{"id":"https://openalex.org/W7127090657","doi":"https://doi.org/10.25276/2410-1257-2025-4-19-24","title":"Morphological changes in the cornea of experimental animals after corneal collagen cross-linking","display_name":"Morphological changes in the cornea of experimental animals after corneal collagen cross-linking","publication_year":2025,"publication_date":"2025-12-16","ids":{"openalex":"https://openalex.org/W7127090657","doi":"https://doi.org/10.25276/2410-1257-2025-4-19-24"},"language":"en","primary_location":{"id":"doi:10.25276/2410-1257-2025-4-19-24","doi":"https://doi.org/10.25276/2410-1257-2025-4-19-24","is_oa":true,"landing_page_url":"https://doi.org/10.25276/2410-1257-2025-4-19-24","pdf_url":"https://east-west-journal.ru/index.php/east-west/article/download/571/797","source":{"id":"https://openalex.org/S4210199748","display_name":"POINT OF VIEW EAST \u2013 WEST","issn_l":"2410-1257","issn":["2410-1257"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-3"],"host_organization":"https://openalex.org/P4310312600","host_organization_name":"Publishing house\u00a0\"Ophthalmology\"","host_organization_lineage":["https://openalex.org/P4310312600"],"host_organization_lineage_names":["Publishing house\u00a0\"Ophthalmology\""],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"POINT OF VIEW. EAST \u2013 WEST","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W7127090657"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://east-west-journal.ru/index.php/east-west/article/download/571/797","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039644638","display_name":"\u041c.\u041c. Bikbov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120901","display_name":"Bashkir State Medical University","ror":"https://ror.org/02w1g0f30","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210120901"]},{"id":"https://openalex.org/I4210154941","display_name":"Ufa Eye Research Institute","ror":"https://ror.org/04grwn689","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210154941"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"\u041c.\u041c. Bikbov","raw_affiliation_strings":["Ufa Eye Research Institute , Bashkir State Medical University , Ufa , Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ufa Eye Research Institute , Bashkir State Medical University , Ufa , Russian Federation","institution_ids":["https://openalex.org/I4210120901","https://openalex.org/I4210154941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013834504","display_name":"\u0410.\u0420. \u0425\u0430\u043b\u0438\u043c\u043e\u0432","orcid":"https://orcid.org/0000-0001-7470-7330","observed_orcids":["https://orcid.org/0000-0001-7470-7330"]},"institutions":[{"id":"https://openalex.org/I4210120901","display_name":"Bashkir State Medical University","ror":"https://ror.org/02w1g0f30","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210120901"]},{"id":"https://openalex.org/I4210154941","display_name":"Ufa Eye Research Institute","ror":"https://ror.org/04grwn689","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210154941"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"\u0410.R. Khalimov","raw_affiliation_strings":["Ufa Eye Research Institute , Bashkir State Medical University , Ufa , Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ufa Eye Research Institute , Bashkir State Medical University , Ufa , Russian Federation","institution_ids":["https://openalex.org/I4210120901","https://openalex.org/I4210154941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124840014","display_name":"\u0410.I. Lebedeva","orcid":"https://orcid.org/0000-0002-9170-2600","observed_orcids":["https://orcid.org/0000-0002-9170-2600"]},"institutions":[{"id":"https://openalex.org/I4210120901","display_name":"Bashkir State Medical University","ror":"https://ror.org/02w1g0f30","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210120901"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"\u0410.I. Lebedeva","raw_affiliation_strings":["Russian Center for Eye and Plastic Surgery , Bashkir State Medical University , Ufa , Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Russian Center for Eye and Plastic Surgery , Bashkir State Medical University , Ufa , Russian Federation","institution_ids":["https://openalex.org/I4210120901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052796222","display_name":"\u041b. \u0410. \u041c\u0443\u0441\u0438\u043d\u0430","orcid":"https://orcid.org/0000-0003-1237-9284","observed_orcids":["https://orcid.org/0000-0003-1237-9284"]},"institutions":[{"id":"https://openalex.org/I4210120901","display_name":"Bashkir State Medical University","ror":"https://ror.org/02w1g0f30","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210120901"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"L.