{"id":"https://openalex.org/W7127568258","doi":"https://doi.org/10.1021/acsomega.5c12212","title":"Copper-Mediated Late-Stage Radical Trifluoromethylation of Pyrazole-Type Scaffolds","display_name":"Copper-Mediated Late-Stage Radical Trifluoromethylation of Pyrazole-Type Scaffolds","publication_year":2026,"publication_date":"2026-02-04","ids":{"openalex":"https://openalex.org/W7127568258","doi":"https://doi.org/10.1021/acsomega.5c12212","pmid":"https://pubmed.ncbi.nlm.nih.gov/41726639"},"language":"en","primary_location":{"id":"doi:10.1021/acsomega.5c12212","doi":"https://doi.org/10.1021/acsomega.5c12212","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.5c12212","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.5c12212?ref=article_openPDF","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.5c12212?ref=article_openPDF","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5125095754","display_name":"Lucie S. Eisen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]},{"id":"https://openalex.org/I4210138838","display_name":"Sanofi (Germany)","ror":"https://ror.org/03ytdtb31","country_code":"DE","type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210138838"]}],"countries":["DE","ES"],"is_corresponding":false,"raw_author_name":"Lucie S. Eisen","raw_affiliation_strings":["Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country, Manuel Lardizabal 3, 20080 San Sebasti\u00e1n, Spain","Sanofi R&D, Integrated Drug Discovery, Industriepark H\u00f6chst, Building G838, 65926 Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country, Manuel Lardizabal 3, 20080 San Sebasti\u00e1n, Spain","institution_ids":["https://openalex.org/I169108374"]},{"raw_affiliation_string":"Sanofi R&D, Integrated Drug Discovery, Industriepark H\u00f6chst, Building G838, 65926 Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I4210138838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065522038","display_name":"Jan H. Griwatz","orcid":"https://orcid.org/0000-0003-2028-0938","observed_orcids":["https://orcid.org/0000-0003-2028-0938"]},"institutions":[{"id":"https://openalex.org/I4210138838","display_name":"Sanofi (Germany)","ror":"https://ror.org/03ytdtb31","country_code":"DE","type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210138838"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jan H. Griwatz","raw_affiliation_strings":["Sanofi R&D, Integrated Drug Discovery, Industriepark H\u00f6chst, Building G838, 65926 Frankfurt am Main, Germany"],"raw_orcid":"https://orcid.org/0000-0003-2028-0938","affiliations":[{"raw_affiliation_string":"Sanofi R&D, Integrated Drug Discovery, Industriepark H\u00f6chst, Building G838, 65926 Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I4210138838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079623049","display_name":"Sven G. Ruf","orcid":"https://orcid.org/0000-0002-2144-2663","observed_orcids":["https://orcid.org/0000-0002-2144-2663"]},"institutions":[{"id":"https://openalex.org/I4210138838","display_name":"Sanofi (Germany)","ror":"https://ror.org/03ytdtb31","country_code":"DE","type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210138838"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sven Ruf","raw_affiliation_strings":["Sanofi R&D, Integrated Drug Discovery, Industriepark H\u00f6chst, Building G838, 65926 Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanofi R&D, Integrated Drug Discovery, Industriepark H\u00f6chst, Building G838, 65926 Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I4210138838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056872646","display_name":"Mar\u00eda M. M\u00e9ndez","orcid":"https://orcid.org/0000-0002-6832-2714","observed_orcids":["https://orcid.org/0000-0002-6832-2714"]},"institutions":[{"id":"https://openalex.org/I4210138838","display_name":"Sanofi (Germany)","ror":"https://ror.org/03ytdtb31","country_code":"DE","type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210138838"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Mar\u00eda M\u00e9ndez","raw_affiliation_strings":["Sanofi R&D, Integrated Drug Discovery, Industriepark H\u00f6chst, Building G838, 65926 Frankfurt am Main, Germany"],"raw_orcid":"https://orcid.org/0000-0002-6832-2714","affiliations":[{"raw_affiliation_string":"Sanofi R&D, Integrated Drug Discovery, Industriepark H\u00f6chst, Building G838, 65926 Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I4210138838"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081666499","display_name":"Enrique G\u00f3mez\u2010Bengoa","orcid":"https://orcid.org/0000-0002-8753-3760","observed_orcids":["https://orcid.org/0000-0002-8753-3760"]},"institutions":[{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Enrique Gomez-Bengoa","raw_affiliation_strings":["Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country, Manuel Lardizabal 3, 20080 San