{"id":"https://openalex.org/W7127735239","doi":"https://doi.org/10.5281/zenodo.18478530","title":"FORMULATION AND EVALUATION OF OXYMETAZOLINE AS NASAL DECONGESTANT","display_name":"FORMULATION AND EVALUATION OF OXYMETAZOLINE AS NASAL DECONGESTANT","publication_year":2026,"publication_date":"2026-02-04","ids":{"openalex":"https://openalex.org/W7127735239","doi":"https://doi.org/10.5281/zenodo.18478530"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.18478530","doi":"https://doi.org/10.5281/zenodo.18478530","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.18478530","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.18478530","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5125074520","display_name":"R. Gayathri*","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Gayathri*","raw_affiliation_strings":["B. Pharm Final Year Student, Aadhibhagawan College of Pharmacy, Rantham, Thiruvannamalai, Tamilnadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"B. Pharm Final Year Student, Aadhibhagawan College of Pharmacy, Rantham, Thiruvannamalai, Tamilnadu, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123019557","display_name":"Dr. V. Kalvimoorthi","orcid":"https://orcid.org/0009-0009-9488-7805","observed_orcids":["https://orcid.org/0009-0009-9488-7805"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dr. V. Kalvimoorthi","raw_affiliation_strings":["HOD Cum Vice Principal, Aadhibhagawan College of Pharmacy, Rantham, Thiruvannamalai, Tamilnadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HOD Cum Vice Principal, Aadhibhagawan College of Pharmacy, Rantham, Thiruvannamalai, Tamilnadu, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5123035942","display_name":"L. Gopi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Gopi","raw_affiliation_strings":["Assistant Professor, Department of Pharmaceutics, Aadhibhagawan College of Pharmacy, Rantham, Thiruvannamalai, Tamilnadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor, Department of Pharmaceutics, Aadhibhagawan College of Pharmacy, Rantham, Thiruvannamalai, Tamilnadu, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05293644,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxymetazoline-hydrochloride","display_name":"oxymetazoline hydrochloride","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nasal-spray","display_name":"nasal spray","score":0.7590000033378601},{"id":"https://openalex.org/keywords/nasal-decongestants","display_name":"nasal decongestants","score":0.9589999914169312},{"id":"https://openalex.org/keywords/intranasal-drug-delivery","display_name":"intranasal drug delivery","score":0.781000018119812},{"id":"https://openalex.org/keywords/propylene-glycol","display_name":"propylene glycol","score":0.9490000009536743},{"id":"https://openalex.org/keywords/solubilizers","display_name":"solubilizing agents","score":0.777999997138977},{"id":"https://openalex.org/keywords/nasal-congestion","display_name":"nasal congestion","score":0.7319999933242798},{"id":"https://openalex.org/keywords/spray-characteristics","display_name":"spray characteristics","score":0.5899999737739563},{"id":"https://openalex.org/keywords/droplet-size-distribution","display_name":"droplet size distribution","score":0.9900000095367432},{"id":"https://openalex.org/keywords/spray-stability","display_name":"spray stability","score":0.5830000042915344},{"id":"https://openalex.org/keywords/irritancy","display_name":"irritancy","score":0.6629999876022339},{"id":"https://openalex.org/keywords/viscosity","display_name":"viscosity","score":0.453000009059906},{"id":"https://openalex.org/keywords/drug-content","display_name":"drug content","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C2780042274","wikidata":"https://www.wikidata.org/wiki/Q417813","display_name":"Oxymetazoline","level":4,"score":0.9750000238418579},{"id":"https://openalex.org/C2910477827","wikidata":"https://www.wikidata.org/wiki/Q430719","display_name":"Nasal decongestant","level":2,"score":0.866599977016449},{"id":"https://openalex.org/C2780973058","wikidata":"https://www.wikidata.org/wiki/Q1755275","display_name":"Nasal