{"id":"https://openalex.org/W7128310824","doi":"https://doi.org/10.3390/antiox15020220","title":"Neuron-Derived Sema3B Facilitates Microglial Hematoma Clearance After Intracerebral Hemorrhage","display_name":"Neuron-Derived Sema3B Facilitates Microglial Hematoma Clearance After Intracerebral Hemorrhage","publication_year":2026,"publication_date":"2026-02-08","ids":{"openalex":"https://openalex.org/W7128310824","doi":"https://doi.org/10.3390/antiox15020220","pmid":"https://pubmed.ncbi.nlm.nih.gov/41750601"},"language":"en","primary_location":{"id":"doi:10.3390/antiox15020220","doi":"https://doi.org/10.3390/antiox15020220","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antiox15020220","pdf_url":null,"source":{"id":"https://openalex.org/S2737566431","display_name":"Antioxidants","issn_l":"2076-3921","issn":["2076-3921"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/antiox15020220","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101382171","display_name":"Baisong Huang","orcid":"https://orcid.org/0009-0002-1480-0749","observed_orcids":["https://orcid.org/0009-0002-1480-0749"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Baisong Huang","raw_affiliation_strings":["Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100312044","display_name":"Anqi Chen","orcid":"https://orcid.org/0009-0004-0813-8415","observed_orcids":["https://orcid.org/0009-0004-0813-8415"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Anqi Chen","raw_affiliation_strings":["Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125362646","display_name":"Tong Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tong Zhou","raw_affiliation_strings":["Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125349647","display_name":"Ying Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Xu","raw_affiliation_strings":["Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043849638","display_name":"Yuanyuan Sun","orcid":"https://orcid.org/0000-0003-1873-0151","observed_orcids":["https://orcid.org/0000-0003-1873-0151"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Sun","raw_affiliation_strings":["Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011874331","display_name":"Quanwei He","orcid":"https://orcid.org/0000-0002-8318-6976","observed_orcids":["https://orcid.org/0000-0002-8318-6976","https://orcid.org/0009-0003-2134-4814"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Quanwei He","raw_affiliation_strings":["Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5011874331"],"corresponding_institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":4.3279,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.88967128,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"15","issue":"2","first_page":"220","last_page":"220"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.05290000140666962,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intracerebral-hemorrhage","display_name":"intracerebral hemorrhage","score":0.9599999785423279},{"id":"https://openalex.org/keywords/sema3b","display_name":"SEMA3B","score":0.8529999852180481},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.8149999976158142},{"id":"https://openalex.org/keywords/hematoma-clearance","display_name":"hematoma clearance","score":0.9829999804496765},{"id":"https://openalex.org/keywords/microglial-phagocytosis","display_name":"microglial phagocytosis","score":0.9350000023841858},{"id":"https://openalex.org/keywords/plexin-a1","display_name":"PLXNA1","score":0.9470000267028809},{"id":"https://openalex.org/keywords/trem2","display_name":"TREM2","score":0.9629999995231628},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.984000027179718},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9599999785423279},{"id":"https://openalex.org/keywords/microglial-m2-polarization","display_name":"microglial M2 polarization","score":0.8870000243186951},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9359999895095825},{"id":"https://openalex.org/keywords/neuron-microglia-communication","display_name":"neuron-microglia communication","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C2777094939","wikidata":"https://www.wikidata.org/wiki/Q1368943","display_name":"Intracerebral hemorrhage","level":3,"score":0.7416999936103821},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.7196999788284302},{"id":"https://openalex.org/C2779662492","wikidata":"https://www.wikidata.org/wiki/Q468787","display_name":"Hematoma","level":2,"score":0.6729999780654907},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.6608999967575073},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6527000069618225},{"id":"https://openalex.org/C3017656743","wikidata":"https://www.wikidata.org/wiki/Q1368943","display_name":"Intracerebral hematoma","level":3,"score":0.5468999743461609},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.48249998688697815},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4449999928474426},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43779999017715454},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.41760000586509705},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41659998893737793},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3921999931335449},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.33550000190734863},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3327000141143799},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3303999900817871},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.32109999656677246},{"id":"https://openalex.org/C2779685842","wikidata":"https://www.wikidata.org/wiki/Q18040973","display_name":"TREM2","level":4,"score":0.3190000057220459},{"id":"https://openalex.org/C2910341952","wikidata":"https://www.wikidata.org/wiki/Q570425","display_name":"Leukocyte