{"id":"https://openalex.org/W7127635668","doi":"https://doi.org/10.1128/jcm.01510-25","title":"Leveraging patient data to detect systematic shifts in daptomycin susceptibility testing associated with reduced prescribing","display_name":"Leveraging patient data to detect systematic shifts in daptomycin susceptibility testing associated with reduced prescribing","publication_year":2026,"publication_date":"2026-02-04","ids":{"openalex":"https://openalex.org/W7127635668","doi":"https://doi.org/10.1128/jcm.01510-25","pmid":"https://pubmed.ncbi.nlm.nih.gov/41636497"},"language":"en","primary_location":{"id":"doi:10.1128/jcm.01510-25","doi":"https://doi.org/10.1128/jcm.01510-25","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jcm.01510-25","pdf_url":"https://journals.asm.org/doi/pdf/10.1128/jcm.01510-25?download=true","source":{"id":"https://openalex.org/S53087977","display_name":"Journal of Clinical Microbiology","issn_l":"0095-1137","issn":["0095-1137","1070-633X","1098-660X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://journals.asm.org/doi/pdf/10.1128/jcm.01510-25?download=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082399394","display_name":"Mark A. Zaydman","orcid":"https://orcid.org/0000-0002-4236-1459","observed_orcids":["https://orcid.org/0000-0002-4236-1459"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark A. Zaydman","raw_affiliation_strings":["Department of Pathology & Immunology, Washington University School of Medicine"],"raw_orcid":"https://orcid.org/0000-0002-4236-1459","affiliations":[{"raw_affiliation_string":"Department of Pathology & Immunology, Washington University School of Medicine","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012558440","display_name":"Laurel\u00a0J. Glaser","orcid":"https://orcid.org/0000-0001-8463-5107","observed_orcids":["https://orcid.org/0000-0001-8463-5107"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurel Glaser","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Daniel S. Herman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel S. Herman","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125024247","display_name":"Mason Kressloff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mason Kressloff","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101565245","display_name":"Vahid Azimi","orcid":"https://orcid.org/0000-0003-3875-8012","observed_orcids":["https://orcid.org/0000-0003-3875-8012"]},"institutions":[{"id":"https://openalex.org/I2800769186","display_name":"Alameda Health System","ror":"https://ror.org/04hcg0q34","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800769186"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vahid Azimi","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, Alameda Health System"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Alameda Health System","institution_ids":["https://openalex.org/I2800769186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093898173","display_name":"Christine R Lockowitz","orcid":"https://orcid.org/0000-0002-5881-2752","observed_orcids":["https://orcid.org/0000-0002-5881-2752"]},"institutions":[{"id":"https://openalex.org/I1324021844","display_name":"St. Louis Children's Hospital","ror":"https://ror.org/00qw1qw03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324021844","https://openalex.org/I1328499231"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine R. Lockowitz","raw_affiliation_strings":["Department of Pharmacy, St. Louis Children\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, St. Louis Children\u2019s Hospital","institution_ids":["https://openalex.org/I1324021844"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019339569","display_name":"Rebekah E. Dumm","orcid":"https://orcid.org/0000-0003-3139-3153","observed_orcids":["https://orcid.org/0000-0003-3139-3153"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebekah E. Dumm","raw_affiliation_strings":["Department of Pathology & Immunology, Washington University School of Medicine"],"raw_orcid":"https://orcid.org/0000-0003-3139-3153","affiliations":[{"raw_affiliation_string":"Department of Pathology & Immunology, Washington University School of Medicine","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07379202,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"64","issue":"3","first_page":"e0151025","last_page":"e0151025"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12167","display_name":"Bacterial Identification and Susceptibility Testing","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12167","display_name":"Bacterial Identification and Susceptibility Testing","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.013000000268220901,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/daptomycin","display_name":"daptomycin","score":0.9490000009536743},{"id":"https://openalex.org/keywords/antimicrobial-susceptibility-testing","display_name":"antimicrobial susceptibility testing","score":0.9950000047683716},{"id":"https://openalex.org/keywords/quality-control","display_name":"quality control","score":0.7170000076293945},{"id":"https://openalex.org/keywords/technical-variation","display_name":"technical variability","score":0.722000002861023},{"id":"https://openalex.org/keywords/enterococcus-faecium","display_name":"Enterococcus faecium","score":0.859000027179718},{"id":"https://openalex.org/keywords/antimicrobial-resistance","display_name":"antimicrobial resistance","score":0.7250000238418579},{"id":"https://openalex.org/keywords/antimicrobial-prescribing","display_name":"antimicrobial prescribing","score":0.8429999947547913},{"id":"https://openalex.org/keywords/gradient-diffusion","display_name":"gradient