{"id":"https://openalex.org/W7127953045","doi":"https://doi.org/10.3389/fonc.2026.1636634","title":"Primary pulmonary histiocytic sarcoma with CNS metastasis: a case report and molecular profiling insights","display_name":"Primary pulmonary histiocytic sarcoma with CNS metastasis: a case report and molecular profiling insights","publication_year":2026,"publication_date":"2026-02-06","ids":{"openalex":"https://openalex.org/W7127953045","doi":"https://doi.org/10.3389/fonc.2026.1636634","pmid":"https://pubmed.ncbi.nlm.nih.gov/41727642"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2026.1636634","doi":"https://doi.org/10.3389/fonc.2026.1636634","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1636634","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1636634/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://public-pages-files-2025.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1636634/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5125238326","display_name":"Kai Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102208913","display_name":"Shihezi University","ror":"https://ror.org/04x0kvm78","country_code":"CN","type":"education","lineage":["https://openalex.org/I102208913"]},{"id":"https://openalex.org/I4210136213","display_name":"First Affiliated Hospital of Shihezi University Medical College","ror":"https://ror.org/03qwdkr25","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Chen","raw_affiliation_strings":["Department of Pathology and National Health Commission(NHC) Key Laboratory of Prevention and Treatment of Central High Asia Diseases Incidence, Shihezi University School of Medicine/The First Affiliated Hospital, Shihezi University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and National Health Commission(NHC) Key Laboratory of Prevention and Treatment of Central High Asia Diseases Incidence, Shihezi University School of Medicine/The First Affiliated Hospital, Shihezi University","institution_ids":["https://openalex.org/I102208913","https://openalex.org/I4210136213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100434072","display_name":"Lei Zhang","orcid":"https://orcid.org/0009-0008-9783-092X","observed_orcids":["https://orcid.org/0009-0008-9783-092X"]},"institutions":[{"id":"https://openalex.org/I102208913","display_name":"Shihezi University","ror":"https://ror.org/04x0kvm78","country_code":"CN","type":"education","lineage":["https://openalex.org/I102208913"]},{"id":"https://openalex.org/I4210136213","display_name":"First Affiliated Hospital of Shihezi University Medical College","ror":"https://ror.org/03qwdkr25","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Zhang","raw_affiliation_strings":["Department of Clinical Laboratory, The First Affiliated Hospital of Shihezi University, Shihezi University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, The First Affiliated Hospital of Shihezi University, Shihezi University","institution_ids":["https://openalex.org/I102208913","https://openalex.org/I4210136213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125154209","display_name":"Ruotong Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102208913","display_name":"Shihezi University","ror":"https://ror.org/04x0kvm78","country_code":"CN","type":"education","lineage":["https://openalex.org/I102208913"]},{"id":"https://openalex.org/I4210136213","display_name":"First Affiliated Hospital of Shihezi University Medical College","ror":"https://ror.org/03qwdkr25","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruotong Wu","raw_affiliation_strings":["Department of Pathology and National Health Commission(NHC) Key Laboratory of Prevention and Treatment of Central High Asia Diseases Incidence, Shihezi University School of Medicine/The First Affiliated Hospital, Shihezi University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and National Health Commission(NHC) Key Laboratory of Prevention and Treatment of Central High Asia Diseases Incidence, Shihezi University School of Medicine/The First Affiliated Hospital, Shihezi University","institution_ids":["https://openalex.org/I102208913","https://openalex.org/I4210136213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051586174","display_name":"Jingxian Wei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102208913","display_name":"Shihezi University","ror":"https://ror.org/04x0kvm78","country_code":"CN","type":"education","lineage":["https://openalex.org/I102208913"]},{"id":"https://openalex.org/I4210136213","display_name":"First Affiliated Hospital of Shihezi University Medical College","ror":"https://ror.org/03qwdkr25","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingxian Wei","raw_affiliation_strings":["Department of Pathology and National Health Commission(NHC) Key Laboratory of Prevention and Treatment of