{"id":"https://openalex.org/W7127636624","doi":"https://doi.org/10.1007/s13105-026-01138-6","title":"Temporal changes in first-phase ejection fraction during evolution of heart failure with preserved ejection fraction and afterload-induced heart failure in mice","display_name":"Temporal changes in first-phase ejection fraction during evolution of heart failure with preserved ejection fraction and afterload-induced heart failure in mice","publication_year":2026,"publication_date":"2026-02-04","ids":{"openalex":"https://openalex.org/W7127636624","doi":"https://doi.org/10.1007/s13105-026-01138-6","pmid":"https://pubmed.ncbi.nlm.nih.gov/41637013"},"language":"en","primary_location":{"id":"doi:10.1007/s13105-026-01138-6","doi":"https://doi.org/10.1007/s13105-026-01138-6","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13105-026-01138-6","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13105-026-01138-6.pdf","source":{"id":"https://openalex.org/S68195922","display_name":"Journal of Physiology and Biochemistry","issn_l":"1138-7548","issn":["1138-7548","1877-8755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","latindex","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Physiology and Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s13105-026-01138-6.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103060733","display_name":"Haotian Gu","orcid":"https://orcid.org/0000-0003-3270-4347","observed_orcids":["https://orcid.org/0000-0003-3270-4347"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Haotian Gu","raw_affiliation_strings":["School of Cardiovascular and Metabolic Medicine & Sciences, King's College London BHF Centre of Research Excellence, 125 Coldharbour Lane, London, SE5 9NU, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Cardiovascular and Metabolic Medicine & Sciences, King's College London BHF Centre of Research Excellence, 125 Coldharbour Lane, London, SE5 9NU, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059209039","display_name":"Norman Catibog","orcid":"https://orcid.org/0000-0002-4482-084X","observed_orcids":["https://orcid.org/0000-0002-4482-084X"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Norman Catibog","raw_affiliation_strings":["School of Cardiovascular and Metabolic Medicine & Sciences, King's College London BHF Centre of Research Excellence, 125 Coldharbour Lane, London, SE5 9NU, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Cardiovascular and Metabolic Medicine & Sciences, King's College London BHF Centre of Research Excellence, 125 Coldharbour Lane, London, SE5 9NU, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101972014","display_name":"Yue Zhao","orcid":"https://orcid.org/0000-0002-6818-2352","observed_orcids":["https://orcid.org/0000-0002-6818-2352"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yue Zhao","raw_affiliation_strings":["School of Cardiovascular and Metabolic Medicine & Sciences, King's College London BHF Centre of Research Excellence, 125 Coldharbour Lane, London, SE5 9NU, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Cardiovascular and Metabolic Medicine & Sciences, King's College London BHF Centre of Research Excellence, 125 Coldharbour Lane, London, SE5 9NU, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108082826","display_name":"Asjad Visnagri","orcid":"https://orcid.org/0000-0003-0191-2629","observed_orcids":["https://orcid.org/0000-0003-0191-2629"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Asjad Visnagri","raw_affiliation_strings":["School of Cardiovascular and Metabolic Medicine & Sciences, King's College London BHF Centre of Research Excellence, 125 Coldharbour Lane, London, SE5 9NU, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Cardiovascular and Metabolic Medicine & Sciences, King's College London BHF Centre of Research Excellence, 125 Coldharbour Lane, London, SE5 9NU, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134352878","display_name":"Phil J. Chowienczyk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Philip J. Chowienczyk","raw_affiliation_strings":["School of Cardiovascular and Metabolic Medicine & Sciences, King's College London BHF Centre of Research Excellence, 125 Coldharbour Lane, London, SE5 9NU, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Cardiovascular and Metabolic Medicine & Sciences, King's College London BHF Centre of Research Excellence, 125 Coldharbour Lane, London, SE5 9NU, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081626253","display_name":"Ajay