{"id":"https://openalex.org/W7127586885","doi":"https://doi.org/10.1021/acs.analchem.5c06799","title":"Intracellular Oxygen Sensing Using Long-Phosphorescence-Lifetime Cationic Ir(III) Complexes With Coumarin 6 and 545T Ligands","display_name":"Intracellular Oxygen Sensing Using Long-Phosphorescence-Lifetime Cationic Ir(III) Complexes With Coumarin 6 and 545T Ligands","publication_year":2026,"publication_date":"2026-02-04","ids":{"openalex":"https://openalex.org/W7127586885","doi":"https://doi.org/10.1021/acs.analchem.5c06799","pmid":"https://pubmed.ncbi.nlm.nih.gov/41635959"},"language":"en","primary_location":{"id":"doi:10.1021/acs.analchem.5c06799","doi":"https://doi.org/10.1021/acs.analchem.5c06799","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.analchem.5c06799","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093330757","display_name":"Aoi Horikoshi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Aoi Horikoshi","raw_affiliation_strings":["Department of Chemistry, Graduate School of Science and Technology, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Graduate School of Science and Technology, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124985793","display_name":"Tatsuya Hirose","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuya Hirose","raw_affiliation_strings":["Department of Chemistry, Graduate School of Science and Technology, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Graduate School of Science and Technology, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089570133","display_name":"Shuichi Shiozaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuichi Shiozaki","raw_affiliation_strings":["Department of Chemistry, Graduate School of Science and Technology, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Graduate School of Science and Technology, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069986511","display_name":"Toshitada Yoshihara","orcid":"https://orcid.org/0000-0002-7960-0740","observed_orcids":["https://orcid.org/0000-0002-7960-0740"]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Toshitada Yoshihara","raw_affiliation_strings":["Department of Chemistry, Graduate School of Science and Technology, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan"],"raw_orcid":"https://orcid.org/0000-0002-7960-0740","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Graduate School of Science and Technology, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan","institution_ids":["https://openalex.org/I165735259"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5069986511"],"corresponding_institution_ids":["https://openalex.org/I165735259"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.6013,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.76605934,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"98","issue":"6","first_page":"4823","last_page":"4833"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10532","display_name":"Molecular Sensors and Ion Detection","score":0.8687000274658203,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10532","display_name":"Molecular Sensors and Ion Detection","score":0.8687000274658203,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11240","display_name":"Luminescence and Fluorescent Materials","score":0.0940999984741211,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11472","display_name":"Analytical Chemistry and Sensors","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/1502","display_name":"Bioengineering"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coumarin-6","display_name":"coumarin 6","score":0.9340000152587891},{"id":"https://openalex.org/keywords/phosphorescence-lifetime","display_name":"phosphorescence lifetime","score":0.7210000157356262},{"id":"https://openalex.org/keywords/oxygen-sensors","display_name":"oxygen sensors","score":0.7900000214576721},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.656000018119812},{"id":"https://openalex.org/keywords/time-resolved-emission","display_name":"time-resolved emission","score":0.6570000052452087},{"id":"https://openalex.org/keywords/cellular-uptake","display_name":"cellular uptake","score":0.4300000071525574},{"id":"https://openalex.org/keywords/metabolic-stimulation","display_name":"metabolic stimulation","score":0.5070000290870667}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9315000176429749},{"id":"https://openalex.org/C181817918","wikidata":"https://www.wikidata.org/wiki/Q192275","display_name":"Phosphorescence","level":3,"score":0.7921000123023987},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.7470999956130981},{"id":"https://openalex.org/C2781338262","wikidata":"https://www.wikidata.org/wiki/Q111812","display_name":"Coumarin","level":2,"score":0.6632999777793884},{"id":"https://openalex.org/C183882617","wikidata":"https://www.wikidata.org/wiki/Q3046749","display_name":"Cationic polymerization","level":2,"score":0.663100004196167},{"id":"https://openalex.org/C2777516457","wikidata":"https://www.wikidata.org/wiki/Q2413613","display_name":"Singlet oxygen","level":3,"score":0.5899999737739563},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.5889999866485596},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.5509999990463257},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5228999853134155},{"id":"https://openalex.org/C171001562","wikidata":"https://www.wikidata.org/wiki/Q2856048","display_name":"Quantum yield","level":3,"score":0.4584999978542328},{"id":"https://openalex.org/C169274487","wikidata":"https://www.wikidata.org/wiki/Q840211","display_name":"Fluorescence microscope","level":3,"score":0.4214000105857849},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.38690000772476196},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.38280001282691956},{"id":"https://openalex.org/C134897140","wikidata":"https://www.wikidata.org/wiki/Q6058355","display_name":"Intracellular