{"id":"https://openalex.org/W7127915897","doi":"https://doi.org/10.1016/j.tjnut.2026.101394","title":"Untargeted Metabolomics Analysis of Human Milk from Breastfeeding Bangladeshi Women Reveals Amino Acid Metabolic Pathways Associated with Maternal Nutritional Status and Infant Growth","display_name":"Untargeted Metabolomics Analysis of Human Milk from Breastfeeding Bangladeshi Women Reveals Amino Acid Metabolic Pathways Associated with Maternal Nutritional Status and Infant Growth","publication_year":2026,"publication_date":"2026-02-05","ids":{"openalex":"https://openalex.org/W7127915897","doi":"https://doi.org/10.1016/j.tjnut.2026.101394","pmid":"https://pubmed.ncbi.nlm.nih.gov/41651070","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13084589"},"language":"en","primary_location":{"id":"doi:10.1016/j.tjnut.2026.101394","doi":"https://doi.org/10.1016/j.tjnut.2026.101394","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tjnut.2026.101394","pdf_url":null,"source":{"id":"https://openalex.org/S88153332","display_name":"Journal of Nutrition","issn_l":"0022-3166","issn":["0022-3166","1541-6100"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Nutrition","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.tjnut.2026.101394","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085691369","display_name":"Carmen Month\u00e9\u2010Dr\u00e8ze","orcid":"https://orcid.org/0000-0002-1062-9852","observed_orcids":["https://orcid.org/0000-0002-1062-9852"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210133025","display_name":"Women & Infants Hospital of Rhode Island","ror":"https://ror.org/03z8sn326","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210133025"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carmen Monthe-Dreze","raw_affiliation_strings":["Department Pediatrics, Division of Newborn Medicine, Brigham and Women's Hospital, Boston, MA, United States; Department of Pediatrics, Harvard Medical School, Boston, MA, United States; Department of Pediatrics, Division of Neonatology, Women and Infants Hospital, Providence, RI, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Pediatrics, Division of Newborn Medicine, Brigham and Women's Hospital, Boston, MA, United States; Department of Pediatrics, Harvard Medical School, Boston, MA, United States; Department of Pediatrics, Division of Neonatology, Women and Infants Hospital, Providence, RI, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210133025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070046951","display_name":"Brij Bhushan","orcid":"https://orcid.org/0000-0003-4036-5816","observed_orcids":["https://orcid.org/0000-0003-4036-5816"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brij Bhushan","raw_affiliation_strings":["Department Pediatrics, Division of Newborn Medicine, Brigham and Women's Hospital, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Pediatrics, Division of Newborn Medicine, Brigham and Women's Hospital, Boston, MA, United States","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088863555","display_name":"Chloe Andrews","orcid":"https://orcid.org/0000-0002-4282-8215","observed_orcids":["https://orcid.org/0000-0002-4282-8215"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210133025","display_name":"Women & Infants Hospital of Rhode Island","ror":"https://ror.org/03z8sn326","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210133025"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chloe Andrews","raw_affiliation_strings":["Department Pediatrics, Division of Newborn Medicine, Brigham and Women's Hospital, Boston, MA, United States; Department of Pediatrics, Division of Neonatology, Women and Infants Hospital, Providence, RI, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Pediatrics, Division of Newborn Medicine, Brigham and Women's Hospital, Boston, MA, United States; Department of Pediatrics, Division of Neonatology, Women and Infants Hospital, Providence, RI, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I4210133025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006527765","display_name":"Sara Cherkerzian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara Cherkerzian","raw_affiliation_strings":["Department Pediatrics, Division of Newborn Medicine, Brigham and Women's Hospital, Boston, MA, United States; Department of Pediatrics, Harvard Medical School, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Pediatrics, Division of Newborn Medicine, Brigham and Women's Hospital, Boston, MA, United