{"id":"https://openalex.org/W7127219443","doi":null,"title":"Abstract omitted from Cell Stress & Chaperones Volume 3 Supplement 1 September 1998: Enzymatic removal of the ER retention signal KDEL from heat shock proteins","display_name":"Abstract omitted from Cell Stress & Chaperones Volume 3 Supplement 1 September 1998: Enzymatic removal of the ER retention signal KDEL from heat shock proteins","publication_year":1998,"publication_date":"1998-12-01","ids":{"openalex":"https://openalex.org/W7127219443","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/312973"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:312973","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC312973/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Stress Chaperones","raw_type":"Text"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC312973/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050511907","display_name":"Heinemann Fs","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heinemann, F. Scott","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5009100025","display_name":"Juris Ozols","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ozols, Juris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.01889999955892563,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/er-retention-signal","display_name":"ER retention signal","score":0.75},{"id":"https://openalex.org/keywords/er-chaperones","display_name":"ER chaperones","score":0.7459999918937683},{"id":"https://openalex.org/keywords/grp94","display_name":"GRP94","score":0.847000002861023},{"id":"https://openalex.org/keywords/erp72","display_name":"ERp72","score":0.9929999709129333},{"id":"https://openalex.org/keywords/calreticulin","display_name":"calreticulin","score":1.0},{"id":"https://openalex.org/keywords/rat-liver-microsomes","display_name":"rat liver microsomes","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C2779377555","wikidata":"https://www.wikidata.org/wiki/Q6327751","display_name":"KDEL","level":4,"score":0.9535999894142151},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6491000056266785},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.6462000012397766},{"id":"https://openalex.org/C2778043179","wikidata":"https://www.wikidata.org/wiki/Q5324093","display_name":"ER retention","level":4,"score":0.5849000215530396},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5331000089645386},{"id":"https://openalex.org/C47450691","wikidata":"https://www.wikidata.org/wiki/Q634510","display_name":"Calreticulin","level":3,"score":0.5288000106811523},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.48500001430511475},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.48170000314712524},{"id":"https://openalex.org/C2776350231","wikidata":"https://www.wikidata.org/wiki/Q7166509","display_name":"Pepstatin","level":4,"score":0.4417000114917755},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40369999408721924},{"id":"https://openalex.org/C2775883766","wikidata":"https://www.wikidata.org/wiki/Q11350119","display_name":"Leupeptin","level":4,"score":0.40149998664855957},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.39469999074935913},{"id":"https://openalex.org/C10858879","wikidata":"https://www.wikidata.org/wiki/Q899790","display_name":"Signal peptide","level":4,"score":0.3774000108242035},{"id":"https://openalex.org/C2781373781","wikidata":"https://www.wikidata.org/wiki/Q168790","display_name":"Brefeldin A","level":4,"score":0.3714999854564667},{"id":"https://openalex.org/C130361206","wikidata":"https://www.wikidata.org/wiki/Q908443","display_name":"Calnexin","level":4,"score":0.3553999960422516},{"id":"https://openalex.org/C103878061","wikidata":"https://www.wikidata.org/wiki/Q28840674","display_name":"Sf9","level":5,"score":0.33649998903274536},{"id":"https://openalex.org/C175656101","wikidata":"https://www.wikidata.org/wiki/Q56646","display_name":"Chinese hamster ovary cell","level":3,"score":0.32120001316070557},{"id":"https://openalex.org/C2778917187","wikidata":"https://www.wikidata.org/wiki/Q15322133","display_name":"RHOB","level":4,"score":0.3084999918937683},{"id":"https://openalex.org/C2776148510","wikidata":"https://www.wikidata.org/wiki/Q6468907","display_name":"Lactacystin","level":4,"score":0.30090001225471497},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.2824999988079071},{"id":"https://openalex.org/C2777575526","wikidata":"https://www.wikidata.org/wiki/Q3542091","display_name":"Tunicamycin","level":4,"score":0.2761000096797943},{"id":"https://openalex.org/C2776817266","wikidata":"https://www.wikidata.org/wiki/Q83141460","display_name":"PNGase F","level":4,"score":0.27410000562667847},{"id":"https://openalex.org/C2780683386","wikidata":"https://www.wikidata.org/wiki/Q5065296","display_name":"Cerulenin","level":4,"score":0.272599995136261},{"id":"https://openalex.org/C3019223276","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Proteolytic enzymes","level":3,"score":0.2685000002384186},{"id":"https://openalex.org/C5098756","wikidata":"https://www.wikidata.org/wiki/Q1641611","display_name":"Protein