{"id":"https://openalex.org/W7127097249","doi":"https://doi.org/10.5281/zenodo.18457568","title":"Attenuative Effect of Zingerone on Behavioural Anomalies and Oxidative Stress in The Cerebellum of Prenatal Valproic Acid Induced Autism Spectrum Disorder Like Symptoms in F1 Female Pups: In Vivo Modelling","display_name":"Attenuative Effect of Zingerone on Behavioural Anomalies and Oxidative Stress in The Cerebellum of Prenatal Valproic Acid Induced Autism Spectrum Disorder Like Symptoms in F1 Female Pups: In Vivo Modelling","publication_year":2025,"publication_date":"2025-10-01","ids":{"openalex":"https://openalex.org/W7127097249","doi":"https://doi.org/10.5281/zenodo.18457568"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.18457568","doi":"https://doi.org/10.5281/zenodo.18457568","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.18457568","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.18457568","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004485595","display_name":"Thangarajan Sumathi","orcid":"https://orcid.org/0000-0003-0830-3498","observed_orcids":["https://orcid.org/0000-0003-0830-3498"]},"institutions":[{"id":"https://openalex.org/I215927","display_name":"University of Madras","ror":"https://ror.org/04jmt9361","country_code":"IN","type":"education","lineage":["https://openalex.org/I215927"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Sumathi Thangarajan","raw_affiliation_strings":["*Associate Professor, Department of Medical Biochemistry, Dr A.L.M. Post Graduate  Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600113, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Associate Professor, Department of Medical Biochemistry, Dr A.L.M. Post Graduate  Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600113, Tamil Nadu, India","institution_ids":["https://openalex.org/I215927"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5004485595"],"corresponding_institution_ids":["https://openalex.org/I215927"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.4909212,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.9189000129699707,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.9189000129699707,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.019099999219179153,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zingerone","display_name":"zingerone","score":1.0},{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":0.9200000166893005},{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.9879999756813049},{"id":"https://openalex.org/keywords/prenatal-valproic-acid-exposure","display_name":"prenatal valproic acid exposure","score":0.8270000219345093},{"id":"https://openalex.org/keywords/cerebellum","display_name":"cerebellum","score":0.871999979019165},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.859000027179718},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8560000061988831},{"id":"https://openalex.org/keywords/antioxidant-status","display_name":"antioxidant status","score":0.6159999966621399},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9150000214576721},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.921999990940094},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.8420000076293945},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9900000095367432},{"id":"https://openalex.org/keywords/behavioural-abnormalities","display_name":"behavioural abnormalities","score":0.6480000019073486},{"id":"https://openalex.org/keywords/developmental-neurotoxicity","display_name":"developmental neurotoxicity","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8011999726295471},{"id":"https://openalex.org/C2777172819","wikidata":"https://www.wikidata.org/wiki/Q240642","display_name":"Valproic Acid","level":3,"score":0.7096999883651733},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6474999785423279},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6392999887466431},{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.6122000217437744},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.5896999835968018},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.578000009059906},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5412999987602234},{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.5248000025749207},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.49799999594688416},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.483599990606308},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.45809999108314514},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.43220001459121704},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.36340001225471497},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3625999987125397},{"id":"https://openalex.org/C2778538070","wikidata":"https://www.wikidata.org/wiki/Q1436063","display_name":"Autism spectrum disorder","level":3,"score":0.3549000024795532},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33329999446868896},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.30709999799728394},{"id":"https://openalex.org/C2780783007","wikidata":"https://www.wikidata.org/wiki/Q181923","display_name":"Attention deficit hyperactivity disorder","level":2,"score":0.2971999943256378},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.27559998631477356},{"id":"https://openalex.org/C2777551382","wikidata":"https://www.wikidata.org/wiki/Q141180","display_name":"Vitamin E","level":3,"score":0.27000001072883606},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.2685999870300293},{"id":"https://openalex.org/C3018923374","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Prenatal exposure","level":4,"score":0.265500009059906},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2651999890804291},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.26269999146461487}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.18457568","doi":"https://doi.org/10.5281/zenodo.18457568","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.18457568","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.5281/zenodo.18457569","doi":"https://doi.org/10.5281/zenodo.18457569","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.18457569","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.5281/zenodo.18457568","doi":"https://doi.org/10.5281/zenodo.18457568","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.18457568","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"The":[1,52],"pilot":[2],"study":[3],"aimed":[4],"to":[5,48],"evaluate":[6],"the":[7,24,43,137,145,148,152,172],"attenuative":[8],"effect":[9,53,170],"of":[10,26,46,54,120,139,175],"zingerone":[11],"(ZNO)":[12],"against":[13,171],"valproic":[14],"acid":[15],"(VPA)-induced":[16],"autism":[17],"spectrum":[18],"disorder":[19],"(ASD)":[20],"like":[21],"symptoms":[22,174],"in":[23,107,144,162],"cerebellum":[25],"female":[27,31,115,177],"rat":[28,179],"pups.":[29,180],"Pregnant":[30],"rats":[32],"were":[33,99,104,126],"administered":[34],"with":[35,132],"VPA":[36],"(500mg/Kg/i.p)":[37],"as":[38],"a":[39,108,167],"single":[40],"dose":[41],"on":[42,60],"12th":[44],"day":[45],"gestation":[47],"induce":[49],"autistic":[50,176],"phenotypes.":[51],"ZNO":[55,112,133,158],"at":[56],"30mg/Kg/p.o":[57],"and":[58,71,91,94,122,142],"60mg/Kg/p.o":[59],"VPA-induced":[61,164],"neurobehavioural":[62],"anomalies":[63,103],"(open":[64],"field":[65],"test,":[66,70],"rotarod,":[67],"forced":[68],"swim":[69],"y-maze),":[72],"oxidative":[73],"stress":[74],"(lipid":[75],"peroxidation":[76],"(LPO),":[77],"total":[78,123],"nitric":[79],"oxide":[80],"(NO)),":[81],"altered":[82],"antioxidative":[83],"status":[84],"(reduced":[85],"glutathione":[86],"(GSH),":[87],"vitamin":[88],"C":[89],"(Vit-C)":[90],"catalase":[92],"(CAT)),":[93],"histopathological":[95],"staining":[96,191],"(H&E":[97],"staining)":[98],"assessed.":[100],"Autistic":[101],"behavioural":[102],"substantially":[105,135],"diminished":[106],"dose-dependent":[109],"manner":[110],"following":[111],"administration.":[113],"VPAexposed":[114],"pups":[116],"had":[117],"elevated":[118],"levels":[119,138],"LPO":[121],"NO,":[124],"which":[125],"significantly":[127],"attenuated":[128],"by":[129],"ZNO.":[130],"Treatment":[131],"also":[134],"promoted":[136],"GSH,":[140],"Vit-C,":[141],"CAT":[143],"cerebellum.":[146],"In":[147],"present":[149],"study,":[150],"for":[151],"first":[153],"time,":[154],"we":[155],"report":[156],"that":[157],"showed":[159],"promising":[160],"results":[161],"attenuating":[163],"symptoms,":[165],"indicating":[166],"possible":[168],"neuroprotective":[169],"core":[173],"F1":[178],"Keywords":[181],"Neuroprotection,":[182],"Autism":[183],"Spectrum":[184],"Disorder,":[185],"Zingerone,":[186],"Oxidative":[187],"Stress,":[188],"Anti-oxidant,":[189],"H&E":[190]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2026-02-03T00:00:00"}