States; Department of Pediatrics, Harvard Medical School, Boston, MA, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125203568","display_name":"Wei Perng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Perng","raw_affiliation_strings":["Department of Epidemiology and the Lifecourse Epidemiology of Adiposity and Diabetes Center, University of Colorado, Anschutz Medical Campus, Aurora, CO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and the Lifecourse Epidemiology of Adiposity and Diabetes Center, University of Colorado, Anschutz Medical Campus, Aurora, CO, United States","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122844073","display_name":"Salahuddin Ahmed","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Salahuddin Ahmed","raw_affiliation_strings":["Projahnmo Research Foundation, Dhaka, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Projahnmo Research Foundation, Dhaka, Bangladesh","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110971809","display_name":"Abdullah H. Baqui","orcid":"https://orcid.org/0000-0001-8350-1983","observed_orcids":["https://orcid.org/0000-0001-8350-1983"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdullah H Baqui","raw_affiliation_strings":["Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore MD, United States","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033061529","display_name":"Nabidul Haque Chowdhury","orcid":"https://orcid.org/0000-0002-6149-1152","observed_orcids":["https://orcid.org/0000-0002-6149-1152"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nabidul Chowdhury","raw_affiliation_strings":["Projahnmo Research Foundation, Dhaka, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Projahnmo Research Foundation, Dhaka, Bangladesh","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068453185","display_name":"Rasheda Khanam","orcid":"https://orcid.org/0000-0002-9365-8594","observed_orcids":["https://orcid.org/0000-0002-9365-8594"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rasheda Khanam","raw_affiliation_strings":["Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore MD, United States","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063684900","display_name":"Sayedur Rahman","orcid":"https://orcid.org/0000-0002-4445-3699","observed_orcids":["https://orcid.org/0000-0002-4445-3699"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sayedur Rahman","raw_affiliation_strings":["Projahnmo Research Foundation, Dhaka, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Projahnmo Research Foundation, Dhaka, Bangladesh","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083966221","display_name":"Patricia Ann Sheridan","orcid":"https://orcid.org/0000-0003-3332-9577","observed_orcids":["https://orcid.org/0000-0003-3332-9577"]},"institutions":[{"id":"https://openalex.org/I4210123764","display_name":"Metabolon (United States)","ror":"https://ror.org/033qhvk72","country_code":"US","type":"company","lineage":["https://openalex.org/I4210123764"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia A Sheridan","raw_affiliation_strings":["Metabolon, Inc., Morrisville, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolon, Inc., Morrisville, NC, United States","institution_ids":["https://openalex.org/I4210123764"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Gregory Michelotti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123764","display_name":"Metabolon (United States)","ror":"https://ror.org/033qhvk72","country_code":"US","type":"company","lineage":["https://openalex.org/I4210123764"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory Michelotti","raw_affiliation_strings":["Metabolon, Inc., Morrisville, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolon, Inc., Morrisville, NC, United States","institution_ids":["https://openalex.org/I4210123764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125146915","display_name":"Camilia R. Martin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Camilia R Martin","raw_affiliation_strings":["Division of Neonatology, Weill Cornell Medicine New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neonatology, Weill Cornell Medicine New York, NY, United States","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125197184","display_name":"Anne C.C. Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne CC Lee","raw_affiliation_strings":["Department Pediatrics, Division of Newborn Medicine, Brigham and Women's Hospital, Boston, MA, United States; Warren Alpert Medical School, Brown University, Providence, RI, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Pediatrics, Division of Newborn Medicine, Brigham and Women's Hospital, Boston, MA, United States; Warren Alpert Medical School, Brown University, Providence, RI, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I27804330"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015725120","display_name":"Sarbattama Sen","orcid":"https://orcid.org/0000-0003-0138-7668","observed_orcids":["https://orcid.org/0000-0003-0138-7668"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sarbattama Sen","raw_affiliation_strings":["Department Pediatrics, Division of Newborn Medicine, Brigham and Women's Hospital, Boston, MA, United States; Department of Pediatrics, Division of Neonatology, Women and Infants Hospital, Providence, RI, United States; Warren Alpert Medical School, Brown University, Providence, RI, United States. Electronic address: Sarbattama_sen@brown.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Pediatrics, Division of Newborn Medicine, Brigham and Women's Hospital, Boston, MA, United States; Department of Pediatrics, Division of Neonatology, Women and Infants Hospital, Providence, RI, United States; Warren Alpert Medical School, Brown University, Providence, RI, United States. Electronic address: Sarbattama_sen@brown.edu","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I27804330"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5015725120"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I27804330"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":{"value":5200,"currency":"USD","value_usd":5200},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05545246,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"156","issue":"4","first_page":"101394","last_page":"101394"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10979","display_name":"Breastfeeding Practices and Influences","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breastfeeding","display_name":"breastfeeding","score":0.6000000238418579},{"id":"https://openalex.org/keywords/maternal-nutritional-status","display_name":"maternal nutritional status","score":0.828000009059906},{"id":"https://openalex.org/keywords/infant-growth","display_name":"infant growth","score":0.8560000061988831},{"id":"https://openalex.org/keywords/amino-acids","display_name":"amino acids","score":0.6940000057220459},{"id":"https://openalex.org/keywords/glutathione-metabolism","display_name":"glutathione metabolism","score":0.7319999933242798},{"id":"https://openalex.org/keywords/ammonia-recycling","display_name":"ammonia recycling","score":0.6510000228881836},{"id":"https://openalex.org/keywords/sphingolipids","display_name":"sphingolipids","score":0.7620000243186951},{"id":"https://openalex.org/keywords/phospholipids","display_name":"phospholipids","score":0.9430000185966492},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.7829999923706055},{"id":"https://openalex.org/keywords/lactation","display_name":"lactation","score":0.5960000157356262},{"id":"https://openalex.org/keywords/low-middle-income-countries","display_name":"low-middle income countries","score":0.7549999952316284},{"id":"https://openalex.org/keywords/bangladeshi-women","display_name":"Bangladeshi women","score":0.7739999890327454},{"id":"https://openalex.org/keywords/preterm-birth","display_name":"preterm birth","score":0.5789999961853027},{"id":"https://openalex.org/keywords/mother-infant-dyads","display_name":"mother-infant dyads","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C2776283161","wikidata":"https://www.wikidata.org/wiki/Q174876","display_name":"Breastfeeding","level":2,"score":0.861299991607666},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.7462000250816345},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.5552999973297119},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4966999888420105},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.4514000117778778},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4291999936103821},{"id":"https://openalex.org/C2775871700","wikidata":"https://www.wikidata.org/wiki/Q22728","display_name":"Breast milk","level":2,"score":0.42669999599456787},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4120999872684479},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.41019999980926514},{"id":"https://openalex.org/C2776659692","wikidata":"https://www.wikidata.org/wiki/Q719426","display_name":"Lactation","level":3,"score":0.3725000023841858},{"id":"https://openalex.org/C2779150110","wikidata":"https://www.wikidata.org/wiki/Q2287198","display_name":"Infant