{"id":"https://openalex.org/W7128360377","doi":"https://doi.org/10.1021/acsnano.5c16884","title":"Astrocyte-Targeted Nanotherapeutics Modulate Iron Homeostasis in Cerebral Amyloid Angiopathy by Restoring the Astrocytic Trafficking Hub Function","display_name":"Astrocyte-Targeted Nanotherapeutics Modulate Iron Homeostasis in Cerebral Amyloid Angiopathy by Restoring the Astrocytic Trafficking Hub Function","publication_year":2026,"publication_date":"2026-02-09","ids":{"openalex":"https://openalex.org/W7128360377","doi":"https://doi.org/10.1021/acsnano.5c16884","pmid":"https://pubmed.ncbi.nlm.nih.gov/41660978"},"language":"en","primary_location":{"id":"doi:10.1021/acsnano.5c16884","doi":"https://doi.org/10.1021/acsnano.5c16884","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsnano.5c16884","pdf_url":null,"source":{"id":"https://openalex.org/S145476921","display_name":"ACS Nano","issn_l":"1936-0851","issn":["1936-0851","1936-086X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Nano","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5124715770","display_name":"Lingling Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4405271954","display_name":"Key Laboratory of Smart Drug Delivery, Ministry of Education","ror":"https://ror.org/03av49852","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271954"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingling Zhou","raw_affiliation_strings":["Ministry of Education","School of Pharmacy, Fudan University, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Key Laboratory of Smart Drug Delivery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ministry of Education","institution_ids":[]},{"raw_affiliation_string":"School of Pharmacy, Fudan University, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Key Laboratory of Smart Drug Delivery","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4405271954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125375769","display_name":"Yanjun Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanjun Xu","raw_affiliation_strings":["Department of Radiology","Shanghai Jiao Tong University School of Medicine Affiliated Sixth People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology","institution_ids":[]},{"raw_affiliation_string":"Shanghai Jiao Tong University School of Medicine Affiliated Sixth People\u2019s Hospital","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125401698","display_name":"Peng Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4405271954","display_name":"Key Laboratory of Smart Drug Delivery, Ministry of Education","ror":"https://ror.org/03av49852","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271954"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Yang","raw_affiliation_strings":["Ministry of Education","School of Pharmacy, Fudan University, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Key Laboratory of Smart Drug Delivery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ministry of Education","institution_ids":[]},{"raw_affiliation_string":"School of Pharmacy, Fudan University, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Key Laboratory of Smart Drug Delivery","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4405271954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100684817","display_name":"Jia Zhou","orcid":"https://orcid.org/0000-0001-9292-3838","observed_orcids":["https://orcid.org/0000-0001-9292-3838"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Zhou","raw_affiliation_strings":["Department of Radiology","Shanghai Jiao Tong University School of Medicine Affiliated Sixth People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology","institution_ids":[]},{"raw_affiliation_string":"Shanghai Jiao Tong University School of Medicine Affiliated Sixth People\u2019s Hospital","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003157905","display_name":"Mingkang Wang","orcid":"https://orcid.org/0009-0000-3119-5320","observed_orcids":["https://orcid.org/0009-0000-3119-5320"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mingkang Wang","raw_affiliation_strings":["Wuhan United Imaging Life Science Instruments Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuhan United Imaging Life Science Instruments Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034559445","display_name":"Yixian Li","orcid":"https://orcid.org/0009-0006-8130-543X","observed_orcids":["https://orcid.org/0009-0006-8130-543X"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]},{"id":"https://openalex.org/I4405271954","display_name":"Key Laboratory of Smart Drug Delivery, Ministry of Education","ror":"https://ror.org/03av49852","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271954"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yixian Li","raw_affiliation_strings":["Department of Radiology","Ministry of Education","School of Pharmacy, Fudan University, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Key Laboratory of Smart Drug Delivery","Shanghai Jiao Tong University School of Medicine Affiliated Sixth People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology","institution_ids":[]},{"raw_affiliation_string":"Ministry of Education","institution_ids":[]},{"raw_affiliation_string":"School of Pharmacy, Fudan University, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Key Laboratory of Smart Drug Delivery","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4405271954"]},{"raw_affiliation_string":"Shanghai Jiao Tong University School of Medicine