Sebasti\u00e1n, Spain"],"raw_orcid":"https://orcid.org/0000-0002-8753-3760","affiliations":[{"raw_affiliation_string":"Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country, Manuel Lardizabal 3, 20080 San Sebasti\u00e1n, Spain","institution_ids":["https://openalex.org/I169108374"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5056872646","https://openalex.org/A5081666499"],"corresponding_institution_ids":["https://openalex.org/I169108374","https://openalex.org/I4210138838"],"apc_list":{"value":1935,"currency":"USD","value_usd":1935},"apc_paid":{"value":1935,"currency":"USD","value_usd":1935},"fwci":3.1191,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.86075741,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"11","issue":"6","first_page":"10664","last_page":"10673"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10947","display_name":"Fluorine in Organic Chemistry","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10947","display_name":"Fluorine in Organic Chemistry","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10701","display_name":"Radical Photochemical Reactions","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10354","display_name":"Catalytic C\u2013H Functionalization Methods","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyrazoles","display_name":"pyrazole derivatives","score":0.8889999985694885},{"id":"https://openalex.org/keywords/copper-catalysis","display_name":"copper catalysis","score":0.8159999847412109},{"id":"https://openalex.org/keywords/copper-ii-salts","display_name":"copper(II) salts","score":0.8349999785423279},{"id":"https://openalex.org/keywords/trifluoromethyl-radical","display_name":"trifluoromethyl radical","score":0.8980000019073486},{"id":"https://openalex.org/keywords/radical-addition","display_name":"radical addition","score":0.7149999737739563},{"id":"https://openalex.org/keywords/functional-group-tolerance","display_name":"functional group tolerance","score":0.7870000004768372},{"id":"https://openalex.org/keywords/dft-calculations","display_name":"DFT calculations","score":0.7310000061988831},{"id":"https://openalex.org/keywords/electronic-effects","display_name":"electronic effects","score":0.628000020980835},{"id":"https://openalex.org/keywords/room-temperature-reaction","display_name":"room temperature reaction","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C144000664","wikidata":"https://www.wikidata.org/wiki/Q7841506","display_name":"Trifluoromethylation","level":4,"score":0.9818999767303467},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.736299991607666},{"id":"https://openalex.org/C2776910235","wikidata":"https://www.wikidata.org/wiki/Q18574","display_name":"Reactivity (psychology)","level":3,"score":0.6391000151634216},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.6345000267028809},{"id":"https://openalex.org/C139066938","wikidata":"https://www.wikidata.org/wiki/Q185056","display_name":"Radical","level":2,"score":0.6046000123023987},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.46860000491142273},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.41780000925064087},{"id":"https://openalex.org/C2777332933","wikidata":"https://www.wikidata.org/wiki/Q170409","display_name":"Functional group","level":3,"score":0.4120999872684479},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2802000045776367},{"id":"https://openalex.org/C2991944050","wikidata":"https://www.wikidata.org/wiki/Q36534","display_name":"Reaction conditions","level":3,"score":0.2721000015735626},{"id":"https://openalex.org/C2777682936","wikidata":"https://www.wikidata.org/wiki/Q408908","display_name":"Pyrazole","level":2,"score":0.26030001044273376}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1021/acsomega.5c12212","doi":"https://doi.org/10.1021/acsomega.5c12212","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.5c12212","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.5c12212?ref=article_openPDF","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},{"id":"pmid:41726639","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41726639","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS omega","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8e31463db71d44918aab241ba40b5e7a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8e31463db71d44918aab241ba40b5e7a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ACS Omega, Vol 11, Iss 6, Pp 10664-10673 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12917629","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12917629/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ACS Omega","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1021/acsomega.5c12212","doi":"https://doi.org/10.1021/acsomega.5c12212","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.5c12212","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.5c12212?ref=article_openPDF","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2449526044","display_name":"Advancing