{"id":"https://openalex.org/W7127969616","doi":"https://doi.org/10.1038/s41577-026-01277-3","title":"Affinity-dependent local antibody feedback shapes germinal centre dynamics","display_name":"Affinity-dependent local antibody feedback shapes germinal centre dynamics","publication_year":2026,"publication_date":"2026-02-06","ids":{"openalex":"https://openalex.org/W7127969616","doi":"https://doi.org/10.1038/s41577-026-01277-3","pmid":"https://pubmed.ncbi.nlm.nih.gov/41651930"},"language":"en","primary_location":{"id":"doi:10.1038/s41577-026-01277-3","doi":"https://doi.org/10.1038/s41577-026-01277-3","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41577-026-01277-3","pdf_url":null,"source":{"id":"https://openalex.org/S93373720","display_name":"Nature reviews. Immunology","issn_l":"1474-1733","issn":["1474-1733","1474-1741"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050446020","display_name":"Annette Wu","orcid":"https://orcid.org/0009-0005-8343-4748","observed_orcids":["https://orcid.org/0009-0005-8343-4748"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Annette Wu","raw_affiliation_strings":["Preprint Club, University of Texas MD Anderson Cancer Center, Houston, TX, USA. highlights@preprintclub.com"],"raw_orcid":"https://orcid.org/0009-0005-8343-4748","affiliations":[{"raw_affiliation_string":"Preprint Club, University of Texas MD Anderson Cancer Center, Houston, TX, USA. highlights@preprintclub.com","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017997501","display_name":"Betty Y.S. Kim","orcid":"https://orcid.org/0000-0001-6890-8355","observed_orcids":["https://orcid.org/0000-0001-6890-8355"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Betty Y. S. Kim","raw_affiliation_strings":["Preprint Club, University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":"https://orcid.org/0000-0001-6890-8355","affiliations":[{"raw_affiliation_string":"Preprint Club, University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5050446020"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05283986,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"3","first_page":"169","last_page":"169"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/germinal-center","display_name":"germinal center","score":0.8069999814033508},{"id":"https://openalex.org/keywords/local-antibody-production","display_name":"local antibody production","score":0.8270000219345093},{"id":"https://openalex.org/keywords/antibody-affinity","display_name":"antibody affinity","score":0.5960000157356262},{"id":"https://openalex.org/keywords/negative-feedback","display_name":"negative feedback","score":0.8669999837875366},{"id":"https://openalex.org/keywords/b-cell-selection","display_name":"B cell selection","score":0.6140000224113464},{"id":"https://openalex.org/keywords/epitope-competition","display_name":"epitope competition","score":0.43700000643730164},{"id":"https://openalex.org/keywords/b-cell-tolerance","display_name":"B cell tolerance","score":0.40700000524520874}],"concepts":[{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.6223000288009644},{"id":"https://openalex.org/C96926380","wikidata":"https://www.wikidata.org/wiki/Q1737968","display_name":"Germinal center","level":4,"score":0.531000018119812},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.46970000863075256},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35519999265670776},{"id":"https://openalex.org/C93586867","wikidata":"https://www.wikidata.org/wiki/Q62527","display_name":"Negative feedback","level":3,"score":0.33059999346733093},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.31349998712539673},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3077000081539154},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.27459999918937683},{"id":"https://openalex.org/C3018913218","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody response","level":3,"score":0.27410000562667847},{"id":"https://openalex.org/C2778348673","wikidata":"https://www.wikidata.org/wiki/Q739302","display_name":"Production (economics)","level":2,"score":0.2669000029563904},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.26170000433921814},{"id":"https://openalex.org/C3018651601","wikidata":"https://www.wikidata.org/wiki/Q183635","display_name":"Feedback control","level":2,"score":0.2587999999523163}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1038/s41577-026-01277-3","doi":"https://doi.org/10.1038/s41577-026-01277-3","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41577-026-01277-3","pdf_url":null,"source":{"id":"https://openalex.org/S93373720","display_name":"Nature reviews. Immunology","issn_l":"1474-1733","issn":["1474-1733","1474-1741"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Immunology","raw_type":"journal-article"},{"id":"pmid:41651930","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41651930","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4000000059604645}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W7128765845"],"related_works":["https://openalex.org/W2969471343","https://openalex.org/W7148886592","https://openalex.org/W2006702905","https://openalex.org/W2159476211","https://openalex.org/W7134884164","https://openalex.org/W4416347519","https://openalex.org/W7131260461","https://openalex.org/W4417502623","https://openalex.org/W4392359305","https://openalex.org/W7172481681"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-02-07T00:00:00"}