{"id":"https://openalex.org/W7128022003","doi":"https://doi.org/10.1093/eurheartj/ehaf784.3504","title":"Age and risk scores for detecting coronary artery calcification in heterozygous familial hypercholesterolemia","display_name":"Age and risk scores for detecting coronary artery calcification in heterozygous familial hypercholesterolemia","publication_year":2025,"publication_date":"2025-11-01","ids":{"openalex":"https://openalex.org/W7128022003","doi":"https://doi.org/10.1093/eurheartj/ehaf784.3504"},"language":"en","primary_location":{"id":"doi:10.1093/eurheartj/ehaf784.3504","doi":"https://doi.org/10.1093/eurheartj/ehaf784.3504","is_oa":false,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehaf784.3504","pdf_url":null,"source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112846903","display_name":"Ot\u00e1vio Silva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4405258467","display_name":"Instituto do Cora\u00e7\u00e3o - HCFMUSP","ror":"https://ror.org/00q3jak84","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210145268","https://openalex.org/I4405258467"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"O Decanini Cantarella Silva","raw_affiliation_strings":["Heart Institute of the University of Sao Paulo (InCor) , Sao Paulo ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Institute of the University of Sao Paulo (InCor) , Sao Paulo ,","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4405258467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119334707","display_name":"Thomas Vidal Reigas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4405258467","display_name":"Instituto do Cora\u00e7\u00e3o - HCFMUSP","ror":"https://ror.org/00q3jak84","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210145268","https://openalex.org/I4405258467"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"T Vidal Reigas","raw_affiliation_strings":["Heart Institute of the University of Sao Paulo (InCor) , Sao Paulo ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Institute of the University of Sao Paulo (InCor) , Sao Paulo ,","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4405258467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116844814","display_name":"Fernanda Del Castanhel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4405258467","display_name":"Instituto do Cora\u00e7\u00e3o - HCFMUSP","ror":"https://ror.org/00q3jak84","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210145268","https://openalex.org/I4405258467"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"F Del Castanhel","raw_affiliation_strings":["Heart Institute of the University of Sao Paulo (InCor) , Sao Paulo ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Institute of the University of Sao Paulo (InCor) , Sao Paulo ,","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4405258467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125245064","display_name":"M U Figueiredo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4405258467","display_name":"Instituto do Cora\u00e7\u00e3o - HCFMUSP","ror":"https://ror.org/00q3jak84","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210145268","https://openalex.org/I4405258467"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"M U Figueiredo","raw_affiliation_strings":["Heart Institute of the University of Sao Paulo (InCor) , Sao Paulo ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Institute of the University of Sao Paulo (InCor) , Sao Paulo ,","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4405258467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125253577","display_name":"C Salgueiro Alvo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4405258467","display_name":"Instituto do Cora\u00e7\u00e3o - HCFMUSP","ror":"https://ror.org/00q3jak84","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210145268","https://openalex.org/I4405258467"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"C Salgueiro Alvo","raw_affiliation_strings":["Heart Institute of the University of Sao Paulo (InCor) , Sao Paulo ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Institute of the University of Sao Paulo (InCor) , Sao Paulo ,","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4405258467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125126856","display_name":"V Zorzanelli Rocha Giraldez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4405258467","display_name":"Instituto do Cora\u00e7\u00e3o - HCFMUSP","ror":"https://ror.org/00q3jak84","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210145268","https://openalex.org/I4405258467"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"V