{"id":"https://openalex.org/W7128370407","doi":"https://doi.org/10.57647/jnsc.2026.1601.04","title":"Gold Nanoisland Microelectrode Micro-Aptamer Sensor with SWASV Readout for EGFR-Positive Lung Cancer Exosomes","display_name":"Gold Nanoisland Microelectrode Micro-Aptamer Sensor with SWASV Readout for EGFR-Positive Lung Cancer Exosomes","publication_year":2025,"publication_date":"2025-10-29","ids":{"openalex":"https://openalex.org/W7128370407","doi":"https://doi.org/10.57647/jnsc.2026.1601.04"},"language":"en","primary_location":{"id":"doi:10.57647/jnsc.2026.1601.04","doi":"https://doi.org/10.57647/jnsc.2026.1601.04","is_oa":true,"landing_page_url":"https://doi.org/10.57647/jnsc.2026.1601.04","pdf_url":null,"source":{"id":"https://openalex.org/S7407052463","display_name":"OICC Press Journals","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4394709092","host_organization_name":"OICC Press (United Kingdom)","host_organization_lineage":["https://openalex.org/I4394709092"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.57647/jnsc.2026.1601.04","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5125394849","display_name":"Wenxin Yuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan, Wenxin","raw_affiliation_strings":["The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China","China-Japan Friendship Jiangxi Hospital, National Regional Center for Respiratory Medicine, Nanchang, Jiangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China","institution_ids":["https://openalex.org/I4210164024"]},{"raw_affiliation_string":"China-Japan Friendship Jiangxi Hospital, National Regional Center for Respiratory Medicine, Nanchang, Jiangxi, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088109795","display_name":"Sicong Jiang","orcid":"https://orcid.org/0000-0001-8974-6770","observed_orcids":["https://orcid.org/0000-0001-8974-6770"]},"institutions":[{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiang, Sicong","raw_affiliation_strings":["The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China","China-Japan Friendship Jiangxi Hospital, National Regional Center for Respiratory Medicine, Nanchang, Jiangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China","institution_ids":["https://openalex.org/I4210164024"]},{"raw_affiliation_string":"China-Japan Friendship Jiangxi Hospital, National Regional Center for Respiratory Medicine, Nanchang, Jiangxi, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125430138","display_name":"Chenghong Mao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174442536","display_name":"South Central Minzu University","ror":"https://ror.org/03d7sax13","country_code":"CN","type":"education","lineage":["https://openalex.org/I174442536"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mao, Chenghong","raw_affiliation_strings":["Department of Clinical Medicine, South Central MinZu University, Wuhan, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, South Central MinZu University, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I174442536"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125382543","display_name":"Jiaru Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162246","display_name":"Loudi Central Hospital","ror":"https://ror.org/04jref587","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162246"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiang, Jiaru","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, Loudi Central Hospital, Loudi, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, Loudi Central Hospital, Loudi, Hunan, China","institution_ids":["https://openalex.org/I4210162246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070558697","display_name":"Ke Zhang","orcid":"https://orcid.org/0000-0001-5606-428X","observed_orcids":["https://orcid.org/0000-0001-5606-428X"]},"institutions":[{"id":"https://openalex.org/I4210097309","display_name":"Jiangxi Provincial Cancer Hospital","ror":"https://ror.org/00v8g0168","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097309"]},{"id":"https://openalex.org/I4405282134","display_name":"Nanchang Medical College","ror":"https://ror.org/05cgtpd39","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405282134"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhang, Ke","raw_affiliation_strings":["Department of Pathology, Jiangxi Cancer Hospital \uff06Institute, Jiangxi Clinical Research Center for Cancer, The Second Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Jiangxi