{"id":"https://openalex.org/W7128093679","doi":"https://doi.org/10.22541/au.177028044.40839935/v1","title":"Nasal IFN and UPR Transcriptomic Signatures Complement Clinical Predictors of Frequent Exacerbations in Pediatric Asthma","display_name":"Nasal IFN and UPR Transcriptomic Signatures Complement Clinical Predictors of Frequent Exacerbations in Pediatric Asthma","publication_year":2026,"publication_date":"2026-02-05","ids":{"openalex":"https://openalex.org/W7128093679","doi":"https://doi.org/10.22541/au.177028044.40839935/v1"},"language":"en","primary_location":{"id":"doi:10.22541/au.177028044.40839935/v1","doi":"https://doi.org/10.22541/au.177028044.40839935/v1","is_oa":false,"landing_page_url":"https://doi.org/10.22541/au.177028044.40839935/v1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048051067","display_name":"Yu-xiang Zhang","orcid":"https://orcid.org/0009-0007-9436-521X","observed_orcids":["https://orcid.org/0009-0007-9436-521X"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuxiang Zhang","raw_affiliation_strings":["Children's Hospital of Soochow University"],"raw_orcid":"https://orcid.org/0009-0007-9436-521X","affiliations":[{"raw_affiliation_string":"Children's Hospital of Soochow University","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125123531","display_name":"Yu Miao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Miao","raw_affiliation_strings":["Children's Hospital of Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital of Soochow University","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125215380","display_name":"Jiating Xue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiating Xue","raw_affiliation_strings":["Children's Hospital of Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital of Soochow University","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100364735","display_name":"Nana Wang","orcid":"https://orcid.org/0000-0001-6131-5012","observed_orcids":["https://orcid.org/0000-0001-6131-5012"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nana Wang","raw_affiliation_strings":["Children's Hospital of Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital of Soochow University","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007558456","display_name":"Chuangli Hao","orcid":"https://orcid.org/0000-0002-8203-0603","observed_orcids":["https://orcid.org/0000-0002-8203-0603","https://orcid.org/0009-0006-6097-8926"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chuangli Hao","raw_affiliation_strings":["Children's Hospital of Soochow University"],"raw_orcid":"https://orcid.org/0009-0006-6097-8926","affiliations":[{"raw_affiliation_string":"Children's Hospital of Soochow University","institution_ids":["https://openalex.org/I3923682"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007558456"],"corresponding_institution_ids":["https://openalex.org/I3923682"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/childhood-asthma","display_name":"childhood asthma","score":0.9890000224113464},{"id":"https://openalex.org/keywords/interferon","display_name":"interferon","score":0.5839999914169312},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.9679999947547913},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9890000224113464},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.6639999747276306},{"id":"https://openalex.org/keywords/elastic-net","display_name":"elastic net","score":0.6069999933242798},{"id":"https://openalex.org/keywords/clinical-predictors","display_name":"clinical predictors","score":0.5699999928474426},{"id":"https://openalex.org/keywords/airway-epithelium","display_name":"airway epithelium","score":0.7009999752044678},{"id":"https://openalex.org/keywords/asthma-endotypes","display_name":"asthma endotypes","score":0.44600000977516174}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8130999803543091},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.6780999898910522},{"id":"https://openalex.org/C2779278377","wikidata":"https://www.wikidata.org/wiki/Q1351647","display_name":"Rhinovirus","level":3,"score":0.663100004196167},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.656499981880188},{"id":"https://openalex.org/C2781293274","wikidata":"https://www.wikidata.org/wiki/Q5376560","display_name":"Endotype","level":3,"score":0.6266000270843506},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5662000179290771},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5590999722480774},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5299999713897705},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.5231000185012817},{"id":"https://openalex.org/C2909082789","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma exacerbations","level":3,"score":0.48260000348091125},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.42260000109672546},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3564999997615814},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.3564999997615814},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.3465999960899353},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.34549999237060547},{"id":"https://openalex.org/C3020225094","wikidata":"https://www.wikidata.org/wiki/Q80091","display_name":"Area under