M. Shah","orcid":"https://orcid.org/0000-0002-6547-0631","observed_orcids":["https://orcid.org/0000-0002-6547-0631","https://orcid.org/0000-0002-2825-3419"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Ajay M. Shah","raw_affiliation_strings":["School of Cardiovascular and Metabolic Medicine & Sciences, King's College London BHF Centre of Research Excellence, 125 Coldharbour Lane, London, SE5 9NU, UK. ajay.shah@kcl.ac.uk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Cardiovascular and Metabolic Medicine & Sciences, King's College London BHF Centre of Research Excellence, 125 Coldharbour Lane, London, SE5 9NU, UK. ajay.shah@kcl.ac.uk","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100402981","display_name":"Min Zhang","orcid":"https://orcid.org/0000-0003-1657-1337","observed_orcids":["https://orcid.org/0000-0003-1657-1337"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Min Zhang","raw_affiliation_strings":["School of Cardiovascular and Metabolic Medicine & Sciences, King's College London BHF Centre of Research Excellence, 125 Coldharbour Lane, London, SE5 9NU, UK. min.zhang@kcl.ac.uk"],"raw_orcid":"https://orcid.org/0000-0003-1657-1337","affiliations":[{"raw_affiliation_string":"School of Cardiovascular and Metabolic Medicine & Sciences, King's College London BHF Centre of Research Excellence, 125 Coldharbour Lane, London, SE5 9NU, UK. min.zhang@kcl.ac.uk","institution_ids":["https://openalex.org/I183935753"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5081626253","https://openalex.org/A5100402981"],"corresponding_institution_ids":["https://openalex.org/I183935753"],"apc_list":{"value":4490,"currency":"USD","value_usd":4490},"apc_paid":{"value":4490,"currency":"USD","value_usd":4490},"fwci":4.6669,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.90214391,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"82","issue":"1","first_page":"7","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-failure-with-preserved-ejection-fraction","display_name":"heart failure with preserved ejection fraction","score":0.9990000128746033},{"id":"https://openalex.org/keywords/systolic-dysfunction","display_name":"systolic dysfunction","score":0.824999988079071},{"id":"https://openalex.org/keywords/diastolic-dysfunction","display_name":"diastolic dysfunction","score":0.9980000257492065},{"id":"https://openalex.org/keywords/abdominal-aortic-banding","display_name":"abdominal aortic banding","score":0.9879999756813049},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.871999979019165},{"id":"https://openalex.org/keywords/high-fat-feeding","display_name":"high-fat feeding","score":0.7459999918937683},{"id":"https://openalex.org/keywords/isovolumic-relaxation-time","display_name":"isovolumic relaxation time","score":0.9279999732971191},{"id":"https://openalex.org/keywords/global-longitudinal-strain","display_name":"global longitudinal strain","score":0.9269999861717224},{"id":"https://openalex.org/keywords/left-atrial-enlargement","display_name":"left atrial enlargement","score":0.8320000171661377},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C2777099384","wikidata":"https://www.wikidata.org/wiki/Q3799239","display_name":"Heart failure with preserved ejection fraction","level":4,"score":0.8712000250816345},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8296999931335449},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.8126999735832214},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7843999862670898},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.7425000071525574},{"id":"https://openalex.org/C2779868719","wikidata":"https://www.wikidata.org/wiki/Q6086610","display_name":"Isovolumic relaxation time","level":5,"score":0.6513000130653381},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.6430000066757202},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.633400022983551},{"id":"https://openalex.org/C2779781611","wikidata":"https://www.wikidata.org/wiki/Q3799239","display_name":"Diastolic heart failure","level":4,"score":0.45559999346733093},{"id":"https://openalex.org/C2780829959","wikidata":"https://www.wikidata.org/wiki/Q30314111","display_name":"Diastolic function","level":4,"score":0.4187999963760376},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.3781999945640564},{"id":"https://openalex.org/C169554166","wikidata":"https://www.wikidata.org/wiki/Q496359","display_name":"Systole","level":4,"score":0.35429999232292175},{"id":"https://openalex.org/C80461066","wikidata":"https://www.wikidata.org/wiki/Q1698533","display_name":"Stroke