Cancer Hospital \uff06Institute, Jiangxi Clinical Research Center for Cancer, The Second Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China","institution_ids":["https://openalex.org/I4210097309","https://openalex.org/I4405282134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102220966","display_name":"Dongmei Lin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lin, Dongmei","raw_affiliation_strings":["Department of Intensive Care Unit, Qingpu District Central Hospital, Shanghai, China Wenxin Yuan and Sicong Jiang contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Intensive Care Unit, Qingpu District Central Hospital, Shanghai, China Wenxin Yuan and Sicong Jiang contributed equally to this work","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5125409194","display_name":"Jianjun Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tang, Jianjun","raw_affiliation_strings":["The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China","China-Japan Friendship Jiangxi Hospital, National Regional Center for Respiratory Medicine, Nanchang, Jiangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China","institution_ids":["https://openalex.org/I4210164024"]},{"raw_affiliation_string":"China-Japan Friendship Jiangxi Hospital, National Regional Center for Respiratory Medicine, Nanchang, Jiangxi, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.36440914,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11434","display_name":"Electrochemical Analysis and Applications","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1603","display_name":"Electrochemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exosome-detection","display_name":"exosome detection","score":0.8040000200271606},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8980000019073486},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.8709999918937683},{"id":"https://openalex.org/keywords/cd63","display_name":"CD63","score":0.7590000033378601},{"id":"https://openalex.org/keywords/cds-quantum-dots","display_name":"CdS quantum dots","score":0.9629999995231628},{"id":"https://openalex.org/keywords/square-wave-anodic-stripping-voltammetry","display_name":"square wave anodic stripping voltammetry","score":0.8899999856948853},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.921999990940094},{"id":"https://openalex.org/keywords/t790m-resistance","display_name":"T790M resistance","score":0.7179999947547913},{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.7260000109672546},{"id":"https://openalex.org/keywords/therapeutic-monitoring","display_name":"therapeutic monitoring","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C128972844","wikidata":"https://www.wikidata.org/wiki/Q418722","display_name":"Aptamer","level":2,"score":0.8331000208854675},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5570999979972839},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5148000121116638},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.5097000002861023},{"id":"https://openalex.org/C2779529041","wikidata":"https://www.wikidata.org/wiki/Q22349364","display_name":"Liquid biopsy","level":3,"score":0.4796999990940094},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.446399986743927},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.4187999963760376},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.4124000072479248},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39579999446868896},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.39320001006126404},{"id":"https://openalex.org/C104819515","wikidata":"https://www.wikidata.org/wiki/Q900961","display_name":"Colloidal gold","level":3,"score":0.32580000162124634},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.3249000012874603},{"id":"https://openalex.org/C87892846","wikidata":"https://www.wikidata.org/wiki/Q864256","display_name":"Biochip","level":2,"score":0.3248000144958496},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.31869998574256897},{"id":"https://openalex.org/C111670793","wikidata":"https://www.wikidata.org/wiki/Q16979465","display_name":"Microelectrode","level":3,"score":0.3163999915122986},{"id":"https://openalex.org/C2777002142","wikidata":"https://www.wikidata.org/wiki/Q5031432","display_name":"Cancer biomarkers","level":3,"score":0.2842999994754791},{"id":"https://openalex.org/C182606246","wikidata":"https://www.wikidata.org/wiki/Q7187926","display_name":"Photothermal