{"id":"https://openalex.org/W7128024488","doi":"https://doi.org/10.1177/17474930261423387","title":"Low-dose rivaroxaban plus antiplatelet therapy for symptomatic intracranial atherosclerotic stenosis: A prospective cohort study","display_name":"Low-dose rivaroxaban plus antiplatelet therapy for symptomatic intracranial atherosclerotic stenosis: A prospective cohort study","publication_year":2026,"publication_date":"2026-02-05","ids":{"openalex":"https://openalex.org/W7128024488","doi":"https://doi.org/10.1177/17474930261423387","pmid":"https://pubmed.ncbi.nlm.nih.gov/41641760"},"language":"en","primary_location":{"id":"doi:10.1177/17474930261423387","doi":"https://doi.org/10.1177/17474930261423387","is_oa":false,"landing_page_url":"https://doi.org/10.1177/17474930261423387","pdf_url":null,"source":{"id":"https://openalex.org/S150089136","display_name":"International Journal of Stroke","issn_l":"1747-4930","issn":["1747-4930","1747-4949"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Stroke","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5125165811","display_name":"Ding Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ding Zhang","raw_affiliation_strings":["Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101667644","display_name":"Zhaoyang Zhao","orcid":"https://orcid.org/0000-0002-8962-3161","observed_orcids":["https://orcid.org/0000-0002-8962-3161"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhaoyang Zhao","raw_affiliation_strings":["Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111344612","display_name":"Yiwei Qian","orcid":"https://orcid.org/0009-0007-4644-4597","observed_orcids":["https://orcid.org/0009-0007-4644-4597"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiwei Qian","raw_affiliation_strings":["Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lulu Pei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lulu Pei","raw_affiliation_strings":["Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China","Henan Key Laboratory of Cerebrovascular Diseases, Zhengzhou University, Zhengzhou, China","NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Henan Key Laboratory of Cerebrovascular Diseases, Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I38877650"]},{"raw_affiliation_string":"NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases, Zhengzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092039036","display_name":"Kai Liu","orcid":"https://orcid.org/0009-0006-5910-3524","observed_orcids":["https://orcid.org/0009-0006-5910-3524"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Liu","raw_affiliation_strings":["Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China","Henan Key Laboratory of Cerebrovascular Diseases, Zhengzhou University, Zhengzhou, China","NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Henan Key Laboratory of Cerebrovascular Diseases, Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I38877650"]},{"raw_affiliation_string":"NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases, Zhengzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125150907","display_name":"Yuan Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Cao","raw_affiliation_strings":["Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China","Henan Key Laboratory of Cerebrovascular Diseases, Zhengzhou University, Zhengzhou, China","NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Henan Key Laboratory of Cerebrovascular Diseases, Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I38877650"]},{"raw_affiliation_string":"NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases, Zhengzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125249615","display_name":"Wenzheng Rong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenzheng Rong","raw_affiliation_strings":["Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China","Henan Key Laboratory of Cerebrovascular Diseases, Zhengzhou University, Zhengzhou, China","NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Henan Key Laboratory of Cerebrovascular Diseases, Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I38877650"]},{"raw_affiliation_string":"NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases, Zhengzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067136103","display_name":"Haiman Hou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiman Hou","raw_affiliation_strings":["Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China","Henan Key Laboratory of Cerebrovascular Diseases, Zhengzhou University, Zhengzhou, China","NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Henan Key Laboratory of Cerebrovascular Diseases, Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I38877650"]},{"raw_affiliation_string":"NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases, Zhengzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101449908","display_name":"Yige Zhang","orcid":"https://orcid.org/0000-0001-6213-1899","observed_orcids":["https://orcid.org/0000-0001-6213-1899"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yige Zhang","raw_affiliation_strings":["Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000461506","display_name":"W Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wan Zhang","raw_affiliation_strings":["Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022050140","display_name":"Ce Zong","orcid":"https://orcid.org/0000-0003-0282-0769","observed_orcids":["https://orcid.org/0000-0003-0282-0769"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ce Zong","raw_affiliation_strings":["Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100525647","display_name":"Yifang