{"id":"https://openalex.org/W7128314837","doi":"https://doi.org/10.1038/s41598-026-38587-4","title":"Impact of venetoclax trough levels on safety and efficacy in the treatment of acute myeloid leukemia","display_name":"Impact of venetoclax trough levels on safety and efficacy in the treatment of acute myeloid leukemia","publication_year":2026,"publication_date":"2026-02-07","ids":{"openalex":"https://openalex.org/W7128314837","doi":"https://doi.org/10.1038/s41598-026-38587-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/41654609","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12946174"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-38587-4","doi":"https://doi.org/10.1038/s41598-026-38587-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-38587-4","pdf_url":"https://www.nature.com/articles/s41598-026-38587-4_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-026-38587-4_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059571915","display_name":"Hiromi Hayashi","orcid":"https://orcid.org/0000-0002-4599-5465","observed_orcids":["https://orcid.org/0000-0002-4599-5465"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromi Hayashi","raw_affiliation_strings":["Department of Hematology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023515506","display_name":"Takeo Yamagiwa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeo Yamagiwa","raw_affiliation_strings":["Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan","institution_ids":["https://openalex.org/I4210150196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072808833","display_name":"Junya Kanda","orcid":"https://orcid.org/0000-0002-6704-3633","observed_orcids":["https://orcid.org/0000-0002-6704-3633"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Junya Kanda","raw_affiliation_strings":["Department of Hematology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan. jkanda16@kuhp.kyoto-u.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan. jkanda16@kuhp.kyoto-u.ac.jp","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017171769","display_name":"Takayuki Ishikawa","orcid":"https://orcid.org/0000-0002-2098-9616","observed_orcids":["https://orcid.org/0000-0002-2098-9616"]},"institutions":[{"id":"https://openalex.org/I4210161700","display_name":"Kobe City Medical Center General Hospital","ror":"https://ror.org/04j4nak57","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161700","https://openalex.org/I4405284131"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayuki Ishikawa","raw_affiliation_strings":["Department of Hematology, Kobe City Medical Center General Hospital, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Kobe City Medical Center General Hospital, Kobe, Japan","institution_ids":["https://openalex.org/I4210161700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105939393","display_name":"Masashi Sawa","orcid":"https://orcid.org/0009-0001-1513-2255","observed_orcids":["https://orcid.org/0009-0001-1513-2255"]},"institutions":[{"id":"https://openalex.org/I4210144551","display_name":"Anjo Kosei Hospital","ror":"https://ror.org/05c06ww48","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210144551"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masashi Sawa","raw_affiliation_strings":["Department of Hematology and Oncology, Anjo Kosei Hospital, Anjo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Anjo Kosei Hospital, Anjo, Japan","institution_ids":["https://openalex.org/I4210144551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026083087","display_name":"Yasuko Miyahara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104574","display_name":"Kyoto City Hospital","ror":"https://ror.org/01605g366","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104574","https://openalex.org/I4405282747"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuko Miyahara","raw_affiliation_strings":["Department of Hematology, Kyoto City Hospital, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Kyoto City Hospital, Kyoto, Japan","institution_ids":["https://openalex.org/I4210104574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034388223","display_name":"Takayoshi Tachibana","orcid":"https://orcid.org/0000-0002-7780-4459","observed_orcids":["https://orcid.org/0000-0002-7780-4459"]},"institutions":[{"id":"https://openalex.org/I4387152949","display_name":"Kanagawa Cancer Center","ror":"https://ror.org/00aapa202","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4387152949"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayoshi Tachibana","raw_affiliation_strings":["Department of Hematology and Oncology, Kanagawa Cancer Center, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Kanagawa Cancer Center, Yokohama, Japan","institution_ids":["https://openalex.org/I4387152949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004542504","display_name":"Mitsumasa Watanabe","orcid":"https://orcid.org/0000-0003-4889-7999","observed_orcids":["https://orcid.org/0000-0003-4889-7999"]},"institutions":[{"id":"https://openalex.org/I4210134765","display_name":"Hyogo