Affiliated Sixth People\u2019s Hospital","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034559445","display_name":"Yixian Li","orcid":"https://orcid.org/0009-0006-8130-543X","observed_orcids":["https://orcid.org/0009-0006-8130-543X"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]},{"id":"https://openalex.org/I4405271954","display_name":"Key Laboratory of Smart Drug Delivery, Ministry of Education","ror":"https://ror.org/03av49852","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271954"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yixian Li","raw_affiliation_strings":["Department of Radiology","Ministry of Education","School of Pharmacy, Fudan University, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Key Laboratory of Smart Drug Delivery","Shanghai Jiao Tong University School of Medicine Affiliated Sixth People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology","institution_ids":[]},{"raw_affiliation_string":"Ministry of Education","institution_ids":[]},{"raw_affiliation_string":"School of Pharmacy, Fudan University, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Key Laboratory of Smart Drug Delivery","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4405271954"]},{"raw_affiliation_string":"Shanghai Jiao Tong University School of Medicine Affiliated Sixth People\u2019s Hospital","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111556139","display_name":"Xiyu Yang","orcid":"https://orcid.org/0000-0002-9617-3410","observed_orcids":["https://orcid.org/0000-0002-9617-3410"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4405271954","display_name":"Key Laboratory of Smart Drug Delivery, Ministry of Education","ror":"https://ror.org/03av49852","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271954"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiyu Yang","raw_affiliation_strings":["Ministry of Education","School of Pharmacy, Fudan University, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Key Laboratory of Smart Drug Delivery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ministry of Education","institution_ids":[]},{"raw_affiliation_string":"School of Pharmacy, Fudan University, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Key Laboratory of Smart Drug Delivery","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4405271954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5131258989","display_name":"Xuan Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4405271954","display_name":"Key Laboratory of Smart Drug Delivery, Ministry of Education","ror":"https://ror.org/03av49852","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271954"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuan Liu","raw_affiliation_strings":["Ministry of Education","School of Pharmacy, Fudan University, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Key Laboratory of Smart Drug Delivery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ministry of Education","institution_ids":[]},{"raw_affiliation_string":"School of Pharmacy, Fudan University, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Key Laboratory of Smart Drug Delivery","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4405271954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002121694","display_name":"Tianying Wang","orcid":"https://orcid.org/0000-0002-2826-5364","observed_orcids":["https://orcid.org/0000-0002-2826-5364"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4405271954","display_name":"Key Laboratory of Smart Drug Delivery, Ministry of Education","ror":"https://ror.org/03av49852","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271954"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianying Wang","raw_affiliation_strings":["Ministry of Education","School of Pharmacy, Fudan University, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Key Laboratory of Smart Drug Delivery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ministry of Education","institution_ids":[]},{"raw_affiliation_string":"School of Pharmacy, Fudan University, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Key Laboratory of Smart Drug Delivery","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4405271954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5131232722","display_name":"Cui Yao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cui Yao","raw_affiliation_strings":["Department of Radiology","Shanghai Jiao Tong University School of Medicine Affiliated Sixth People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology","institution_ids":[]},{"raw_affiliation_string":"Shanghai Jiao Tong University School of Medicine Affiliated Sixth People\u2019s Hospital","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113403336","display_name":"Kang Qian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4405271954","display_name":"Key Laboratory of Smart Drug Delivery, Ministry of Education","ror":"https://ror.org/03av49852","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271954"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kang Qian","raw_affiliation_strings":["Ministry of Education","School of Pharmacy, Fudan University, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Key Laboratory of Smart Drug Delivery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ministry of Education","institution_ids":[]},{"raw_affiliation_string":"School of Pharmacy, Fudan University, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Key Laboratory of Smart Drug