{"id":"https://openalex.org/W7127090064","doi":"https://doi.org/10.23736/s0392-9590.26.05497-0","title":"Histopathological evaluation of lower limb reticular veins treated with Nd:YAG 1064 nm laser: a prospective cohort pilot study","display_name":"Histopathological evaluation of lower limb reticular veins treated with Nd:YAG 1064 nm laser: a prospective cohort pilot study","publication_year":2026,"publication_date":"2026-02-02","ids":{"openalex":"https://openalex.org/W7127090064","doi":"https://doi.org/10.23736/s0392-9590.26.05497-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/41627196"},"language":"en","primary_location":{"id":"doi:10.23736/s0392-9590.26.05497-0","doi":"https://doi.org/10.23736/s0392-9590.26.05497-0","is_oa":true,"landing_page_url":"https://doi.org/10.23736/s0392-9590.26.05497-0","pdf_url":null,"source":{"id":"https://openalex.org/S55497336","display_name":"International Angiology","issn_l":"0392-9590","issn":["0392-9590","1827-1839"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4320800528","host_organization_name":"Edizioni Minerva Medica","host_organization_lineage":["https://openalex.org/P4320800528"],"host_organization_lineage_names":["Edizioni Minerva Medica"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Angiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.23736/s0392-9590.26.05497-0","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5124750539","display_name":"Felipe COELHO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40034438","display_name":"Universidade do Estado do Rio de Janeiro","ror":"https://ror.org/0198v2949","country_code":"BR","type":"education","lineage":["https://openalex.org/I40034438"]},{"id":"https://openalex.org/I4210099359","display_name":"Hospital Universit\u00e1rio Pedro Ernesto","ror":"https://ror.org/00hrmgq26","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210099359"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Felipe COELHO","raw_affiliation_strings":["CT Vascular - Academic and Clinical Unit of Vascular Surgery, Pedro Ernesto University Hospital (HUPE), Rio de Janeiro State University (UERJ), Rio de Janeiro, Brazil - contato@drfelipecoelho.com.br","Vascular Hospital of Londrina, Londrina, Brazil - contato@drfelipecoelho.com.br"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CT Vascular - Academic and Clinical Unit of Vascular Surgery, Pedro Ernesto University Hospital (HUPE), Rio de Janeiro State University (UERJ), Rio de Janeiro, Brazil - contato@drfelipecoelho.com.br","institution_ids":["https://openalex.org/I40034438","https://openalex.org/I4210099359"]},{"raw_affiliation_string":"Vascular Hospital of Londrina, Londrina, Brazil - contato@drfelipecoelho.com.br","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051842685","display_name":"Fernando Tr\u00e9s Silveira","orcid":"https://orcid.org/0000-0001-6909-180X","observed_orcids":["https://orcid.org/0000-0001-6909-180X","https://orcid.org/0000-0003-0240-8854"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fernando T. SILVEIRA","raw_affiliation_strings":["Cardiodiagn\u00f3stico, Vila Velha, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiodiagn\u00f3stico, Vila Velha, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027881600","display_name":"Paulo Roberto Bignardi","orcid":"https://orcid.org/0000-0002-4730-0946","observed_orcids":["https://orcid.org/0000-0002-4730-0946"]},"institutions":[{"id":"https://openalex.org/I176838256","display_name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1","ror":"https://ror.org/02x1vjk79","country_code":"BR","type":"education","lineage":["https://openalex.org/I176838256"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Paulo R. BIGNARDI","raw_affiliation_strings":["School of Medicine, Campus of Londrina, Pontifical Catholic University of Paran\u00e1 (PUCPR), Londrina, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Campus of Londrina, Pontifical Catholic University of Paran\u00e1 (PUCPR), Londrina, Brazil","institution_ids":["https://openalex.org/I176838256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079659880","display_name":"Glenio Bitencourt Mizubuti","orcid":"https://orcid.org/0000-0002-5515-829X","observed_orcids":["https://orcid.org/0000-0002-5515-829X"]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Glenio B. MIZUBUTI","raw_affiliation_strings":["Department of Anesthesiology and Perioperative Medicine, Queen's University, Kingston, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Perioperative Medicine, Queen's University, Kingston, ON, Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023542627","display_name":"Carlos Eduardo Virgini\u2010Magalh\u00e3es","orcid":"https://orcid.org/0000-0002-0422-2298","observed_orcids":["https://orcid.org/0000-0002-0422-2298"]},"institutions":[{"id":"https://openalex.org/I40034438","display_name":"Universidade do Estado do Rio de Janeiro","ror":"https://ror.org/0198v2949","country_code":"BR","type":"education","lineage":["https://openalex.org/I40034438"]},{"id":"https://openalex.org/I4210099359","display_name":"Hospital Universit\u00e1rio Pedro Ernesto","ror":"https://ror.org/00hrmgq26","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210099359"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Carlos E. VIRGINI-MAGALH\u00c3ES","raw_affiliation_strings":["CT Vascular - Academic and Clinical Unit of Vascular