formula","level":2,"score":0.3707999885082245},{"id":"https://openalex.org/C3020294031","wikidata":"https://www.wikidata.org/wiki/Q174876","display_name":"Breast feeding","level":2,"score":0.367900013923645},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3409999907016754},{"id":"https://openalex.org/C2776962008","wikidata":"https://www.wikidata.org/wiki/Q39087014","display_name":"Infant nutrition","level":4,"score":0.3237000107765198},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.31529998779296875},{"id":"https://openalex.org/C2778816673","wikidata":"https://www.wikidata.org/wiki/Q245282","display_name":"Essential amino acid","level":3,"score":0.3077000081539154},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.28450000286102295},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28369998931884766},{"id":"https://openalex.org/C2993643364","wikidata":"https://www.wikidata.org/wiki/Q8495","display_name":"Milk protein","level":2,"score":0.2827000021934509},{"id":"https://openalex.org/C2780320433","wikidata":"https://www.wikidata.org/wiki/Q3403879","display_name":"Weight gain","level":3,"score":0.2800000011920929},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26829999685287476},{"id":"https://openalex.org/C3018216841","wikidata":"https://www.wikidata.org/wiki/Q2287198","display_name":"Formula feeding","level":3,"score":0.2667999863624573},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.2660999894142151},{"id":"https://openalex.org/C3020541086","wikidata":"https://www.wikidata.org/wiki/Q637776","display_name":"Milk production","level":2,"score":0.2651999890804291},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.2619999945163727},{"id":"https://openalex.org/C2994280701","wikidata":"https://www.wikidata.org/wiki/Q4862551","display_name":"Amino acid metabolism","level":3,"score":0.2578999996185303},{"id":"https://openalex.org/C40231798","wikidata":"https://www.wikidata.org/wiki/Q1333743","display_name":"Composition (language)","level":2,"score":0.25780001282691956}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001459","descriptor_name":"Bangladesh","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001942","descriptor_name":"Breast Feeding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002657","descriptor_name":"Child Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008895","descriptor_name":"Milk, Human","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008895","descriptor_name":"Milk, Human","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009752","descriptor_name":"Nutritional Status","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039382","descriptor_name":"Maternal Nutritional Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.tjnut.2026.101394","doi":"https://doi.org/10.1016/j.tjnut.2026.101394","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tjnut.2026.101394","pdf_url":null,"source":{"id":"https://openalex.org/S88153332","display_name":"Journal of Nutrition","issn_l":"0022-3166","issn":["0022-3166","1541-6100"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Nutrition","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13084589","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13084589/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13084589/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Nutr","raw_type":"Text"},{"id":"pmid:41651070","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41651070","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of nutrition","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.tjnut.2026.101394","doi":"https://doi.org/10.1016/j.tjnut.2026.101394","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tjnut.2026.101394","pdf_url":null,"source":{"id":"https://openalex.org/S88153332","display_name":"Journal of Nutrition","issn_l":"0022-3166","issn":["0022-3166","1541-6100"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Nutrition","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899},{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.9208999872207642}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G151151836","display_name":null,"funder_award_id":"5K23HD091390","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"},{"id":"https://openalex.org/G2189984535","display_name":null,"funder_award_id":"164438","funder_id":"https://openalex.org/F4320307856","funder_display_name":"World