diffusion","score":0.6909999847412109},{"id":"https://openalex.org/keywords/patient-data-analysis","display_name":"patient data analysis","score":0.6549999713897705},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.824999988079071},{"id":"https://openalex.org/keywords/quality-assurance","display_name":"quality assurance","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C2778651397","wikidata":"https://www.wikidata.org/wiki/Q418747","display_name":"Daptomycin","level":5,"score":0.7736999988555908},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7601000070571899},{"id":"https://openalex.org/C106436119","wikidata":"https://www.wikidata.org/wiki/Q836575","display_name":"Quality assurance","level":3,"score":0.6093999743461609},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5120999813079834},{"id":"https://openalex.org/C2776040555","wikidata":"https://www.wikidata.org/wiki/Q19903321","display_name":"Antimicrobial stewardship","level":4,"score":0.49000000953674316},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3228999972343445},{"id":"https://openalex.org/C3018822202","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Patient data","level":2,"score":0.32190001010894775},{"id":"https://openalex.org/C24756922","wikidata":"https://www.wikidata.org/wiki/Q1757694","display_name":"Data quality","level":3,"score":0.32179999351501465},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.30809998512268066},{"id":"https://openalex.org/C2779530757","wikidata":"https://www.wikidata.org/wiki/Q1207505","display_name":"Quality (philosophy)","level":2,"score":0.30410000681877136},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3018999993801117},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.29420000314712524},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.28349998593330383},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2752000093460083},{"id":"https://openalex.org/C2779328685","wikidata":"https://www.wikidata.org/wiki/Q1475557","display_name":"Patient safety","level":3,"score":0.26589998602867126},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.2540999948978424}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D011307","descriptor_name":"Drug Prescriptions","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D011307","descriptor_name":"Drug Prescriptions","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D011307","descriptor_name":"Drug Prescriptions","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D011307","descriptor_name":"Drug Prescriptions","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D011307","descriptor_name":"Drug Prescriptions","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D011786","descriptor_name":"Quality Control","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011786","descriptor_name":"Quality Control","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011786","descriptor_name":"Quality Control","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011786","descriptor_name":"Quality Control","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011786","descriptor_name":"Quality Control","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011786","descriptor_name":"Quality Control","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011786","descriptor_name":"Quality Control","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011786","descriptor_name":"Quality Control","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016984","descriptor_name":"Enterococcus faecium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016984","descriptor_name":"Enterococcus faecium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016984","descriptor_name":"Enterococcus faecium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016984","descriptor_name":"Enterococcus faecium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016984","descriptor_name":"Enterococcus faecium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016984","descriptor_name":"Enterococcus faecium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016984","descriptor_name":"Enterococcus faecium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016984","descriptor_name":"Enterococcus faecium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017576","descriptor_name":"Daptomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017576","descriptor_name":"Daptomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017576","descriptor_name":"Daptomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017576","descriptor_name":"Daptomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017576","descriptor_name":"Daptomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017576","descriptor_name":"Daptomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017576","descriptor_name":"Daptomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017576","descriptor_name":"Daptomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017576","descriptor_name":"Daptomycin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017576","descriptor_name":"Daptomycin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017576","descriptor_name":"Daptomycin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017576","descriptor_name":"Daptomycin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017576","descriptor_name":"Daptomycin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017576","descriptor_name":"Daptomycin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017576","descriptor_name":"Daptomycin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017576","descriptor_name":"Daptomycin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1128/jcm.01510-25","doi":"https://doi.org/10.1128/jcm.01510-25","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jcm.01510-25","pdf_url":"https://journals.asm.org/doi/pdf/10.1128/jcm.01510-25?download=true","source":{"id":"https://openalex.org/S53087977","display_name":"Journal