{"id":"https://openalex.org/W7128364795","doi":"https://doi.org/10.32889/actabioina.210","title":"Effect of turmeric (Curcuma longa L.) extract on gastric histopathology of diclofenac sodium-induced rats","display_name":"Effect of turmeric (Curcuma longa L.) extract on gastric histopathology of diclofenac sodium-induced rats","publication_year":2025,"publication_date":"2025-12-04","ids":{"openalex":"https://openalex.org/W7128364795","doi":"https://doi.org/10.32889/actabioina.210"},"language":"en","primary_location":{"id":"doi:10.32889/actabioina.210","doi":"https://doi.org/10.32889/actabioina.210","is_oa":true,"landing_page_url":"https://doi.org/10.32889/actabioina.210","pdf_url":"https://jurnal.pbbmi.org/index.php/actabioina/article/download/210/114","source":{"id":"https://openalex.org/S4210182433","display_name":"Acta Biochimica Indonesiana","issn_l":"2654-3222","issn":["2654-3222","2654-6108"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310320278","host_organization_name":"American Society for Biochemistry and Molecular Biology","host_organization_lineage":["https://openalex.org/P4310320278"],"host_organization_lineage_names":["American Society for Biochemistry and Molecular Biology"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Biochimica Indonesiana","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jurnal.pbbmi.org/index.php/actabioina/article/download/210/114","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5125387215","display_name":"Melania Lie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I315861787","display_name":"University of Nusa Cendana","ror":"https://ror.org/04yf4aj88","country_code":"ID","type":"education","lineage":["https://openalex.org/I315861787"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Melania Lie","raw_affiliation_strings":["Faculty of Medicine and Veterinary Medicine, Nusa Cendana University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine and Veterinary Medicine, Nusa Cendana University","institution_ids":["https://openalex.org/I315861787"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122610487","display_name":"Anita Lidesna Shinta Amat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I315861787","display_name":"University of Nusa Cendana","ror":"https://ror.org/04yf4aj88","country_code":"ID","type":"education","lineage":["https://openalex.org/I315861787"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Anita Lidesna Shinta Amat","raw_affiliation_strings":["Department of Biomedical Sciences, Faculty of Medicine and Veterinary Medicine, Nusa Cendana University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Faculty of Medicine and Veterinary Medicine, Nusa Cendana University","institution_ids":["https://openalex.org/I315861787"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030432297","display_name":"Rahel Rara Woda","orcid":"https://orcid.org/0009-0006-5748-2583","observed_orcids":["https://orcid.org/0009-0006-5748-2583"]},"institutions":[{"id":"https://openalex.org/I315861787","display_name":"University of Nusa Cendana","ror":"https://ror.org/04yf4aj88","country_code":"ID","type":"education","lineage":["https://openalex.org/I315861787"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Rahel Rara Woda","raw_affiliation_strings":["Department of Dryland and Archipelagic Medicine, Community Medicine, Faculty of Medicine and Veterinary Medicine, Nusa Cendana University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dryland and Archipelagic Medicine, Community Medicine, Faculty of Medicine and Veterinary Medicine, Nusa Cendana University","institution_ids":["https://openalex.org/I315861787"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068671985","display_name":"Kartini Lidia","orcid":"https://orcid.org/0000-0003-0436-2239","observed_orcids":["https://orcid.org/0000-0003-0436-2239"]},"institutions":[{"id":"https://openalex.org/I315861787","display_name":"University of Nusa Cendana","ror":"https://ror.org/04yf4aj88","country_code":"ID","type":"education","lineage":["https://openalex.org/I315861787"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Kartini Lidia","raw_affiliation_strings":["Department of Biomedical Sciences, Pharmacology and Therapy, Faculty of Medicine and Veterinary Medicine, Nusa Cendana University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Pharmacology and Therapy, Faculty of Medicine and Veterinary Medicine, Nusa Cendana