Delivery","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4405271954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5131138697","display_name":"Jing Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4405271954","display_name":"Key Laboratory of Smart Drug Delivery, Ministry of Education","ror":"https://ror.org/03av49852","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271954"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Wu","raw_affiliation_strings":["Ministry of Education","School of Pharmacy, Fudan University, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Key Laboratory of Smart Drug Delivery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ministry of Education","institution_ids":[]},{"raw_affiliation_string":"School of Pharmacy, Fudan University, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Key Laboratory of Smart Drug Delivery","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4405271954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101362846","display_name":"Yongkang Mu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4405271954","display_name":"Key Laboratory of Smart Drug Delivery, Ministry of Education","ror":"https://ror.org/03av49852","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271954"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongkang Mu","raw_affiliation_strings":["Ministry of Education","School of Pharmacy, Fudan University, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Key Laboratory of Smart Drug Delivery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ministry of Education","institution_ids":[]},{"raw_affiliation_string":"School of Pharmacy, Fudan University, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Key Laboratory of Smart Drug Delivery","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4405271954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020547568","display_name":"Wenxian Du","orcid":"https://orcid.org/0009-0000-0917-0987","observed_orcids":["https://orcid.org/0009-0000-0917-0987"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wenxian Du","raw_affiliation_strings":["Department of Radiology","Shanghai Jiao Tong University School of Medicine Affiliated Sixth People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology","institution_ids":[]},{"raw_affiliation_string":"Shanghai Jiao Tong University School of Medicine Affiliated Sixth People\u2019s Hospital","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125386094","display_name":"Yuehua Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]},{"id":"https://openalex.org/I4405271954","display_name":"Key Laboratory of Smart Drug Delivery, Ministry of Education","ror":"https://ror.org/03av49852","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271954"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuehua Li","raw_affiliation_strings":["Department of Radiology","Ministry of Education","School of Pharmacy, Fudan University, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Key Laboratory of Smart Drug Delivery","Shanghai Jiao Tong University School of Medicine Affiliated Sixth People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology","institution_ids":[]},{"raw_affiliation_string":"Ministry of Education","institution_ids":[]},{"raw_affiliation_string":"School of Pharmacy, Fudan University, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Key Laboratory of Smart Drug Delivery","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4405271954"]},{"raw_affiliation_string":"Shanghai Jiao Tong University School of Medicine Affiliated Sixth People\u2019s Hospital","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125386094","display_name":"Yuehua Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]},{"id":"https://openalex.org/I4405271954","display_name":"Key Laboratory of Smart Drug Delivery, Ministry of Education","ror":"https://ror.org/03av49852","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271954"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuehua Li","raw_affiliation_strings":["Department of Radiology","Ministry of Education","School of Pharmacy, Fudan University, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Key Laboratory of Smart Drug Delivery","Shanghai Jiao Tong University School of Medicine Affiliated Sixth People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology","institution_ids":[]},{"raw_affiliation_string":"Ministry of Education","institution_ids":[]},{"raw_affiliation_string":"School of Pharmacy, Fudan University, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Key Laboratory of Smart Drug Delivery","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4405271954"]},{"raw_affiliation_string":"Shanghai Jiao Tong University School of Medicine Affiliated Sixth People\u2019s Hospital","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5124699864","display_name":"Qizhi Zhang","orcid":"https://orcid.org/0000-0002-8544-609X","observed_orcids":["https://orcid.org/0000-0002-8544-609X"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4405271954","display_name":"Key Laboratory of Smart Drug Delivery, Ministry of Education","ror":"https://ror.org/03av49852","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271954"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qizhi Zhang","raw_affiliation_strings":["Ministry of Education","School of Pharmacy, Fudan University, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Key Laboratory of Smart Drug