{"id":"https://openalex.org/W7128314027","doi":"https://doi.org/10.20944/preprints202602.0529.v1","title":"Compensated Structural Savantism: Neurogenomic Characterization of High Cognitive Ability in a Phenotype at Risk for Autism Spectrum Disorder","display_name":"Compensated Structural Savantism: Neurogenomic Characterization of High Cognitive Ability in a Phenotype at Risk for Autism Spectrum Disorder","publication_year":2026,"publication_date":"2026-02-06","ids":{"openalex":"https://openalex.org/W7128314027","doi":"https://doi.org/10.20944/preprints202602.0529.v1"},"language":"en","primary_location":{"id":"doi:10.20944/preprints202602.0529.v1","doi":"https://doi.org/10.20944/preprints202602.0529.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202602.0529.v1","pdf_url":"https://www.preprints.org/frontend/manuscript/f0849138000a53c9722d232a32d7dc33/download_pub","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"parent_works":[],"lineage":["https://openalex.org/W7128314027"],"child_works_count":0,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.preprints.org/frontend/manuscript/f0849138000a53c9722d232a32d7dc33/download_pub","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015782389","display_name":"Fabiano de Abreu Agrela Rodrigues","orcid":"https://orcid.org/0000-0002-5487-5852","observed_orcids":["https://orcid.org/0000-0002-5487-5852"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fabiano de Abreu Agrela Rodrigues","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5487-5852","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5031576850","display_name":"Adriel Pereira da Silva","orcid":"https://orcid.org/0009-0003-1157-8318","observed_orcids":["https://orcid.org/0009-0003-1157-8318"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adriel Pereira Silva","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-1157-8318","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10547","display_name":"Education, Achievement, and Giftedness","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3204","display_name":"Developmental and Educational Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.9509999752044678},{"id":"https://openalex.org/keywords/polygenic-risk-score","display_name":"polygenic risk score","score":0.6899999976158142},{"id":"https://openalex.org/keywords/executive-function","display_name":"executive function","score":0.628000020980835},{"id":"https://openalex.org/keywords/neurodivergence","display_name":"neurodivergence","score":0.800000011920929},{"id":"https://openalex.org/keywords/giftedness","display_name":"giftedness","score":0.7160000205039978},{"id":"https://openalex.org/keywords/hyperfocus","display_name":"hyperfocus","score":0.7860000133514404},{"id":"https://openalex.org/keywords/exceptional-memory","display_name":"exceptional memory","score":0.8299999833106995},{"id":"https://openalex.org/keywords/neurogenomics","display_name":"neurogenomics","score":0.6890000104904175},{"id":"https://openalex.org/keywords/structural-neuroimaging","display_name":"structural neuroimaging","score":0.6890000104904175},{"id":"https://openalex.org/keywords/compensatory-mechanisms","display_name":"compensatory mechanisms","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.7315000295639038},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.7177000045776367},{"id":"https://openalex.org/C2778538070","wikidata":"https://www.wikidata.org/wiki/Q1436063","display_name":"Autism spectrum disorder","level":3,"score":0.7124999761581421},{"id":"https://openalex.org/C2993137441","wikidata":"https://www.wikidata.org/wiki/Q28135712","display_name":"Polygenic risk score","level":5,"score":0.5777999758720398},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5297999978065491},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5181000232696533},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4767000079154968},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.45509999990463257},{"id":"https://openalex.org/C9287583","wikidata":"https://www.wikidata.org/wiki/Q5532883","display_name":"Genetic architecture","level":4,"score":0.41370001435279846},{"id":"https://openalex.org/C2779632907","wikidata":"https://www.wikidata.org/wiki/Q13444883","display_name":"Brain Structure and Function","level":3,"score":0.3986000120639801},{"id":"https://openalex.org/C2779985164","wikidata":"https://www.wikidata.org/wiki/Q5419936","display_name":"Executive