{"id":"https://openalex.org/W7127984480","doi":"https://doi.org/10.64898/2026.02.03.703438","title":"Integrative Multi-Omics Analysis Identifies a Functional Enhancer Driving Tumorigenesis in Head and Neck Squamous Cell Carcinoma","display_name":"Integrative Multi-Omics Analysis Identifies a Functional Enhancer Driving Tumorigenesis in Head and Neck Squamous Cell Carcinoma","publication_year":2026,"publication_date":"2026-02-05","ids":{"openalex":"https://openalex.org/W7127984480","doi":"https://doi.org/10.64898/2026.02.03.703438"},"language":"en","primary_location":{"id":"doi:10.64898/2026.02.03.703438","doi":"https://doi.org/10.64898/2026.02.03.703438","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.02.03.703438","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/02/05/2026.02.03.703438.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/02/05/2026.02.03.703438.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Pengfei Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Pengfei Xu","raw_affiliation_strings":["Division of Applied Oral Sciences and Community Dental Care, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Applied Oral Sciences and Community Dental Care, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125102440","display_name":"Xiaorong Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152664","display_name":"Shenzhen Children's Hospital","ror":"https://ror.org/0409k5a27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152664"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaorong Liu","raw_affiliation_strings":["Department of Laboratory Medicine, Shenzhen Children\u2019s Hospital, Futian District, 7019 Yitian Road, Shenzhen, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Shenzhen Children\u2019s Hospital, Futian District, 7019 Yitian Road, Shenzhen, Guangdong, China","institution_ids":["https://openalex.org/I4210152664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147793308","display_name":"Jane Jingya Pu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Jane Jingya Pu","raw_affiliation_strings":["Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101601790","display_name":"Xiaoling Lu","orcid":"https://orcid.org/0000-0002-1854-2532","observed_orcids":["https://orcid.org/0000-0002-1854-2532"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Xiaoling Lu","raw_affiliation_strings":["Division of Applied Oral Sciences and Community Dental Care, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Applied Oral Sciences and Community Dental Care, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100743993","display_name":"Victor Ho-Fun Lee","orcid":"https://orcid.org/0000-0002-6283-978X","observed_orcids":["https://orcid.org/0000-0002-6283-978X"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Victor Lee","raw_affiliation_strings":["Department of Clinical Oncology, The University of Hong Kong, Hong Kong 00852, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Oncology, The University of Hong Kong, Hong Kong 00852, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147728528","display_name":"Evelyn Yilin Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Evelyn Yilin Wang","raw_affiliation_strings":["Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120238431","display_name":"Qianhui Jiang","orcid":"https://orcid.org/0009-0003-2690-7583","observed_orcids":["https://orcid.org/0009-0003-2690-7583"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Qianhui Jiang","raw_affiliation_strings":["Division of Applied Oral Sciences and Community Dental Care, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Applied Oral Sciences and Community Dental Care, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103252012","display_name":"Dan Yu","orcid":"https://orcid.org/0000-0002-8671-3129","observed_orcids":["https://orcid.org/0000-0002-8671-3129"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Dan Yu","raw_affiliation_strings":["Division of Applied Oral Sciences and Community Dental Care, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Applied Oral Sciences and Community Dental Care, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147687656","display_name":"Bin Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Bin Yan","raw_affiliation_strings":["Division of Applied Oral Sciences and Community Dental Care, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Applied Oral Sciences and Community Dental Care, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039575606","display_name":"Jinlin Song","orcid":"https://orcid.org/0000-0002-0224-6640","observed_orcids":["https://orcid.org/0000-0002-0224-6640"]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinlin Song","raw_affiliation_strings":["College of Stomatology, Chongqing Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Stomatology, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147694322","display_name":"Qi Zhong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294606314","display_name":"Beijing Tongren