Reaction Platforms for Drug Discovery","funder_award_id":"101069949","funder_id":"https://openalex.org/F4320338438","funder_display_name":"HORIZON EUROPE Marie Sklodowska-Curie Actions"},{"id":"https://openalex.org/G2671301202","display_name":null,"funder_award_id":"IT-1741-22","funder_id":"https://openalex.org/F4320321705","funder_display_name":"Eusko Jaurlaritza"},{"id":"https://openalex.org/G3345895242","display_name":null,"funder_award_id":"H2020-MSCA","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G8512683158","display_name":null,"funder_award_id":"H2020-MSCA","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321705","display_name":"Eusko Jaurlaritza","ror":"https://ror.org/00pz2fp31"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320338438","display_name":"HORIZON EUROPE Marie Sklodowska-Curie Actions","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7127568258.pdf","grobid_xml":"https://content.openalex.org/works/W7127568258.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W1170512841","https://openalex.org/W1967525927","https://openalex.org/W1969545648","https://openalex.org/W1973556406","https://openalex.org/W1974414831","https://openalex.org/W1978990046","https://openalex.org/W1982746475","https://openalex.org/W1987939006","https://openalex.org/W1994685053","https://openalex.org/W2002387886","https://openalex.org/W2004489626","https://openalex.org/W2008761458","https://openalex.org/W2008906735","https://openalex.org/W2009008810","https://openalex.org/W2012367650","https://openalex.org/W2013066211","https://openalex.org/W2015976431","https://openalex.org/W2020422911","https://openalex.org/W2033498682","https://openalex.org/W2039594187","https://openalex.org/W2041152444","https://openalex.org/W2048535159","https://openalex.org/W2053927228","https://openalex.org/W2054040491","https://openalex.org/W2068393258","https://openalex.org/W2071491849","https://openalex.org/W2073753893","https://openalex.org/W2077586875","https://openalex.org/W2077895811","https://openalex.org/W2079445167","https://openalex.org/W2080854581","https://openalex.org/W2093606226","https://openalex.org/W2093750721","https://openalex.org/W2093788608","https://openalex.org/W2101491611","https://openalex.org/W2121850944","https://openalex.org/W2144968884","https://openalex.org/W2145009980","https://openalex.org/W2146496405","https://openalex.org/W2157497879","https://openalex.org/W2157873278","https://openalex.org/W2168076350","https://openalex.org/W2178819670","https://openalex.org/W2188186545","https://openalex.org/W2206072133","https://openalex.org/W2236168432","https://openalex.org/W2237872262","https://openalex.org/W2316766720","https://openalex.org/W2318953729","https://openalex.org/W2323669102","https://openalex.org/W2333129245","https://openalex.org/W2578888346","https://openalex.org/W2744093496","https://openalex.org/W2799857091","https://openalex.org/W2887304743","https://openalex.org/W2910407119","https://openalex.org/W2923266271","https://openalex.org/W2949268087","https://openalex.org/W2949371018","https://openalex.org/W2950027245","https://openalex.org/W2950213391","https://openalex.org/W2976320977","https://openalex.org/W3116504074","https://openalex.org/W3201218478","https://openalex.org/W4200546445","https://openalex.org/W4220921948","https://openalex.org/W4376866695","https://openalex.org/W4391300223","https://openalex.org/W4403138866"],"related_works":[],"abstract_inverted_index":{"High":[0],"Resolution":[1],"Image":[2],"Download":[3],"MS":[4],"PowerPoint":[5],"Slide":[6],"Trifluoromethylated":[7],"pyrazoles":[8,48,101],"and":[9,20,40,56,79,106],"their":[10,18,27],"derivatives":[11],"are":[12],"of":[13,47,98,102],"great":[14],"interest":[15,103],"due":[16],"to":[17],"biological":[19],"pharmacological":[21],"relevance.":[22],"However,":[23],"efficient":[24,41],"methods":[25],"for":[26,43,95],"preparation":[28],"via":[29],"late-stage":[30],"trifluoromethylation":[31,46],"strategies":[32],"remain":[33],"limited.":[34],"Herein,":[35],"we":[36],"report":[37],"a":[38],"practical":[39],"method":[42,66],"the":[44,75,83,96],"direct":[45],"using":[49],"in":[50,104],"situ":[51],"generated":[52],"CF":[53,87],"3":[54,88],"radicals":[55],"inexpensive":[57],"copper(II)":[58],"salts":[59],"as":[60],"catalysts":[61],"at":[62],"room":[63],"temperature.":[64],"The":[65],"exhibits":[67],"excellent":[68],"functional":[69],"group":[70],"tolerance.":[71],"DFT":[72],"studies":[73],"support":[74],"observed":[76],"reactivity":[77],"trends":[78],"provide":[80],"insight":[81],"into":[82],"electronic":[84],"effects":[85],"governing":[86],"radical":[89],"addition.":[90],"This":[91],"strategy":[92],"holds":[93],"promise":[94],"generation":[97],"highly":[99],"substituted":[100],"biomedical":[105],"crop-science":[107],"applications.":[108]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2026-02-06T00:00:00"}