Delivery"],"raw_orcid":"https://orcid.org/0000-0002-8544-609X","affiliations":[{"raw_affiliation_string":"Ministry of Education","institution_ids":[]},{"raw_affiliation_string":"School of Pharmacy, Fudan University, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Key Laboratory of Smart Drug Delivery","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4405271954"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5020547568","https://openalex.org/A5034559445","https://openalex.org/A5124699864","https://openalex.org/A5125386094"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I24943067","https://openalex.org/I4210144482","https://openalex.org/I4405271954"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04600138,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"7","first_page":"5629","last_page":"5649"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.7695000171661377,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.7695000171661377,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.1014999970793724,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.026599999517202377,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebral-amyloid-angiopathy","display_name":"cerebral amyloid angiopathy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8220000267028809},{"id":"https://openalex.org/keywords/iron-homeostasis","display_name":"iron homeostasis","score":0.9089999794960022},{"id":"https://openalex.org/keywords/ceruloplasmin","display_name":"ceruloplasmin","score":0.9259999990463257},{"id":"https://openalex.org/keywords/iron-dyshomeostasis","display_name":"iron dyshomeostasis","score":0.7889999747276306},{"id":"https://openalex.org/keywords/edelfosine","display_name":"edelfosine","score":0.8500000238418579},{"id":"https://openalex.org/keywords/divalent-metal-transporter-1","display_name":"DMT1","score":0.8159999847412109},{"id":"https://openalex.org/keywords/ferroportin-1","display_name":"ferroportin 1","score":0.8119999766349792},{"id":"https://openalex.org/keywords/iron-transport","display_name":"iron transport","score":0.39800000190734863},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8399999737739563},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.7860000133514404},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8169999718666077},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.7329999804496765},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C2777790613","wikidata":"https://www.wikidata.org/wiki/Q191562","display_name":"Cerebral amyloid angiopathy","level":4,"score":0.708299994468689},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5720999836921692},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5454999804496765},{"id":"https://openalex.org/C101054994","wikidata":"https://www.wikidata.org/wiki/Q15474254","display_name":"Glymphatic system","level":3,"score":0.5116000175476074},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.48089998960494995},{"id":"https://openalex.org/C28452662","wikidata":"https://www.wikidata.org/wiki/Q422752","display_name":"Ceruloplasmin","level":2,"score":0.4781999886035919},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.476500004529953},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.47189998626708984},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.4090000092983246},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4075999855995178},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3912999927997589},{"id":"https://openalex.org/C2776156579","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid beta","level":3,"score":0.37369999289512634},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.36899998784065247},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.36629998683929443},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.35589998960494995},{"id":"https://openalex.org/C157541749","wikidata":"https://www.wikidata.org/wiki/Q3612637","display_name":"Allostasis","level":2,"score":0.35409998893737793},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.3465000092983246},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.3418999910354614},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.336899995803833},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.33570000529289246},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.33090001344680786},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.33000001311302185},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31299999356269836},{"id":"https://openalex.org/C3019447875","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid \u03b2","level":3,"score":0.31139999628067017},{"id":"https://openalex.org/C15083742","wikidata":"https://www.wikidata.org/wiki/Q261659","display_name":"Nanomedicine","level":3,"score":0.30379998683929443},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.30000001192092896},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.2971999943256378},{"id":"https://openalex.org/C2777697756","wikidata":"https://www.wikidata.org/wiki/Q721849","display_name":"Iron