{"id":"https://openalex.org/W7128360922","doi":"https://doi.org/10.1016/j.neo.2026.101281","title":"Integrating single-cell and spatial transcriptomics to dissect mast-cell heterogeneity and arginine-metabolism-associated markers in BRCA","display_name":"Integrating single-cell and spatial transcriptomics to dissect mast-cell heterogeneity and arginine-metabolism-associated markers in BRCA","publication_year":2026,"publication_date":"2026-02-07","ids":{"openalex":"https://openalex.org/W7128360922","doi":"https://doi.org/10.1016/j.neo.2026.101281","pmid":"https://pubmed.ncbi.nlm.nih.gov/41655499","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12907235"},"language":"en","primary_location":{"id":"doi:10.1016/j.neo.2026.101281","doi":"https://doi.org/10.1016/j.neo.2026.101281","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neo.2026.101281","pdf_url":null,"source":{"id":"https://openalex.org/S20008548","display_name":"Neoplasia","issn_l":"1476-5586","issn":["1476-5586","1522-8002"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasia","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W7128360922"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.neo.2026.101281","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5125429794","display_name":"Mengli Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210167027","display_name":"Tangshan Gongren Hospital","ror":"https://ror.org/00sr40296","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210167027"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengli Gao","raw_affiliation_strings":["Department of Oncology, Tangshan Gongren Hospital, Tangshan, Hebei 063000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Tangshan Gongren Hospital, Tangshan, Hebei 063000, China","institution_ids":["https://openalex.org/I4210167027"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125413361","display_name":"Yuge Ran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140680","display_name":"Affiliated Hospital of Hebei University","ror":"https://ror.org/049vsq398","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140680"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuge Ran","raw_affiliation_strings":["Department of Radiotherapy, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiotherapy, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, China","institution_ids":["https://openalex.org/I4210140680"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158993107","display_name":"Juan Qi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140680","display_name":"Affiliated Hospital of Hebei University","ror":"https://ror.org/049vsq398","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140680"]},{"id":"https://openalex.org/I43337087","display_name":"Hebei University","ror":"https://ror.org/01p884a79","country_code":"CN","type":"education","lineage":["https://openalex.org/I43337087"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Qi","raw_affiliation_strings":["Department of Breast Surgery, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, China","institution_ids":["https://openalex.org/I4210140680","https://openalex.org/I43337087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125403537","display_name":"Xiao Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140680","display_name":"Affiliated Hospital of Hebei University","ror":"https://ror.org/049vsq398","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140680"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Han","raw_affiliation_strings":["Department of Oncology, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, China","institution_ids":["https://openalex.org/I4210140680"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125431458","display_name":"Yali Wei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140680","display_name":"Affiliated Hospital of Hebei University","ror":"https://ror.org/049vsq398","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140680"]},{"id":"https://openalex.org/I43337087","display_name":"Hebei University","ror":"https://ror.org/01p884a79","country_code":"CN","type":"education","lineage":["https://openalex.org/I43337087"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yali Wei","raw_affiliation_strings":["Department of Breast Surgery, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, China","institution_ids":["https://openalex.org/I4210140680","https://openalex.org/I43337087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034295491","display_name":"K. Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140680","display_name":"Affiliated Hospital of Hebei University","ror":"https://ror.org/049vsq398","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140680"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kunjie Wang","raw_affiliation_strings":["Department of Oncology, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, China","institution_ids":["https://openalex.org/I4210140680"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087376074","display_name":"Xiaoxi Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140680","display_name":"Affiliated Hospital of Hebei University","ror":"https://ror.org/049vsq398","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140680"]},{"id":"https://openalex.org/I43337087","display_name":"Hebei University","ror":"https://ror.org/01p884a79","country_code":"CN","type":"education","lineage":["https://openalex.org/I43337087"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoxi Wu","raw_affiliation_strings":["Department of Nutrition, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, China","institution_ids":["https://openalex.org/I4210140680","https://openalex.org/I43337087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084235512","display_name":"Chengcheng Sun","orcid":"https://orcid.org/0009-0002-0767-1862","observed_orcids":["https://orcid.org/0009-0002-0767-1862"]},"institutions":[{"id":"https://openalex.org/I4210140680","display_name":"Affiliated Hospital of Hebei University","ror":"https://ror.org/049vsq398","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140680"]},{"id":"https://openalex.org/I43337087","display_name":"Hebei University","ror":"https://ror.org/01p884a79","country_code":"CN","type":"education","lineage":["https://openalex.org/I43337087"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengcheng Sun","raw_affiliation_strings":["Department of Breast Surgery, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, China","institution_ids":["https://openalex.org/I4210140680","https://openalex.org/I43337087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100420259","display_name":"Yanhong Li","orcid":"https://orcid.org/0009-0007-8361-3310","observed_orcids":["https://orcid.org/0009-0007-8361-3310"]},"institutions":[{"id":"https://openalex.org/I4210140680","display_name":"Affiliated Hospital of Hebei University","ror":"https://ror.org/049vsq398","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140680"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanhong Li","raw_affiliation_strings":["Department of Radiotherapy, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, China"],"raw_orcid":"https://orcid.org/0009-0007-8361-3310","affiliations":[{"raw_affiliation_string":"Department of Radiotherapy, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, China","institution_ids":["https://openalex.org/I4210140680"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029092978","display_name":"W Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099373","display_name":"Second Hospital of Hebei Medical University","ror":"https://ror.org/015ycqv20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099373"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenyan Wang","raw_affiliation_strings":["Department of Radiotherapy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiotherapy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China","institution_ids":["https://openalex.org/I4210099373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101429836","display_name":"Wenjie Xie","orcid":"https://orcid.org/0000-0003-2637-1881","observed_orcids":["https://orcid.org/0000-0003-2637-1881"]},"institutions":[{"id":"https://openalex.org/I4387152107","display_name":"Baoding No.1 Central Hospital","ror":"https://ror.org/022nvaw58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4387152107"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wenjie Xie","raw_affiliation_strings":["Department of Gastrointestinal Surgery, Baoding First Central Hospital, Baoding, Hebei 071000, China. Electronic address: 47609140@qq.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, Baoding First Central Hospital, Baoding, Hebei 071000, China. Electronic address: 47609140@qq.com","institution_ids":["https://openalex.org/I4387152107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125392355","display_name":"Peng Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140680","display_name":"Affiliated Hospital of Hebei University","ror":"https://ror.org/049vsq398","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140680"]},{"id":"https://openalex.org/I43337087","display_name":"Hebei University","ror":"https://ror.org/01p884a79","country_code":"CN","type":"education","lineage":["https://openalex.org/I43337087"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Peng Zhang","raw_affiliation_strings":["Department of Breast Surgery, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, China. Electronic address: popluxifa@sina.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, China. Electronic address: popluxifa@sina.com","institution_ids":["https://openalex.org/I4210140680","https://openalex.org/I43337087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100728991","display_name":"Kuan Liu","orcid":"https://orcid.org/0000-0001-5620-8685","observed_orcids":["https://orcid.org/0000-0001-5620-8685"]},"institutions":[{"id":"https://openalex.org/I4210140680","display_name":"Affiliated Hospital of Hebei University","ror":"https://ror.org/049vsq398","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140680"]},{"id":"https://openalex.org/I43337087","display_name":"Hebei University","ror":"https://ror.org/01p884a79","country_code":"CN","type":"education","lineage":["https://openalex.org/I43337087"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Kuan Liu","raw_affiliation_strings":["Department of Radiotherapy, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, China. Electronic address: liukuanhdfs@sina.