Zhou","orcid":"https://orcid.org/0000-0002-3245-212X","observed_orcids":["https://orcid.org/0000-0002-3245-212X"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yifang Zhou","raw_affiliation_strings":["Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065086896","display_name":"Jiaxin Wang","orcid":"https://orcid.org/0000-0001-9007-2259","observed_orcids":["https://orcid.org/0000-0001-9007-2259"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaxin Wang","raw_affiliation_strings":["Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047048946","display_name":"Chao Lan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao Lan","raw_affiliation_strings":["Department of Emergency Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101553959","display_name":"Xinsheng Han","orcid":"https://orcid.org/0000-0003-1772-6652","observed_orcids":["https://orcid.org/0000-0003-1772-6652"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xinsheng Han","raw_affiliation_strings":["Department of Neurology, Kai Feng Central Hospital, Kaifeng, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Kai Feng Central Hospital, Kaifeng, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123309286","display_name":"Duolao Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194839184","display_name":"Liverpool School of Tropical Medicine","ror":"https://ror.org/03svjbs84","country_code":"GB","type":"funder","lineage":["https://openalex.org/I194839184"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Duolao Wang","raw_affiliation_strings":["Global Health Trials Unit, Liverpool School of Tropical Medicine, Liverpool, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Health Trials Unit, Liverpool School of Tropical Medicine, Liverpool, UK","institution_ids":["https://openalex.org/I194839184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078248814","display_name":"Yuesong Pan","orcid":"https://orcid.org/0000-0003-3082-6789","observed_orcids":["https://orcid.org/0000-0003-3082-6789"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210087691","display_name":"Beijing Tian Tan Hospital","ror":"https://ror.org/003regz62","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087691"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuesong Pan","raw_affiliation_strings":["China National Clinical Research Center for Neurological Diseases, Beijing, China","Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0003-3082-6789","affiliations":[{"raw_affiliation_string":"China National Clinical Research Center for Neurological Diseases, Beijing, China","institution_ids":[]},{"raw_affiliation_string":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210087691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034622744","display_name":"MingMing Ning","orcid":"https://orcid.org/0000-0003-0472-2337","observed_orcids":["https://orcid.org/0000-0003-0472-2337"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MingMing Ning","raw_affiliation_strings":["Cardio-Neurology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardio-Neurology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079264434","display_name":"F. S. Buonanno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ferdinando S. Buonanno","raw_affiliation_strings":["Cardio-Neurology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardio-Neurology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052189680","display_name":"Xinyi Leng","orcid":"https://orcid.org/0000-0001-7300-6647","observed_orcids":["https://orcid.org/0000-0001-7300-6647"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Xinyi Leng","raw_affiliation_strings":["Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China"],"raw_orcid":"https://orcid.org/0000-0001-7300-6647","affiliations":[{"raw_affiliation_string":"Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I177725633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121077336","display_name":"Y. Xu","orcid":"https://orcid.org/0000-0003-2689-9897","observed_orcids":["https://orcid.org/0000-0003-2689-9897"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuming Xu","raw_affiliation_strings":["Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China","Henan Key Laboratory of Cerebrovascular Diseases, Zhengzhou University, Zhengzhou, China","NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases, Zhengzhou, China"],"raw_orcid":"https://orcid.org/0000-0003-2689-9897","affiliations":[{"raw_affiliation_string":"Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Henan Key Laboratory of Cerebrovascular Diseases, Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I38877650"]},{"raw_affiliation_string":"NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases, Zhengzhou, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060144147","display_name":"Bo Song","orcid":"https://orcid.org/0000-0002-4563-0781","observed_orcids":["https://orcid.org/0000-0002-4563-0781"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bo Song","raw_affiliation_strings":["Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China","Henan Key Laboratory of Cerebrovascular Diseases, Zhengzhou University, Zhengzhou, China","NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases, Zhengzhou, China"],"raw_orcid":"https://orcid.org/0000-0002-4563-0781","affiliations":[{"raw_affiliation_string":"Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Henan Key Laboratory of Cerebrovascular