pH","level":3,"score":0.37709999084472656},{"id":"https://openalex.org/C119824511","wikidata":"https://www.wikidata.org/wiki/Q13553575","display_name":"Absorption spectroscopy","level":2,"score":0.3357999920845032},{"id":"https://openalex.org/C148869448","wikidata":"https://www.wikidata.org/wiki/Q184240","display_name":"Luminescence","level":2,"score":0.3203999996185303},{"id":"https://openalex.org/C57477423","wikidata":"https://www.wikidata.org/wiki/Q1434196","display_name":"Fluorescence-lifetime imaging microscopy","level":3,"score":0.31619998812675476},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.3086000084877014},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.3077999949455261},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3070000112056732},{"id":"https://openalex.org/C33062035","wikidata":"https://www.wikidata.org/wiki/Q3296863","display_name":"Singlet state","level":3,"score":0.2903999984264374},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.289000004529953},{"id":"https://openalex.org/C2776892249","wikidata":"https://www.wikidata.org/wiki/Q2324668","display_name":"Formazan","level":2,"score":0.28630000352859497},{"id":"https://openalex.org/C15526883","wikidata":"https://www.wikidata.org/wiki/Q6657126","display_name":"Live cell imaging","level":3,"score":0.2818000018596649},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.26980000734329224},{"id":"https://openalex.org/C67649825","wikidata":"https://www.wikidata.org/wiki/Q196538","display_name":"Microscope","level":2,"score":0.2669000029563904},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.257999986410141},{"id":"https://openalex.org/C2910654035","wikidata":"https://www.wikidata.org/wiki/Q1259242","display_name":"Intracellular Fluid","level":3,"score":0.25609999895095825},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.25110000371932983}],"mesh":[{"descriptor_ui":"D000098984","descriptor_name":"Fluorescent Chemosensor Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098984","descriptor_name":"Fluorescent Chemosensor Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098984","descriptor_name":"Fluorescent Chemosensor Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098984","descriptor_name":"Fluorescent Chemosensor Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098984","descriptor_name":"Fluorescent Chemosensor Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002412","descriptor_name":"Cations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002412","descriptor_name":"Cations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002412","descriptor_name":"Cations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002412","descriptor_name":"Cations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002412","descriptor_name":"Cations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002412","descriptor_name":"Cations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002412","descriptor_name":"Cations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003374","descriptor_name":"Coumarins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003374","descriptor_name":"Coumarins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003374","descriptor_name":"Coumarins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003374","descriptor_name":"Coumarins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003374","descriptor_name":"Coumarins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003374","descriptor_name":"Coumarins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003374","descriptor_name":"Coumarins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007495","descriptor_name":"Iridium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007495","descriptor_name":"Iridium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007495","descriptor_name":"Iridium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007495","descriptor_name":"Iridium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007495","descriptor_name":"Iridium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007495","descriptor_name":"Iridium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007495","descriptor_name":"Iridium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008163","descriptor_name":"Luminescent Measurements","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008163","descriptor_name":"Luminescent Measurements","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008163","descriptor_name":"Luminescent Measurements","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008163","descriptor_name":"Luminescent Measurements","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008163","descriptor_name":"Luminescent Measurements","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008163","descriptor_name":"Luminescent Measurements","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008163","descriptor_name":"Luminescent Measurements","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D056831","descriptor_name":"Coordination Complexes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D056831","descriptor_name":"Coordination Complexes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D056831","descriptor_name":"Coordination Complexes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D056831","descriptor_name":"Coordination Complexes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D056831","descriptor_name":"Coordination Complexes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D056831","descriptor_name":"Coordination Complexes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D056831","descriptor_name":"Coordination