curve","level":3,"score":0.3246000111103058},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.3025999963283539},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.2973000109195709},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.2797999978065491},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.27619999647140503},{"id":"https://openalex.org/C157585117","wikidata":"https://www.wikidata.org/wiki/Q158666","display_name":"Omics","level":2,"score":0.26109999418258667},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.26100000739097595},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.2603999972343445},{"id":"https://openalex.org/C2781406822","wikidata":"https://www.wikidata.org/wiki/Q904140","display_name":"Tryptase","level":3,"score":0.2574000060558319},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2565999925136566},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.25529998540878296}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.22541/au.177028044.40839935/v1","doi":"https://doi.org/10.22541/au.177028044.40839935/v1","is_oa":false,"landing_page_url":"https://doi.org/10.22541/au.177028044.40839935/v1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.48123106360435486,"id":"https://metadata.un.org/sdg/16","display_name":"Peace, justice, and strong institutions"},{"score":0.45415613055229187,"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4404101548","https://openalex.org/W2795963349","https://openalex.org/W4319082919","https://openalex.org/W4416168474","https://openalex.org/W2736783104","https://openalex.org/W4415346016","https://openalex.org/W2912581705","https://openalex.org/W2783203299","https://openalex.org/W4224939160","https://openalex.org/W4406135821"],"abstract_inverted_index":{"Background:":[0],"Frequent":[1],"exacerbations":[2,27],"in":[3,95,195,204],"pediatric":[4],"asthma":[5,111],"cause":[6],"substantial":[7],"morbidity,":[8],"yet":[9],"tools":[10],"for":[11,216,269],"prospective":[12],"risk":[13],"stratification":[14],"remain":[15],"limited.":[16],"We":[17],"aimed":[18],"to":[19,54,62,114],"identify":[20],"nasal":[21],"transcriptomic":[22,67,172,244],"signatures":[23,245],"associated":[24],"with":[25,38,110,177,200],"frequent":[26,248],"(FE),":[28],"test":[29,78],"their":[30,35],"virus":[31],"responsiveness,":[32],"and":[33,57,61,74,85,134,156,161,183,210,242,251],"compare":[34,55],"predictive":[36],"performance":[37],"a":[39,116,147,184,201,211,247],"model":[40,121,225],"based":[41],"on":[42],"routine":[43],"clinical":[44,267],"variables.":[45],"Methods:":[46],"Nasal":[47,240],"RNA-seq":[48],"data":[49],"from":[50],"GSE211158":[51],"were":[52,192],"analyzed":[53],"FE":[56,141,150],"non-frequent":[58],"exacerbators":[59],"(NFE)":[60],"derive":[63],"an":[64,75],"Elastic":[65,170],"Net":[66],"model,":[68],"evaluated":[69],"by":[70],"stratified":[71],"5-fold":[72,229],"cross-validation":[73],"internal":[76],"hold-out":[77,185,235],"set.":[79],"External":[80],"validation":[81],"of":[82,107,154,163,188],"interferon":[83],"(IFN)":[84],"unfolded":[86],"protein":[87],"response/endoplasmic":[88],"reticulum":[89],"(UPR/ER)":[90],"stress":[91,158],"modules":[92,191],"was":[93,112,143],"performed":[94,226],"the":[96,196,205,217,223],"experimental":[97],"human":[98],"rhinovirus":[99],"(HRV-A16)":[100],"cohort":[101,106],"GSE97668.":[102],"An":[103,169],"independent":[104],"hospital":[105],"134":[108],"children":[109,151],"used":[113],"build":[115],"multivariable":[117],"\u201cclinical-only\u201d":[118],"logistic":[119],"regression":[120],"using":[122],"age,":[123],"sex,":[124],"lung":[125],"function,":[126],"inhaled":[127],"corticosteroid":[128],"dose,":[129],"blood":[130],"eosinophils,":[131],"total":[132],"IgE":[133],"bedside":[135],"variables;":[136],"prior":[137],"exacerbation":[138],"count":[139],"defined":[140],"but":[142,213],"not":[144],"entered":[145],"as":[146],"predictor.":[148],"Results:":[149],"showed":[152,174],"upregulation":[153],"IFN-stimulated":[155],"UPR/ER":[157],"gene":[159],"sets":[160],"attenuation":[162],"epithelial":[164],"barrier":[165],"programs":[166],"versus":[167],"NFE.":[168],"Net\u2013derived":[171],"signature":[173],"modest":[175],"discrimination,":[176],"cross-validated":[178],"AUCs":[179],"clustered":[180],"around":[181],"~0.47":[182],"ROC":[186],"AUC":[187,232,236],"0.628.":[189],"IFN/IED":[190],"directionally":[193],"increased":[194],"HRV":[197],"challenge":[198],"dataset,":[199],"significant":[202],"increase":[203],"IFN":[206,241],"module":[207,219],"(t-test":[208],"p=0.00474)":[209],"similar":[212],"non-significant":[214],"trend":[215],"IED":[218],"(p=0.077).":[220],"In":[221],"contrast,":[222],"clinical-only":[224,256],"poorly":[227],"(repeated":[228],"CV":[230],"mean/median":[231],"=":[233,237],"0.44;":[234],"0.38).":[238],"Conclusion:":[239],"UPR":[243],"define":[246],"exacerbator":[249],"endotype":[250],"provide":[252],"moderate":[253],"discrimination":[254],"where":[255],"models":[257],"perform":[258],"poorly,":[259],"suggesting":[260],"that":[261],"airway":[262],"transcriptomics":[263],"may":[264],"complement":[265],"conventional":[266],"assessment":[268],"identifying":[270],"high-risk":[271],"children.":[272]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-02-07T00:00:00"}