Prefectural Amagasaki General Medical Center","ror":"https://ror.org/04e8mq383","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210134765"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsumasa Watanabe","raw_affiliation_strings":["Department of Hematology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan","institution_ids":["https://openalex.org/I4210134765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103131907","display_name":"Yasunori Ueda","orcid":"https://orcid.org/0000-0002-4487-5808","observed_orcids":["https://orcid.org/0000-0002-4487-5808"]},"institutions":[{"id":"https://openalex.org/I4210089671","display_name":"Kurashiki Central Hospital","ror":"https://ror.org/00947s692","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210089671"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasunori Ueda","raw_affiliation_strings":["Department of Hematology, Kurashiki Central Hospital, Kurashiki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Kurashiki Central Hospital, Kurashiki, Japan","institution_ids":["https://openalex.org/I4210089671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110387448","display_name":"Yasuhiko Tsutsumi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151725","display_name":"Japanese Red Cross Society Kyoto Daini Hospital","ror":"https://ror.org/04xesg978","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2799517759","https://openalex.org/I4210151725"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhiko Tsutsumi","raw_affiliation_strings":["Department of Hematology, Japanese Red Cross Society Kyoto Daini Hospital, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Japanese Red Cross Society Kyoto Daini Hospital, Kyoto, Japan","institution_ids":["https://openalex.org/I4210151725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038837090","display_name":"Kazunori Imada","orcid":"https://orcid.org/0000-0002-0945-0513","observed_orcids":["https://orcid.org/0000-0002-0945-0513"]},"institutions":[{"id":"https://openalex.org/I4210124582","display_name":"Osaka Hospital","ror":"https://ror.org/02wcsw791","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210124582","https://openalex.org/I4210132540"]},{"id":"https://openalex.org/I4210151887","display_name":"Osaka Red Cross Hospital","ror":"https://ror.org/05h4q5j46","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2799517759","https://openalex.org/I4210151887"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazunori Imada","raw_affiliation_strings":["Department of Hematology, Japanese Red Cross Osaka Hospital, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Japanese Red Cross Osaka Hospital, Osaka, Japan","institution_ids":["https://openalex.org/I4210124582","https://openalex.org/I4210151887"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013574242","display_name":"Shin\u2010ichiro Fujiwara","orcid":"https://orcid.org/0000-0002-4523-2994","observed_orcids":["https://orcid.org/0000-0002-4523-2994"]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shin-ichiro Fujiwara","raw_affiliation_strings":["Division of Hematology, Jichi Medical University, Shimotsuke, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Jichi Medical University, Shimotsuke, Japan","institution_ids":["https://openalex.org/I146500386"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071643003","display_name":"Tomomi Toubai","orcid":"https://orcid.org/0000-0001-6658-7543","observed_orcids":["https://orcid.org/0000-0001-6658-7543"]},"institutions":[{"id":"https://openalex.org/I4210165438","display_name":"Yamagata University Hospital","ror":"https://ror.org/05gg4qm19","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210165438"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomomi Toubai","raw_affiliation_strings":["Division of Hematology and Cell Therapy, Yamagata University Hospital, Yamagata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology and Cell Therapy, Yamagata University Hospital, Yamagata, Japan","institution_ids":["https://openalex.org/I4210165438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082056388","display_name":"Kota Yoshifuji","orcid":"https://orcid.org/0009-0000-9206-3137","observed_orcids":["https://orcid.org/0009-0000-9206-3137"]},"institutions":[{"id":"https://openalex.org/I4400009020","display_name":"Institute of Science Tokyo","ror":"https://ror.org/05dqf9946","country_code":"JP","type":"education","lineage":["https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kota Yoshifuji","raw_affiliation_strings":["Department of Hematology, Institute of Science Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Institute of Science Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4400009020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024683649","display_name":"Hirokazu Hirata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800996768","display_name":"Kansai