{"id":"https://openalex.org/W7127544975","doi":null,"title":"Endocrine predictors of frailty in ageing men.","display_name":"Endocrine predictors of frailty in ageing men.","publication_year":2019,"publication_date":"2019-12-01","ids":{"openalex":"https://openalex.org/W7127544975"},"language":"en","primary_location":{"id":"pmh:oai:pure.atira.dk:studenttheses/5a44d60f-29ee-40eb-b294-e6ab2b111cb3","doi":null,"is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/studentTheses/5a44d60f-29ee-40eb-b294-e6ab2b111cb3","pdf_url":"https://pure.manchester.ac.uk/ws/files/194692844/FULL_TEXT.PDF","source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"synchronisedUnifiedStudentThesis","raw_type":"Phd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pure.manchester.ac.uk/ws/files/194692844/FULL_TEXT.PDF","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043861812","display_name":"Agnieszka \u015awi\u0119cicka","orcid":"https://orcid.org/0000-0003-1438-6867","observed_orcids":["https://orcid.org/0000-0003-1438-6867"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Swiecicka, Agnieszka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5043861812"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.05510000139474869,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/frailty","display_name":"frailty","score":0.6970000267028809},{"id":"https://openalex.org/keywords/older-men","display_name":"older men","score":0.871999979019165},{"id":"https://openalex.org/keywords/androgens","display_name":"androgens","score":0.9120000004768372},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.9900000095367432},{"id":"https://openalex.org/keywords/free-testosterone","display_name":"free testosterone","score":0.9559999704360962},{"id":"https://openalex.org/keywords/dehydroepiandrosterone-sulfate","display_name":"dehydroepiandrosterone sulfate","score":0.9810000061988831},{"id":"https://openalex.org/keywords/gonadotropins","display_name":"gonadotropins","score":0.949999988079071},{"id":"https://openalex.org/keywords/physical-functioning","display_name":"physical function","score":0.9169999957084656},{"id":"https://openalex.org/keywords/walking-speed","display_name":"walking speed","score":0.5950000286102295},{"id":"https://openalex.org/keywords/chair-stand","display_name":"chair stand","score":0.7020000219345093},{"id":"https://openalex.org/keywords/frailty-index","display_name":"frailty index","score":0.6740000247955322},{"id":"https://openalex.org/keywords/frailty-phenotype","display_name":"Fried frailty phenotype","score":0.8169999718666077},{"id":"https://openalex.org/keywords/european-male-ageing-study","display_name":"European Male Ageing Study","score":0.8679999709129333},{"id":"https://openalex.org/keywords/community-dwelling-men","display_name":"community-dwelling men","score":0.8709999918937683}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7689999938011169},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.7013000249862671},{"id":"https://openalex.org/C2779665388","wikidata":"https://www.wikidata.org/wiki/Q5959159","display_name":"Androgen deficiency","level":4,"score":0.6238999962806702},{"id":"https://openalex.org/C2910497653","wikidata":"https://www.wikidata.org/wiki/Q1318776","display_name":"Free testosterone","level":5,"score":0.5967000126838684},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.5884000062942505},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4564000070095062},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.44999998807907104},{"id":"https://openalex.org/C2776405666","wikidata":"https://www.wikidata.org/wiki/Q5500183","display_name":"Free androgen index","level":5,"score":0.4490000009536743},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.413100004196167},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.398499995470047},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.39640000462532043},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.39149999618530273},{"id":"https://openalex.org/C3020255362","wikidata":"https://www.wikidata.org/wiki/Q747883","display_name":"Physical activity","level":2,"score":0.3878999948501587},{"id":"https://openalex.org/C2780657110","wikidata":"https://www.wikidata.org/wiki/Q2505402","display_name":"Dehydroepiandrosterone sulfate","level":4,"score":0.36390000581741333},{"id":"https://openalex.org/C3019419337","wikidata":"https://www.wikidata.org/wiki/Q4759440","display_name":"Testosterone replacement","level":4,"score":0.3481000065803528},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.34200000762939453},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.337799996137619},{"id":"https://openalex.org/C2776992908","wikidata":"https://www.wikidata.org/wiki/Q408376","display_name":"Dehydroepiandrosterone","level":4,"score":0.32359999418258667},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3203999996185303},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.2955999970436096},{"id":"https://openalex.org/C54183767","wikidata":"https://www.wikidata.org/wiki/Q10384","display_name":"Geriatrics","level":2,"score":0.2890999913215637},{"id":"https://openalex.org/C3019892597","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Healthy ageing","level":3,"score":0.28380000591278076},{"id":"https://openalex.org/C3017819807","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Healthy aging","level":2,"score":0.2827000021934509},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.27720001339912415},{"id":"https://openalex.org/C2775871022","wikidata":"https://www.wikidata.org/wiki/Q7458776","display_name":"Sexual