Health Organization"},{"id":"https://openalex.org/G3662483284","display_name":"The Roles of Perinatal Nutrition, Infection and Inflammation in the Neurodevelopment of Bangladeshi Infants","funder_award_id":"K23HD091390","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G7703511878","display_name":null,"funder_award_id":"I64438","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"}],"funders":[{"id":"https://openalex.org/F4320306137","display_name":"Bill and Melinda Gates Foundation","ror":"https://ror.org/0456r8d26"},{"id":"https://openalex.org/F4320307856","display_name":"World Health Organization","ror":"https://ror.org/01f80g185"},{"id":"https://openalex.org/F4320308347","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94"},{"id":"https://openalex.org/F4320312826","display_name":"Massachusetts Life Sciences Center","ror":"https://ror.org/033km2469"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":81,"referenced_works":["https://openalex.org/W188962219","https://openalex.org/W204171329","https://openalex.org/W1511789008","https://openalex.org/W1891967301","https://openalex.org/W1922230241","https://openalex.org/W1980270094","https://openalex.org/W2017384459","https://openalex.org/W2033509297","https://openalex.org/W2073176366","https://openalex.org/W2097590023","https://openalex.org/W2103740411","https://openalex.org/W2108819945","https://openalex.org/W2110065044","https://openalex.org/W2111603618","https://openalex.org/W2114110961","https://openalex.org/W2116480311","https://openalex.org/W2116880052","https://openalex.org/W2120866264","https://openalex.org/W2123938699","https://openalex.org/W2128106102","https://openalex.org/W2129314505","https://openalex.org/W2138127318","https://openalex.org/W2139343763","https://openalex.org/W2144636739","https://openalex.org/W2145265944","https://openalex.org/W2147537998","https://openalex.org/W2160831048","https://openalex.org/W2168462106","https://openalex.org/W2170746536","https://openalex.org/W2267159071","https://openalex.org/W2288139400","https://openalex.org/W2315639289","https://openalex.org/W2341244791","https://openalex.org/W2501562812","https://openalex.org/W2594453885","https://openalex.org/W2618894344","https://openalex.org/W2752713655","https://openalex.org/W2767360135","https://openalex.org/W2797872547","https://openalex.org/W2803406529","https://openalex.org/W2803664483","https://openalex.org/W2889065670","https://openalex.org/W2891231485","https://openalex.org/W2916926472","https://openalex.org/W2940384378","https://openalex.org/W2945486404","https://openalex.org/W2967600646","https://openalex.org/W2973697021","https://openalex.org/W3007363313","https://openalex.org/W3008469932","https://openalex.org/W3023079928","https://openalex.org/W3030574348","https://openalex.org/W3044680628","https://openalex.org/W3081013724","https://openalex.org/W3127195093","https://openalex.org/W3131997154","https://openalex.org/W3135616221","https://openalex.org/W3172702698","https://openalex.org/W3178300564","https://openalex.org/W3208011182","https://openalex.org/W3216692191","https://openalex.org/W4200257567","https://openalex.org/W4212888212","https://openalex.org/W4285098127","https://openalex.org/W4285390237","https://openalex.org/W4289861187","https://openalex.org/W4289885558","https://openalex.org/W4297051244","https://openalex.org/W4310526916","https://openalex.org/W4378576257","https://openalex.org/W4380686468","https://openalex.org/W4388905435","https://openalex.org/W4400509176","https://openalex.org/W4403807477","https://openalex.org/W4404938389","https://openalex.org/W4405318107","https://openalex.org/W4405930891","https://openalex.org/W4406023889","https://openalex.org/W4410779521","https://openalex.org/W4411227663","https://openalex.org/W4415809738"],"related_works":["https://openalex.org/W7132823662","https://openalex.org/W7116052006","https://openalex.org/W4415809738","https://openalex.org/W4404938389","https://openalex.org/W3127195093","https://openalex.org/W4385309548","https://openalex.org/W1511789008","https://openalex.org/W4285390237","https://openalex.org/W4385309911","https://openalex.org/W2964539472"],"abstract_inverted_index":{"BACKGROUND:":[0],"Human":[1],"milk":[2],"(HM)":[3],"contains":[4],"bioactive":[5],"constituents":[6],"that":[7,13,153,219,284,424],"continuously":[8],"change":[9],"throughout":[10],"lactation":[11,112],"and":[12,32,49,54,82,133,157,189,192,196,239,241,297,299,301,353,360,387,429],"are":[14,52,94,414],"critical":[15,288],"for":[16,211,275,310,343],