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiotherapy, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, China. Electronic address: liukuanhdfs@sina.com","institution_ids":["https://openalex.org/I4210140680","https://openalex.org/I43337087"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058091061","display_name":"Hongyun Shi","orcid":"https://orcid.org/0000-0002-4954-1057","observed_orcids":["https://orcid.org/0000-0002-4954-1057"]},"institutions":[{"id":"https://openalex.org/I4210140680","display_name":"Affiliated Hospital of Hebei University","ror":"https://ror.org/049vsq398","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140680"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hongyun Shi","raw_affiliation_strings":["Department of Radiotherapy, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, China. Electronic address: hyshihbuniversity@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiotherapy, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, China. Electronic address: hyshihbuniversity@163.com","institution_ids":["https://openalex.org/I4210140680"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5058091061","https://openalex.org/A5100728991","https://openalex.org/A5101429836","https://openalex.org/A5125392355"],"corresponding_institution_ids":["https://openalex.org/I4210140680","https://openalex.org/I43337087","https://openalex.org/I4387152107"],"apc_list":{"value":3530,"currency":"USD","value_usd":3530},"apc_paid":{"value":3530,"currency":"USD","value_usd":3530},"fwci":26.6142,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.99686395,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"73","issue":null,"first_page":"101281","last_page":"101281"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9101999998092651,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9101999998092651,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.02930000051856041,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.019099999219179153,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":0.9769999980926514},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9599999785423279},{"id":"https://openalex.org/keywords/arginine-metabolism","display_name":"arginine metabolism","score":0.9440000057220459},{"id":"https://openalex.org/keywords/mast-cell-heterogeneity","display_name":"mast cell heterogeneity","score":0.8370000123977661},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.871999979019165},{"id":"https://openalex.org/keywords/oat","display_name":"oat","score":0.7519999742507935},{"id":"https://openalex.org/keywords/arginase","display_name":"arginase","score":0.4740000069141388},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9210000038146973},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.6669999957084656},{"id":"https://openalex.org/keywords/prognostic-signature","display_name":"prognostic signature","score":0.8019999861717224},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.8460000157356262},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.625},{"id":"https://openalex.org/keywords/cell-proliferation-and-invasion","display_name":"cell proliferation and invasion","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7016000151634216},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5587999820709229},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5529000163078308},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5253000259399414},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4366999864578247},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.42590001225471497},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36629998683929443},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.3644999861717224},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3490999937057495},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33869999647140503},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32330000400543213},{"id":"https://openalex.org/C2994423619","wikidata":"https://www.wikidata.org/wiki/Q9103","display_name":"Human breast","level":4,"score":0.2759999930858612},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.2685000002384186},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.257999986410141}],"mesh":[{"descriptor_ui":"D000092386","descriptor_name":"Single-Cell Gene Expression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099285","descriptor_name":"Spatial Transcriptomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.neo.2026.101281","doi":"https://doi.org/10.1016/j.neo.2026.101281","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neo.2026.101281","pdf_url":null,"source":{"id":"https://openalex.org/S20008548","display_name":"Neoplasia","issn_l":"1476-5586","issn":["1476-5586","1522-8002"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasia","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12907235","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12907235/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12907235/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasia","raw_type":"Text"},{"id":"pmid:41655499","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41655499","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasia (New York, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:0c0252a6e5414f22b4c66a00b25e25dc","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/0c0252a6e5414f22b4c66a00b25e25dc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neoplasia: An International Journal for Oncology Research, Vol 73, Iss , Pp 101281- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.neo.2026.101281","doi":"https://doi.org/10.1016/j.neo.2026.101281","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neo.2026.101281","pdf_url":null,"source":{"id":"https://openalex.org/S20008548","display_name":"Neoplasia","issn_l":"1476-5586","issn":["1476-5586","1522-8002"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1775594497","display_name":null,"funder_award_id":"2022QB24","funder_id":"https://openalex.org/F4320324851","funder_display_name":"Hebei University"}],"funders":[{"id":"https://openalex.org/F4320324851","display_name":"Hebei University","ror":"https://ror.org/01p884a79"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7128360922.pdf","grobid_xml":"https://content.openalex.org/works/W7128360922.