{"id":"https://openalex.org/W7127935404","doi":"https://doi.org/10.6084/m9.figshare.31271804","title":"Transcriptomic profile and gene expression of human breast cancer cell lines treated with herbal extract of clinacanthus nutans leaves","display_name":"Transcriptomic profile and gene expression of human breast cancer cell lines treated with herbal extract of clinacanthus nutans leaves","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7127935404","doi":"https://doi.org/10.6084/m9.figshare.31271804"},"language":"en","primary_location":{"id":"doi:10.6084/m9.figshare.31271804","doi":"https://doi.org/10.6084/m9.figshare.31271804","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.31271804","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.6084/m9.figshare.31271804","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039188220","display_name":"Zaleha Md Toha","orcid":"https://orcid.org/0000-0003-2201-8335","observed_orcids":["https://orcid.org/0000-0003-2201-8335"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toha, Zaleha Md","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125168852","display_name":"Norhasyimah Haron","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haron, Norhasyimah","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087091641","display_name":"Kristine Sandra Pey Adum","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adum, Kristine Sandra Pey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072228436","display_name":"Nik Nur Syazni Nik Mohamed Kamal","orcid":"https://orcid.org/0000-0001-5473-1245","observed_orcids":["https://orcid.org/0000-0001-5473-1245"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kamal, Nik Nur Syazni Nik Mohamed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048772214","display_name":"Melati Khairuddean","orcid":"https://orcid.org/0000-0001-7280-302X","observed_orcids":["https://orcid.org/0000-0001-7280-302X","https://orcid.org/0000-0002-6152-2684"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Khairuddean, Melati","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5033791161","display_name":"Hasni Arsad","orcid":"https://orcid.org/0000-0002-3188-8052","observed_orcids":["https://orcid.org/0000-0002-3188-8052"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arsad, Hasni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14461","display_name":"Medicinal Plant Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T14461","display_name":"Medicinal Plant Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13185","display_name":"Phytochemistry and Bioactive Compounds","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clinacanthus-nutans","display_name":"Clinacanthus nutans","score":0.9980000257492065},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9459999799728394},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9380000233650208},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6510000228881836},{"id":"https://openalex.org/keywords/plant-extracts","display_name":"plant extracts","score":0.6549999713897705},{"id":"https://openalex.org/keywords/transcriptomic-profiles","display_name":"transcriptomic profiles","score":0.7369999885559082},{"id":"https://openalex.org/keywords/differential-gene-expression","display_name":"differential gene expression","score":0.9309999942779541},{"id":"https://openalex.org/keywords/aldh3a1","display_name":"ALDH3A1","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cyp1a1","display_name":"CYP1A1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/nos3","display_name":"NOS3","score":0.9580000042915344},{"id":"https://openalex.org/keywords/carboxylesterase-1","display_name":"CES1","score":0.824999988079071}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7980999946594238},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.7141000032424927},{"id":"https://openalex.org/C2994423619","wikidata":"https://www.wikidata.org/wiki/Q9103","display_name":"Human breast","level":4,"score":0.6345999836921692},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.6330999732017517},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6032000184059143},{"id":"https://openalex.org/C2987395477","wikidata":"https://www.wikidata.org/wiki/Q135085","display_name":"Gene ontology","level":4,"score":0.5688999891281128},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5376999974250793},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5302000045776367},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5213000178337097},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5169000029563904},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5063999891281128},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4936000108718872},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48840001225471497},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4580000042915344},{"id":"https://openalex.org/C109541995","wikidata":"https://www.wikidata.org/wiki/Q1881253","display_name":"MCF-7","level":5,"score":0.3675000071525574},{"id":"https://openalex.org/C2779230013","wikidata":"https://www.wikidata.org/wiki/Q25303877","display_name":"Pathway analysis","level":4,"score":0.35760000348091125},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3506999909877777},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.33469998836517334},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.32919999957084656},{"id":"https://openalex.org/C2994372470","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell lines","level":4,"score":0.32910001277923584},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32589998841285706},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.3240000009536743},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31060001254081726},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.3043000102043152},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2808000147342682},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27790001034736633},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2694000005722046},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.2632000148296356},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.26159998774528503}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.6084/m9.figshare.31271804","doi":"https://doi.org/10.6084/m9.figshare.31271804","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.31271804","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.6084/m9.figshare.31271804.v1","doi":"https://doi.org/10.6084/m9.figshare.31271804.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.31271804.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.6084/m9.figshare.31271804","doi":"https://doi.org/10.6084/m9.figshare.31271804","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.31271804","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7198290988","https://openalex.org/W4206251471","https://openalex.org/W4283315513","https://openalex.org/W4311119198","https://openalex.org/W7093507168","https://openalex.org/W7063828030","https://openalex.org/W2560552839","https://openalex.org/W6958583817","https://openalex.org/W6902310066","https://openalex.org/W4210652619"],"abstract_inverted_index":{"Clinacanthus":[0],"nutans":[1],"(CN)":[2],"is":[3],"traditionally":[4],"used":[5],"in":[6,30],"medicine,":[7],"but":[8],"its":[9],"apoptotic":[10,22],"effects":[11],"on":[12],"breast":[13,82],"cancer":[14,83],"cells":[15,32],"remain":[16],"unclear.":[17],"This":[18],"study":[19],"investigated":[20],"the":[21],"potential":[23,79],"of":[24],"CN":[25],"dichloromethane":[26],"leaf":[27],"extract":[28],"(CNDCM)":[29],"MCF-7":[31],"using":[33],"RNA-Seq":[34],"analysis.":[35],"Differential":[36],"gene":[37],"expression":[38],"analysis":[39],"identified":[40],"843":[41],"genes,":[42,60],"with":[43],"395":[44],"upregulated":[45],"and":[46,51,66],"448":[47],"downregulated.":[48],"Gene":[49],"ontology":[50],"KEGG":[52],"pathway":[53],"analyses":[54],"revealed":[55],"apoptosis-related":[56],"pathways.":[57],"Key":[58],"apoptosis-associated":[59],"including":[61],"ALDH3A1,":[62],"CYP1A1,":[63],"NOS3,":[64],"MT1X,":[65],"CES1,":[67],"were":[68],"further":[69],"validated":[70],"by":[71],"RT-qPCR.":[72],"These":[73],"findings":[74],"suggest":[75],"CNDCM":[76],"as":[77],"a":[78],"candidate":[80],"for":[81],"therapy.":[84]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-02-07T00:00:00"}