Complexes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D056831","descriptor_name":"Coordination Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D056831","descriptor_name":"Coordination Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D056831","descriptor_name":"Coordination Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D056831","descriptor_name":"Coordination Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D056831","descriptor_name":"Coordination Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D056831","descriptor_name":"Coordination Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D056831","descriptor_name":"Coordination Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.analchem.5c06799","doi":"https://doi.org/10.1021/acs.analchem.5c06799","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.analchem.5c06799","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"pmid:41635959","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41635959","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G78592732","display_name":null,"funder_award_id":"JPMJTR23U8","funder_id":"https://openalex.org/F4320338117","funder_display_name":"Adaptable and Seamless Technology Transfer Program through Target-Driven R and D"}],"funders":[{"id":"https://openalex.org/F4320338117","display_name":"Adaptable and Seamless Technology Transfer Program through Target-Driven R and D","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1965612889","https://openalex.org/W1999444078","https://openalex.org/W2001443197","https://openalex.org/W2007627271","https://openalex.org/W2042812106","https://openalex.org/W2050023299","https://openalex.org/W2054415154","https://openalex.org/W2063529107","https://openalex.org/W2085058795","https://openalex.org/W2087377825","https://openalex.org/W2088789349","https://openalex.org/W2095979443","https://openalex.org/W2097172537","https://openalex.org/W2100432666","https://openalex.org/W2123359125","https://openalex.org/W2133154940","https://openalex.org/W2146601273","https://openalex.org/W2158422033","https://openalex.org/W2161039998","https://openalex.org/W2162282633","https://openalex.org/W2195194158","https://openalex.org/W2294251708","https://openalex.org/W2315213594","https://openalex.org/W2322685739","https://openalex.org/W2324430022","https://openalex.org/W2333924519","https://openalex.org/W2343868875","https://openalex.org/W2415774514","https://openalex.org/W2416000321","https://openalex.org/W2513682993","https://openalex.org/W2575244367","https://openalex.org/W2751844984","https://openalex.org/W2790030757","https://openalex.org/W2794624239","https://openalex.org/W2800885536","https://openalex.org/W2806353626","https://openalex.org/W2885109987","https://openalex.org/W2901538230","https://openalex.org/W2973116678","https://openalex.org/W2987284967","https://openalex.org/W3021331637","https://openalex.org/W3106566553","https://openalex.org/W3128190274","https://openalex.org/W3163863322","https://openalex.org/W4210631850","https://openalex.org/W4210792491","https://openalex.org/W4293659445","https://openalex.org/W4307352655","https://openalex.org/W4319663030","https://openalex.org/W4378516206","https://openalex.org/W4382461436","https://openalex.org/W4383906895","https://openalex.org/W4386840761","https://openalex.org/W4401410201","https://openalex.org/W4415207431"],"related_works":[],"abstract_inverted_index":{"Real-time":[0],"monitoring":[1],"of":[2,101,160,163,187,206,224,248],"intracellular":[3,42,70],"oxygen":[4],"(O":[5],"2":[6,44,72,154,182,212,243,254],")":[7],"is":[8],"crucial":[9],"for":[10,21,134,137,146,150],"understanding":[11],"cell":[12],"proliferation,":[13],"differentiation,":[14],"and":[15,35,53,63,68,80,120,124,139,169,178,250],"metabolic":[16,217,234],"processes,":[17],"as":[18,20,32],"well":[19],"observing":[22],"cellular":[23,161,210],"behavior":[24],"within":[25,245],"hypoxic":[26],"tissues":[27],"associated":[28],"with":[29,96,129,191,216,228,233],"conditions":[30],"such":[31],"cancer,":[33],"ischemia,":[34],"chronic":[36],"kidney":[37],"disease.":[38],"We":[39],"developed":[40],"small-molecule":[41],"O":[43,71,181,211,242,253],"probes":[45],"based":[46],"on":[47],"the":[48,118,246],"cationic":[49],"Ir(III)":[50,88,193],"complexes":[51,89,165],"C6-BA":[52,123,168,229],"C545T-BA":[54,125,170],"(C6":[55],"=":[56,60,65],"coumarin":[57,61],"6,":[58],"C545T":[59,121],"545T,":[62],"BA":[64],"N,N\u2032":[66],"-dibutylethylenediamine)":[67],"investigated":[69],"levels":[73],"using":[74,200],"a":[75,91,97,201,240],"commercially":[76],"available":[77],"microplate":[78,202],"reader":[79,203],"phosphorescence":[81,185],"lifetime":[82,186],"imaging":[83],"microscope":[84],"(PLIM).":[85],"The":[86,184],"synthesized":[87],"exhibited":[90,126],"strong":[92],"visible":[93],"absorption":[94,99],"band":[95],"molar":[98],"coefficient":[100],"approximately":[102],"100,000":[103],"dm":[104],"\u20133":[105],"mol":[106],"\u20131":[107,109],"cm":[108],"due":[110],"to":[111],"singlet":[112],"ligand-centered":[113],"\u03c0,\u03c0*":[114],"transitions":[115],"originating":[116],"from":[117],"C6":[119],"ligands.":[122],"bright":[127],"emission":[128,142,199],"high":[130,180],"quantum":[131],"yield":[132],"(0.65":[133],"C6-BA,":[135,147],"0.44":[136],"C545T-BA)":[138,151],"remarkably":[140],"long":[141],"lifetimes":[143],"(34.8":[144],"\u03bcs":[145,149],"53.7":[148],"in":[152,209,252],"N":[153],"-saturated":[155],"acetonitrile.":[156],"A":[157],"comprehensive":[158],"study":[159],"analyses":[162],"these":[164],"revealed":[166],"that":[167],"are":[171],"efficiently":[172],"taken":[173],"up":[174],"by":[175,196,231],"cultured":[176],"cells":[177,189,226],"exhibit":[179],"sensitivity.":[183],"living":[188,225],"stained":[190,227],"each":[192],"complex":[194],"determined":[195],"measuring":[197],"time-resolved":[198],"enabled":[204],"tracking":[205],"real-time":[207],"changes":[208],"tension":[213],"after":[214],"treatment":[215,232],"stimulants.":[218,235],"Furthermore,":[219],"we":[220],"acquired":[221],"PLIM":[222,237],"images":[223],"followed":[230],"Time-lapse":[236],"analysis":[238],"showed":[239],"heterogeneous":[241],"distribution":[244],"field":[247],"view":[249],"variations":[251],"partial":[255],"pressure":[256],"between":[257],"individual":[258],"cells.":[259]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2026-02-06T00:00:00"}