Central High Asia Diseases Incidence, Shihezi University School of Medicine/The First Affiliated Hospital, Shihezi University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and National Health Commission(NHC) Key Laboratory of Prevention and Treatment of Central High Asia Diseases Incidence, Shihezi University School of Medicine/The First Affiliated Hospital, Shihezi University","institution_ids":["https://openalex.org/I102208913","https://openalex.org/I4210136213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080050836","display_name":"Kaige Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102208913","display_name":"Shihezi University","ror":"https://ror.org/04x0kvm78","country_code":"CN","type":"education","lineage":["https://openalex.org/I102208913"]},{"id":"https://openalex.org/I4210136213","display_name":"First Affiliated Hospital of Shihezi University Medical College","ror":"https://ror.org/03qwdkr25","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kaige Yang","raw_affiliation_strings":["Department of Pathology and National Health Commission(NHC) Key Laboratory of Prevention and Treatment of Central High Asia Diseases Incidence, Shihezi University School of Medicine/The First Affiliated Hospital, Shihezi University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and National Health Commission(NHC) Key Laboratory of Prevention and Treatment of Central High Asia Diseases Incidence, Shihezi University School of Medicine/The First Affiliated Hospital, Shihezi University","institution_ids":["https://openalex.org/I102208913","https://openalex.org/I4210136213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032662871","display_name":"Chenghua Luo","orcid":"https://orcid.org/0000-0002-5939-7888","observed_orcids":["https://orcid.org/0000-0002-5939-7888","https://orcid.org/0000-0003-2453-3429"]},"institutions":[{"id":"https://openalex.org/I102208913","display_name":"Shihezi University","ror":"https://ror.org/04x0kvm78","country_code":"CN","type":"education","lineage":["https://openalex.org/I102208913"]},{"id":"https://openalex.org/I4210136213","display_name":"First Affiliated Hospital of Shihezi University Medical College","ror":"https://ror.org/03qwdkr25","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenghua Luo","raw_affiliation_strings":["Department of Pathology and National Health Commission(NHC) Key Laboratory of Prevention and Treatment of Central High Asia Diseases Incidence, Shihezi University School of Medicine/The First Affiliated Hospital, Shihezi University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and National Health Commission(NHC) Key Laboratory of Prevention and Treatment of Central High Asia Diseases Incidence, Shihezi University School of Medicine/The First Affiliated Hospital, Shihezi University","institution_ids":["https://openalex.org/I102208913","https://openalex.org/I4210136213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115596896","display_name":"Haijun Zhang","orcid":"https://orcid.org/0000-0002-9198-8098","observed_orcids":["https://orcid.org/0000-0002-9198-8098"]},"institutions":[{"id":"https://openalex.org/I102208913","display_name":"Shihezi University","ror":"https://ror.org/04x0kvm78","country_code":"CN","type":"education","lineage":["https://openalex.org/I102208913"]},{"id":"https://openalex.org/I4210136213","display_name":"First Affiliated Hospital of Shihezi University Medical College","ror":"https://ror.org/03qwdkr25","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haijun Zhang","raw_affiliation_strings":["Department of Pathology and National Health Commission(NHC) Key Laboratory of Prevention and Treatment of Central High Asia Diseases Incidence, Shihezi University School of Medicine/The First Affiliated Hospital, Shihezi University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and National Health Commission(NHC) Key Laboratory of Prevention and Treatment of Central High Asia Diseases Incidence, Shihezi University School of Medicine/The First Affiliated Hospital, Shihezi University","institution_ids":["https://openalex.org/I102208913","https://openalex.org/I4210136213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111949701","display_name":"Tao Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102208913","display_name":"Shihezi University","ror":"https://ror.org/04x0kvm78","country_code":"CN","type":"education","lineage":["https://openalex.org/I102208913"]},{"id":"https://openalex.org/I4210136213","display_name":"First Affiliated Hospital of Shihezi University Medical College","ror":"https://ror.org/03qwdkr25","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Tao","raw_affiliation_strings":["Department of Pathology and National Health Commission(NHC) Key Laboratory of Prevention and Treatment of Central High Asia Diseases Incidence, Shihezi