disulfide-isomerase","level":3,"score":0.2678999900817871},{"id":"https://openalex.org/C2779384962","wikidata":"https://www.wikidata.org/wiki/Q5201346","display_name":"Cytochrome b5","level":4,"score":0.26330000162124634},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2619999945163727},{"id":"https://openalex.org/C57581600","wikidata":"https://www.wikidata.org/wiki/Q2449730","display_name":"Transport protein","level":2,"score":0.2596000134944916},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.2581999897956848},{"id":"https://openalex.org/C167844969","wikidata":"https://www.wikidata.org/wiki/Q426245","display_name":"Cathepsin","level":3,"score":0.25619998574256897}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:312973","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC312973/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Stress Chaperones","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:312973","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC312973/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Stress Chaperones","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2073977577","https://openalex.org/W7100457242","https://openalex.org/W2110303189","https://openalex.org/W2065114693","https://openalex.org/W7099118821","https://openalex.org/W2109851858","https://openalex.org/W6959716164","https://openalex.org/W2129498461","https://openalex.org/W1972702843","https://openalex.org/W2052813695"],"abstract_inverted_index":{"We":[0,21],"have":[1,41],"identified":[2,42],"a":[3,16,54,170,192,292],"proteolytic":[4],"activity":[5,25],"in":[6,124,142,215,259,303],"rat":[7],"liver":[8],"microsomes":[9],"that":[10,39,91,197,211,265],"specifically":[11],"removes":[12],"the":[13,35,47,82,101,111,118,125,128,150,158,165,174,181,202,216,222,231,247,257,266,274,285,288,316],"C-terminus":[14],"from":[15,278],"spectrum":[17],"of":[18,34,62,72,84,117,127,164,176,183,188,204,227,249,269,287,294,318],"ER":[19,58,89,177,184,217,228,258,275],"chaperones.":[20],"refer":[22],"to":[23,95,156,201,221,230,237,241,256,272],"this":[24],"as":[26,108],"heat":[27,280],"shock":[28,281],"protein":[29,178,307,311],"(hsp":[30],"convertase":[31],"(HSPC).":[32],"All":[33],"substrates":[36,109],"for":[37,57,110,173,195],"HSPC":[38,60,159,189,270],"we":[40],"are":[43,92,212,219],"hsp,":[44],"and":[45,65,69,100,114,131,137,240,315],"contain":[46],"KDEL":[48,166,205],"or":[49,149,180,298],"KEEL":[50],"at":[51],"their":[52],"C-termini,":[53],"signal":[55,167,277],"sequence":[56],"retention.":[59,206],"conversion":[61,78],"GRP94,":[63],"ERp72":[64,243],"calreticulin":[66],"was":[67,75,79],"rapid":[68],"no":[70,122],"evidence":[71],"N-terminal":[73],"alteration":[74,123],"detected.":[76],"The":[77,145,186,225],"unaffected":[80],"by":[81],"presence":[83],"other":[85],"membrane":[86],"proteins.":[87],"Two":[88],"proteins":[90,282],"very":[93],"sensitive":[94],"non-specific":[96],"proteases,":[97],"cytochrome":[98,129],"b5":[99,103,130],"NADH-cytochrome":[102],"reductase":[104],"were":[105,140,198],"also":[106,154],"tested":[107],"HSPC.":[112,144],"SDS-PAGE":[113],"immunoblot":[115],"analysis":[116],"incubation":[119],"mixture":[120],"showed":[121],"mobilities":[126],"its":[132],"reductase.":[133],"Lysomotropic":[134],"agents":[135],"leupeptin":[136],"pepstatin":[138],"A":[139],"ineffective":[141],"inhibiting":[143],"calpain":[146],"inhibitor,":[147],"N-acetyl-leucyl-leucyl-methional,":[148],"teosome":[151],"inhibitor":[152],"lactacystin":[153],"failed":[155],"inhibit":[157],"activity.":[160],"Specific":[161],"enzymatic":[162],"removal":[163],"may":[168,190,301],"represent":[169],"novel":[171],"mechanism":[172],"regulation":[175,317],"trafficking":[179],"function":[182],"hsp.":[185],"discovery":[187],"provide":[191],"biochemical":[193],"explanation":[194],"observations":[196],"previously":[199],"attributed":[200],"inefficiency":[203],"Under":[207],"special":[208],"circumstances,":[209],"hsp":[210],"normally":[213],"localized":[214],"lumen":[218],"transported":[220],"plasma":[223],"membrane.":[224],"relocalization":[226],"hsps":[229],"cell":[232,313],"surface":[233,248],"has":[234],"been":[235],"linked":[236],"malignant":[238],"transformation":[239],"apoptosis.":[242],"is":[244,254,263,271],"expressed":[245],"on":[246],"human":[250],"tumor":[251],"cells,":[252],"but":[253],"confined":[255],"normal":[260],"cells.":[261],"It":[262],"proposed":[264],"physiological":[267],"role":[268],"remove":[273],"retention":[276],"lumenal":[279],"thereby":[283],"permitting":[284],"translocation":[286],"modified":[289,299],"chaperones":[290,300],"into":[291],"variety":[293],"non-ER":[295],"locales.":[296],"Relocated,":[297],"participate":[302],"cellular":[304],"functions":[305],"including":[306],"degradation,":[308],"antigen":[309],"presentation,":[310],"folding,":[312],"adhesion,":[314],"gene":[319],"expression.":[320]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-02-03T00:00:00"}