\u0410. Musina","raw_affiliation_strings":["Russian Center for Eye and Plastic Surgery , Bashkir State Medical University , Ufa , Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Russian Center for Eye and Plastic Surgery , Bashkir State Medical University , Ufa , Russian Federation","institution_ids":["https://openalex.org/I4210120901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014234740","display_name":"K.Kh. Titoyan","orcid":"https://orcid.org/0000-0003-3529-3491","observed_orcids":["https://orcid.org/0000-0003-3529-3491"]},"institutions":[{"id":"https://openalex.org/I4210120901","display_name":"Bashkir State Medical University","ror":"https://ror.org/02w1g0f30","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210120901"]},{"id":"https://openalex.org/I4210154941","display_name":"Ufa Eye Research Institute","ror":"https://ror.org/04grwn689","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210154941"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"K.K. Titoyan","raw_affiliation_strings":["Ufa Eye Research Institute , Bashkir State Medical University , Ufa , Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ufa Eye Research Institute , Bashkir State Medical University , Ufa , Russian Federation","institution_ids":["https://openalex.org/I4210120901","https://openalex.org/I4210154941"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012457576","display_name":"L.I. Gilemzyanova","orcid":"https://orcid.org/0000-0002-0583-013X","observed_orcids":["https://orcid.org/0000-0002-0583-013X"]},"institutions":[{"id":"https://openalex.org/I4210120901","display_name":"Bashkir State Medical University","ror":"https://ror.org/02w1g0f30","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210120901"]},{"id":"https://openalex.org/I4210154941","display_name":"Ufa Eye Research Institute","ror":"https://ror.org/04grwn689","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210154941"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"L.I. Gilemzyanova","raw_affiliation_strings":["Ufa Eye Research Institute , Bashkir State Medical University , Ufa , Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ufa Eye Research Institute , Bashkir State Medical University , Ufa , Russian Federation","institution_ids":["https://openalex.org/I4210120901","https://openalex.org/I4210154941"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"4","first_page":"19","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/corneal-cross-linking","display_name":"corneal cross-linking","score":0.996999979019165},{"id":"https://openalex.org/keywords/keratoconus","display_name":"keratoconus","score":0.9419999718666077},{"id":"https://openalex.org/keywords/corneal-ultrastructure","display_name":"corneal ultrastructure","score":0.9470000267028809},{"id":"https://openalex.org/keywords/corneal-stromal-edema","display_name":"corneal stromal edema","score":0.8579999804496765},{"id":"https://openalex.org/keywords/corneal-endothelium","display_name":"corneal endothelium","score":0.8320000171661377},{"id":"https://openalex.org/keywords/corneal-epithelium","display_name":"corneal epithelium","score":0.6949999928474426},{"id":"https://openalex.org/keywords/rabbit-cornea","display_name":"rabbit cornea","score":0.5989999771118164},{"id":"https://openalex.org/keywords/uv-irradiation","display_name":"UV irradiation","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.8148000240325928},{"id":"https://openalex.org/C87555872","wikidata":"https://www.wikidata.org/wiki/Q3141316","display_name":"Ultrastructure","level":2,"score":0.7803999781608582},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5113999843597412},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.47429999709129333},{"id":"https://openalex.org/C3017420807","wikidata":"https://www.wikidata.org/wiki/Q11391","display_name":"Ultraviolet a","level":2,"score":0.4602999985218048},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.44110000133514404},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.4350000023841858},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.4025000035762787},{"id":"https://openalex.org/C2909399601","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Corneal Diseases","level":3,"score":0.3564000129699707},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3495999872684479},{"id":"https://openalex.org/C93877712","wikidata":"https://www.wikidata.org/wiki/Q132560","display_name":"Electron microscope","level":2,"score":0.3384999930858612},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33809998631477356},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.32760000228881836},{"id":"https://openalex.org/C2987116853","wikidata":"https://www.wikidata.org/wiki/Q11391","display_name":"Ultraviolet light","level":2,"score":0.32690000534057617},{"id":"https://openalex.org/C499950583","wikidata":"https://www.wikidata.org/wiki/Q183252","display_name":"Morphology (biology)","level":2,"score":0.3165999948978424},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29109999537467957},{"id":"https://openalex.org/C2779133491","wikidata":"https://www.wikidata.org/wiki/Q25401","display_name":"Lagomorpha","level":2,"score":0.28540000319480896},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.2802000045776367},{"id":"https://openalex.org/C2992327504","wikidata":"https://www.wikidata.org/wiki/Q11391","display_name":"Ultraviolet irradiation","level":3,"score":0.27559998631477356},{"id":"https://openalex.org/C2780980610","wikidata":"https://www.wikidata.org/wiki/Q2805908","display_name":"Bullous keratopathy","level":3,"score":0.27059999108314514},{"id":"https://openalex.org/C52124034","wikidata":"https://www.wikidata.org/wiki/Q557179","display_name":"Stroma","level":3,"score":0.2615000009536743},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.2551000118255615}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.25276/2410-1257-2025-4-19-24","doi":"https://doi.org/10.25276/2410-1257-2025-4-19-24","is_oa":true,"landing_page_url":"https://doi.org/10.25276/2410-1257-2025-4-19-24","pdf_url":"https://east-west-journal.ru/index.php/east-west/article/download/571/797","source":{"id":"https://openalex.org/S4210199748","display_name":"POINT