Diseases, Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I38877650"]},{"raw_affiliation_string":"NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases, Zhengzhou, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5060144147"],"corresponding_institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210156804"],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":9.2355,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.96689315,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"21","issue":"8","first_page":"1130","last_page":"1139"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":0.8511000275611877,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":0.8511000275611877,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.11190000176429749,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.027899999171495438,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intracranial-atherosclerotic-stenosis","display_name":"intracranial atherosclerotic stenosis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/low-dose-rivaroxaban","display_name":"low-dose rivaroxaban","score":0.9039999842643738},{"id":"https://openalex.org/keywords/antiplatelet-therapy","display_name":"antiplatelet therapy","score":0.8939999938011169},{"id":"https://openalex.org/keywords/dual-pathway-inhibition","display_name":"dual pathway inhibition","score":0.9710000157356262},{"id":"https://openalex.org/keywords/recurrent-ischemic-stroke","display_name":"recurrent ischemic stroke","score":0.906000018119812},{"id":"https://openalex.org/keywords/transient-ischemic-attack","display_name":"transient ischemic attack","score":0.902999997138977},{"id":"https://openalex.org/keywords/major-adverse-cardiovascular-events","display_name":"major adverse cardiovascular events","score":0.9829999804496765},{"id":"https://openalex.org/keywords/antithrombotic-therapy","display_name":"antithrombotic therapy","score":0.7329999804496765},{"id":"https://openalex.org/keywords/acute-coronary-syndrome","display_name":"acute coronary syndrome","score":0.8600000143051147},{"id":"https://openalex.org/keywords/ischemic-stroke-recurrence","display_name":"ischemic stroke recurrence","score":0.45899999141693115},{"id":"https://openalex.org/keywords/win-ratio","display_name":"win ratio","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9882000088691711},{"id":"https://openalex.org/C2778661090","wikidata":"https://www.wikidata.org/wiki/Q420262","display_name":"Rivaroxaban","level":4,"score":0.7315000295639038},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.6658999919891357},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6119999885559082},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.545799970626831},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4754999876022339},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.45190000534057617},{"id":"https://openalex.org/C2909112448","wikidata":"https://www.wikidata.org/wiki/Q721432","display_name":"Platelet aggregation inhibitor","level":3,"score":0.43560001254081726},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.41269999742507935},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.3937000036239624},{"id":"https://openalex.org/C2777849778","wikidata":"https://www.wikidata.org/wiki/Q410237","display_name":"Clopidogrel","level":3,"score":0.3822999894618988},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3659999966621399},{"id":"https://openalex.org/C2993316766","wikidata":"https://www.wikidata.org/wiki/Q215118","display_name":"Anticoagulant therapy","level":2,"score":0.3553999960422516},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.34139999747276306},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.3321000039577484},{"id":"https://openalex.org/C2779820409","wikidata":"https://www.wikidata.org/wiki/Q258591","display_name":"Cilostazol","level":3,"score":0.32089999318122864},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.29350000619888306},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.28619998693466187},{"id":"https://openalex.org/C2779281540","wikidata":"https://www.wikidata.org/wiki/Q5062122","display_name":"Central nervous system disease","level":2,"score":0.2802000045776367},{"id":"https://openalex.org/C2778205648","wikidata":"https://www.wikidata.org/wiki/Q215118","display_name":"Anticoagulant","level":2,"score":0.2759999930858612},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2727000117301941},{"id":"https://openalex.org/C2777265216","wikidata":"https://www.wikidata.org/wiki/Q721432","display_name":"Antiplatelet drug","level":4,"score":0.2685999870300293},{"id":"https://openalex.org/C2992477034","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Clinical neurology","level":2,"score":0.2621999979019165},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.25040000677108765}],"mesh":[{"descriptor_ui":"D000069552","descriptor_name":"Rivaroxaban","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000069552","descriptor_name":"Rivaroxaban","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002537","descriptor_name":"Intracranial Arteriosclerosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D002537","descriptor_name":"Intracranial Arteriosclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002546","descriptor_name":"Ischemic Attack, Transient","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003251","descriptor_name":"Constriction, Pathologic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065427","descriptor_name":"Factor Xa Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D065427","descriptor_name":"Factor