{"id":"https://openalex.org/W7128313435","doi":"https://doi.org/10.1002/nano.70066","title":"Gold Nanoparticles Loaded With Lutetium\u2010177 Labeled DOTA\u2010TATE Exhibit Superior AR42J Cell Affinity and Extended Blood Circulation in AR42J Tumor Xenografts","display_name":"Gold Nanoparticles Loaded With Lutetium\u2010177 Labeled DOTA\u2010TATE Exhibit Superior AR42J Cell Affinity and Extended Blood Circulation in AR42J Tumor Xenografts","publication_year":2026,"publication_date":"2026-02-01","ids":{"openalex":"https://openalex.org/W7128313435","doi":"https://doi.org/10.1002/nano.70066"},"language":"en","primary_location":{"id":"doi:10.1002/nano.70066","doi":"https://doi.org/10.1002/nano.70066","is_oa":true,"landing_page_url":"https://doi.org/10.1002/nano.70066","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/nano.70066","source":{"id":"https://openalex.org/S4210201393","display_name":"Nano Select","issn_l":"2688-4011","issn":["2688-4011"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nano Select","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/nano.70066","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5125358189","display_name":"Dheeraj Kumar","orcid":"https://orcid.org/0009-0008-5667-537X","observed_orcids":["https://orcid.org/0009-0008-5667-537X"]},"institutions":[{"id":"https://openalex.org/I200207707","display_name":"Homi Bhabha National Institute","ror":"https://ror.org/02bv3zr67","country_code":"IN","type":"education","lineage":["https://openalex.org/I200207707"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Dheeraj Kumar","raw_affiliation_strings":["Homi Bhabha National Institute  Mumbai India","Radiopharmaceuticals Program Board of Radiation and Isotope Technology  Navi Mumbai India"],"raw_orcid":"https://orcid.org/0009-0008-5667-537X","affiliations":[{"raw_affiliation_string":"Homi Bhabha National Institute  Mumbai India","institution_ids":["https://openalex.org/I200207707"]},{"raw_affiliation_string":"Radiopharmaceuticals Program Board of Radiation and Isotope Technology  Navi Mumbai India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012864430","display_name":"Rani Gnanasekar","orcid":"https://orcid.org/0000-0001-6176-685X","observed_orcids":["https://orcid.org/0000-0001-6176-685X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rani Gnanasekar","raw_affiliation_strings":["Radiopharmaceuticals Program Board of Radiation and Isotope Technology  Navi Mumbai India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiopharmaceuticals Program Board of Radiation and Isotope Technology  Navi Mumbai India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079945524","display_name":"Sheela Muralidharan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sheela Muralidharan","raw_affiliation_strings":["Radiopharmaceuticals Program Board of Radiation and Isotope Technology  Navi Mumbai India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiopharmaceuticals Program Board of Radiation and Isotope Technology  Navi Mumbai India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009326546","display_name":"Shubhangi Mirapurkar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shubhangi Mirapurkar","raw_affiliation_strings":["Radiopharmaceuticals Program Board of Radiation and Isotope Technology  Navi Mumbai India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiopharmaceuticals Program Board of Radiation and Isotope Technology  Navi Mumbai India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060438523","display_name":"Krishna Mohan Repaka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Krishna Mohan Repaka","raw_affiliation_strings":["Radiopharmaceuticals Program Board of Radiation and Isotope Technology  Navi Mumbai India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiopharmaceuticals Program Board of Radiation and Isotope Technology  Navi Mumbai India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067616533","display_name":"Anupam Mathur","orcid":"https://orcid.org/0000-0003-2619-001X","observed_orcids":["https://orcid.org/0000-0003-2619-001X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Anupam Mathur","raw_affiliation_strings":["Radiopharmaceuticals Program Board of Radiation and Isotope Technology  Navi Mumbai India"],"raw_orcid":"https://orcid.org/0000-0003-2619-001X","affiliations":[{"raw_affiliation_string":"Radiopharmaceuticals Program Board of Radiation and Isotope Technology  Navi Mumbai India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067958404","display_name":"Madhava B. Mallia","orcid":"https://orcid.org/0000-0001-6487-3802","observed_orcids":["https://orcid.org/0000-0001-6487-3802"]},"institutions":[{"id":"https://openalex.org/I1329621470","display_name":"Bhabha Atomic Research