oxide","level":2,"score":0.2971000075340271},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.289000004529953},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.2881999909877777},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.28369998931884766},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.2750000059604645},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.26750001311302185},{"id":"https://openalex.org/C43310041","wikidata":"https://www.wikidata.org/wiki/Q1981297","display_name":"Neuromelanin","level":5,"score":0.2621000111103058},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.26179999113082886},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2574000060558319},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2549999952316284},{"id":"https://openalex.org/C2776531687","wikidata":"https://www.wikidata.org/wiki/Q14914133","display_name":"DMT1","level":4,"score":0.2547000050544739},{"id":"https://openalex.org/C2780416994","wikidata":"https://www.wikidata.org/wiki/Q419462","display_name":"Peroxiredoxin","level":4,"score":0.251800000667572}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002563","descriptor_name":"Cerium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002563","descriptor_name":"Cerium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002563","descriptor_name":"Cerium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002563","descriptor_name":"Cerium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002563","descriptor_name":"Cerium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002563","descriptor_name":"Cerium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002570","descriptor_name":"Ceruloplasmin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002570","descriptor_name":"Ceruloplasmin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002570","descriptor_name":"Ceruloplasmin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006046","descriptor_name":"Gold","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006046","descriptor_name":"Gold","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006046","descriptor_name":"Gold","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016657","descriptor_name":"Cerebral Amyloid Angiopathy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016657","descriptor_name":"Cerebral Amyloid Angiopathy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016657","descriptor_name":"Cerebral Amyloid Angiopathy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016657","descriptor_name":"Cerebral Amyloid Angiopathy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016657","descriptor_name":"Cerebral Amyloid Angiopathy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016657","descriptor_name":"Cerebral Amyloid Angiopathy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016657","descriptor_name":"Cerebral Amyloid Angiopathy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016657","descriptor_name":"Cerebral Amyloid Angiopathy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016657","descriptor_name":"Cerebral Amyloid Angiopathy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016657","descriptor_name":"Cerebral Amyloid Angiopathy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016657","descriptor_name":"Cerebral Amyloid Angiopathy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016657","descriptor_name":"Cerebral Amyloid Angiopathy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016657","descriptor_name":"Cerebral Amyloid Angiopathy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016657","descriptor_name":"Cerebral Amyloid Angiopathy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016657","descriptor_name":"Cerebral Amyloid Angiopathy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016657","descriptor_name":"Cerebral Amyloid Angiopathy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016657","descriptor_name":"Cerebral Amyloid Angiopathy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016657","descriptor_name":"Cerebral Amyloid Angiopathy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D050997","descriptor_name":"Nanomedicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050997","descriptor_name":"Nanomedicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050997","descriptor_name":"Nanomedicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050997","descriptor_name":"Nanomedicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050997","descriptor_name":"Nanomedicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050997","descriptor_name":"Nanomedicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acsnano.5c16884","doi":"https://doi.org/10.1021/acsnano.5c16884","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsnano.5c16884","pdf_url":null,"source":{"id":"https://openalex.org/S145476921","display_name":"ACS Nano","issn_l":"1936-0851","issn":["1936-0851","1936-086X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Nano","raw_type":"journal-article"},{"id":"pmid:41660978","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41660978","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS nano","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1456372310","display_name":null,"funder_award_id":"32401157","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7170621725","display_name":null,"funder_award_id":"82273868","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":92,"referenced_works":["https://openalex.org/W190731049","https://openalex.org/W1570476699","https://openalex.org/W1593684700","https://openalex.org/W1965128141","https://openalex.org/W1968367833","https://openalex.org/W1972306266","https://openalex.org/W1974932784","https://openalex.org/W1979055828","https://openalex.org/W1997933042","https://openalex.org/W2006035554","https://openalex.org/W2014463750","https://openalex.org/W2015541518","https://openalex.org/W2021143949","https://openalex.org/W2023831307","https://openalex.org/W2025048194","https://openalex.org/W2027381692","https