therapy","level":2,"score":0.2818000018596649},{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.26570001244544983},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.25600001215934753},{"id":"https://openalex.org/C102951782","wikidata":"https://www.wikidata.org/wiki/Q49295","display_name":"Atomic force microscopy","level":2,"score":0.250900000333786}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.57647/jnsc.2026.1601.04","doi":"https://doi.org/10.57647/jnsc.2026.1601.04","is_oa":true,"landing_page_url":"https://doi.org/10.57647/jnsc.2026.1601.04","pdf_url":null,"source":{"id":"https://openalex.org/S7407052463","display_name":"OICC Press Journals","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4394709092","host_organization_name":"OICC Press (United Kingdom)","host_organization_lineage":["https://openalex.org/I4394709092"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.57647/jnsc.2026.1601.04","doi":"https://doi.org/10.57647/jnsc.2026.1601.04","is_oa":true,"landing_page_url":"https://doi.org/10.57647/jnsc.2026.1601.04","pdf_url":null,"source":{"id":"https://openalex.org/S7407052463","display_name":"OICC Press Journals","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4394709092","host_organization_name":"OICC Press (United Kingdom)","host_organization_lineage":["https://openalex.org/I4394709092"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/9","display_name":"Industry, innovation and infrastructure","score":0.5102373361587524}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Non-small":[0],"cell":[1],"lung":[2,65],"cancer":[3,66],"(NSCLC)":[4],"requires":[5],"highly":[6],"sensitive":[7],"liquid":[8],"biopsy":[9],"tools":[10],"capable":[11],"of":[12,44,62,70,77,165,167,208],"detecting":[13],"EGFR":[14,47,63,112],"driven":[15],"disease":[16],"and":[17,42,90,113,152,175,186,188,219],"resistance":[18],"mutations":[19],"such":[20],"as":[21,211],"T790M,":[22],"which":[23,86],"often":[24],"evade":[25],"conventional":[26],"circulating":[27],"free":[28],"DNA":[29],"assays.":[30,179],"Exosomes":[31],"provide":[32],"a":[33,78,88,104,122,161,212],"more":[34],"reliable":[35],"biomarker":[36],"due":[37],"to":[38,116,158,195],"their":[39],"abundance,":[40],"stability,":[41,187],"enrichment":[43],"tumor":[45],"specific":[46],"cargo.":[48],"Here,":[49],"we":[50],"report":[51],"an":[52],"ultrasensitive":[53],"electrochemical":[54,177],"microaptasensor":[55],"specifically":[56],"designed":[57],"for":[58,95,215],"the":[59,75,101,205],"quantitative":[60],"detection":[61,166],"positive":[64],"exosomes.":[67],"The":[68,180],"innovation":[69],"this":[71,209],"work":[72],"lies":[73],"in":[74,160,197],"integration":[76],"thermally":[79],"dewetted":[80],"gold":[81],"nanoisland":[82],"microelectrode":[83],"(AuNI":[84],"ME)":[85],"offers":[87],"large":[89],"Au(111)":[91],"enriched":[92],"electroactive":[93],"surface":[94],"high":[96,190],"density":[97],"aptamer":[98,106,150],"immobilization.":[99],"Additionally,":[100],"system":[102,130],"utilizes":[103],"dual":[105,149],"AND":[107],"gate":[108],"recognition":[109],"strategy":[110],"using":[111],"CD63":[114],"aptamers":[115],"ensure":[117],"exceptional":[118],"specificity":[119],"along":[120],"with":[121],"cadmium":[123],"sulfide":[124],"quantum":[125],"dot":[126],"(CdS":[127],"QD)":[128],"amplification":[129,142,157],"quantified":[131],"via":[132],"square":[133],"wave":[134],"anodic":[135],"stripping":[136],"voltammetry":[137],"(SWASV).":[138],"This":[139,170],"multi":[140],"tiered":[141],"architecture":[143],"combines":[144],"nanostructured":[145],"electrode":[146],"design,":[147],"orthogonal":[148],"recognition,":[151],"QD":[153],"based":[154],"metal":[155],"ion":[156],"result":[159],"remarkably":[162],"low":[163],"limit":[164],"150":[168],"particles/mL.":[169],"performance":[171],"outperforms":[172],"ELISA,":[173],"NTA,":[174],"recent":[176],"exosome":[178],"sensor":[181],"exhibits":[182],"excellent":[183],"selectivity,":[184],"reproducibility,":[185],"demonstrates":[189],"recovery":[191],"ranging":[192],"from":[193],"97.8%":[194],"105.0%":[196],"spiked":[198],"human":[199],"serum":[200],"samples.":[201],"These":[202],"results":[203],"highlight":[204],"translational":[206],"potential":[207],"platform":[210],"noninvasive":[213],"tool":[214],"early":[216],"NSCLC":[217],"diagnosis":[218],"real":[220],"time":[221],"therapeutic":[222],"monitoring.":[223]},"counts_by_year":[],"updated_date":"2026-09-23T05:00:35.095934","created_date":"2026-02-10T00:00:00"}