Electric Power (Japan)","ror":"https://ror.org/03xrg8731","country_code":"JP","type":"company","lineage":["https://openalex.org/I2800996768"]},{"id":"https://openalex.org/I4210123101","display_name":"Kansai Electric Power Hospital","ror":"https://ror.org/02srt1z47","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210123101"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirokazu Hirata","raw_affiliation_strings":["Department of Hematology, Kansai Electric Power Hospital, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Kansai Electric Power Hospital, Osaka, Japan","institution_ids":["https://openalex.org/I2800996768","https://openalex.org/I4210123101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020613096","display_name":"Hiroshi Kawabata","orcid":"https://orcid.org/0000-0002-1918-8635","observed_orcids":["https://orcid.org/0000-0002-1918-8635"]},"institutions":[{"id":"https://openalex.org/I3017590076","display_name":"Kyoto Medical Center","ror":"https://ror.org/045kb1d14","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I3017590076","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Kawabata","raw_affiliation_strings":["Department of Hematology, NHO Kyoto Medical Center, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, NHO Kyoto Medical Center, Kyoto, Japan","institution_ids":["https://openalex.org/I3017590076"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089860514","display_name":"Masaaki Tsuji","orcid":"https://orcid.org/0000-0001-5049-2398","observed_orcids":["https://orcid.org/0000-0001-5049-2398"]},"institutions":[{"id":"https://openalex.org/I4210134192","display_name":"Otsu Red Cross Hospital","ror":"https://ror.org/033647p67","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2799517759","https://openalex.org/I4210134192"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaaki Tsuji","raw_affiliation_strings":["Department of Hematology, Japanese Red Cross Otsu Hospital, Otsu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Japanese Red Cross Otsu Hospital, Otsu, Japan","institution_ids":["https://openalex.org/I4210134192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080244541","display_name":"Satoshi Wakita","orcid":"https://orcid.org/0000-0002-5810-5433","observed_orcids":["https://orcid.org/0000-0002-5810-5433"]},"institutions":[{"id":"https://openalex.org/I80188885","display_name":"Nippon Medical School","ror":"https://ror.org/00krab219","country_code":"JP","type":"education","lineage":["https://openalex.org/I80188885"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Wakita","raw_affiliation_strings":["Department of Hematology, Nippon Medical School, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Nippon Medical School, Tokyo, Japan","institution_ids":["https://openalex.org/I80188885"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103276510","display_name":"Hiroki Yokoyama","orcid":"https://orcid.org/0000-0003-0704-5941","observed_orcids":["https://orcid.org/0000-0003-0704-5941"]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroki Yokoyama","raw_affiliation_strings":["Division of Clinical Oncology/Hematology, Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Oncology/Hematology, Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062492623","display_name":"Toshiyuki Kitano","orcid":"https://orcid.org/0000-0002-4194-1638","observed_orcids":["https://orcid.org/0000-0002-4194-1638"]},"institutions":[{"id":"https://openalex.org/I4210161392","display_name":"Kitano Hospital","ror":"https://ror.org/05rsbck92","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161392"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiyuki Kitano","raw_affiliation_strings":["Department of Hematology, Medical Research Institute Kitano Hospital, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Medical Research Institute Kitano Hospital, Osaka, Japan","institution_ids":["https://openalex.org/I4210161392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086856159","display_name":"Kazunori Murai","orcid":"https://orcid.org/0000-0002-7353-3495","observed_orcids":["https://orcid.org/0000-0002-7353-3495"]},"institutions":[{"id":"https://openalex.org/I4210090926","display_name":"Iwate Prefectural Central Hospital","ror":"https://ror.org/00g916n77","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210090926"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazunori Murai","raw_affiliation_strings":["Department of Hematology, Iwate Prefectural Central Hospital, Morioka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Iwate Prefectural Central Hospital, Morioka, Japan","institution_ids":["https://openalex.org/I4210090926"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035121584","display_name":"Yoshihisa Kataoka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102296","display_name":"Ikeda Municipal Hospital","ror":"https://ror.org/00qezxe61","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210102296"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihisa Kataoka","raw_affiliation_strings":["Department of Hematology, Ikeda City Hospital, Ikeda, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Ikeda City Hospital, Ikeda, Japan","institution_ids":["https://openalex.org/I4210102296"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044994496","display_name":"Eri Kawata","orcid":"https://orcid.org/0000-0002-9377-443X","observed_orcids":["https://orcid.org/0000-0002-9377-443X"]},"institutions":[{"id":"https://openalex.org/I4210133417","display_name":"Matsushita Memorial Hospital","ror":"https://ror.org/03ycmew18","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210133417"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eri Kawata","raw_affiliation_strings":["Department of Hematology, Matsushita Memorial Hospital, Moriguchi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Matsushita Memorial Hospital, Moriguchi, Japan","institution_ids":["https://openalex.org/I4210133417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068184151","display_name":"Shun\u2010ichi Kimura","orcid":"https://orcid.org/0000-0001-9827-8526","observed_orcids":["https://orcid.org/0000-0001-9827-8526"]},"institutions":[{"id":"https://openalex.org/I4210166222","display_name":"Jichi Medical University Saitama Medical Center","ror":"https://ror.org/05rq8j339","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210166222"]},{"id":"https://openalex.org/I8588240","display_name":"Saitama Medical University","ror":"https://ror.org/04zb31v77","country_code":"JP","type":"education","lineage":["https://openalex.org/I8588240"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shun-ichi Kimura","raw_affiliation_strings":["Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan","institution_ids":["https://openalex.org/I4210166222","https://openalex.org/I8588240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015803263","display_name":"Ryusuke Yamamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161700","display_name":"Kobe City Medical Center General Hospital","ror":"https://ror.org/04j4nak57","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161700","https://openalex.org/I4405284131"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryusuke Yamamoto","raw_affiliation_strings":["Department of Hematology, Kobe City Medical Center General Hospital, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Kobe City Medical Center General Hospital, Kobe, Japan","institution_ids":["https://openalex.org/I4210161700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073657213","display_name":"Kotaro Miyao","orcid":"https://orcid.org/0000-0003-0716-1424","observed_orcids":["https://orcid.org/0000-0003-0716-1424"]},"institutions":[{"id":"https://openalex.org/I4210144551","display_name":"Anjo Kosei Hospital","ror":"https://ror.org/05c06ww48","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210144551"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kotaro Miyao","raw_affiliation_strings":["Department of Hematology and Oncology, Anjo Kosei Hospital, Anjo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Anjo Kosei Hospital, Anjo, Japan","institution_ids":["https://openalex.org/I4210144551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071892867","display_name":"Daisuke Nakayama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104574","display_name":"Kyoto City Hospital","ror":"https://ror.org/01605g366","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104574","https://openalex.org/I4405282747"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daisuke Nakayama","raw_affiliation_strings":["Department of Hematology, Kyoto City Hospital, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Kyoto City Hospital, Kyoto, Japan","institution_ids":["https://openalex.org/I4210104574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008684437","display_name":"Akihiko Izumi","orcid":"https://orcid.org/0009-0007-9900-4421","observed_orcids":["https://orcid.org/0009-0007-9900-4421"]},"institutions":[{"id":"https://openalex.org/I4387152949","display_name":"Kanagawa Cancer Center","ror":"https://ror.org/00aapa202","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4387152949"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akihiko Izumi","raw_affiliation_strings":["Department of Hematology and Oncology, Kanagawa Cancer Center, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Kanagawa Cancer Center, Yokohama, Japan","institution_ids":["https://openalex.org/I4387152949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067740255","display_name":"Takahito Kawata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134765","display_name":"Hyogo Prefectural Amagasaki General Medical Center","ror":"https://ror.org/04e8mq383","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210134765"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahito Kawata","raw_affiliation_strings":["Department of