Zorzanelli Rocha Giraldez","raw_affiliation_strings":["Heart Institute of the University of Sao Paulo (InCor) , Sao Paulo ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Institute of the University of Sao Paulo (InCor) , Sao Paulo ,","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4405258467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039877202","display_name":"A.P. Marte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4405258467","display_name":"Instituto do Cora\u00e7\u00e3o - HCFMUSP","ror":"https://ror.org/00q3jak84","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210145268","https://openalex.org/I4405258467"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"A P Marte","raw_affiliation_strings":["Heart Institute of the University of Sao Paulo (InCor) , Sao Paulo ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Institute of the University of Sao Paulo (InCor) , Sao Paulo ,","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4405258467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068799842","display_name":"Marjorie Hayashida Mizuta","orcid":"https://orcid.org/0000-0001-9107-052X","observed_orcids":["https://orcid.org/0000-0001-9107-052X"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4405258467","display_name":"Instituto do Cora\u00e7\u00e3o - HCFMUSP","ror":"https://ror.org/00q3jak84","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210145268","https://openalex.org/I4405258467"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"M Mizuta","raw_affiliation_strings":["Heart Institute of the University of Sao Paulo (InCor) , Sao Paulo ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Institute of the University of Sao Paulo (InCor) , Sao Paulo ,","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4405258467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109396521","display_name":"Raul Dias dos Santos Filho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4405258467","display_name":"Instituto do Cora\u00e7\u00e3o - HCFMUSP","ror":"https://ror.org/00q3jak84","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210145268","https://openalex.org/I4405258467"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"R Dias Dos Santos Filho","raw_affiliation_strings":["Heart Institute of the University of Sao Paulo (InCor) , Sao Paulo ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Institute of the University of Sao Paulo (InCor) , Sao Paulo ,","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4405258467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088604083","display_name":"Jos\u00e9 Eduardo Krieger","orcid":"https://orcid.org/0000-0001-5464-1792","observed_orcids":["https://orcid.org/0000-0001-5464-1792"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4405258467","display_name":"Instituto do Cora\u00e7\u00e3o - HCFMUSP","ror":"https://ror.org/00q3jak84","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210145268","https://openalex.org/I4405258467"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"J E Krieger","raw_affiliation_strings":["Heart Institute of the University of Sao Paulo (InCor) , Sao Paulo ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Institute of the University of Sao Paulo (InCor) , Sao Paulo ,","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4405258467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083485666","display_name":"Marcio Hiroshi Miname","orcid":"https://orcid.org/0000-0002-4487-5701","observed_orcids":["https://orcid.org/0000-0002-4487-5701"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4405258467","display_name":"Instituto do Cora\u00e7\u00e3o - HCFMUSP","ror":"https://ror.org/00q3jak84","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210145268","https://openalex.org/I4405258467"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"M Hiroshi Miname","raw_affiliation_strings":["Heart Institute of the University of Sao Paulo (InCor) , Sao Paulo ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Institute of the University of Sao Paulo (InCor) , Sao Paulo ,","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4405258467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5240,"currency":"EUR","value_usd":5922},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.55957338,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"46","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.042100001126527786,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/familial-hypercholesterolemia","display_name":"familial