University School of Medicine/The First Affiliated Hospital, Shihezi University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and National Health Commission(NHC) Key Laboratory of Prevention and Treatment of Central High Asia Diseases Incidence, Shihezi University School of Medicine/The First Affiliated Hospital, Shihezi University","institution_ids":["https://openalex.org/I102208913","https://openalex.org/I4210136213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125227679","display_name":"Lan Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102208913","display_name":"Shihezi University","ror":"https://ror.org/04x0kvm78","country_code":"CN","type":"education","lineage":["https://openalex.org/I102208913"]},{"id":"https://openalex.org/I4210136213","display_name":"First Affiliated Hospital of Shihezi University Medical College","ror":"https://ror.org/03qwdkr25","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lan Yang","raw_affiliation_strings":["Department of Pathology and National Health Commission(NHC) Key Laboratory of Prevention and Treatment of Central High Asia Diseases Incidence, Shihezi University School of Medicine/The First Affiliated Hospital, Shihezi University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and National Health Commission(NHC) Key Laboratory of Prevention and Treatment of Central High Asia Diseases Incidence, Shihezi University School of Medicine/The First Affiliated Hospital, Shihezi University","institution_ids":["https://openalex.org/I102208913","https://openalex.org/I4210136213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068638213","display_name":"Lian Meng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102208913","display_name":"Shihezi University","ror":"https://ror.org/04x0kvm78","country_code":"CN","type":"education","lineage":["https://openalex.org/I102208913"]},{"id":"https://openalex.org/I4210136213","display_name":"First Affiliated Hospital of Shihezi University Medical College","ror":"https://ror.org/03qwdkr25","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lian Meng","raw_affiliation_strings":["Department of Pathology and National Health Commission(NHC) Key Laboratory of Prevention and Treatment of Central High Asia Diseases Incidence, Shihezi University School of Medicine/The First Affiliated Hospital, Shihezi University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and National Health Commission(NHC) Key Laboratory of Prevention and Treatment of Central High Asia Diseases Incidence, Shihezi University School of Medicine/The First Affiliated Hospital, Shihezi University","institution_ids":["https://openalex.org/I102208913","https://openalex.org/I4210136213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109735090","display_name":"Weixia Nong","orcid":"https://orcid.org/0009-0000-6614-3379","observed_orcids":["https://orcid.org/0009-0000-6614-3379"]},"institutions":[{"id":"https://openalex.org/I102208913","display_name":"Shihezi University","ror":"https://ror.org/04x0kvm78","country_code":"CN","type":"education","lineage":["https://openalex.org/I102208913"]},{"id":"https://openalex.org/I4210136213","display_name":"First Affiliated Hospital of Shihezi University Medical College","ror":"https://ror.org/03qwdkr25","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136213"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Weixia Nong","raw_affiliation_strings":["Department of Hematology, The First Affiliated Hospital of Shihezi University, Shihezi University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, The First Affiliated Hospital of Shihezi University, Shihezi University","institution_ids":["https://openalex.org/I102208913","https://openalex.org/I4210136213"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101445592","display_name":"Jianming Hu","orcid":"https://orcid.org/0000-0001-7790-7979","observed_orcids":["https://orcid.org/0000-0001-7790-7979"]},"institutions":[{"id":"https://openalex.org/I102208913","display_name":"Shihezi University","ror":"https://ror.org/04x0kvm78","country_code":"CN","type":"education","lineage":["https://openalex.org/I102208913"]},{"id":"https://openalex.org/I4210136213","display_name":"First Affiliated Hospital of Shihezi University Medical College","ror":"https://ror.org/03qwdkr25","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136213"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianming Hu","raw_affiliation_strings":["Department of Pathology and National Health Commission(NHC) Key Laboratory of Prevention and Treatment of Central High Asia Diseases Incidence, Shihezi University School of Medicine/The First Affiliated Hospital, Shihezi University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and National Health Commission(NHC) Key Laboratory of Prevention and Treatment of Central High