of Clinical Microbiology","issn_l":"0095-1137","issn":["0095-1137","1070-633X","1098-660X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Microbiology","raw_type":"journal-article"},{"id":"pmid:41636497","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41636497","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.wustl.edu:oa_4-7737","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wustl.edu/oa_4/6744","pdf_url":"https://digitalcommons.wustl.edu/cgi/viewcontent.cgi?article=7737&context=oa_4","source":{"id":"https://openalex.org/S4306400764","display_name":"Digital Commons@Becker (Washington University School of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2020-Current year OA Pubs","raw_type":"text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12977467","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12977467/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12977467/pdf/jcm.01510-25.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Clin Microbiol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:3358f8c508ca4444bc38a0f77b24f7a5","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3358f8c508ca4444bc38a0f77b24f7a5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical Microbiology, Vol 64, Iss 3 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1128/jcm.01510-25","doi":"https://doi.org/10.1128/jcm.01510-25","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jcm.01510-25","pdf_url":"https://journals.asm.org/doi/pdf/10.1128/jcm.01510-25?download=true","source":{"id":"https://openalex.org/S53087977","display_name":"Journal of Clinical Microbiology","issn_l":"0095-1137","issn":["0095-1137","1070-633X","1098-660X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7127635668.pdf","grobid_xml":"https://content.openalex.org/works/W7127635668.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W2021676863","https://openalex.org/W2022320315","https://openalex.org/W2065561172","https://openalex.org/W2084251527","https://openalex.org/W2091154552","https://openalex.org/W2108433768","https://openalex.org/W2109684694","https://openalex.org/W2110980415","https://openalex.org/W2122986771","https://openalex.org/W2166433876","https://openalex.org/W2194639874","https://openalex.org/W2784087577","https://openalex.org/W2809959622","https://openalex.org/W3041660580","https://openalex.org/W3199730003","https://openalex.org/W4289521685"],"related_works":[],"abstract_inverted_index":{"ABSTRACT":[0],"Systemic":[1],"shifts":[2,12,19,270],"in":[3,13,24,33,57,69,77,80,111,136,142,193,257,271],"antimicrobial":[4,25,34,246],"resistance":[5,137,256],"rates":[6,114,138],"can":[7],"be":[8],"due":[9],"to":[10,31,107,174,184,228,243,265,269],"epidemiologic":[11],"microbial":[14],"susceptibility":[15,26,113,247,260],"patterns":[16],"or":[17],"artifactual":[18],"introduced":[20],"by":[21,48],"technical":[22,38,206],"biases":[23],"testing":[27,248,261],"(AST)\u2014both":[28],"ultimately":[29],"leading":[30],"changes":[32,192],"prescribing.":[35],"To":[36],"reduce":[37],"variability,":[39],"quality":[40,218,240],"control":[41,219],"(QC)":[42],"criteria":[43],"for":[44,115,130,145],"AST":[45,71,90,194],"are":[46,59,263],"published":[47],"manufacturers":[49],"and":[50,75,92,159,267],"standards":[51],"organizations.":[52],"However,":[53],"traditional":[54],"QC":[55,96,157,182],"metrics,":[56],"isolation,":[58],"fallible.":[60],"In":[61,197],"this":[62,99,134,151,198,223],"study,":[63,199],"we":[64,200],"describe":[65],"a":[66,102,108,126,140,202,238],"systematic":[67,164],"shift":[68,104],"daptomycin":[70,124,144,209],"results":[72,91,262],"between":[73],"2022":[74],"2025":[76],"isolates":[78],"tested":[79],"two":[81],"independent":[82],"health":[83],"systems.":[84],"Comprehensive":[85],"analysis":[86,179],"of":[87,95,166,187,205,254],"clinical":[88,234],"isolate":[89],"retrospective":[93],"mining":[94],"data":[97,178],"from":[98],"period":[100],"revealed":[101],"subtle":[103,188],"that":[105,213],"led":[106],"5%\u201322%":[109],"decrease":[110,141],"overall":[112],"certain":[116],"organisms,":[117],"most":[118],"notably":[119],"Enterococcus":[120],"faecium":[121],".":[122],"As":[123],"is":[125],"key":[127],"treatment":[128],"option":[129],"these":[131,148],"difficult-to-treat":[132],"infections,":[133],"increase":[135],"paralleled":[139],"prescribing":[143],"infections":[146],"with":[147],"organisms.":[149],"Importantly,":[150],"trend":[152],"was":[153,214],"undetectable":[154,215],"through":[155,163],"routine":[156,176,217],"processes":[158],"only":[160],"became":[161],"apparent":[162],"review":[165],"patient":[167,177,235],"data.":[168],"Our":[169],"findings":[170],"highlight":[171],"the":[172,226,251],"opportunity":[173,227],"integrate":[175],"into":[180,237],"microbiology":[181],"practices":[183],"enhance":[185],"detection":[186],"but":[189],"clinically":[190],"relevant":[191],"performance.":[195],"IMPORTANCE":[196],"report":[201],"critical":[203,264],"incident":[204],"variability":[207],"using":[208,216],"gradient":[210],"diffusion":[211],"methodology":[212],"metrics.":[220],"More":[221],"broadly,":[222],"study":[224],"underscores":[225],"incorporate":[229],"additional":[230],"modalities,":[231],"such":[232],"as":[233],"results,":[236],"comprehensive":[239],"assurance":[241],"plan":[242],"ensure":[244],"high-quality":[245],"results.":[249],"Given":[250],"dynamic":[252],"spread":[253],"multidrug":[255],"bacteria,":[258],"accurate":[259],"identify":[266],"respond":[268],"local":[272],"epidemiology.":[273]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2026-02-06T00:00:00"}