://openalex.org/W2030232097","https://openalex.org/W2036269616","https://openalex.org/W2038892692","https://openalex.org/W2048047884","https://openalex.org/W2060349323","https://openalex.org/W2062588841","https://openalex.org/W2069498125","https://openalex.org/W2074276325","https://openalex.org/W2086138798","https://openalex.org/W2111878380","https://openalex.org/W2112223455","https://openalex.org/W2120276926","https://openalex.org/W2125236750","https://openalex.org/W2148948489","https://openalex.org/W2318182558","https://openalex.org/W2342691188","https://openalex.org/W2401624005","https://openalex.org/W2510806376","https://openalex.org/W2525173725","https://openalex.org/W2753636297","https://openalex.org/W2756282825","https://openalex.org/W2767607317","https://openalex.org/W2773552244","https://openalex.org/W2801655409","https://openalex.org/W2803975242","https://openalex.org/W2810782256","https://openalex.org/W2898933196","https://openalex.org/W2912943191","https://openalex.org/W2950453599","https://openalex.org/W2969700256","https://openalex.org/W2969998884","https://openalex.org/W2974872675","https://openalex.org/W2998231051","https://openalex.org/W3009462395","https://openalex.org/W3082687067","https://openalex.org/W3090811789","https://openalex.org/W3132240972","https://openalex.org/W3162484413","https://openalex.org/W3163596592","https://openalex.org/W3163986707","https://openalex.org/W3190032209","https://openalex.org/W3193668998","https://openalex.org/W3202046769","https://openalex.org/W3207485372","https://openalex.org/W4220768707","https://openalex.org/W4221086068","https://openalex.org/W4224251603","https://openalex.org/W4224315749","https://openalex.org/W4229022537","https://openalex.org/W4285891064","https://openalex.org/W4307895613","https://openalex.org/W4310179103","https://openalex.org/W4310461604","https://openalex.org/W4318070529","https://openalex.org/W4321789269","https://openalex.org/W4361216897","https://openalex.org/W4377695484","https://openalex.org/W4379207351","https://openalex.org/W4382345303","https://openalex.org/W4382986186","https://openalex.org/W4386203917","https://openalex.org/W4386284835","https://openalex.org/W4387311036","https://openalex.org/W4389371471","https://openalex.org/W4391512181","https://openalex.org/W4392764309","https://openalex.org/W4392905873","https://openalex.org/W4394855058","https://openalex.org/W4402339165","https://openalex.org/W4402883991","https://openalex.org/W4402932871","https://openalex.org/W4404024063","https://openalex.org/W4404776918","https://openalex.org/W4407923397","https://openalex.org/W4408770418","https://openalex.org/W4410774461"],"related_works":[],"abstract_inverted_index":{"Cerebral":[0],"amyloid":[1],"angiopathy":[2],"(CAA)":[3],"is":[4,9,34],"increasingly":[5],"prevalent,":[6],"and":[7,14,85,94,106,112,124,140,159],"it":[8],"characterized":[10],"by":[11,70,197],"frequent":[12],"recurrence":[13],"complex":[15],"etiology.":[16],"Aberrant":[17],"ceruloplasmin":[18],"(Cp)":[19],"localization":[20],"at":[21,102],"the":[22,39,77,80,91,103,108],"astrocytic":[23,104,168],"endfeet,":[24],"coupled":[25],"with":[26,65,189],"oxidative":[27],"stress-induced":[28],"dysregulation":[29],"of":[30,38,79,110],"iron":[31,40,52,142,152,169,198],"regulatory":[32],"proteins,":[33],"a":[35,134,185,202],"central":[36],"trigger":[37],"dyshomeostasis":[41,199],"that":[42,49,166],"drives":[43],"CAA":[44],"progression.":[45],"However,":[46],"therapeutic":[47,178],"strategies":[48],"specifically":[50],"target":[51],"transport":[53],"regulation":[54],"in":[55],"astrocytes":[56],"remain":[57],"lacking.":[58],"Here,":[59],"we":[60],"develop":[61],"lattice-expanded":[62],"Au/CeO":[63],"2":[64],"strong":[66],"antioxidant":[67],"capacity":[68],"validated":[69],"DFT":[71],"calculations.":[72],"Its":[73],"mesoporous":[74],"architecture":[75],"enables":[76],"loading":[78],"phospholipase":[81],"C":[82],"inhibitor":[83],"ET-18-OCH3,":[84],"further":[86],"DAG":[87],"peptide":[88],"conjugation":[89],"yields":[90],"astrocyte-targeted,":[92],"biocompatible,":[93],"pluripotent":[95],"nanomedicine":[96],"DACe@ET.":[97],"This":[98,163],"nanoplatform":[99],"stabilizes":[100],"Cp":[101],"endfeet":[105],"restores":[107,141],"expression":[109],"DMT1":[111],"FPN1.":[113],"By":[114],"suppressing":[115],"anomalous":[116],"Fe":[117,130,136],"2+":[118,137],"influx":[119],"while":[120,200],"promoting":[121],"efficient":[122],"efflux":[123],"subsequent":[125],"extracellular":[126],"oxidation":[127],"to":[128,192],"nontoxic":[129],"3+,":[131],"DACe@ET":[132,149,183],"reestablishes":[133],"closed-loop":[135],"export\u2013oxidation":[138],"system":[139],"homeostasis.":[143],"In":[144],"3":[145],"\u00d7":[146],"Tg":[147],"mice,":[148],"reduces":[150],"cerebral":[151],"deposition,":[153],"decreases":[154],"amyloid-\u03b2":[155],"burden,":[156],"attenuates":[157],"neurodegeneration,":[158],"improves":[160],"cognitive":[161],"performance.":[162],"work":[164],"demonstrates":[165],"restoring":[167],"trafficking":[170],"hub":[171],"function":[172],"can":[173],"serve":[174],"as":[175,184],"an":[176],"effective":[177],"strategy":[179],"for":[180,204],"CAA,":[181],"highlighting":[182],"promising":[186],"disease-modifying":[187],"therapy":[188],"potential":[190],"applicability":[191],"other":[193],"neurological":[194],"disorders":[195],"marked":[196],"establishing":[201],"foundation":[203],"future":[205],"translational":[206],"research.":[207]},"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2026-02-10T00:00:00"}