Asia Diseases Incidence, Shihezi University School of Medicine/The First Affiliated Hospital, Shihezi University","institution_ids":["https://openalex.org/I102208913","https://openalex.org/I4210136213"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101445592","https://openalex.org/A5109735090"],"corresponding_institution_ids":["https://openalex.org/I102208913","https://openalex.org/I4210136213"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0780463,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":null,"first_page":"1636634","last_page":"1636634"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11909","display_name":"Histiocytic Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11909","display_name":"Histiocytic Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11571","display_name":"Sarcoidosis and Beryllium Toxicity Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.7239999771118164},{"id":"https://openalex.org/keywords/pi3k-mtor-pathway","display_name":"PI3K/mTOR pathway","score":0.8980000019073486},{"id":"https://openalex.org/keywords/drug-sensitivity-profiling","display_name":"drug sensitivity profiling","score":0.8009999990463257},{"id":"https://openalex.org/keywords/sunitinib","display_name":"sunitinib","score":0.9750000238418579},{"id":"https://openalex.org/keywords/mek-inhibitors","display_name":"MEK inhibitors","score":0.9950000047683716},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7960000038146973},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.8100000023841858},{"id":"https://openalex.org/keywords/tumor-size","display_name":"tumor size","score":0.781000018119812},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.44200000166893005}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6873000264167786},{"id":"https://openalex.org/C2777578932","wikidata":"https://www.wikidata.org/wiki/Q5773034","display_name":"Histiocytic sarcoma","level":3,"score":0.6035000085830688},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.5166000127792358},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.510699987411499},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4632999897003174},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.46050000190734863},{"id":"https://openalex.org/C37307934","wikidata":"https://www.wikidata.org/wiki/Q18030422","display_name":"PDGFRA","level":4,"score":0.4544000029563904},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4368000030517578},{"id":"https://openalex.org/C111829193","wikidata":"https://www.wikidata.org/wiki/Q1108970","display_name":"Fusion gene","level":3,"score":0.39800000190734863},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.3790000081062317},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.37630000710487366},{"id":"https://openalex.org/C43100952","wikidata":"https://www.wikidata.org/wiki/Q654612","display_name":"Histiocyte","level":2,"score":0.2915000021457672},{"id":"https://openalex.org/C2908861226","wikidata":"https://www.wikidata.org/wiki/Q417542","display_name":"Sunitinib malate","level":4,"score":0.2879999876022339},{"id":"https://openalex.org/C2781447767","wikidata":"https://www.wikidata.org/wiki/Q369148","display_name":"Schwannoma","level":2,"score":0.2784999907016754},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27799999713897705},{"id":"https://openalex.org/C21790070","wikidata":"https://www.wikidata.org/wiki/Q18030215","display_name":"Neuroblastoma RAS viral oncogene homolog","level":5,"score":0.27149999141693115},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2653999924659729},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.26409998536109924},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.26339998841285706},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.26330000162124634},{"id":"https://openalex.org/C3019892230","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib mesylate","level":4,"score":0.26080000400543213},{"id":"https://openalex.org/C2778173781","wikidata":"https://www.wikidata.org/wiki/Q654485","display_name":"Malignant peripheral nerve sheath tumor","level":3,"score":0.25290000438690186}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fonc.2026.1636634","doi":"https://doi.org/10.3389/fonc.2026.1636634","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1636634","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1636634/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},{"id":"pmid:41727642","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41727642","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in oncology","raw_type":"Case Reports"},{"id":"pmh:oai:doaj.org/article:754fb9d82d3a4617aee2fcb048e320bf","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/754fb9d82d3a4617aee2fcb048e320bf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oncology, Vol 