{"id":"https://openalex.org/W7127713291","doi":"https://doi.org/10.6084/m9.figshare.31246308","title":"Additional file 5 of Calcineurin depletion coincides with phosphorylated TDP-43 deposition in a mouse model of ALS/FTLD-TDP","display_name":"Additional file 5 of Calcineurin depletion coincides with phosphorylated TDP-43 deposition in a mouse model of ALS/FTLD-TDP","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7127713291","doi":"https://doi.org/10.6084/m9.figshare.31246308"},"language":"en","primary_location":{"id":"doi:10.6084/m9.figshare.31246308","doi":"https://doi.org/10.6084/m9.figshare.31246308","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.31246308","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Image"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.6084/m9.figshare.31246308","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049317637","display_name":"Sarah M. Waldherr","orcid":"https://orcid.org/0000-0002-8873-4185","observed_orcids":["https://orcid.org/0000-0002-8873-4185"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210110523","display_name":"Geriatric Research Education and Clinical Center","ror":"https://ror.org/01nh3sx96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110523","https://openalex.org/I4210133905","https://openalex.org/I4210147340"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Waldherr, Sarah M.","raw_affiliation_strings":["University of Washington","Geriatric Research Education and Clinical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Geriatric Research Education and Clinical Center","institution_ids":["https://openalex.org/I4210110523"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067704809","display_name":"Randall J. Eck","orcid":"https://orcid.org/0000-0003-0461-7721","observed_orcids":["https://orcid.org/0000-0003-0461-7721"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eck, Randall J.","raw_affiliation_strings":["University of Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055762953","display_name":"Joshua C. Hincks","orcid":"https://orcid.org/0000-0001-7852-737X","observed_orcids":["https://orcid.org/0000-0001-7852-737X"]},"institutions":[{"id":"https://openalex.org/I4210110523","display_name":"Geriatric Research Education and Clinical Center","ror":"https://ror.org/01nh3sx96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110523","https://openalex.org/I4210133905","https://openalex.org/I4210147340"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hincks, Joshua C.","raw_affiliation_strings":["Geriatric Research Education and Clinical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geriatric Research Education and Clinical Center","institution_ids":["https://openalex.org/I4210110523"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085732376","display_name":"Heather N. Currey","orcid":"https://orcid.org/0000-0001-6428-4880","observed_orcids":["https://orcid.org/0000-0001-6428-4880"]},"institutions":[{"id":"https://openalex.org/I4210110523","display_name":"Geriatric Research Education and Clinical Center","ror":"https://ror.org/01nh3sx96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110523","https://openalex.org/I4210133905","https://openalex.org/I4210147340"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Currey, Heather N.","raw_affiliation_strings":["Geriatric Research Education and Clinical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geriatric Research Education and Clinical Center","institution_ids":["https://openalex.org/I4210110523"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113408900","display_name":"Matvey Goldberg","orcid":"https://orcid.org/0009-0004-0757-5656","observed_orcids":["https://orcid.org/0009-0004-0757-5656"]},"institutions":[{"id":"https://openalex.org/I4210110523","display_name":"Geriatric Research Education and Clinical Center","ror":"https://ror.org/01nh3sx96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110523","https://openalex.org/I4210133905","https://openalex.org/I4210147340"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Goldberg, Matvey","raw_affiliation_strings":["Geriatric Research Education and Clinical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geriatric Research Education and Clinical Center","institution_ids":["https://openalex.org/I4210110523"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040684625","display_name":"Pamela J. McMillan","orcid":"https://orcid.org/0000-0003-1243-1951","observed_orcids":["https://orcid.org/0000-0003-1243-1951"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210110523","display_name":"Geriatric Research Education and Clinical Center","ror":"https://ror.org/01nh3sx96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110523","https://openalex.org/I4210133905","https://openalex.org/I4210147340"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"McMillan, Pamela J.","raw_affiliation_strings":["University of Washington","Geriatric Research Education and Clinical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Geriatric Research Education and Clinical Center","institution_ids":["https://openalex.org/I4210110523"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051999033","display_name":"Aleen D. Saxton","orcid":"https://orcid.org/0000-0002-5055-5755","observed_orcids":["https://orcid.org/0000-0002-5055-5755"]},"institutions":[{"id":"https://openalex.org/I4210110523","display_name":"Geriatric Research Education and Clinical Center","ror":"https://ror.org/01nh3sx96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110523","https://openalex.org/I4210133905","https://openalex.org/I4210147340"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saxton, Aleen D.","raw_affiliation_strings":["Geriatric Research Education and Clinical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geriatric Research Education and Clinical Center","institution_ids":["https://openalex.org/I4210110523"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022075609","display_name":"Heino Hulsey-Vincent","orcid":"https://orcid.org/0009-0000-9806-6435","observed_orcids":["https://orcid.org/0009-0000-9806-6435"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hulsey-Vincent, Heino J.","raw_affiliation_strings":["University of Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035909512","display_name":"Caitlin S. Latimer","orcid":"https://orcid.org/0000-0003-3727-4278","observed_orcids":["https://orcid.org/0000-0003-3727-4278"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Latimer, Caitlin