Hematology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan","institution_ids":["https://openalex.org/I4210134765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006505836","display_name":"Yoshiyuki Onda","orcid":"https://orcid.org/0000-0003-3093-4974","observed_orcids":["https://orcid.org/0000-0003-3093-4974"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiyuki Onda","raw_affiliation_strings":["Department of Hematology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136399270","display_name":"Takashi Sakamoto","orcid":"https://orcid.org/0000-0001-8868-1661","observed_orcids":["https://orcid.org/0000-0001-8868-1661"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Sakamoto","raw_affiliation_strings":["Department of Hematology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036645626","display_name":"Chisaki Mizumoto","orcid":"https://orcid.org/0009-0006-8867-7287","observed_orcids":["https://orcid.org/0009-0006-8867-7287"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chisaki Mizumoto","raw_affiliation_strings":["Department of Hematology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123325223","display_name":"Toshio Kitawaki","orcid":"https://orcid.org/0000-0002-6373-3442","observed_orcids":["https://orcid.org/0000-0002-6373-3442"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshio Kitawaki","raw_affiliation_strings":["Department of Hematology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008039726","display_name":"Kouhei Yamashita","orcid":"https://orcid.org/0000-0003-4247-3407","observed_orcids":["https://orcid.org/0000-0003-4247-3407"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kouhei Yamashita","raw_affiliation_strings":["Department of Hematology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028127032","display_name":"Atsushi Yonezawa","orcid":"https://orcid.org/0000-0002-8057-6768","observed_orcids":["https://orcid.org/0000-0002-8057-6768"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Yonezawa","raw_affiliation_strings":["Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan","Division of Integrative Clinical Pharmacology, Faculty of Pharmacy, Keio University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan","institution_ids":["https://openalex.org/I4210150196"]},{"raw_affiliation_string":"Division of Integrative Clinical Pharmacology, Faculty of Pharmacy, Keio University, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157815250","display_name":"Tomoya Kawakami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoya Kawakami","raw_affiliation_strings":["Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan","institution_ids":["https://openalex.org/I4210150196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124274046","display_name":"S. Nakagawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shunsaku Nakagawa","raw_affiliation_strings":["Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan","institution_ids":["https://openalex.org/I4210150196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027554589","display_name":"Risa Taniguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Risa Taniguchi","raw_affiliation_strings":["Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan","institution_ids":["https://openalex.org/I4210150196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102710291","display_name":"Tomohiro Terada","orcid":"https://orcid.org/0000-0002-4559-9753","observed_orcids":["https://orcid.org/0000-0002-4559-9753"]},"institutions":[{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomohiro Terada","raw_affiliation_strings":["Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan","institution_ids":["https://openalex.org/I4210150196"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021783559","display_name":"Akifumi Takaori\u2010Kondo","orcid":"https://orcid.org/0000-0001-7678-4284","observed_orcids":["https://orcid.org/0000-0001-7678-4284"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akifumi Takaori-Kondo","raw_affiliation_strings":["Department of Hematology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":27,"corresponding_author_ids":["https://openalex.org/A5072808833"],"corresponding_institution_ids":["https://openalex.org/I22299242"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":3.7298,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.86245353,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"16","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/venetoclax","display_name":"venetoclax","score":1.0},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9279999732971191},{"id":"https://openalex.org/keywords/trough-concentration","display_name":"trough concentration","score":0.6880000233650208},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7110000252723694},{"id":"https://openalex.org/keywords/dose-optimization","display_name":"dose optimization","score":0.6819999814033508},{"id":"https://openalex.org/keywords/hematological-toxicity","display_name":"hematologic