"optimal":[17],"infant":[18,36,99,193,325,375,427],"development.":[19],"However,":[20],"the":[21,25,69,216,225,259,302,382],"temporal":[22,66],"variation":[23],"of":[24,104,292,384],"HM":[26,50,70,79,86,126,255,336,394,422],"metabolome,":[27,71],"its":[28,33],"maternal":[29,55,74,91,182,418],"nutritional":[30,56,75,92,183],"determinants,":[31],"links":[34],"to":[35,63,150,161,178,203,416,431],"outcomes":[37],"remain":[38],"insufficiently":[39],"characterized":[40,123,281,349],"in":[41,68,78,95,101,125,221,258,286,356,397,407,421,434],"low-middle-income":[42],"countries":[43],"(LMIC)":[44],"where":[45],"childhood":[46],"disease":[47],"burden":[48],"exposure":[51],"substantial,":[53],"status":[57,93],"is":[58],"poor.":[59],"OBJECTIVES:":[60],"We":[61,145,173],"aimed":[62],"1)":[64],"characterize":[65,204],"changes":[67],"2)":[72],"quantify":[73],"status-related":[76],"differences":[77,396,420],"metabolomic":[80,87,277,345],"patterns,":[81],"3)":[83],"determine":[84,179],"whether":[85],"patterns":[88],"associated":[89,97,314,373],"with":[90,98,262,315,374,399],"turn":[96],"growth,":[100],"a":[102,111,147,276,344],"cohort":[103,113],"rural":[105],"Bangladeshi":[106],"maternal-infant":[107],"dyads.":[108],"METHODS:":[109],"In":[110,306,378],"(n":[114,130,135],"=":[115,131,136,318],"99,":[116],"6%":[117],"preterm":[118],"at":[119,128,165,187,328],"34-36":[120],"wk),":[121],"we":[122],"metabolites":[124,152,163,218,231,389],"samples":[127],"2":[129,188,226],"94)":[132],"5":[134,190],"88)":[137],"mo":[138,330],"postpartum":[139],"(PP)":[140],"using":[141],"untargeted":[142],"metabolomics":[143],"profiling.":[144],"performed":[146,197],"paired":[148],"t-test":[149],"identify":[151],"differed":[154,220],"between":[155,181],"timepoints":[156],"principal":[158],"component":[159],"analysis":[160,201],"consolidate":[162],"measured":[164],"each":[166],"timepoint":[167],"into":[168],"\"factors,\"":[169],"representing":[170],"metabolite":[171,198],"patterns.":[172],"used":[174],"linear":[175],"regression":[176],"models":[177],"associations":[180],"predictors,":[184],"factor":[185],"scores":[186,274,309,342],"mo,":[191],"growth":[194,428],"outcomes,":[195],"set":[199],"enrichment":[200],"(MSEA)":[202],"relevant":[205],"pathways.":[206],"P":[207],"values":[208],"were":[209,313,366],"adjusted":[210],"multiple":[212],"comparisons.":[213],"RESULTS:":[214],"Among":[215],"51":[217],"relative":[222],"abundance":[223,383],"across":[224],"time":[227],"points,":[228],"37":[229],"(73%)":[230],"decreased":[232],"over":[233,253,391],"time,":[234],"mainly":[235,350],"comprising":[236],"lipids":[237],"(sphingolipids":[238],"phospholipids),":[240],"amino":[242],"acids":[243,362],"(AA).":[244],"MSEA":[245,365],"did":[246],"not":[247,332,367,372],"reveal":[248],"specific":[249],"metabolic":[250,289],"pathway":[251],"alterations":[252],"time.":[254,392],"from":[256,337,412],"mothers":[257,339,398],"highest":[260],"(compared":[261],"middle,":[263],"ref)":[264],"body":[265],"mass":[266],"index":[267],"(BMI)":[268],"tertile":[269],"PP":[270],"had":[271,340],"significantly":[272],"lower":[273,308,341],"pattern":[278,346,370],"(factor":[279,347],"5)":[280],"by":[282,351],"AA":[283,352,359,388],"enriched":[285],"6":[287,333],"pathways":[290],"(metabolism":[291],"glutathione,":[293],"glutamate,":[294],"alanine,":[295],"glycine":[296],"serine,":[298],"aspartate;":[300],"ammonia":[303],"recycling":[304],"pathway).":[305],"turn,":[307],"this":[311,379],"profile":[312],"greater":[316],"(\u03b2":[317],"0.22;":[319],"95%":[320],"confidence":[321],"interval:":[322],"0.00,":[323],"0.43)":[324],"weight-for-age":[326],"z-score":[327],"3":[329],"but":[331],"mo.":[334],"Additionally,":[335],"undernourished":[338],"4)":[348],"acylcarnitines":[354],"involved":[355],"branched":[357],"chain":[358],"fatty":[361],"metabolism,":[363],"although":[364],"significant.":[368],"This":[369],"was":[371],"growth.":[376],"CONCLUSIONS:":[377],"LMIC":[380],"cohort,":[381],"several":[385],"lipid":[386],"declined":[390],"Furthermore,":[393],"metabolome":[395],"high":[400],"BMI":[401],"may":[402,425],"underpin":[403],"early":[404],"weight":[405],"gain":[406],"their":[408],"infants.":[409],"More":[410],"studies":[411],"LMICs":[413],"needed":[415],"understand":[417],"nutrition-driven":[419],"composition":[423],"impact":[426],"development":[430],"guide":[432],"interventions":[433],"these":[435],"high-risk":[436],"breastfeeding":[437],"populations.":[438]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-02-07T00:00:00"}