{"id":"https://openalex.org/W7128059487","doi":"https://doi.org/10.6084/m9.figshare.c.8294696","title":"The c-di-AMP binding protein NadD from Mesomycoplasma ovipneumoniae functions as a phosphodiesterase that inhibits host inflammatory responses","display_name":"The c-di-AMP binding protein NadD from Mesomycoplasma ovipneumoniae functions as a phosphodiesterase that inhibits host inflammatory responses","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7128059487","doi":"https://doi.org/10.6084/m9.figshare.c.8294696"},"language":"en","primary_location":{"id":"doi:10.6084/m9.figshare.c.8294696","doi":"https://doi.org/10.6084/m9.figshare.c.8294696","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.c.8294696","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Collection"},"volume":null,"type":"supplementary-materials","is_traditional":false,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.6084/m9.figshare.c.8294696","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5125148427","display_name":"Ying Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127460","display_name":"Ningxia Medical University","ror":"https://ror.org/02h8a1848","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210127460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhang, Ying","raw_affiliation_strings":["Ningxia Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ningxia Medical University","institution_ids":["https://openalex.org/I4210127460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125101945","display_name":"Zhaokun Xu","orcid":"https://orcid.org/0000-0002-0696-9029","observed_orcids":["https://orcid.org/0000-0002-0696-9029"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xu, Zhaokun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125122152","display_name":"Min Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21642278","display_name":"Ningxia University","ror":"https://ror.org/04j7b2v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I21642278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li, Min","raw_affiliation_strings":["Ningxia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ningxia University","institution_ids":["https://openalex.org/I21642278"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017970558","display_name":"Xiujing Hao","orcid":"https://orcid.org/0000-0001-7545-5139","observed_orcids":["https://orcid.org/0000-0001-7545-5139"]},"institutions":[{"id":"https://openalex.org/I21642278","display_name":"Ningxia University","ror":"https://ror.org/04j7b2v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I21642278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao, Xiujing","raw_affiliation_strings":["Ningxia University"],"raw_orcid":"https://orcid.org/0000-0001-7545-5139","affiliations":[{"raw_affiliation_string":"Ningxia University","institution_ids":["https://openalex.org/I21642278"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.7753999829292297,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.7753999829292297,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.18790000677108765,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-di-amp","display_name":"c-di-AMP","score":0.953000009059906},{"id":"https://openalex.org/keywords/phosphodiesterase","display_name":"phosphodiesterase","score":0.8700000047683716},{"id":"https://openalex.org/keywords/alveolar-macrophages","display_name":"alveolar macrophages","score":0.8629999756813049},{"id":"https://openalex.org/keywords/host-inflammatory-response","display_name":"host inflammatory response","score":0.8090000152587891},{"id":"https://openalex.org/keywords/bacterial-second-messenger","display_name":"bacterial second messenger","score":0.718999981880188},{"id":"https://openalex.org/keywords/host-pathogen-interaction","display_name":"host-pathogen interaction","score":0.5879999995231628},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.3630000054836273}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.738099992275238},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6920999884605408},{"id":"https://openalex.org/C153726182","wikidata":"https://www.wikidata.org/wiki/Q3720909","display_name":"Intracellular parasite","level":3,"score":0.5580999851226807},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.5105999708175659},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4848000109195709},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.4666000008583069},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.46389999985694885},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.462799996137619},{"id":"https://openalex.org/C62826618","wikidata":"https://www.wikidata.org/wiki/Q424304","display_name":"Phosphodiesterase","level":3,"score":0.46160000562667847},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4262999892234802},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4146000146865845},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4108000099658966},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.40450000762939453},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3418999910354614},{"id":"https://openalex.org/C2779215961","wikidata":"https://www.wikidata.org/wiki/Q310904","display_name":"Mycoplasma