spray","level":3,"score":0.5946000218391418},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5292999744415283},{"id":"https://openalex.org/C2778385066","wikidata":"https://www.wikidata.org/wiki/Q430719","display_name":"Decongestant","level":3,"score":0.5073999762535095},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4025000035762787},{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.3903000056743622},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.38609999418258667},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.38269999623298645},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.375},{"id":"https://openalex.org/C46821324","wikidata":"https://www.wikidata.org/wiki/Q7094540","display_name":"Onset of action","level":2,"score":0.3675000071525574},{"id":"https://openalex.org/C2778311950","wikidata":"https://www.wikidata.org/wiki/Q7363","display_name":"Nose","level":2,"score":0.3280999958515167},{"id":"https://openalex.org/C2776460385","wikidata":"https://www.wikidata.org/wiki/Q420060","display_name":"Hydrochloride","level":2,"score":0.30169999599456787},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3005000054836273},{"id":"https://openalex.org/C2778551929","wikidata":"https://www.wikidata.org/wiki/Q146339","display_name":"Polyvinyl alcohol","level":2,"score":0.2727000117301941},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.25940001010894775},{"id":"https://openalex.org/C102652120","wikidata":"https://www.wikidata.org/wiki/Q2419430","display_name":"Therapeutic effect","level":2,"score":0.25780001282691956}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.18478530","doi":"https://doi.org/10.5281/zenodo.18478530","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.18478530","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.5281/zenodo.18478531","doi":"https://doi.org/10.5281/zenodo.18478531","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.18478531","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.5281/zenodo.18478530","doi":"https://doi.org/10.5281/zenodo.18478530","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.18478530","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4452354311943054}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Nasal":[0],"drug":[1,81,100,114],"delivery":[2],"systems":[3],"offer":[4],"rapid":[5],"onset":[6],"of":[7,22,64],"action,":[8],"improved":[9],"patient":[10],"compliance,":[11],"and":[12,55,76,90,103,121,137],"localized":[13],"therapeutic":[14],"effects,":[15],"making":[16],"them":[17],"suitable":[18],"for":[19,78],"the":[20,146],"treatment":[21],"nasal":[23,38,47,59,139],"congestion.":[24],"Oxymetazoline":[25],"hydrochloride,":[26],"a":[27,36,68,134],"selective":[28],"\u03b1-adrenergic":[29],"receptor":[30],"agonist,":[31],"is":[32],"widely":[33],"used":[34],"as":[35,67,133,145],"topical":[37],"decongestant":[39],"due":[40],"to":[41,53],"its":[42],"potent":[43],"vasoconstrictive":[44],"action":[45],"on":[46],"mucosa.":[48],"The":[49,92,123],"present":[50],"study":[51],"aimed":[52],"formulate":[54],"evaluate":[56],"oxymetazoline":[57,127],"hydrochloride":[58,128],"spray":[60,84],"using":[61],"different":[62],"concentrations":[63],"propylene":[65],"glycol":[66],"solubilizing":[69],"agent.":[70],"Five":[71],"formulations":[72,93],"(F1\u2013F5)":[73],"were":[74],"prepared":[75],"evaluated":[77],"physicochemical":[79],"properties,":[80],"content,":[82,101],"viscosity,":[83,112],"characteristics,":[85],"droplet":[86,118],"size":[87,119],"distribution,":[88,120],"sterility,":[89],"irritancy.":[91],"exhibited":[94],"acceptable":[95],"pH":[96],"values":[97],"(6.9\u20137.4),":[98],"uniform":[99],"clarity,":[102],"non-irritant":[104],"behavior.":[105],"Among":[106],"all":[107],"formulations,":[108],"F5":[109,143],"showed":[110],"optimum":[111],"highest":[113],"content":[115],"(98.45%),":[116],"appropriate":[117],"stability.":[122],"results":[124],"indicate":[125],"that":[126],"can":[129],"be":[130],"effectively":[131],"formulated":[132],"stable,":[135],"safe,":[136],"efficient":[138],"decongestant,":[140],"with":[141],"formulation":[142],"identified":[144],"optimized":[147],"batch.":[148]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2026-02-06T00:00:00"}