Centre","ror":"https://ror.org/05w6wfp17","country_code":"IN","type":"facility","lineage":["https://openalex.org/I1329621470","https://openalex.org/I2799351866","https://openalex.org/I3149292468"]},{"id":"https://openalex.org/I200207707","display_name":"Homi Bhabha National Institute","ror":"https://ror.org/02bv3zr67","country_code":"IN","type":"education","lineage":["https://openalex.org/I200207707"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Madhava B. Mallia","raw_affiliation_strings":["Homi Bhabha National Institute  Mumbai India","Radiopharmaceuticals Division Bhabha Atomic Research Centre  Mumbai India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Homi Bhabha National Institute  Mumbai India","institution_ids":["https://openalex.org/I200207707"]},{"raw_affiliation_string":"Radiopharmaceuticals Division Bhabha Atomic Research Centre  Mumbai India","institution_ids":["https://openalex.org/I1329621470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5067616533","https://openalex.org/A5125358189"],"corresponding_institution_ids":["https://openalex.org/I200207707"],"apc_list":{"value":2660,"currency":"USD","value_usd":2660},"apc_paid":{"value":2660,"currency":"USD","value_usd":2660},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07402257,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gold-nanoparticles","display_name":"gold nanoparticles","score":0.9819999933242798},{"id":"https://openalex.org/keywords/lutetium-177","display_name":"lutetium-177","score":0.9909999966621399},{"id":"https://openalex.org/keywords/dotatate","display_name":"DOTATATE","score":0.9950000047683716},{"id":"https://openalex.org/keywords/somatostatin-receptor-2","display_name":"somatostatin receptor 2","score":0.8019999861717224},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.5450000166893005},{"id":"https://openalex.org/keywords/nanoparticle-labeling","display_name":"nanoparticle labeling","score":0.6100000143051147},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.6299999952316284},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.9739999771118164},{"id":"https://openalex.org/keywords/ar42j-cells","display_name":"AR42J cells","score":0.8069999814033508},{"id":"https://openalex.org/keywords/neuroendocrine-tumors","display_name":"neuroendocrine tumors","score":0.8320000171661377},{"id":"https://openalex.org/keywords/tumor-uptake","display_name":"tumor uptake","score":0.4309999942779541},{"id":"https://openalex.org/keywords/blood-circulation-time","display_name":"blood circulation time","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7883999943733215},{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.7875000238418579},{"id":"https://openalex.org/C104819515","wikidata":"https://www.wikidata.org/wiki/Q900961","display_name":"Colloidal gold","level":3,"score":0.6718999743461609},{"id":"https://openalex.org/C2993559085","wikidata":"https://www.wikidata.org/wiki/Q2126444","display_name":"Radionuclide therapy","level":2,"score":0.6126999855041504},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5543000102043152},{"id":"https://openalex.org/C2776297358","wikidata":"https://www.wikidata.org/wiki/Q407166","display_name":"Somatostatin","level":2,"score":0.4174000024795532},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.41609999537467957},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4117000102996826},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4050000011920929},{"id":"https://openalex.org/C2985453986","wikidata":"https://www.wikidata.org/wiki/Q11068","display_name":"Blood circulation","level":2,"score":0.3806000053882599},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3375999927520752},{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.33169999718666077},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.3228999972343445},{"id":"https://openalex.org/C177322064","wikidata":"https://www.wikidata.org/wiki/Q750955","display_name":"Radiochemistry","level":1,"score":0.30489999055862427},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2678999900817871},{"id":"https://openalex.org/C2776557347","wikidata":"https://www.wikidata.org/wiki/Q37187","display_name":"Red blood cell","level":2,"score":0.26159998774528503},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.26109999418258667}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/nano.70066","doi":"https://doi.org/10.1002/nano.70066","is_oa":true,"landing_page_url":"https://doi.org/10.1002/nano.70066","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/nano.70066","source":{"id":"https://openalex.org/S4210201393","display_name":"Nano Select","issn_l":"2688-4011","issn":["2688-4011"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nano Select","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:89048d9a9cbb4dddbcb629b81fc75903","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/89048d9a9cbb4dddbcb629b81fc75903","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nano