hypercholesterolemia","score":0.9570000171661377},{"id":"https://openalex.org/keywords/heterozygous-familial-hypercholesterolemia","display_name":"heterozygous familial hypercholesterolemia","score":0.9240000247955322},{"id":"https://openalex.org/keywords/coronary-artery-calcification","display_name":"coronary artery calcification","score":0.949999988079071},{"id":"https://openalex.org/keywords/coronary-artery-calcium-score","display_name":"coronary artery calcium score","score":0.8349999785423279},{"id":"https://openalex.org/keywords/cardiovascular-risk-score","display_name":"cardiovascular risk score","score":0.796999990940094},{"id":"https://openalex.org/keywords/atherosclerotic-cardiovascular-disease","display_name":"atherosclerotic cardiovascular disease","score":0.8450000286102295},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.7950000166893005},{"id":"https://openalex.org/keywords/subclinical-atherosclerosis","display_name":"subclinical atherosclerosis","score":0.8339999914169312},{"id":"https://openalex.org/keywords/age-as-predictor","display_name":"age as predictor","score":0.5910000205039978},{"id":"https://openalex.org/keywords/statin-treated-patients","display_name":"statin-treated patients","score":0.8610000014305115},{"id":"https://openalex.org/keywords/lipid-lowering-therapy","display_name":"lipid-lowering therapy","score":0.4399999976158142}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.941100001335144},{"id":"https://openalex.org/C2779120738","wikidata":"https://www.wikidata.org/wiki/Q2711291","display_name":"Familial hypercholesterolemia","level":3,"score":0.8892999887466431},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6536999940872192},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.641700029373169},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.5727999806404114},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.503600001335144},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.48330000042915344},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.47620001435279846},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.46869999170303345},{"id":"https://openalex.org/C2909478654","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Atherosclerotic cardiovascular disease","level":3,"score":0.4163999855518341},{"id":"https://openalex.org/C2779339615","wikidata":"https://www.wikidata.org/wiki/Q2698596","display_name":"Intima-media thickness","level":3,"score":0.3801000118255615},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.3776000142097473},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.3700999915599823},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.35929998755455017},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.3573000133037567},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.3492000102996826},{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.3158999979496002},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.31470000743865967},{"id":"https://openalex.org/C2909917808","wikidata":"https://www.wikidata.org/wiki/Q5629407","display_name":"Coronary Calcium Score","level":4,"score":0.3070000112056732},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.3021000027656555},{"id":"https://openalex.org/C141341695","wikidata":"https://www.wikidata.org/wiki/Q2368661","display_name":"Surrogate endpoint","level":2,"score":0.29989999532699585},{"id":"https://openalex.org/C2994533308","wikidata":"https://www.wikidata.org/wiki/Q5629407","display_name":"Coronary artery calcium","level":3,"score":0.28999999165534973},{"id":"https://openalex.org/C2991716557","wikidata":"https://www.wikidata.org/wiki/Q12252367","display_name":"Coronary atherosclerosis","level":3,"score":0.2896000146865845},{"id":"https://openalex.org/C43346845","wikidata":"https://www.wikidata.org/wiki/Q8057732","display_name":"Youden's J statistic","level":3,"score":0.2872999906539917},{"id":"https://openalex.org/C2778425758","wikidata":"https://www.wikidata.org/wiki/Q180762","display_name":"Angina","level":3,"score":0.28619998693466187},{"id":"https://openalex.org/C3019550498","wikidata":"https://www.wikidata.org/wiki/Q28749","display_name":"Ldl