dysfunction","level":4,"score":0.3903999924659729},{"id":"https://openalex.org/C2775968953","wikidata":"https://www.wikidata.org/wiki/Q783092","display_name":"Executive functions","level":3,"score":0.3756999969482422},{"id":"https://openalex.org/C2986811735","wikidata":"https://www.wikidata.org/wiki/Q4692577","display_name":"Cognitive aging","level":3,"score":0.3634999990463257},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.3458000123500824},{"id":"https://openalex.org/C185711340","wikidata":"https://www.wikidata.org/wiki/Q5347381","display_name":"Effects of sleep deprivation on cognitive performance","level":3,"score":0.34150001406669617},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.3239000141620636},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30820000171661377},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.29789999127388},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.2888000011444092},{"id":"https://openalex.org/C55112680","wikidata":"https://www.wikidata.org/wiki/Q190549","display_name":"Functional analysis","level":3,"score":0.28760001063346863},{"id":"https://openalex.org/C2777154362","wikidata":"https://www.wikidata.org/wiki/Q7575316","display_name":"Spectrum disorder","level":2,"score":0.28349998593330383},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.27950000762939453},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.2791999876499176},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2621000111103058},{"id":"https://openalex.org/C18183760","wikidata":"https://www.wikidata.org/wiki/Q6002833","display_name":"Imaging genetics","level":3,"score":0.2549000084400177},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.25290000438690186}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.20944/preprints202602.0529.v1","doi":"https://doi.org/10.20944/preprints202602.0529.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202602.0529.v1","pdf_url":"https://www.preprints.org/frontend/manuscript/f0849138000a53c9722d232a32d7dc33/download_pub","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.20944/preprints202602.0529.v1","doi":"https://doi.org/10.20944/preprints202602.0529.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202602.0529.v1","pdf_url":"https://www.preprints.org/frontend/manuscript/f0849138000a53c9722d232a32d7dc33/download_pub","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7128314027.pdf","grobid_xml":"https://content.openalex.org/works/W7128314027.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7117477804","https://openalex.org/W2102481201","https://openalex.org/W7163668937","https://openalex.org/W7131132402","https://openalex.org/W7127067909","https://openalex.org/W7160028482","https://openalex.org/W4401389265","https://openalex.org/W2129475546","https://openalex.org/W2977699704","https://openalex.org/W1991186460"],"abstract_inverted_index":{"This":[0],"case":[1],"study":[2],"(N=1)":[3],"investigates":[4],"the":[5,101,112],"neurobiological":[6],"and":[7,38,81,94,108],"genomic":[8],"architecture":[9],"of":[10,17,27,31,115],"a":[11,15,42,54,57],"male":[12],"individual":[13],"with":[14,24,69],"history":[16],"exceptional":[18,109],"cognitive":[19,39],"performance":[20],"(profound":[21],"giftedness),":[22],"contrasted":[23],"behavioral":[25],"traits":[26],"neurodivergence.":[28],"Integrated":[29],"analysis":[30],"polygenic":[32,59],"risk":[33,60],"scores":[34],"(PRS),":[35],"structural":[36],"neuroimaging,":[37],"assessment":[40],"reveals":[41],"rare":[43],"phenotype":[44],"termed":[45],"here":[46],"as":[47,97],"\"Compensated":[48],"Structural":[49],"Savantism\".":[50],"The":[51],"results":[52],"demonstrate":[53],"paradoxical":[55],"coexistence:":[56],"high":[58,91],"for":[61,76],"Autism":[62],"Spectrum":[63],"Disorder":[64],"(81.6th":[65],"percentile),":[66],"typically":[67],"associated":[68],"functional":[70],"deficits,":[71],"superimposed":[72],"on":[73],"elite":[74],"markers":[75],"Executive":[77],"Function":[78],"(99.7th":[79],"percentile)":[80],"Hippocampal":[82],"CA1":[83],"Volume":[84],"(99.8th":[85],"percentile).":[86],"It":[87],"is":[88],"concluded":[89],"that":[90],"executive":[92],"efficiency":[93],"hyperplasticity":[95],"act":[96],"compensatory":[98],"mechanisms,":[99],"converting":[100],"predisposition":[102],"to":[103],"autism":[104],"into":[105],"productive":[106],"hyperfocus":[107],"memory,":[110],"preventing":[111],"clinical":[113],"manifestation":[114],"impairments.":[116]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-02-09T00:00:00"}