toxicity","score":0.8059999942779541},{"id":"https://openalex.org/keywords/complete-remission","display_name":"complete remission","score":0.9380000233650208},{"id":"https://openalex.org/keywords/antifungal-agents","display_name":"antifungal agents","score":0.6470000147819519},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.6729999780654907},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.6240000128746033},{"id":"https://openalex.org/keywords/liver-function","display_name":"liver function","score":0.31700000166893005}],"concepts":[{"id":"https://openalex.org/C2779675984","wikidata":"https://www.wikidata.org/wiki/Q23671272","display_name":"Venetoclax","level":4,"score":0.9427000284194946},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7407000064849854},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.7361999750137329},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5681999921798706},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5159000158309937},{"id":"https://openalex.org/C32239851","wikidata":"https://www.wikidata.org/wiki/Q7846538","display_name":"Trough (economics)","level":2,"score":0.491100013256073},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.43549999594688416},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.43309998512268066},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.40220001339912415},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3955000042915344},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.3831000030040741},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3463999927043915},{"id":"https://openalex.org/C2777513400","wikidata":"https://www.wikidata.org/wiki/Q104219","display_name":"Bilirubin","level":2,"score":0.34299999475479126},{"id":"https://openalex.org/C2780366003","wikidata":"https://www.wikidata.org/wiki/Q246147","display_name":"Cytopenia","level":3,"score":0.34279999136924744},{"id":"https://openalex.org/C2781021840","wikidata":"https://www.wikidata.org/wiki/Q411659","display_name":"Daunorubicin","level":3,"score":0.33230000734329224},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.3212999999523163},{"id":"https://openalex.org/C2910800852","wikidata":"https://www.wikidata.org/wiki/Q7846541","display_name":"Trough Concentration","level":3,"score":0.3084000051021576},{"id":"https://openalex.org/C31785415","wikidata":"https://www.wikidata.org/wiki/Q7846541","display_name":"Trough level","level":4,"score":0.3005000054836273},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.299699991941452},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.2996000051498413},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.2978000044822693},{"id":"https://openalex.org/C2780272996","wikidata":"https://www.wikidata.org/wiki/Q1261151","display_name":"Therapeutic drug monitoring","level":3,"score":0.2903999984264374},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.2782000005245209},{"id":"https://openalex.org/C3018657049","wikidata":"https://www.wikidata.org/wiki/Q1595418","display_name":"Complete remission","level":3,"score":0.2782000005245209},{"id":"https://openalex.org/C2780817109","wikidata":"https://www.wikidata.org/wiki/Q954625","display_name":"Myelodysplastic syndromes","level":3,"score":0.26840001344680786},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2574000060558319},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.2549999952316284}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019086","descriptor_name":"Bridged Bicyclo Compounds, Heterocyclic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D019086","descriptor_name":"Bridged Bicyclo Compounds, Heterocyclic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D019086","descriptor_name":"Bridged Bicyclo Compounds, Heterocyclic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D019086","descriptor_name":"Bridged Bicyclo Compounds, Heterocyclic","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D019086","descriptor_name":"Bridged Bicyclo Compounds, Heterocyclic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1038/s41598-026-38587-4","doi":"https://doi.org/10.1038/s41598-026-38587-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-38587-4","pdf_url":"https://www.nature.com/articles/s41598-026-38587-4_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-6994976/v1","doi":"https://doi.org/10.21203/rs.3.rs-6994976/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-6994976/v1","pdf_url":"https://www.researchsquare.com/article/rs-6994976/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:41654609","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41654609","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12946174","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12946174/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:e7ea31b8879b4128ab371458f6ee7ab6","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/e7ea31b8879b4128ab371458f6ee7ab6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 