Hospital","ror":"https://ror.org/013e4n276","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294606314"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Zhong","raw_affiliation_strings":["Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China","Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I183519381"]},{"raw_affiliation_string":"Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education, Beijing, China","institution_ids":["https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147791358","display_name":"Ping Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ping Yang","raw_affiliation_strings":["Department of Quantitative Health Science, Mayo Clinic, Scottsdale, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Quantitative Health Science, Mayo Clinic, Scottsdale, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016790638","display_name":"Nhan L. Tran","orcid":"https://orcid.org/0000-0003-0908-9964","observed_orcids":["https://orcid.org/0000-0003-0908-9964"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nhan L. Tran","raw_affiliation_strings":["Department of Cancer Biology, Mayo Clinic Arizona, 5777 E. Mayo Blvd., IERB-3-504A, Phoenix, Arizona, 85054, USA","Department of Neurological Surgery, Mayo Clinic Arizona, 5777 E. Mayo Blvd., IERB-3-504A, Phoenix, Arizona, 85054, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Mayo Clinic Arizona, 5777 E. Mayo Blvd., IERB-3-504A, Phoenix, Arizona, 85054, USA","institution_ids":["https://openalex.org/I4210125099"]},{"raw_affiliation_string":"Department of Neurological Surgery, Mayo Clinic Arizona, 5777 E. Mayo Blvd., IERB-3-504A, Phoenix, Arizona, 85054, USA","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135838535","display_name":"Xinyuan Guan","orcid":"https://orcid.org/0000-0002-4485-6017","observed_orcids":["https://orcid.org/0000-0002-4485-6017"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Xinyuan Guan","raw_affiliation_strings":["Department of Clinical Oncology, The University of Hong Kong, Hong Kong 00852, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Oncology, The University of Hong Kong, Hong Kong 00852, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044938573","display_name":"Yu-Xiong Su","orcid":"https://orcid.org/0000-0001-7143-3370","observed_orcids":["https://orcid.org/0000-0001-7143-3370"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Yu-Xiong Su","raw_affiliation_strings":["Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"last","author":{"id":null,"display_name":"Junwen Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":true,"raw_author_name":"Junwen Wang","raw_affiliation_strings":["Division of Applied Oral Sciences and Community Dental Care, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Applied Oral Sciences and Community Dental Care, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I889458895"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.023099999874830246,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.021299999207258224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/enhancers","display_name":"enhancers","score":0.7940000295639038},{"id":"https://openalex.org/keywords/tert","display_name":"telomerase reverse transcriptase","score":0.6890000104904175},{"id":"https://openalex.org/keywords/cis-regulatory-elements","display_name":"cis-regulatory elements","score":0.8370000123977661},{"id":"https://openalex.org/keywords/h3k27ac","display_name":"H3K27ac","score":0.859000027179718},{"id":"https://openalex.org/keywords/atac-seq","display_name":"ATAC-seq","score":0.7480000257492065},{"id":"https://openalex.org/keywords/enhancer-deletion","display_name":"enhancer deletion","score":0.4860000014305115},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7400000095367432},{"id":"https://openalex.org/keywords/il-17-signaling","display_name":"IL-17 signaling","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.9472000002861023},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6693999767303467},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.661300003528595},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6419000029563904},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6302000284194946},{"id":"https://openalex.org/C21784809","wikidata":"https://www.wikidata.org/wiki/Q17119097","display_name":"Enhancer RNAs","level":5,"score":0.6219000220298767},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.6054999828338623},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5669000148773193},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.46380001306533813},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4268999993801117},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.36719998717308044},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3628999888896942},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.35679998993873596},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34470000863075256},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.3416999876499176},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33180001378059387},{"id":"https://openalex.org/C179463898","wikidata":"https://www.wikidata.org/wiki/Q10273301","display_name":"Epigenesis","level":5,"score":0.3312000036239624},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.3158999979496002},{"id":"https://openalex.org/C3018411727","wikidata":"https://www.wikidata.org/wiki/Q3867488","display_name":"Head and