University","institution_ids":["https://openalex.org/I315861787"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I315861787"],"apc_list":{"value":1000000,"currency":"IDR","value_usd":75},"apc_paid":{"value":1000000,"currency":"IDR","value_usd":75},"fwci":0.3331,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.47039199,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"8","issue":"1","first_page":"210","last_page":"210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/turmeric-extract","display_name":"turmeric extract","score":0.9419999718666077},{"id":"https://openalex.org/keywords/turmeric","display_name":"turmeric","score":0.9990000128746033},{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":0.9369999766349792},{"id":"https://openalex.org/keywords/diclofenac-sodium","display_name":"diclofenac sodium","score":0.9639999866485596},{"id":"https://openalex.org/keywords/nsaid-induced-gastropathy","display_name":"NSAID-induced gastropathy","score":0.8040000200271606},{"id":"https://openalex.org/keywords/gastroprotective-effect","display_name":"gastroprotection","score":0.8740000128746033},{"id":"https://openalex.org/keywords/gastric-mucosal-histopathology","display_name":"gastric mucosal histopathology","score":0.8539999723434448},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.8999999761581421},{"id":"https://openalex.org/keywords/cyclooxygenase-inhibition","display_name":"cyclooxygenase inhibition","score":0.8859999775886536},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.871999979019165},{"id":"https://openalex.org/keywords/gastric-erosions","display_name":"gastric erosions","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C2779826273","wikidata":"https://www.wikidata.org/wiki/Q244408","display_name":"Diclofenac","level":2,"score":0.9182999730110168},{"id":"https://openalex.org/C2908765736","wikidata":"https://www.wikidata.org/wiki/Q244408","display_name":"Diclofenac Sodium","level":2,"score":0.8442999720573425},{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.8015000224113464},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.6891000270843506},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5702000260353088},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5544000267982483},{"id":"https://openalex.org/C2777230291","wikidata":"https://www.wikidata.org/wiki/Q33551","display_name":"Curcuma","level":2,"score":0.5396000146865845},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.453900009393692},{"id":"https://openalex.org/C2781443798","wikidata":"https://www.wikidata.org/wiki/Q383249","display_name":"Gastric mucosa","level":3,"score":0.3937999904155731},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3725000023841858},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.35089999437332153},{"id":"https://openalex.org/C2779703632","wikidata":"https://www.wikidata.org/wiki/Q581996","display_name":"Anti-inflammatory","level":2,"score":0.34389999508857727},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.2847999930381775},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.2831000089645386},{"id":"https://openalex.org/C3020196126","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammatory response","level":3,"score":0.2685999870300293},{"id":"https://openalex.org/C160492267","wikidata":"https://www.wikidata.org/wiki/Q319616","display_name":"Pharmacognosy","level":4,"score":0.2671999931335449},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.2630000114440918},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.2621999979019165},{"id":"https://openalex.org/C2776798904","wikidata":"https://www.wikidata.org/wiki/Q93978","display_name":"Antispasmodic","level":2,"score":0.25369998812675476},{"id":"https://openalex.org/C3020296196","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative damage","level":3,"score":0.250900000333786}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.32889/actabioina.210","doi":"https://doi.org/10.32889/actabioina.210","is_oa":true,"landing_page_url":"https://doi.org/10.32889/actabioina.210","pdf_url":"https://jurnal.pbbmi.org/index.php/actabioina/article/download/210/114","source":{"id":"https://openalex.org/S4210182433","display_name":"Acta Biochimica Indonesiana","issn_l":"2654-3222","issn":["2654-3222","2654-6108"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310320278","host_organization_name":"American Society for Biochemistry and Molecular