S.","raw_affiliation_strings":["University of Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085067820","display_name":"Brian C. Kraemer","orcid":"https://orcid.org/0000-0002-2252-7634","observed_orcids":["https://orcid.org/0000-0002-2252-7634"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210110523","display_name":"Geriatric Research Education and Clinical Center","ror":"https://ror.org/01nh3sx96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110523","https://openalex.org/I4210133905","https://openalex.org/I4210147340"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kraemer, Brian C.","raw_affiliation_strings":["University of Washington","Geriatric Research Education and Clinical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Geriatric Research Education and Clinical Center","institution_ids":["https://openalex.org/I4210110523"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072409826","display_name":"Nicole F. Liachko","orcid":"https://orcid.org/0000-0003-1250-3871","observed_orcids":["https://orcid.org/0000-0003-1250-3871"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210110523","display_name":"Geriatric Research Education and Clinical Center","ror":"https://ror.org/01nh3sx96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110523","https://openalex.org/I4210133905","https://openalex.org/I4210147340"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liachko, Nicole F.","raw_affiliation_strings":["University of Washington","Geriatric Research Education and Clinical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Geriatric Research Education and Clinical Center","institution_ids":["https://openalex.org/I4210110523"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcineurin","display_name":"calcineurin","score":0.9039999842643738},{"id":"https://openalex.org/keywords/tdp-43-phosphorylation","display_name":"TDP-43 phosphorylation","score":0.9559999704360962},{"id":"https://openalex.org/keywords/glutamatergic-neurons","display_name":"glutamatergic neurons","score":0.9419999718666077},{"id":"https://openalex.org/keywords/differential-gene-expression","display_name":"differential gene expression","score":0.8299999833106995},{"id":"https://openalex.org/keywords/gene-ontology","display_name":"Gene Ontology","score":0.8700000047683716},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.6571000218391418},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6292999982833862},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5393000245094299},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4952000081539154},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47530001401901245},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46889999508857727},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4320000112056732},{"id":"https://openalex.org/C2987395477","wikidata":"https://www.wikidata.org/wiki/Q135085","display_name":"Gene ontology","level":4,"score":0.4316999912261963},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.3953999876976013},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3752000033855438},{"id":"https://openalex.org/C64297162","wikidata":"https://www.wikidata.org/wiki/Q1987070","display_name":"Deposition (geology)","level":3,"score":0.3702000081539154},{"id":"https://openalex.org/C2779227376","wikidata":"https://www.wikidata.org/wiki/Q6505497","display_name":"Layer (electronics)","level":2,"score":0.36980000138282776},{"id":"https://openalex.org/C93226319","wikidata":"https://www.wikidata.org/wiki/Q193137","display_name":"Differential (mechanical device)","level":2,"score":0.36559998989105225},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3562000095844269},{"id":"https://openalex.org/C2780648746","wikidata":"https://www.wikidata.org/wiki/Q28208871","display_name":"Glutamatergic","level":4,"score":0.34860000014305115},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3425999879837036},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.32359999418258667},{"id":"https://openalex.org/C128057223","wikidata":"https://www.wikidata.org/wiki/Q420566","display_name":"Calcineurin","level":3,"score":0.29190000891685486},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.2897999882698059},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.26330000162124634},{"id":"https://openalex.org/C124681953","wikidata":"https://www.wikidata.org/wiki/Q339062","display_name":"Decomposition","level":2,"score":0.2606000006198883},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2565000057220459},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25209999084472656}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.6084/m9.figshare.31246308","doi":"https://doi.org/10.6084/m9.figshare.31246308","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.31246308","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Image"},{"id":"doi:10.6084/m9.figshare.31246308.v1","doi":"https://doi.org/10.6084/m9.figshare.31246308.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.31246308.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Image"}],"best_oa_location":{"id":"doi:10.6084/m9.figshare.31246308","doi":"https://doi.org/10.6084/m9.figshare.31246308","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.31246308","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Image"},"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7127594491","https://openalex.org/W7127594076","https://openalex.org/W7127651229","https://openalex.org/W7118124023","https://openalex.org/W2106000656","https://openalex.org/W4408279595","https://openalex.org/W4362523674","https://openalex.org/W4414796695","https://openalex.org/W949737134","https://openalex.org/W2497005327"],"abstract_inverted_index":{"Supplementary":[0],"Material":[1],"5.":[2],"Figure":[3],"S5:":[4],"Differential":[5,23],"gene":[6,10,24,37,51],"expression":[7,25,38],"changes":[8],"and":[9],"ontology":[11,42],"in":[12,18,26],"a":[13,32],"glutamatergic":[14],"neuron":[15],"cell":[16],"population":[17],"symptomatic":[19],"rNLS8":[20],"mouse":[21],"brain.":[22],"layer":[27],"4/5":[28],"intratelencephalically":[29],"projecting":[30],"neurons.":[31],"Volcano":[33],"plot":[34],"showing":[35],"significant":[36,50],"changes.":[39],"b":[40],"Gene":[41],"analysis":[43],"highlighting":[44],"the":[45],"most":[46],"impacted":[47],"pathways":[48],"by":[49],"upregulation":[52],"or":[53],"downregulation.":[54]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-02-06T00:00:00"}