16, Iss 1 (2026)","raw_type":"article"},{"id":"pmh:oai:irdb.nii.ac.jp:01221:0007265540","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2433/299693","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports","raw_type":"journal article"},{"id":"pmh:oai:repository.kulib.kyoto-u.ac.jp:2433/299693","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2433/299693","pdf_url":null,"source":{"id":"https://openalex.org/S4306401454","display_name":"Kyoto University Research Information Repository (Kyoto University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I22299242","host_organization_name":"Kyoto University","host_organization_lineage":["https://openalex.org/I22299242"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-38587-4","doi":"https://doi.org/10.1038/s41598-026-38587-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-38587-4","pdf_url":"https://www.nature.com/articles/s41598-026-38587-4_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3851107359","display_name":"\u81cd\u5e2f\u8840\u79fb\u690d\u306e\u79fb\u690d\u5f8c\u4e2d\u9577\u671f\u5408\u4f75\u75c7\u306b\u5bfe\u3059\u308b\u56fd\u969b\u6a19\u6e96\u4e88\u6e2c\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u306e\u78ba\u7acb","funder_award_id":"24K11515","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320309807","display_name":"Takeda Science Foundation","ror":"https://ror.org/02y123g31"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7128314837.pdf","grobid_xml":"https://content.openalex.org/works/W7128314837.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W2124221273","https://openalex.org/W2192121806","https://openalex.org/W2328549977","https://openalex.org/W2338674998","https://openalex.org/W2549463667","https://openalex.org/W2559537906","https://openalex.org/W2583145471","https://openalex.org/W2783500974","https://openalex.org/W2898284215","https://openalex.org/W2946882253","https://openalex.org/W3013447738","https://openalex.org/W3027618044","https://openalex.org/W3048827006","https://openalex.org/W3113950740","https://openalex.org/W3164043037","https://openalex.org/W3202266999","https://openalex.org/W4205420304","https://openalex.org/W4224731139","https://openalex.org/W4224871341","https://openalex.org/W4284884567","https://openalex.org/W4380049704","https://openalex.org/W4391247392","https://openalex.org/W4398253270"],"related_works":["https://openalex.org/W4402876662","https://openalex.org/W4387361607","https://openalex.org/W7165560229","https://openalex.org/W4398250996","https://openalex.org/W4389219652","https://openalex.org/W2954497082","https://openalex.org/W4389220336","https://openalex.org/W2972194251","https://openalex.org/W4417019859","https://openalex.org/W4408689745"],"abstract_inverted_index":{"Venetoclax-azacitidine":[0],"chemotherapy":[1],"is":[2,19],"a":[3,160],"key":[4],"treatment":[5,59,119],"for":[6,86,177],"older":[7],"or":[8],"medically":[9],"unfit":[10],"patients":[11,64,136],"with":[12,32,79,96,104,137,159],"acute":[13],"myeloid":[14],"leukemia":[15],"(AML).":[16],"As":[17],"venetoclax":[18,38,55,90,178],"metabolized":[20],"via":[21],"cytochrome":[22],"P450":[23],"3":[24],"A,":[25],"dose":[26,179],"adjustments":[27],"are":[28],"required":[29],"when":[30],"combined":[31],"antifungal":[33,87],"agents.":[34],"However,":[35],"data":[36],"on":[37,43,182],"concentrations":[39,138],"and":[40,45,58,99,189],"their":[41],"impact":[42],"safety":[44,188],"efficacy":[46,190],"remain":[47],"limited.":[48],"This":[49],"study":[50],"analyzed":[51],"the":[52,117,128,149,175],"association":[53],"between":[54],"trough":[56,71,91,105,152],"levels":[57,92,106,153,184],"outcomes":[60],"in":[61,135,191],"152":[62],"AML":[63,192],"(median":[65],"age:":[66],"70":[67],"years).":[68],"The":[69],"median":[70],"level":[72],"was":[73,133],"1,518":[74],"ng/mL":[75,109,141,156],"(range:":[76],"60-11,328":[77],"ng/mL),":[78],"significant":[80],"interindividual":[81],"variability,":[82],"even":[83],"after":[84],"adjusting":[85],"use.":[88],"High":[89],"were":[93,157],"significantly":[94],"associated":[95,158],"elevated":[97],"creatinine":[98],"total":[100],"bilirubin":[101],"levels.":[102],"Patients":[103],"below":[107,139],"1857.3":[108,155],"had":[110],"lower":[111,134],"rates":[112],"of":[113],"hematologic":[114,131],"toxicity":[115,132],"during":[116],"first":[118],"cycle":[120],"(92.9%":[121],"vs.":[122,143,167],"100%,":[123],"P":[124,145,169],"=":[125,146,170],"0.041).":[126],"In":[127,148],"second":[129],"cycle,":[130],"1,299.3":[140],"(68%":[142],"90%,":[144],"0.009).":[147],"treatment-na\u00efve":[150],"group,":[151],"above":[154],"higher":[161],"composite":[162],"complete":[163],"remission":[164],"rate":[165],"(77.3%":[166],"47.8%,":[168],"0.042).":[171],"These":[172],"findings":[173],"highlight":[174],"need":[176],"optimization":[180],"based":[181],"drug":[183],"to":[185],"improve":[186],"both":[187],"treatment.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-02-09T00:00:00"}