function","level":2,"score":0.271699994802475},{"id":"https://openalex.org/C3019887659","wikidata":"https://www.wikidata.org/wiki/Q191089","display_name":"Older people","level":2,"score":0.2637999951839447},{"id":"https://openalex.org/C3018697994","wikidata":"https://www.wikidata.org/wiki/Q191089","display_name":"Elderly people","level":2,"score":0.26330000162124634},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.26269999146461487}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:pure.atira.dk:studenttheses/5a44d60f-29ee-40eb-b294-e6ab2b111cb3","doi":null,"is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/studentTheses/5a44d60f-29ee-40eb-b294-e6ab2b111cb3","pdf_url":"https://pure.manchester.ac.uk/ws/files/194692844/FULL_TEXT.PDF","source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"synchronisedUnifiedStudentThesis","raw_type":"Phd"}],"best_oa_location":{"id":"pmh:oai:pure.atira.dk:studenttheses/5a44d60f-29ee-40eb-b294-e6ab2b111cb3","doi":null,"is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/studentTheses/5a44d60f-29ee-40eb-b294-e6ab2b111cb3","pdf_url":"https://pure.manchester.ac.uk/ws/files/194692844/FULL_TEXT.PDF","source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"synchronisedUnifiedStudentThesis","raw_type":"Phd"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G840959020","display_name":"The consequences of motor unit remodelling for motor control: an important factor in the loss of mobility with old age.","funder_award_id":"MR/K025252/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320331709","display_name":"Mereo BioPharma","ror":"https://ror.org/02g73z327"},{"id":"https://openalex.org/F4320333687","display_name":"Manchester Biomedical Research Centre","ror":"https://ror.org/05njkjr15"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7127544975.pdf","grobid_xml":"https://content.openalex.org/works/W7127544975.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W2169025780"],"related_works":["https://openalex.org/W2766529636","https://openalex.org/W2041481588","https://openalex.org/W2022213805","https://openalex.org/W2289397344","https://openalex.org/W2803387425","https://openalex.org/W2152460830","https://openalex.org/W2135485322","https://openalex.org/W1703838523","https://openalex.org/W4210498828","https://openalex.org/W7081544593"],"abstract_inverted_index":{"Background:":[0],"Circulating":[1],"levels":[2,34],"of":[3,20,54,266,272],"androgens,":[4],"such":[5],"as":[6],"testosterone":[7],"(T)":[8],"and":[9,35,40,78,97,107,113,197,224,253],"dehydroepiandrosterone":[10],"sulphate":[11],"(DHEA-S),":[12],"decline":[13,31,121,230],"with":[14,80,236],"age,":[15],"but":[16],"the":[17,26,95,98,247,258,263,270],"clinical":[18],"importance":[19],"this":[21],"phenomenon":[22],"remains":[23],"unclear.We":[24],"determined":[25],"prospective":[27,51],"association":[28],"between":[29,67,222,251],"age-related":[30],"in":[32,37,42,73,83,122,231,269,274],"androgen":[33],"changes":[36,68,82],"physical":[38,105,201,254],"function":[39,202],"frailty":[41,108,273],"European":[43,62],"Male":[44],"Ageing":[45],"Study":[46],"participants.Methods:":[47],"In":[48,116],"a":[49],"4.4-year":[50],"cohort":[52],"study":[53],"3369":[55],"community-dwelling":[56],"men":[57],"aged":[58],"40-79":[59],"from":[60],"8":[61],"centres,":[63],"we":[64],"assessed":[65],"relationships":[66],"(baseline":[69],"to":[70],"follow":[71],"up)":[72],"T,":[74,76],"free":[75,125,142,158,174,192,209],"DHEA-S,":[77],"gonadotropins":[79],"concomitant":[81],"15-meter":[84],"walk":[85],"time,":[86,90],"5":[87,181],"chair":[88,182],"stands":[89,183],"Physical":[91],"Activity":[92],"Scale":[93],"for":[94,153,169,187,205,220,260],"Elderly":[96],"36-Item":[99],"Short":[100],"Form":[101],"Survey":[102],"(SF-36)":[103],"composite":[104],"scores,":[106],"status":[109],"(frailty":[110],"phenotype":[111],"(FP)":[112],"index":[114],"(FI)).Results:":[115],"unadjusted":[117],"models,":[118],"1":[119,228],"SD":[120,229],"T":[123,126,223],"or":[124],"over":[127],"4.4":[128],"years":[129],"was":[130,234],"associated":[131,235],"with:":[132],"a)":[133],"worsening":[134,148,164,180,199,237],"FP":[135,238],"[T:":[136],"OR":[137],"(95%CI):":[138],"1.14":[139],"(1.01;":[140,241],"1.28);":[141],"T:":[143,154,159,170,175,188,193,206,210],"1.24":[144],"(1.09;":[145],"1.40)];":[146],"b)":[147],"FI":[149],"[%":[150,167,185],"change":[151,168,186],"(95%CI)":[152],"2.5":[155],"(0.5;":[156],"5.1);":[157],"6.0":[160],"(3.1;":[161],"8.3)];":[162],"c)":[163],"walking":[165],"time":[166,184],"1.1":[171],"(0.4;":[172],"1.9);":[173],"2.0":[176],"(1.3;":[177],"2.9)],":[178],"d)":[179],"1.0":[189],"(0.1;":[190],"2.0);":[191],"1.3":[194],"(0.3;":[195],"2.2)]":[196],"e)":[198],"self-perceived":[200],"[SF-36,":[203],"%change":[204],"-6.9":[207],"(-10.5;-3.7);":[208],"-8.1":[211],"(-9.3;":[212],"-1.2)].Associations":[213],"remained":[214],"statistically":[215],"significant":[216],"after":[217],"adjustments,":[218,227],"except":[219],"those":[221],"frailty.On":[225],"multiple":[226],"DHEA-S":[232],"level":[233],"[OR":[239],"1.15":[240],"1.32)]":[242],"Conclusion:":[243],"These":[244],"results":[245],"support":[246],"inferred":[248],"causal":[249],"relationship":[250],"androgens":[252],"function;":[255],"they":[256],"strengthen":[257],"case":[259],"further":[261],"exploring":[262],"potential":[264],"role(s)":[265],"these":[267],"hormones":[268],"development":[271],"ageing":[275],"men.":[276]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-02-04T00:00:00"}