Xa Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1177/17474930261423387","doi":"https://doi.org/10.1177/17474930261423387","is_oa":false,"landing_page_url":"https://doi.org/10.1177/17474930261423387","pdf_url":null,"source":{"id":"https://openalex.org/S150089136","display_name":"International Journal of Stroke","issn_l":"1747-4930","issn":["1747-4930","1747-4949"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Stroke","raw_type":"journal-article"},{"id":"pmid:41641760","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41641760","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of stroke : official journal of the International Stroke Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.5823122262954712,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2221211447","display_name":null,"funder_award_id":"No. 82471349","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3242778827","display_name":null,"funder_award_id":"No. 82171324","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1992944529","https://openalex.org/W2082460690","https://openalex.org/W2103902091","https://openalex.org/W2105084079","https://openalex.org/W2110818436","https://openalex.org/W2118170821","https://openalex.org/W2138595885","https://openalex.org/W2139321584","https://openalex.org/W2167806412","https://openalex.org/W2402599050","https://openalex.org/W2749380187","https://openalex.org/W2899662808","https://openalex.org/W2911614100","https://openalex.org/W2943109321","https://openalex.org/W3013428853","https://openalex.org/W3022423927","https://openalex.org/W3084342028","https://openalex.org/W3107876906","https://openalex.org/W3110213440","https://openalex.org/W3164908038","https://openalex.org/W4211166586","https://openalex.org/W4229001324","https://openalex.org/W4229015896","https://openalex.org/W4281251548","https://openalex.org/W4290793582","https://openalex.org/W4363678138","https://openalex.org/W4391123083","https://openalex.org/W4391123179","https://openalex.org/W4406224614"],"related_works":[],"abstract_inverted_index":{"Background:":[0],"The":[1,93,136,175,256],"antithrombotic":[2],"strategies":[3],"for":[4,281],"symptomatic":[5],"intracranial":[6,275],"atherosclerotic":[7],"stenosis":[8],"(sICAS)":[9],"remains":[10],"challenging.":[11],"Dual":[12],"pathway":[13],"inhibition":[14],"(DPI)":[15],"has":[16],"demonstrated":[17],"clinical":[18],"benefit":[19],"in":[20,89,150,183,286,307],"coronary":[21,103],"and":[22,108,133,161,215,279],"peripheral":[23],"artery":[24],"disease.":[25],"Aims:":[26],"This":[27,53],"study":[28,56],"aimed":[29],"to":[30,79,87,127,141,188],"evaluate":[31],"the":[32,63,69,90,131,143,151,165,184,189,200,216,230,235],"efficacy":[33],"of":[34,68,73,114,121,153,178,202,218,259,299],"DPI":[35,91,132,173,185,197,262,290],"with":[36,44,50,59,118,168,234,295,303,309],"low-dose":[37],"rivaroxaban":[38,83],"plus":[39],"antiplatelet":[40,304],"therapy":[41,263,291,305],"(APT)":[42],"compared":[43,187,302],"APT":[45,134,190],"alone":[46,306],"on":[47],"recurrent":[48,156,300],"stroke":[49,158,180,204,301],"sICAS.":[51,310],"Methods:":[52],"prospective":[54],"cohort":[55,237],"included":[57],"patients":[58,88,167,308],"sICAS":[60],"identified":[61],"from":[62],"Ischemic":[64],"Cerebrovascular":[65],"Disease":[66],"Database":[67],"First":[70],"Affiliated":[71],"Hospital":[72],"Zhengzhou":[74],"University":[75],"between":[76,130],"January":[77],"2019":[78],"August":[80],"2023.":[81],"Low-dose":[82],"was":[84,125,139,181],"prescribed":[85],"off-label":[86],"group.":[92],"outcomes":[94,129],"were":[95,284],"ischemic":[96,99,157,179,203],"stroke,":[97],"transient":[98],"attack":[100],"(TIA),":[101],"acute":[102],"syndrome":[104],"(ACS),":[105],"all-cause":[106,154],"death":[107,110],"cardio-cerebrovascular":[109],"within":[111],"1":[112],"year":[113],"discharge.":[115],"Cox":[116],"regression":[117],"inverse":[119],"probability":[120],"treatment":[122],"weighting":[123],"(IPTW)":[124],"applied":[126],"compare":[128],"groups.":[135],"win-ratio":[137,257],"method":[138],"used":[140],"assess":[142],"major":[144],"adverse":[145],"cardiovascular":[146],"events":[147],"(MACE),":[148],"prioritized":[149],"order":[152],"death,":[155],"or":[159],"TIA,":[160],"ACS.":[162],"Results:":[163],"Among":[164],"1217":[166],"sICAS,":[169],"131":[170],"(10.8%)":[171],"received":[172],"therapy.":[174],"recurrence":[176,205],"rate":[177],"lower":[182,297],"group":[186,191],"(8/131":[192],"[6.1%]":[193],"vs":[194],"136/1086":[195],"[12.5%]).":[196],"significantly":[198],"reduced":[199],"risk":[201,298],"(HR":[206,220,238],"=":[207,213,221,227,239,245,248,254,266,272],"0.46,":[208],"95%":[209,223,241,250,268],"CI:":[210,224,242,251,269],"0.23\u20130.94,":[211],"p":[212,226,244,253,271],"0.034)":[214],"incidence":[217],"MACE":[219,260],"0.53,":[222],"0.29\u20130.97,":[225],"0.041)":[228],"during":[229],"1-year":[231],"follow-up,":[232],"consistent":[233],"IPTW-based":[236],"0.35,":[240],"0.16\u20130.76,":[243],"0.008;":[246],"HR":[247],"0.43,":[249],"0.22\u20130.83,":[252],"0.012).":[255],"analysis":[258],"favored":[261],"(win":[264],"ratio":[265],"2.34,":[267],"1.41\u20133.90,":[270],"0.001).":[273],"Symptomatic":[274],"hemorrhage,":[276],"fatal":[277],"bleeding,":[278],"hospitalization":[280],"gastrointestinal":[282],"bleeding":[283],"infrequent":[285],"this":[287],"cohort.":[288],"Conclusions:":[289],"may":[292],"be":[293],"associated":[294],"a":[296],"These":[311],"findings":[312],"warrant":[313],"further":[314],"investigation":[315],"through":[316],"large-scale":[317],"randomized":[318],"controlled":[319],"trials.":[320]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2026-02-07T00:00:00"}