16 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12920180","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12920180/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Oncol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3389/fonc.2026.1636634","doi":"https://doi.org/10.3389/fonc.2026.1636634","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1636634","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1636634/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/1","display_name":"No poverty","score":0.6195826530456543}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[{"id":"https://openalex.org/G160877443","display_name":null,"funder_award_id":"82460597","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322542","display_name":"Shihezi University","ror":"https://ror.org/04x0kvm78"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7127953045.pdf","grobid_xml":"https://content.openalex.org/works/W7127953045.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W820317546","https://openalex.org/W1946849204","https://openalex.org/W1968278764","https://openalex.org/W1981347911","https://openalex.org/W1983769365","https://openalex.org/W1985391822","https://openalex.org/W1988908852","https://openalex.org/W1994242661","https://openalex.org/W1996662632","https://openalex.org/W1996753426","https://openalex.org/W2008650271","https://openalex.org/W2025393860","https://openalex.org/W2028257398","https://openalex.org/W2052065215","https://openalex.org/W2066599338","https://openalex.org/W2075775411","https://openalex.org/W2094044666","https://openalex.org/W2097110085","https://openalex.org/W2102516089","https://openalex.org/W2105538445","https://openalex.org/W2113470753","https://openalex.org/W2125020145","https://openalex.org/W2159987716","https://openalex.org/W2301043785","https://openalex.org/W2403508887","https://openalex.org/W2734638873","https://openalex.org/W2765919526","https://openalex.org/W2768738345","https://openalex.org/W2769709464","https://openalex.org/W2803287631","https://openalex.org/W2804864214","https://openalex.org/W2883152348","https://openalex.org/W2898954268","https://openalex.org/W2900399253","https://openalex.org/W2969481187","https://openalex.org/W3086613311","https://openalex.org/W3122102740","https://openalex.org/W3183452139","https://openalex.org/W3185817026","https://openalex.org/W4224234031","https://openalex.org/W4235195704","https://openalex.org/W4246217402","https://openalex.org/W4304891648","https://openalex.org/W4311720833","https://openalex.org/W4392196724","https://openalex.org/W4392561085","https://openalex.org/W4400231310","https://openalex.org/W4408241388"],"related_works":[],"abstract_inverted_index":{"Histiocytic":[0],"sarcoma":[1],"(HS),":[2],"reclassified":[3],"in":[4,46],"the":[5,29,47,81,85],"WHO":[6],"fifth":[7],"edition":[8],"as":[9,159],"a":[10,15,32,43,58,134],"Histiocytic/dendritic":[11],"cell":[12,146],"neoplasms,":[13],"represents":[14],"rare":[16],"hematopoietic":[17],"malignancy":[18],"with":[19,36,42,120],"extranodal":[20],"predominance":[21],"and":[22,51,64,76,87,101,113,151],"aggressive":[23],"clinical":[24],"behavior.":[25],"This":[26],"study":[27],"reports":[28],"case":[30,119],"of":[31,60,73,84,125,162],"53-year-old":[33],"female":[34],"diagnosed":[35],"primary":[37],"pulmonary":[38],"HS,":[39,127],"who":[40],"presented":[41],"60-mm":[44],"mass":[45],"right":[48],"middle":[49],"lobe":[50],"later":[52],"developed":[53],"fatal":[54],"brain":[55],"metastases.":[56],"Using":[57],"combination":[59],"pathology,":[61],"whole-exome":[62],"sequencing,":[63],"fusion":[65],"gene":[66,93],"analysis,":[67],"we":[68,128],"identified":[69,158],"key":[70],"molecular":[71],"drivers":[72],"tumor":[74,153],"development":[75],"spread.":[77],"Major":[78],"findings":[79],"include":[80],"concurrent":[82],"activation":[83,90],"RAS/MAPK":[86],"PI3K/mTOR":[88],"pathway":[89],"(118":[91],"combined":[92],"variants),":[94],"TP53":[95],"biallelic":[96],"inactivation,":[97],"HLA":[98],"locus":[99],"alterations,":[100],"persistent":[102],"LOC285045":[103],"fusions.":[104],"Drug":[105],"sensitivity":[106],"profiling":[107],"suggested":[108],"potential":[109],"responses":[110],"to":[111],"sunitinib":[112],"MEK":[114],"inhibitors.":[115],"By":[116],"comparing":[117],"this":[118],"nine":[121],"other":[122,142],"reported":[123],"cases":[124],"lung":[126,131],"found":[129],"that":[130],"HS":[132,140],"has":[133],"significantly":[135],"worse":[136],"survival":[137],"(p=0.03)":[138],"than":[139],"at":[141],"sites.":[143],"A":[144],"high":[145],"growth":[147],"rate":[148],"(Ki-67":[149],">30%)":[150],"large":[152],"size":[154],"(>50":[155],"mm)":[156],"were":[157],"critical":[160],"indicators":[161],"poor":[163],"prognosis.":[164]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2026-02-07T00:00:00"}