Select, Vol 7, Iss 2, Pp n/a-n/a (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/nano.70066","doi":"https://doi.org/10.1002/nano.70066","is_oa":true,"landing_page_url":"https://doi.org/10.1002/nano.70066","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/nano.70066","source":{"id":"https://openalex.org/S4210201393","display_name":"Nano Select","issn_l":"2688-4011","issn":["2688-4011"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nano Select","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334966","display_name":"Bhabha Atomic Research Centre","ror":"https://ror.org/05w6wfp17"},{"id":"https://openalex.org/F4320338100","display_name":"Advanced Centre for Treatment, Research and Education in Cancer","ror":"https://ror.org/05b9pgt88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7128313435.pdf","grobid_xml":"https://content.openalex.org/works/W7128313435.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1980457666","https://openalex.org/W1984092714","https://openalex.org/W2011155894","https://openalex.org/W2020451212","https://openalex.org/W2026494961","https://openalex.org/W2051565538","https://openalex.org/W2070909089","https://openalex.org/W2090257199","https://openalex.org/W2104232700","https://openalex.org/W2108479069","https://openalex.org/W2108579980","https://openalex.org/W2112451160","https://openalex.org/W2116670113","https://openalex.org/W2135913252","https://openalex.org/W2189450260","https://openalex.org/W2268448293","https://openalex.org/W2333562831","https://openalex.org/W2562574147","https://openalex.org/W2611673620","https://openalex.org/W2611902501","https://openalex.org/W2753581915","https://openalex.org/W2762858862","https://openalex.org/W2773668357","https://openalex.org/W2786988345","https://openalex.org/W2938140328","https://openalex.org/W3093860619","https://openalex.org/W4308959210","https://openalex.org/W4323566589","https://openalex.org/W4389733950","https://openalex.org/W4403343963","https://openalex.org/W4404248302","https://openalex.org/W4406032488"],"related_works":[],"abstract_inverted_index":{"ABSTRACT":[0],"Lutetium\u2010177":[1],"(":[2],"177":[3,45,66,118,186],"Lu)":[4],"labeled":[5],"DOTA\u20103\u2010Tyr\u2010Octreotate":[6],"(DOTA\u2010TATE)":[7],"is":[8],"a":[9,32,87,121,177],"peptide\u2010based":[10],"receptor\u2010mediated":[11],"radionuclide":[12],"therapy":[13],"that":[14],"has":[15],"received":[16],"FDA":[17],"authorization":[18],"for":[19,39],"treatment":[20],"of":[21,43,79,82,102,112,152,162,179],"neuroendocrine":[22],"tumors":[23],"expressing":[24],"somatostatin":[25],"sstr2":[26],"receptors.":[27],"The":[28,69,140],"present":[29],"study":[30],"employs":[31],"synthetically":[33],"modified":[34],"gold":[35],"nanoparticle":[36],"(AuNP)":[37],"preparation":[38],"effecting":[40],"increased":[41],"delivery":[42],"[":[44,65,117,185],"Lu]Lu\u2010DOTA\u2010TATE":[46,119,187],"at":[47,167],"the":[48,64,73,99,183,189,193],"targeted":[49],"cancerous":[50],"site.":[51],"Two":[52],"synthetic":[53],"approaches,":[54],"viz.":[55],"pre\u2010labeling":[56,70],"and":[57],"post\u2010labeling":[58],",":[59],"were":[60],"followed":[61],"to":[62,76,134,203],"produce":[63],"Lu]Lu\u2010DOTA\u2010TATE\u2010loaded":[67],"AuNPs.":[68],"approach":[71],"estimated":[72],"peptide":[74,137],"functionalization":[75],"an":[77],"extent":[78],"\u223c20%.":[80],"TEM":[81],"DOTA\u2010TATE":[83,113,136],"functionalized":[84,114],"AuNPs":[85,142,154],"yielded":[86],"particle":[88],"size":[89],"around":[90,107],"5.5":[91],"\u00b1":[92,164],"2.2":[93],"nm.":[94],"A":[95],"theoretical":[96],"estimate":[97],"quantified":[98],"average":[100],"number":[101],"TATE":[103],"molecules":[104],"per":[105],"AuNP":[106,115],"23.":[108],"IC":[109],"50":[110],"determination":[111],"using":[116],"as":[120],"standard":[122,184],"in":[123,132,146,155],"AR42J":[124,147,156],"cell":[125,148],"lines":[126],"exhibited":[127],"superior":[128],"inhibition":[129],"(0.62":[130],"nM)":[131],"comparison":[133],"free":[135],"(4.84":[138],"nM).":[139],"radiolabeled":[141,153],"presented":[143],">80%":[144],"specificity":[145],"lines.":[149],"Biodistribution":[150],"studies":[151],"tumor":[157,160,205],"xenografts":[158],"showed":[159],"uptake":[161],"1.76":[163],"1.08%":[165],"ID/g":[166],"2":[168],"h":[169],"post\u2010injection":[170],"(p.i.),":[171],"which":[172],"remained":[173],"nearly":[174],"constant":[175],"over":[176,207],"period":[178],"48":[180],"h.":[181],"Unlike":[182],"radiotracer,":[188],"NP":[190],"elimination":[191],"from":[192],"blood":[194],"pool":[195],"was":[196],"slower;":[197],"however,":[198],"prolonged":[199],"systemic":[200],"circulation":[201],"failed":[202],"enhance":[204],"accumulation":[206],"time.":[208]},"counts_by_year":[],"updated_date":"2026-09-23T05:00:35.095934","created_date":"2026-02-09T00:00:00"}