Biology","host_organization_lineage":["https://openalex.org/P4310320278"],"host_organization_lineage_names":["American Society for Biochemistry and Molecular Biology"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Biochimica Indonesiana","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.32889/actabioina.210","doi":"https://doi.org/10.32889/actabioina.210","is_oa":true,"landing_page_url":"https://doi.org/10.32889/actabioina.210","pdf_url":"https://jurnal.pbbmi.org/index.php/actabioina/article/download/210/114","source":{"id":"https://openalex.org/S4210182433","display_name":"Acta Biochimica Indonesiana","issn_l":"2654-3222","issn":["2654-3222","2654-6108"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310320278","host_organization_name":"American Society for Biochemistry and Molecular Biology","host_organization_lineage":["https://openalex.org/P4310320278"],"host_organization_lineage_names":["American Society for Biochemistry and Molecular Biology"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Biochimica Indonesiana","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7128364795.pdf","grobid_xml":"https://content.openalex.org/works/W7128364795.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1491808467","https://openalex.org/W1584087237","https://openalex.org/W2068984440","https://openalex.org/W2087724350","https://openalex.org/W2093565689","https://openalex.org/W2339472598","https://openalex.org/W2616879167","https://openalex.org/W2772755903","https://openalex.org/W2894401840","https://openalex.org/W2897848915","https://openalex.org/W3003951247","https://openalex.org/W3005760535","https://openalex.org/W3196262789","https://openalex.org/W4280510749","https://openalex.org/W4283589951","https://openalex.org/W4289532417","https://openalex.org/W4303699610","https://openalex.org/W4317532068","https://openalex.org/W4362575430","https://openalex.org/W4381610089","https://openalex.org/W4385613744","https://openalex.org/W4386241156","https://openalex.org/W4391029420","https://openalex.org/W4393024557"],"related_works":["https://openalex.org/W7128363120","https://openalex.org/W7125476950","https://openalex.org/W7128365951","https://openalex.org/W2738221680","https://openalex.org/W7128357554","https://openalex.org/W2110285935","https://openalex.org/W7128356659","https://openalex.org/W4415574567","https://openalex.org/W2187636815","https://openalex.org/W1994139148"],"abstract_inverted_index":{"Background:":[0],"Prolonged":[1],"use":[2],"of":[3,38],"diclofenac":[4,42,93],"sodium":[5],"can":[6],"cause":[7],"gastric":[8,44,148],"mucosal":[9,45],"damage":[10,124],"through":[11],"cyclooxygenase":[12],"inhibition":[13],"and":[14,23,74,112,125],"oxidative":[15],"stress.":[16],"Turmeric":[17,141],"(Curcuma":[18],"longa":[19],"L.)":[20],"contains":[21],"curcumin":[22],"other":[24],"bioactive":[25],"compounds":[26],"with":[27,121,150],"potential":[28],"gastroprotective":[29,36,119],"properties.":[30],"Objective:":[31],"To":[32],"determine":[33],"the":[34],"dose-dependent":[35,144],"effect":[37],"turmeric":[39,79],"extract":[40,80,142],"against":[41,146],"sodium-induced":[43],"injury":[46],"in":[47],"rats.":[48],"Methods:":[49],"This":[50],"experimental":[51],"study":[52],"used":[53],"28":[54],"male":[55],"Sprague-Dawley":[56],"rats":[57],"randomly":[58],"allocated":[59],"into":[60],"four":[61],"groups":[62,77,117],"(n=7):":[63],"normal":[64],"control,":[65],"negative":[66,106],"control":[67,107],"(diclofenac":[68],"10":[69],"mg/kgBW":[70,83,87,131,152],"for":[71,89],"7":[72],"days),":[73],"two":[75],"treatment":[76,116],"receiving":[78],"at":[81],"100":[82,138],"(P1)":[84],"or":[85],"200":[86,130,151],"(P2)":[88],"14":[90],"days":[91],"following":[92],"induction.":[94],"Gastric":[95],"tissues":[96],"were":[97],"evaluated":[98],"histopathologically":[99],"using":[100],"a":[101],"qualitative":[102],"description.":[103],"Results:":[104],"The":[105,129],"group":[108],"showed":[109,133],"severe":[110],"erosion":[111],"inflammatory":[113,127],"infiltration.":[114],"Both":[115],"demonstrated":[118],"effects":[120],"minimal":[122],"epithelial":[123],"no":[126],"changes.":[128],"dose":[132],"superior":[134,154],"protection":[135],"compared":[136],"to":[137],"mg/kgBW.":[139],"Conclusion:":[140],"provides":[143],"gastroprotection":[145],"diclofenac-induced":[147],"injury,":[149],"demonstrating":[153],"efficacy.":[155]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-02-10T00:00:00"}