neck","level":2,"score":0.3089999854564667},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.301800012588501},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2883000075817108},{"id":"https://openalex.org/C92477616","wikidata":"https://www.wikidata.org/wiki/Q7119217","display_name":"PHD finger","level":5,"score":0.26460000872612},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.2637999951839447},{"id":"https://openalex.org/C21592294","wikidata":"https://www.wikidata.org/wiki/Q3238407","display_name":"Regulatory sequence","level":4,"score":0.2590000033378601},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.25270000100135803},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.2524999976158142},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2500999867916107}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.02.03.703438","doi":"https://doi.org/10.64898/2026.02.03.703438","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.02.03.703438","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/02/05/2026.02.03.703438.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.02.03.703438","doi":"https://doi.org/10.64898/2026.02.03.703438","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.02.03.703438","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/02/05/2026.02.03.703438.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7127984480.pdf","grobid_xml":"https://content.openalex.org/works/W7127984480.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1970390200","https://openalex.org/W2023245620","https://openalex.org/W2033853356","https://openalex.org/W2034258589","https://openalex.org/W2131838114","https://openalex.org/W2600490673","https://openalex.org/W2887181593","https://openalex.org/W2969762476","https://openalex.org/W3021755237","https://openalex.org/W3048820809","https://openalex.org/W3107533236","https://openalex.org/W3108059695","https://openalex.org/W3137668655","https://openalex.org/W3159317682","https://openalex.org/W3173944854","https://openalex.org/W4206043593","https://openalex.org/W4225101027","https://openalex.org/W4289261899","https://openalex.org/W4318913148","https://openalex.org/W4366204259","https://openalex.org/W4383722104","https://openalex.org/W4392462844","https://openalex.org/W4392553433","https://openalex.org/W4399886291","https://openalex.org/W4402004723","https://openalex.org/W4404733546","https://openalex.org/W4405731349","https://openalex.org/W4408106932","https://openalex.org/W4408218786","https://openalex.org/W4410019211","https://openalex.org/W4411856915","https://openalex.org/W4412172574","https://openalex.org/W4415585090"],"related_works":["https://openalex.org/W3191197033","https://openalex.org/W4417499680","https://openalex.org/W7029444012","https://openalex.org/W4286218304","https://openalex.org/W4404918511","https://openalex.org/W2955600887","https://openalex.org/W3183213888","https://openalex.org/W4415681077","https://openalex.org/W4317036822","https://openalex.org/W2972081704"],"abstract_inverted_index":{"Abstract":[0],"Enhancer":[1],"is":[2],"a":[3,90,114,138,148,161],"critical":[4],"epigenetic":[5],"feature":[6],"in":[7,85,100,107,129,154],"head":[8],"and":[9,41,50,56,63,103,134,156],"neck":[10],"squamous":[11],"cell":[12],"carcinoma":[13],"(HNSCC),":[14],"yet":[15],"the":[16,74],"functional":[17,149],"roles":[18],"of":[19,73,89,120],"individual":[20],"enhancers":[21,49,62],"remain":[22],"poorly":[23],"understood.":[24],"Here,":[25],"we":[26,59],"conducted":[27],"an":[28],"integrative":[29],"multi-omics":[30],"analysis":[31,119],"based":[32],"on":[33],"publicly":[34],"available":[35],"ATAC-seq,":[36],"H3K27ac":[37,57],"ChIP-seq,":[38,58],"transcriptomic":[39],"profiling,":[40],"genetic":[42],"association":[43],"datasets":[44],"to":[45],"systematically":[46],"map":[47],"HNSCC-associated":[48],"their":[51],"target":[52],"genes.":[53],"Integrating":[54],"ATAC-seq":[55],"identified":[60],"20,362":[61],"18,040":[64],"enhancer-associated":[65],"genes,":[66],"highlighting":[67],"widespread":[68],"regulatory":[69],"complexity.":[70],"Functional":[71],"characterization":[72],"TERT":[75,95],"-associated":[76],"enhancer":[77,150],"GH05J001312":[78,146],"(GRCh38/hg38:":[79],"chr5:1312099-1317743)":[80],"revealed":[81],"strong":[82],"transcriptional":[83,140],"activity":[84],"HNSCC.":[86],"CRISPR-mediated":[87],"deletion":[88],"core":[91],"sequence":[92],"significantly":[93],"reduced":[94],"expression,":[96],"impaired":[97],"cellular":[98],"proliferation":[99],"vitro":[101],",":[102,109],"suppressed":[104],"tumor":[105],"growth":[106],"vivo":[108],"confirming":[110],"its":[111],"role":[112],"as":[113,147,160],"key":[115],"cis-regulatory":[116],"element.":[117],"RNA-seq":[118],"enhancer-edited":[121],"cells":[122],"uncovered":[123],"742":[124],"differentially":[125],"expressed":[126],"genes":[127],"enriched":[128],"cancer-related":[130],"pathways,":[131],"including":[132],"MAPK":[133],"IL-17":[135],"signaling,":[136],"indicating":[137],"broad":[139],"impact.":[141],"Collectively,":[142],"our":[143],"findings":[144],"establish":[145],"driving":[151],"oncogenic":[152],"programs":[153],"HNSCC":[155],"suggest":[157],"enhancer-targeted":[158],"strategies":[159],"potential":[162],"therapeutic":[163],"avenue.":[164]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-02-07T00:00:00"}