OF VIEW EAST \u2013 WEST","issn_l":"2410-1257","issn":["2410-1257"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-3"],"host_organization":"https://openalex.org/P4310312600","host_organization_name":"Publishing house\u00a0\"Ophthalmology\"","host_organization_lineage":["https://openalex.org/P4310312600"],"host_organization_lineage_names":["Publishing house\u00a0\"Ophthalmology\""],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"POINT OF VIEW. EAST \u2013 WEST","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.25276/2410-1257-2025-4-19-24","doi":"https://doi.org/10.25276/2410-1257-2025-4-19-24","is_oa":true,"landing_page_url":"https://doi.org/10.25276/2410-1257-2025-4-19-24","pdf_url":"https://east-west-journal.ru/index.php/east-west/article/download/571/797","source":{"id":"https://openalex.org/S4210199748","display_name":"POINT OF VIEW EAST \u2013 WEST","issn_l":"2410-1257","issn":["2410-1257"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-3"],"host_organization":"https://openalex.org/P4310312600","host_organization_name":"Publishing house\u00a0\"Ophthalmology\"","host_organization_lineage":["https://openalex.org/P4310312600"],"host_organization_lineage_names":["Publishing house\u00a0\"Ophthalmology\""],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"POINT OF VIEW. EAST \u2013 WEST","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324099","display_name":"Russian Science Foundation","ror":"https://ror.org/03y2gwe85"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7127090657.pdf","grobid_xml":"https://content.openalex.org/works/W7127090657.grobid-xml"},"referenced_works_count":6,"referenced_works":["https://openalex.org/W2071116121","https://openalex.org/W2478135314","https://openalex.org/W3208206674","https://openalex.org/W4223510812","https://openalex.org/W4405395446","https://openalex.org/W4407649876"],"related_works":["https://openalex.org/W7169867918","https://openalex.org/W7204887567","https://openalex.org/W2062814511","https://openalex.org/W4402139860","https://openalex.org/W7055089912","https://openalex.org/W1988802889","https://openalex.org/W2888199485","https://openalex.org/W2615199715","https://openalex.org/W4413039319","https://openalex.org/W4223510812"],"abstract_inverted_index":{"Corneal":[0],"Ultraviolet":[1,92],"Cross-Linking":[2],"(CXL)":[3],"is":[4],"a":[5,105],"recognized":[6],"method":[7],"for":[8,99,118],"stabilizing":[9],"progressive":[10],"keratoconus.":[11],"Despite":[12],"its":[13],"proven":[14],"clinical":[15],"efficacy,":[16],"the":[17,27,44,64,68,75,95,128,139,142,147,160,163,168,177,184,193,199,208,221,226,230,233,245,251],"fundamental":[18],"aspects":[19],"of":[20,39,67,89,94,141,146,156,165,167,172,181,183,187,198,210,216,232,244,250],"how":[21],"CXL":[22,84],"affects":[23],"corneal":[24,150,157,239],"morphology":[25],"at":[26,108,220],"ultrastructural":[28,222,248],"level":[29],"require":[30],"further":[31],"study.":[32],"Purpose.":[33],"A":[34],"comprehensive":[35],"electron":[36,121],"microscopic":[37,122],"study":[38],"morphological":[40,134,242],"changes":[41,135,204,219],"i":[42],"n":[43],"rabbit":[45,200],"cornea":[46,96,252],"after":[47],"CXL.":[48],"Material":[49,117],"and":[50,82,87,120,170],"methods.":[51],"Experiments":[52],"were":[53,78,136,190,205],"performed":[54,103],"on":[55,159,176],"16":[56],"corneas":[57,140],"(8":[58],"rabbits)":[59],"divided":[60],"into":[61],"2":[62],"groups:":[63],"left":[65],"eyes":[66,77],"animals":[69],"remained":[70],"intact":[71,188],"(group":[72,80],"1),":[73],"while":[74],"right":[76],"experimental":[79,143],"2)":[81],"underwent":[83],"with":[85],"de-epithelialization":[86],"instillations":[88],"DEXTRAALINK":[90],"solution.":[91],"irradiation":[93],"(3":[97],"mW/cm\u00b2":[98],"30":[100],"minutes)":[101],"was":[102,114,124],"using":[104],"\u00abUVALINK\u00bb":[106],"device":[107],"\u03bb=370":[109],"nm.":[110],"The":[111,132,214],"observation":[112],"period":[113],"14":[115],"days.":[116],"histological":[119],"examination":[123],"prepared":[125],"according":[126],"to":[127],"standard":[129],"method.":[130],"Results.":[131],"following":[133],"revealed":[137],"in":[138,192,207,225],"group:":[144],"restoration":[145],"removed":[148],"epithelium,":[149],"stromal":[151],"edema":[152],"accompanied":[153],"by":[154],"separation":[155],"lamellae,":[158],"one":[161],"hand,":[162,179],"death":[164],"part":[166],"keratocytes":[169,189],"signs":[171,180],"minor":[173],"leukocyte":[174],"infiltration,":[175],"other":[178],"activation":[182],"synthetic":[185],"activity":[186],"noted":[191],"cells.":[194,212],"In":[195],"all":[196],"samples":[197],"corneas,":[201],"no":[202],"significant":[203],"observed":[206],"layer":[209],"endothelial":[211,227],"Conclusion.":[213],"absence":[215],"pronounced":[217],"pathological":[218],"level,":[223],"including":[224],"cells,":[228],"confirms":[229],"safety":[231],"C":[234],"XL":[235],"protocol":[236],"used.":[237],"Keywords:":[238],"collagen":[240],"cross-linking,":[241],"studies":[243],"corne":[246],"a,":[247],"analysis":[249]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-02-03T00:00:00"}