pneumoniae","level":3,"score":0.33469998836517334},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3215000033378601},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.32010000944137573},{"id":"https://openalex.org/C163235415","wikidata":"https://www.wikidata.org/wiki/Q899814","display_name":"Second messenger system","level":3,"score":0.3127000033855438},{"id":"https://openalex.org/C2778883795","wikidata":"https://www.wikidata.org/wiki/Q804517","display_name":"Pathogenic bacteria","level":3,"score":0.3075000047683716},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3070000112056732},{"id":"https://openalex.org/C2778375072","wikidata":"https://www.wikidata.org/wiki/Q5909198","display_name":"Host\u2013pathogen interaction","level":4,"score":0.30630001425743103},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.30390000343322754},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3010999858379364},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.28220000863075256},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.2784999907016754},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2639999985694885},{"id":"https://openalex.org/C2776668983","wikidata":"https://www.wikidata.org/wiki/Q210041","display_name":"Cyclic adenosine monophosphate","level":3,"score":0.2639999985694885},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2603999972343445},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2567000091075897}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.6084/m9.figshare.c.8294696","doi":"https://doi.org/10.6084/m9.figshare.c.8294696","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.c.8294696","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Collection"},{"id":"doi:10.6084/m9.figshare.c.8294696.v1","doi":"https://doi.org/10.6084/m9.figshare.c.8294696.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.c.8294696.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Collection"}],"best_oa_location":{"id":"doi:10.6084/m9.figshare.c.8294696","doi":"https://doi.org/10.6084/m9.figshare.c.8294696","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.c.8294696","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Collection"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7127882768","https://openalex.org/W7127939324","https://openalex.org/W7127889188","https://openalex.org/W4221070545","https://openalex.org/W4410191540","https://openalex.org/W3014788818","https://openalex.org/W4310458926","https://openalex.org/W2975571234","https://openalex.org/W2724879968","https://openalex.org/W4293532143"],"abstract_inverted_index":{"Abstract":[0],"Cyclic":[1],"dimeric":[2],"adenosine":[3],"monophosphate":[4],"(c-di-AMP)":[5],"is":[6,28,44,80],"a":[7,33,174],"second":[8],"messenger":[9],"commonly":[10],"found":[11],"in":[12,24,36,61,88,111,114,127,158,183,194],"bacteria,":[13,62],"particularly":[14],"within":[15],"the":[16,38,64,70,81,102,129,141,155,165,209,220,232],"Firmicutes":[17],"and":[18,43,52,68,107,132,135,163,215,222],"Actinobacteria":[19],"phyla,":[20],"as":[21,23,228,230],"well":[22,229],"Archaea.":[25],"Phosphodiesterase":[26],"(PDE)":[27],"an":[29],"enzyme":[30],"that":[31,122,136,151,189],"plays":[32],"crucial":[34],"role":[35,104],"regulating":[37],"homeostasis":[39],"of":[40,46,73,105,143,177,212,224,234],"bacterial":[41],"c-di-AMP":[42,106,126,139,152,166],"capable":[45],"hydrolysing":[47],"this":[48,203],"molecule":[49],"both":[50,128],"intracellularly":[51],"extracellularly.":[53],"This":[54,97],"enzymatic":[55],"activity":[56],"influences":[57],"various":[58],"physiological":[59],"functions":[60],"modulates":[63],"host":[65,116,195],"immune":[66,117,156],"response,":[67],"impacts":[69],"pathogenic":[71,92,210],"processes":[72],"infectious":[74],"agents.":[75,236],"Mesomycoplasma":[76],"ovipneumoniae":[77,113,124,214],"(M.":[78],"ovipneumoniae)":[79],"primary":[82,145],"pathogen":[83],"responsible":[84],"for":[85,219,231],"mycoplasma":[86,226],"pneumonia":[87],"sheep,":[89],"but":[90],"its":[91,108],"mechanisms":[93,211],"remain":[94],"poorly":[95],"understood.":[96],"study":[98,187,204],"aimed":[99],"to":[100],"investigate":[101],"potential":[103,217],"binding":[109,167],"proteins":[110],"M.":[112,123,199,213],"affecting":[115],"responses.":[118],"Our":[119],"findings":[120],"confirmed":[121],"produced":[125],"intracellular":[130],"extracts":[131],"culture":[133],"supernatants":[134],"it":[137],"generated":[138],"during":[140],"infection":[142],"sheep":[144],"alveolar":[146],"macrophages.":[147,159],"Transcriptome":[148],"analysis":[149],"revealed":[150],"can":[153],"activate":[154],"response":[157],"Furthermore,":[160],"we":[161],"identified":[162],"characterized":[164],"protein":[168],"nicotinate-nucleotide":[169],"adenylyltransferase":[170],"(NadD),":[171],"which":[172],"represents":[173],"novel":[175],"class":[176],"PDE":[178],"containing":[179],"His-Asp":[180],"(HD)":[181],"domains":[182],"Mycoplasmas.":[184],"Notably,":[185],"our":[186],"demonstrated":[188],"NadD":[190],"suppresses":[191],"inflammatory":[192],"responses":[193],"cells":[196],"infected":[197],"with":[198],"ovipneumoniae.":[200],"In":[201],"conclusion,":[202],"provides":[205],"new":[206],"insights":[207],"into":[208],"develops":[216],"targets":[218],"prevention":[221],"control":[223],"ovine":[225],"pneumonia,":[227],"development":[233],"therapeutic":[235]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-02-07T00:00:00"}