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1966772838","https://openalex.org/W1970705727","https://openalex.org/W1977797021","https://openalex.org/W1985597071","https://openalex.org/W2064180188","https://openalex.org/W2116105625","https://openalex.org/W2143413473","https://openalex.org/W2265419075","https://openalex.org/W2530067632","https://openalex.org/W2755383593","https://openalex.org/W2766084386","https://openalex.org/W2909526968","https://openalex.org/W3068772833","https://openalex.org/W3095217088","https://openalex.org/W3109885192","https://openalex.org/W3112241528","https://openalex.org/W3164569998","https://openalex.org/W3179581056","https://openalex.org/W3193942139","https://openalex.org/W4214849345","https://openalex.org/W4220874458","https://openalex.org/W4225001891","https://openalex.org/W4229688459","https://openalex.org/W4283775935","https://openalex.org/W4312981269","https://openalex.org/W4377226862","https://openalex.org/W4384626710","https://openalex.org/W4388914516","https://openalex.org/W4391826537","https://openalex.org/W4392951752","https://openalex.org/W4396704965","https://openalex.org/W4399718294","https://openalex.org/W4400978609","https://openalex.org/W4403176969","https://openalex.org/W4405224884","https://openalex.org/W4408088254","https://openalex.org/W4408885173","https://openalex.org/W4409189819","https://openalex.org/W4410453591","https://openalex.org/W4414382175","https://openalex.org/W4414873796"],"related_works":["https://openalex.org/W7168138431","https://openalex.org/W4411871612","https://openalex.org/W4295106730","https://openalex.org/W4388793949","https://openalex.org/W7123406079","https://openalex.org/W7148815474","https://openalex.org/W4406379534","https://openalex.org/W7155606386","https://openalex.org/W4313454832"],"abstract_inverted_index":{"BACKGROUND:":[0],"Mast":[1],"cells":[2],"(MCs)":[3],"are":[4],"immunometabolic":[5],"sentinels,":[6],"yet":[7],"their":[8],"heterogeneity":[9],"and":[10,26,49,57,71,83,93,112,139,151,154,173,190,208],"functional":[11],"specialization":[12],"in":[13,109,123,136,162],"breast":[14,95,113,202],"cancer":[15,96,114,203],"(BRCA)":[16],"remain":[17],"unclear.":[18],"We":[19,37],"hypothesized":[20],"that":[21,31,186],"arginine":[22,65],"metabolism":[23,167],"defines":[24],"transcriptionally":[25],"functionally":[27,158],"distinct":[28],"MC":[29,121],"subpopulations":[30],"shape":[32],"the":[33,102],"BRCA":[34,163],"microenvironment.":[35],"METHODS:":[36],"integrated":[38],"single-cell":[39],"RNA-seq":[40,51],"(GSE161529;":[41],"272,592":[42],"cells,":[43],"38":[44],"clusters),":[45],"spatial":[46],"transcriptomics":[47],"(GSE243022)":[48],"bulk":[50],"(TCGA,":[52],"GSE42568).":[53],"After":[54],"harmony":[55],"batch-correction":[56],"Seurat-Louvian":[58],"clustering,":[59],"MCs":[60,169,178],"were":[61,85],"split":[62],"by":[63],"median":[64],"score":[66],"(AUCell/UCell/AddModuleScore/singscore)":[67],"into":[68,170],"high-":[69],"(HAS)":[70],"low-activity":[72],"(LAS)":[73],"subsets.":[74],"Monocle2":[75],"pseudotime,":[76],"CellChat,":[77],"hdWGCNA":[78],"(power":[79],"=":[80,127],"15),":[81],"LASSO-Cox":[82],"MiloR":[84],"used":[86],"to":[87],"trace":[88],"differentiation,":[89],"communication,":[90],"prognostic":[91,194],"value":[92],"triple-negative":[94],"(TNBC)":[97],"enrichment.":[98],"Functional":[99],"validation":[100],"of":[101,143],"model-prioritized":[103],"gene":[104],"OAT":[105,132,144],"was":[106,134],"subsequently":[107],"conducted":[108],"clinical":[110],"tissues":[111,138],"cell":[115,140],"lines":[116],"through":[117,205],"loss-of-function":[118],"assays.":[119],"RESULTS:":[120],"hotspots":[122],"tumor":[124],"cores":[125],"(AUC":[126],"0.89":[128],"vs":[129],"normal).":[130],"Experimentally,":[131],"expression":[133],"elevated":[135],"TNBC":[137,188],"lines.":[141],"Knockdown":[142],"impaired":[145],"proliferation,":[146,206],"induced":[147],"apoptosis,":[148],"suppressed":[149],"migration/invasion,":[150],"modulated":[152],"apoptosis-":[153],"EMT-related":[155],"protein":[156],"expression,":[157],"supporting":[159],"its":[160],"role":[161],"progression.":[164],"CONCLUSION:":[165],"Arginine":[166],"stratifies":[168],"pro-tumorigenic":[171],"HAS":[172],"quiescent":[174],"LAS":[175],"subsets;":[176],"ASL-high":[177],"constitute":[179],"a":[180,197],"metabolically":[181],"wired,":[182],"highly":[183],"communicating":[184],"population":[185],"fuels":[187],"progression":[189],"furnishes":[191],"an":[192],"exploitable":[193],"signature.":[195],"OAT,":[196],"key":[198],"HAS-associated":[199],"gene,":[200],"promotes":[201],"aggressiveness":[204],"survival,":[207],"invasion.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":14}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2026-02-10T00:00:00"}