live-cell imaging","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8198000192642212},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5480999946594238},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5170000195503235},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.49540001153945923},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.48570001125335693},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.46709999442100525},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.4447000026702881},{"id":"https://openalex.org/C175732170","wikidata":"https://www.wikidata.org/wiki/Q9064829","display_name":"Spindle checkpoint","level":5,"score":0.39430001378059387},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.37599998712539673},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.3734000027179718},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.36309999227523804},{"id":"https://openalex.org/C2776879804","wikidata":"https://www.wikidata.org/wiki/Q7630919","display_name":"Subcellular localization","level":3,"score":0.3589000105857849},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35670000314712524},{"id":"https://openalex.org/C47432576","wikidata":"https://www.wikidata.org/wiki/Q918594","display_name":"Spindle apparatus","level":4,"score":0.303600013256073},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3021000027656555},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.2939999997615814},{"id":"https://openalex.org/C141937037","wikidata":"https://www.wikidata.org/wiki/Q14911664","display_name":"Aurora B kinase","level":5,"score":0.2856999933719635},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.28360000252723694},{"id":"https://openalex.org/C2994037739","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle progression","level":4,"score":0.2669000029563904},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2615000009536743},{"id":"https://openalex.org/C66417403","wikidata":"https://www.wikidata.org/wiki/Q20970072","display_name":"Integrin-linked kinase","level":5,"score":0.2531999945640564},{"id":"https://openalex.org/C48103436","wikidata":"https://www.wikidata.org/wiki/Q599031","display_name":"State (computer science)","level":2,"score":0.25119999051094055}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1021/jacs.5c21708","doi":"https://doi.org/10.1021/jacs.5c21708","is_oa":true,"landing_page_url":"https://doi.org/10.1021/jacs.5c21708","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"doi:10.1101/2024.09.12.612697","doi":"https://doi.org/10.1101/2024.09.12.612697","is_oa":false,"landing_page_url":"https://doi.org/10.1101/2024.09.12.612697","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:39314350","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39314350","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:41661146","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41661146","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11419097","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11419097","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12951450","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12951450/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Am Chem Soc","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1021/jacs.5c21708","doi":"https://doi.org/10.1021/jacs.5c21708","is_oa":true,"landing_page_url":"https://doi.org/10.1021/jacs.5c21708","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000039233","display_name":null,"funder_award_id":"GM122475","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000055990","display_name":null,"funder_award_id":"P01 CA265794","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000063105","display_name":null,"funder_award_id":"R01AR077094","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000872565","display_name":"Cell Biological mechanisms of centromere drive","funder_award_id":"5r35gm122475-09","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334041","display_name":"Institute on Aging, University of Pennsylvania","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1968626589","https://openalex.org/W1976934648","https://openalex.org/W1980858525","https://openalex.org/W1988887329","https://openalex.org/W2016036293","https://openalex.org/W2057141116","https://openalex.org/W2122895020","https://openalex.org/W2134178604","https://openalex.org/W2156035728","https://openalex.org/W2171175279","https://openalex.org/W2342538606","https://openalex.org/W2604969293","https://openalex.org/W2796585533","https://openalex.org/W2814854939","https://openalex.org/W3167014491","https://openalex.org/W3199123561","https://openalex.org/W3200599811","https://openalex.org/W4210468891","https://openalex.org/W4385856400","https://openalex.org/W4399888200","https://openalex.org/W4404648011","https://openalex.org/W4407595174"],"related_works":[],"abstract_inverted_index":{"Traditional":[0],"pharmacology":[1,25],"has":[2],"limited":[3],"control":[4,109],"of":[5,37,49,70,103],"drug":[6],"activity":[7,48],"and":[8,12,57,106,116],"localization":[9,24,105],"in":[10,39,60],"space":[11],"time.":[13],"Herein,":[14],"we":[15],"describe":[16],"an":[17,28],"approach":[18],"for":[19],"kinase":[20,75],"regulation":[21],"using":[22,43,65],"conditional":[23],"(CLP),":[26],"where":[27],"inactive":[29],"caged":[30,95],"inhibitor":[31,51,76],"is":[32,101],"localized":[33],"to":[34,85],"a":[35,40,61,68,72,79],"site":[36],"interest":[38],"dormant":[41],"state":[42],"intracellular":[44],"protein":[45],"tethering.":[46],"The":[47],"the":[50,87],"can":[52],"be":[53],"regulated":[54],"with":[55],"spatial":[56],"temporal":[58],"precision":[59],"live":[62],"cellular":[63],"environment":[64],"light.":[66],"As":[67],"proof":[69],"concept,":[71],"photocaged":[73],"MPS1":[74],"(reversine)":[77],"bearing":[78],"HaloTag":[80],"ligand":[81],"tether":[82],"was":[83],"designed":[84],"manipulate":[86],"cell":[88],"cycle.":[89],"We":[90],"demonstrate":[91],"that":[92],"this":[93],"new":[94],"reversine":[96],"halo":[97],"probe":[98],"(CRH)":[99],"strategy":[100],"capable":[102],"efficient":[104],"exceptional":[107],"spatiotemporal":[108],"over":[110],"spindle":[111],"assembly":[112],"checkpoint":[113],"(SAC)":[114],"silencing":[115],"mitotic":[117],"exit.":[118]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2026-02-10T00:00:00"}