cholesterol","level":3,"score":0.2806999981403351},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2775000035762787},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.2662000060081482},{"id":"https://openalex.org/C2776104379","wikidata":"https://www.wikidata.org/wiki/Q21112670","display_name":"Lipoprotein(a)","level":4,"score":0.2547000050544739}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/eurheartj/ehaf784.3504","doi":"https://doi.org/10.1093/eurheartj/ehaf784.3504","is_oa":false,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehaf784.3504","pdf_url":null,"source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3084528625","https://openalex.org/W7116862408","https://openalex.org/W2981367457","https://openalex.org/W3119736727","https://openalex.org/W7212779171","https://openalex.org/W3185121559","https://openalex.org/W4323294184","https://openalex.org/W4413268982","https://openalex.org/W4388915346","https://openalex.org/W2789555898"],"abstract_inverted_index":{"Abstract":[0],"Introduction":[1],"Familial":[2,139,148],"hypercholesterolemia":[3],"(FH)":[4],"is":[5,61,77],"a":[6,62,69,120,308,373],"genetic":[7],"disorder":[8],"characterized":[9],"by":[10],"elevated":[11],"low-density":[12],"lipoprotein":[13],"cholesterol":[14],"(LDL-c)":[15],"levels":[16],"and":[17,38,68,86,152,165,170,192,217,224,249,262,265,280,317,349],"an":[18],"increased":[19],"risk":[20,32,41,44,51,90,245,266,319,341,351],"of":[21,64,72,88,95,101,200,260,301,303,311],"atherosclerotic":[22],"cardiovascular":[23,31],"disease":[24],"(ASCVD).":[25],"However,":[26],"after":[27],"statin":[28],"treatment,":[29],"the":[30,84,93,99,102,108,138,146,153,161,183,186,193,206,238,243,250,327,333,338],"in":[33,74,128,241,247,253,358,377,384],"these":[34],"individuals":[35,104],"becomes":[36],"heterogeneous":[37],"justifies":[39],"further":[40],"stratification.":[42],"FH":[43,89,103,127,214,244,318,340,350,359],"scores":[45,91,267,286,294,320,342,352],"were":[46,180,215],"developed":[47],"to":[48,97,236,367,380],"predict":[49],"ASCVD":[50,73],"specifically":[52],"for":[53,175,268,278,299,343],"this":[54,111,129],"population.":[55],"Coronary":[56],"artery":[57],"calcium":[58],"score":[59,240,246,252],"(CAC)":[60],"marker":[63],"subclinical":[65],"atherosclerosis":[66],"burden":[67],"robust":[70],"predictor":[71],"FH,":[75],"however,":[76,307],"not":[78,229,362],"widely":[79],"available.":[80,232],"Purpose":[81],"To":[82],"evaluate":[83],"association":[85,162],"discrimination":[87,300,335,365],"with":[92,124,212,289,356],"presence":[94,302,383],"CAC":[96,166,177,231,269,304,344,357,382],"improve":[98],"selection":[100],"who":[105,227],"should":[106],"benefit":[107],"most":[109],"from":[110],"imaging":[112],"test.":[113],"Methods":[114],"We":[115],"reviewed":[116],"patients":[117,211,226],"treated":[118],"at":[119],"specialized":[121],"lipid":[122],"clinic":[123],"genetically":[125],"confirmed":[126],"retrospective":[130],"cross-sectional":[131],"study.":[132],"Risk":[133,141,144],"assessment":[134],"was":[135,203,234],"conducted":[136,181],"using":[137,182,205],"Hypercholesterolemia":[140,149],"Score":[142],"(FH":[143],"Score),":[145],"Spanish":[147],"Cohort":[150],"(SAFEHEART),":[151],"Montreal":[154,239,316],"score.":[155],"A":[156,197],"logistic":[157,274],"regression":[158,275],"model":[159],"evaluated":[160],"between":[163],"variables":[164,264],">":[167,178,297],"0.":[168],"Discrimination":[169],"optimal":[171],"cutoff":[172],"point":[173],"analysis":[174,276],"detecting":[176],"0":[179],"area":[184],"under":[185,221],"receiver":[187],"operating":[188],"characteristic":[189],"(ROC)":[190],"curve":[191],"Youden":[194],"Index,":[195],"respectively.":[196],"pairwise":[198,309],"comparison":[199,259,310],"ROC":[201,312],"curves":[202,313],"performed":[204],"DeLong":[207],"method.":[208],"Results":[209],"802":[210],"heterozygous":[213,385],"evaluated,":[216],"we":[218],"excluded":[219],"seven":[220],"18":[222],"years":[223],"376":[225],"did":[228],"have":[230,321],"It":[233],"possible":[235],"calculate":[237],"408,":[242],"229,":[248],"SAFEHEART":[251],"362":[254],"patients.":[255],"Table":[256,388],"1":[257,387],"shows":[258],"clinical":[261,375,378],"laboratory":[263],"zero":[270],"versus":[271],"CAC>0.":[272],"Multivariate":[273],"adjusted":[277],"age":[279,330,368],"hypertension":[281],"showed":[282,295],"that":[283,315],"all":[284,354],"three":[285,293,339],"persisted":[287],"associated":[288,355],"CAC>0":[290],"(p<0.05).":[291],"All":[292],"AUC":[296,323],"0.70":[298],"(Table":[305],"2);":[306],"demonstrated":[314],"higher":[322],"than":[324],"SAFEHEART.":[325],"On":[326],"other":[328],"hand,":[329],"alone":[331],"presented":[332],"same":[334],"value":[336],"as":[337],"presence.":[345],"Conclusion":[346],"Montreal,":[347],"SAFEHEART,":[348],"are":[353],"but":[360],"do":[361],"offer":[363],"additional":[364],"compared":[366],"alone.":[369],"Age":[370],"could":[371],"be":[372],"suitable":[374],"parameter":[376],"practice":[379],"indicate":[381],"FH.Table":[386],"2":[389]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-02-07T00:00:00"}