{"id":"https://openalex.org/W7128090624","doi":"https://doi.org/10.1158/1940-6207.31276806","title":"Supplementary Table 1 from Genome-wide CRISPR Screening Reveals a PKA-Driven Resistance Mechanism to Metformin for Oral Cancer Prevention That Can Be Exploited by Combination with NSAIDs","display_name":"Supplementary Table 1 from Genome-wide CRISPR Screening Reveals a PKA-Driven Resistance Mechanism to Metformin for Oral Cancer Prevention That Can Be Exploited by Combination with NSAIDs","publication_year":2026,"publication_date":"2026-02-06","ids":{"openalex":"https://openalex.org/W7128090624","doi":"https://doi.org/10.1158/1940-6207.31276806"},"language":"en","primary_location":{"id":"doi:10.1158/1940-6207.31276806","doi":"https://doi.org/10.1158/1940-6207.31276806","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.31276806","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1940-6207.31276806","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007358546","display_name":"Thomas S. Hoang","orcid":"https://orcid.org/0000-0003-1282-734X","observed_orcids":["https://orcid.org/0000-0003-1282-734X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas S. Hoang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1282-734X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049371053","display_name":"Farhoud Faraji","orcid":"https://orcid.org/0000-0001-5078-813X","observed_orcids":["https://orcid.org/0000-0001-5078-813X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Farhoud Faraji","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5078-813X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023761409","display_name":"Amaya N. Mendez-Molina","orcid":"https://orcid.org/0000-0002-2571-2405","observed_orcids":["https://orcid.org/0000-0002-2571-2405"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amaya N. Mendez-Molina","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2571-2405","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005618673","display_name":"Sendi Rafael Adame-Garcia","orcid":"https://orcid.org/0000-0002-5665-8333","observed_orcids":["https://orcid.org/0000-0002-5665-8333"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sendi Rafael Adame-Garcia","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5665-8333","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125215317","display_name":"Kuniaki Sato","orcid":"https://orcid.org/0000-0001-6014-1911","observed_orcids":["https://orcid.org/0000-0001-6014-1911"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kuniaki Sato","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6014-1911","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068361265","display_name":"Tomohiko Ishikawa","orcid":"https://orcid.org/0000-0003-3115-0047","observed_orcids":["https://orcid.org/0000-0003-3115-0047"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomohiko Ishikawa","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3115-0047","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017542278","display_name":"Pham Thuy Tien Vo","orcid":"https://orcid.org/0000-0001-5760-8461","observed_orcids":["https://orcid.org/0000-0001-5760-8461"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pham Thuy Tien Vo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5760-8461","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019108499","display_name":"Sydney I. Ramirez","orcid":"https://orcid.org/0000-0002-7166-5195","observed_orcids":["https://orcid.org/0000-0002-7166-5195"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sydney I. Ramirez","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7166-5195","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017048496","display_name":"Paola Y. Anguiano Quiroz","orcid":"https://orcid.org/0000-0002-7317-2191","observed_orcids":["https://orcid.org/0000-0002-7317-2191"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paola Y. Anguiano Quiroz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7317-2191","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112492794","display_name":"Tracy Guo","orcid":"https://orcid.org/0009-0001-1438-985X","observed_orcids":["https://orcid.org/0009-0001-1438-985X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tracy Guo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-1438-985X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109445833","display_name":"Kai-Xi Fan","orcid":"https://orcid.org/0009-0001-4801-6090","observed_orcids":["https://orcid.org/0009-0001-4801-6090"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katie Fan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-4801-6090","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125244058","display_name":"Xingyu Wu","orcid":"https://orcid.org/0000-0001-9289-7115","observed_orcids":["https://orcid.org/0000-0001-9289-7115"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xingyu Wu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9289-7115","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059504870","display_name":"Alfredo Molinolo","orcid":"https://orcid.org/0000-0001-8412-2889","observed_orcids":["https://orcid.org/0000-0001-8412-2889"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alfredo A. Molinolo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8412-2889","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129625352","display_name":"Ezra E.W. Cohen","orcid":"https://orcid.org/0000-0002-9872-6242","observed_orcids":["https://orcid.org/0000-0002-9872-6242"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ezra E.W. Cohen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9872-6242","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102747646","display_name":"Prashant Mali","orcid":"https://orcid.org/0000-0002-3383-1287","observed_orcids":["https://orcid.org/0000-0002-3383-1287"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Prashant Mali","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3383-1287","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069190968","display_name":"Scott Michael Lippman","orcid":"https://orcid.org/0000-0002-1643-4124","observed_orcids":["https://orcid.org/0000-0002-1643-4124"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott M. Lippman","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1643-4124","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5038753309","display_name":"Jorge Silvio Gutkind","orcid":"https://orcid.org/0000-0002-5150-4482","observed_orcids":["https://orcid.org/0000-0002-5150-4482"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Silvio Gutkind","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5150-4482","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metformin-resistance","display_name":"metformin resistance","score":0.9179999828338623},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.9100000262260437},{"id":"https://openalex.org/keywords/oral-cancer-prevention","display_name":"oral cancer prevention","score":0.8370000123977661},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.7839999794960022},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8519999980926514},{"id":"https://openalex.org/keywords/drug-resistance-mechanisms","display_name":"drug resistance mechanisms","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.8896999955177307},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.7348999977111816},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7214999794960022},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.6394000053405762},{"id":"https://openalex.org/C45235069","wikidata":"https://www.wikidata.org/wiki/Q278425","display_name":"Table (database)","level":2,"score":0.6365000009536743},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5199999809265137},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36000001430511475},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.3366999924182892},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3249000012874603},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.30649998784065247},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.27129998803138733},{"id":"https://openalex.org/C2780234812","wikidata":"https://www.wikidata.org/wiki/Q1787013","display_name":"Cancer prevention","level":3,"score":0.25029999017715454}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1940-6207.31276806","doi":"https://doi.org/10.1158/1940-6207.31276806","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.31276806","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1940-6207.31276806","doi":"https://doi.org/10.1158/1940-6207.31276806","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.31276806","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7148692603","https://openalex.org/W4417496294","https://openalex.org/W7128082161","https://openalex.org/W7129045051","https://openalex.org/W7058481780","https://openalex.org/W7129072708","https://openalex.org/W4408219168","https://openalex.org/W7129078877","https://openalex.org/W3123543872","https://openalex.org/W4385698155"],"abstract_inverted_index":{"Supplementary":[0],"Table":[1],"1.":[2],"PKA-related":[3],"resistance":[4],"driving":[5],"hits":[6],"selected":[7],"from":[8],"the":[9],"metformin":[10],"CRISPR":[11],"screen.":[12]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-02-07T00:00:00"}