Trafficking","level":4,"score":0.296099990606308},{"id":"https://openalex.org/C132538176","wikidata":"https://www.wikidata.org/wiki/Q24768287","display_name":"Semaphorin","level":3,"score":0.2919999957084656},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.2883000075817108},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2831999957561493},{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.28290000557899475},{"id":"https://openalex.org/C2778870864","wikidata":"https://www.wikidata.org/wiki/Q3083725","display_name":"Zymosan","level":3,"score":0.2676999866962433},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.26089999079704285}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/antiox15020220","doi":"https://doi.org/10.3390/antiox15020220","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antiox15020220","pdf_url":null,"source":{"id":"https://openalex.org/S2737566431","display_name":"Antioxidants","issn_l":"2076-3921","issn":["2076-3921"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants","raw_type":"journal-article"},{"id":"pmid:41750601","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41750601","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:9fca29d0d19f4f779cd4a5e6c73d2266","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9fca29d0d19f4f779cd4a5e6c73d2266","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Antioxidants, Vol 15, Iss 2, p 220 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12937951","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12937951/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Antioxidants (Basel)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/antiox15020220","doi":"https://doi.org/10.3390/antiox15020220","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antiox15020220","pdf_url":null,"source":{"id":"https://openalex.org/S2737566431","display_name":"Antioxidants","issn_l":"2076-3921","issn":["2076-3921"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7358152866363525}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1347267442","display_name":null,"funder_award_id":"82301508","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3501555916","display_name":null,"funder_award_id":"2023AFB280","funder_id":"https://openalex.org/F4320322186","funder_display_name":"Natural Science Foundation of Hubei Province"},{"id":"https://openalex.org/G4158211185","display_name":null,"funder_award_id":"82071335","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322186","display_name":"Natural Science Foundation of Hubei Province","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Intracerebral":[0],"hemorrhage":[1],"(ICH)":[2],"is":[3,108],"the":[4,14,19,47,50,77,82,128,131,136,145,156,163],"deadliest":[5],"subtype":[6],"of":[7,21,49,79,98,130,155,166,179,186],"stroke,":[8],"and":[9,55,58,71,135,149,181],"its":[10],"primary":[11],"harm":[12],"to":[13,76,120,126],"human":[15],"body":[16],"arises":[17],"from":[18],"formation":[20],"brain":[22],"hematomas.":[23],"Promoting":[24],"microglial-mediated":[25],"endogenous":[26],"hematoma":[27,138,157,180],"clearance":[28,70,139],"has":[29],"become":[30],"a":[31,99,190],"key":[32,137],"focus":[33],"in":[34,46],"current":[35],"ICH":[36,90,101],"treatment":[37],"strategies.":[38],"Semaphorin":[39],"3s":[40],"(Sema3s)":[41],"are":[42,60,74],"molecular":[43],"signals":[44],"involved":[45],"regulation":[48,73,185],"central":[51,65],"nervous":[52,66],"system,":[53],"angiogenesis,":[54],"microenvironment":[56],"homeostasis,":[57],"they":[59],"closely":[61],"associated":[62],"with":[63,196],"various":[64],"system":[67],"diseases.":[68],"Hematoma":[69],"inflammation":[72,182],"crucial":[75],"role":[78],"microglia,":[80,123,167],"yet":[81],"mechanisms":[83],"by":[84],"which":[85],"Sema3s":[86],"regulate":[87],"microglia":[88],"after":[89,110,158],"remain":[91],"unclear.":[92],"Here,":[93],"using":[94],"high-throughput":[95],"RNA":[96],"sequencing":[97],"mouse":[100],"model,":[102],"we":[103],"identified":[104],"that":[105,116,175],"neuron-derived":[106],"Sema3B":[107,117,143,161,187],"downregulated":[109],"ICH.":[111,159,197],"Further":[112],"mechanistic":[113],"studies":[114],"revealed":[115],"can":[118],"bind":[119],"PlexinA1":[121,148],"on":[122],"activating":[124],"NRF2":[125],"promote":[127],"expression":[129],"phagocytic":[132],"receptor":[133],"TREM2":[134],"molecule":[140],"HO-1.":[141],"Furthermore,":[142,160],"enhances":[144],"interaction":[146],"between":[147],"TREM2,":[150],"cooperatively":[151],"boosting":[152],"microglial":[153,177],"phagocytosis":[154,178],"regulates":[162],"M2":[164],"polarization":[165],"exerting":[168],"an":[169],"anti-inflammatory":[170],"effect.":[171],"Our":[172],"findings":[173],"suggest":[174],"manipulating":[176],"suppression":[183],"via":[184],"may":[188],"be":[189],"potential":[191],"strategy":[192],"for":[193],"treating":[194],"patients":[195]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2026-02-09T00:00:00"}