volume","level":4,"score":0.34139999747276306},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.2549000084400177}],"mesh":[{"descriptor_ui":"D000094582","descriptor_name":"Global Longitudinal Strain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000094582","descriptor_name":"Global Longitudinal Strain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000094582","descriptor_name":"Global Longitudinal Strain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000094582","descriptor_name":"Global Longitudinal Strain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003971","descriptor_name":"Diastole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003971","descriptor_name":"Diastole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003971","descriptor_name":"Diastole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003971","descriptor_name":"Diastole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003971","descriptor_name":"Diastole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003971","descriptor_name":"Diastole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003971","descriptor_name":"Diastole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004452","descriptor_name":"Echocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004452","descriptor_name":"Echocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004452","descriptor_name":"Echocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004452","descriptor_name":"Echocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004452","descriptor_name":"Echocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004452","descriptor_name":"Echocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004452","descriptor_name":"Echocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013599","descriptor_name":"Systole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013599","descriptor_name":"Systole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013599","descriptor_name":"Systole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013599","descriptor_name":"Systole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013599","descriptor_name":"Systole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013599","descriptor_name":"Systole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013599","descriptor_name":"Systole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1007/s13105-026-01138-6","doi":"https://doi.org/10.1007/s13105-026-01138-6","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13105-026-01138-6","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13105-026-01138-6.pdf","source":{"id":"https://openalex.org/S68195922","display_name":"Journal of Physiology and Biochemistry","issn_l":"1138-7548","issn":["1138-7548","1877-8755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","latindex","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Physiology and Biochemistry","raw_type":"journal-article"},{"id":"pmid:41637013","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41637013","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11680379","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12872729","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:kclpure.kcl.ac.uk:openaire/72d51bed-2bae-4df7-9b2c-7b55117512f8","doi":null,"is_oa":true,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/72d51bed-2bae-4df7-9b2c-7b55117512f8","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Gu, H, Catibog, N, Zhao, Y, Visnagri, A, Chowienczyk, P J, Shah, A M & Zhang, M 2026, 'Temporal changes in first-phase ejection fraction during evolution of heart failure with preserved ejection fraction and afterload-induced heart failure in mice', JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, vol. 82, 7. https://doi.org/10.1007/s13105-026-01138-6","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12872729","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12872729/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Physiol Biochem","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s13105-026-01138-6","doi":"https://doi.org/10.1007/s13105-026-01138-6","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13105-026-01138-6","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13105-026-01138-6.pdf","source":{"id":"https://openalex.org/S68195922","display_name":"Journal of Physiology and Biochemistry","issn_l":"1138-7548","issn":["1138-7548","1877-8755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","latindex","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Physiology and Biochemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7769401669502258}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4476985772","display_name":"","funder_award_id":"RE/24/130035","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G5879088678","display_name":"NADPH oxidase-2 activation as a pathogenic mechanism and potential therapeutic target in heart failure with preserved ejection fraction","funder_award_id":"PG/22/11055","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G5892252018","display_name":null,"funder_award_id":"CH/1999001/11735","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G5896616042","display_name":null,"funder_award_id":"CH/1999001/11735","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"}],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7127636624.pdf","grobid_xml":"https://content.openalex.org/works/W7127636624.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W896549154","https://openalex.org/W2006698518","https://openalex.org/W2016254275","https://openalex.org/W2021328476","https://openalex.org/W2040622954","https://openalex.org/W2056547068","https://openalex.org/W2118262627","https://openalex.org/W2123302959","https://openalex.org/W2128916765","https://openalex.org/W2146624681","https://openalex.org/W2191896778","https://openalex.org/W2590732834","https://openalex.org/W2763231015","https://openalex.org/W2767058951","https://openalex.org/W2781007923","https://openalex.org/W2901908006","https://openalex.org/W2950275058","https://openalex.org/W2997118474","https://openalex.org/W3017780160","https://openalex.org/W3144555346","https://openalex.org/W3166734244","https://openalex.org/W3198557753","https://openalex.org/W4225536357","https://openalex.org/W4317743470","https://openalex.org/W4389110240","https://openalex.org/W4391919704"],"related_works":[],"abstract_inverted_index":{"The":[0],"interplay":[1,233],"between":[2,234],"systolic":[3,27,212,235],"and":[4,37,53,63,68,105,118,167,189,218,236],"diastolic":[5,138,237],"dysfunction":[6,238],"in":[7,30,34,45,48,184,196,216,239],"heart":[8],"failure":[9],"with":[10,96],"preserved":[11],"ejection":[12,19],"fraction":[13,20],"(HFpEF)":[14],"progression":[15],"is":[16],"unclear.":[17],"First-phase":[18],"(EF1),":[21],"a":[22,181],"sensitive":[23],"marker":[24,210],"of":[25,51,58,137,211],"early":[26,195,209,215],"function,":[28],"aids":[29],"assessing":[31],"systolic-diastolic":[32],"relationships":[33,47],"human":[35],"hypertension":[36,67],"aortic":[38,60],"stenosis.":[39],"This":[40],"study":[41],"examines":[42],"temporal":[43],"changes":[44],"these":[46],"mouse":[49],"models":[50,57],"HFpEF":[52,64,145,198,217,240],"elevated":[54],"afterload.":[55],"Mouse":[56],"abdominal":[59],"banding":[61],"(AAB)":[62],"(induced":[65],"by":[66,201,222],"high":[69],"fat":[70],"feeding)":[71],"underwent":[72],"comprehensive":[73],"serial":[74],"echocardiography.":[75],"In":[76,143],"AAB,":[77],"EF1":[78,147,174],"significantly":[79,148],"decreased":[80,149,175],"at":[81,99,140,150],"week":[82,100,106,126,141,151,172],"1":[83],"post-surgery":[84],"(18.8":[85],"\u00b1":[86,90,103,109,154,158,178],"1.2":[87],"vs":[88,156],"24.3":[89],"0.8%,":[91],"p<0.001)":[92,160],"compared":[93,161],"to":[94,162],"controls,":[95,163],"further":[97,176],"reduction":[98,183],"3":[101],"(16.8":[102],"0.6%)":[104],"6":[107],"(13.9":[108],"0.9%,":[110],"both":[111],"p<0.001).":[112],"EF,":[113,165],"global":[114],"longitudinal":[115,119],"strain":[116,120],"(GLS)":[117],"rate":[121],"(LSR)":[122],"remained":[123,191],"unchanged":[124],"until":[125],"3.":[127],"Isovolumic":[128],"relaxation":[129],"time":[130],"(IVRT)":[131],"was":[132],"the":[133,144,197,232],"only":[134],"abnormal":[135],"index":[136],"function":[139],"1.":[142],"model,":[146,199],"2":[152],"(19.1":[153],"1.1":[155],"25.8":[157],"1.0%,":[159],"while":[164,187],"GLS,":[166],"LSR":[168,190],"were":[169],"unaltered.":[170],"At":[171],"3,":[173],"(18.1":[177],"0.7%)":[179],"alongside":[180],"significant":[182],"GLS":[185],"(p<0.01),":[186],"EF":[188],"unchanged.":[192],"IVRT":[193,223],"increased":[194],"followed":[200],"later":[202],"left":[203],"atrial":[204],"(LA)":[205],"enlargement.":[206],"EF1,":[207],"an":[208],"impairment,":[213],"decreases":[214],"afterload-induced":[219],"dysfunction,":[220],"accompanied":[221],"prolongation.":[224],"LA":[225],"dilatation":[226],"appears":[227],"later.":[228],"These":[229],"findings":[230],"highlight":[231],"progression.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-02-06T00:00:00"}