Surgery, Pedro Ernesto University Hospital (HUPE), Rio de Janeiro State University (UERJ), Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CT Vascular - Academic and Clinical Unit of Vascular Surgery, Pedro Ernesto University Hospital (HUPE), Rio de Janeiro State University (UERJ), Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I40034438","https://openalex.org/I4210099359"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Douglas POSCHINGER-FIGUEIREDO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40034438","display_name":"Universidade do Estado do Rio de Janeiro","ror":"https://ror.org/0198v2949","country_code":"BR","type":"education","lineage":["https://openalex.org/I40034438"]},{"id":"https://openalex.org/I4210099359","display_name":"Hospital Universit\u00e1rio Pedro Ernesto","ror":"https://ror.org/00hrmgq26","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210099359"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Douglas POSCHINGER-FIGUEIREDO","raw_affiliation_strings":["CT Vascular - Academic and Clinical Unit of Vascular Surgery, Pedro Ernesto University Hospital (HUPE), Rio de Janeiro State University (UERJ), Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CT Vascular - Academic and Clinical Unit of Vascular Surgery, Pedro Ernesto University Hospital (HUPE), Rio de Janeiro State University (UERJ), Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I40034438","https://openalex.org/I4210099359"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124761880","display_name":"Eduardo de O. RODRIGUES","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40034438","display_name":"Universidade do Estado do Rio de Janeiro","ror":"https://ror.org/0198v2949","country_code":"BR","type":"education","lineage":["https://openalex.org/I40034438"]},{"id":"https://openalex.org/I4210099359","display_name":"Hospital Universit\u00e1rio Pedro Ernesto","ror":"https://ror.org/00hrmgq26","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210099359"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Eduardo de O. RODRIGUES","raw_affiliation_strings":["CT Vascular - Academic and Clinical Unit of Vascular Surgery, Pedro Ernesto University Hospital (HUPE), Rio de Janeiro State University (UERJ), Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CT Vascular - Academic and Clinical Unit of Vascular Surgery, Pedro Ernesto University Hospital (HUPE), Rio de Janeiro State University (UERJ), Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I40034438","https://openalex.org/I4210099359"]}]},{"author_position":"last","author":{"id":null,"display_name":"Rodrigo G. de OLIVEIRA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rodrigo G. de OLIVEIRA","raw_affiliation_strings":["Vascular Hospital of Londrina, Londrina, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Hospital of Londrina, Londrina, Brazil","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5124750539"],"corresponding_institution_ids":["https://openalex.org/I40034438","https://openalex.org/I4210099359"],"apc_list":null,"apc_paid":null,"fwci":6.317,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.91944488,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"45","issue":"2","first_page":"71","last_page":"76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11453","display_name":"Diagnosis and Treatment of Venous Diseases","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11453","display_name":"Diagnosis and Treatment of Venous Diseases","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10980","display_name":"Vascular Malformations and Hemangiomas","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/telangiectasia","display_name":"telangiectasia","score":0.8130000233650208},{"id":"https://openalex.org/keywords/laser-fluence","display_name":"laser fluence","score":0.8069999814033508},{"id":"https://openalex.org/keywords/pulse-duration","display_name":"pulse duration","score":0.9919999837875366},{"id":"https://openalex.org/keywords/neutrophil-infiltration","display_name":"neutrophil infiltration","score":0.8209999799728394},{"id":"https://openalex.org/keywords/ambulatory-phlebectomy","display_name":"ambulatory phlebectomy","score":0.8169999718666077},{"id":"https://openalex.org/keywords/laser-parameters","display_name":"laser parameters","score":0.3880000114440918}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9718000292778015},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.7766000032424927},{"id":"https://openalex.org/C2989316616","wikidata":"https://www.wikidata.org/wiki/Q6027402","display_name":"Lower limb","level":2,"score":0.642300009727478},{"id":"https://openalex.org/C95190701","wikidata":"https://www.wikidata.org/wiki/Q3268002","display_name":"Reticular connective tissue","level":2,"score":0.6338000297546387},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.41909998655319214},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.3578999936580658},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3564000129699707},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.34950000047683716},{"id":"https://openalex.org/C2780167933","wikidata":"https://www.wikidata.org/wiki/Q1550652","display_name":"Pulse (music)","level":3,"score":0.3246000111103058},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.3224000036716461},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3052999973297119},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.30300000309944153},{"id":"https://openalex.org/C205679159","wikidata":"https://www.wikidata.org/wiki/Q3375179","display_name":"Transdermal","level":2,"score":0.29100000858306885},{"id":"https://openalex.org/C2777202286","wikidata":"https://www.wikidata.org/wiki/Q9609","display_name":"Vein","level":2,"score":0.2840000092983246},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.28369998931884766},{"id":"https://openalex.org/C3018348675","wikidata":"https://www.wikidata.org/wiki/Q4797557","display_name":"Arterial disease","level":3,"score":0.2831000089645386},{"id":"https://openalex.org/C12722491","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microcirculation","level":2,"score":0.2761000096797943},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.2676999866962433},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2605000138282776}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013684","descriptor_name":"Telangiectasis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013684","descriptor_name":"Telangiectasis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013684","descriptor_name":"Telangiectasis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013684","descriptor_name":"Telangiectasis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013684","descriptor_name":"Telangiectasis","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D013684","descriptor_name":"Telangiectasis","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D013684","descriptor_name":"Telangiectasis","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D013684","descriptor_name":"Telangiectasis","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014680","descriptor_name":"Veins","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014680","descriptor_name":"Veins","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014680","descriptor_name":"Veins","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014680","descriptor_name":"Veins","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014680","descriptor_name":"Veins","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D014680","descriptor_name":"Veins","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D014680","descriptor_name":"Veins","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D014680","descriptor_name":"Veins","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D014680","descriptor_name":"Veins","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D014680","descriptor_name":"Veins","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D014680","descriptor_name":"Veins","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D014680","descriptor_name":"Veins","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035002","descriptor_name":"Lower Extremity","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D035002","descriptor_name":"Lower Extremity","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D035002","descriptor_name":"Lower Extremity","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D035002","descriptor_name":"Lower Extremity","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D053685","descriptor_name":"Laser Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D053685","descriptor_name":"Laser Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D053685","descriptor_name":"Laser Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D053685","descriptor_name":"Laser Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D053844","descriptor_name":"Lasers, Solid-State","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D053844","descriptor_name":"Lasers, Solid-State","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D053844","descriptor_name":"Lasers, Solid-State","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D053844","descriptor_name":"Lasers, Solid-State","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D053844","descriptor_name":"Lasers, Solid-State","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D053844","descriptor_name":"Lasers, Solid-State","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D053844","descriptor_name":"Lasers, Solid-State","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D053844","descriptor_name":"Lasers, Solid-State","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.23736/s0392-9590.26.05497-0","doi":"https://doi.org/10.23736/s0392-9590.26.05497-0","is_oa":true,"landing_page_url":"https://doi.org/10.23736/s0392-9590.26.05497-0","pdf_url":null,"source":{"id":"https://openalex.org/S55497336","display_name":"International Angiology","issn_l":"0392-9590","issn":["0392-9590","1827-1839"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4320800528","host_organization_name":"Edizioni Minerva Medica","host_organization_lineage":["https://openalex.org/P4320800528"],"host_organization_lineage_names":["Edizioni Minerva Medica"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Angiology","raw_type":"journal-article"},{"id":"pmid:41627196","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41627196","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International angiology : a journal of the International Union of Angiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.23736/s0392-9590.26.05497-0","doi":"https://doi.org/10.23736/s0392-9590.26.05497-0","is_oa":true,"landing_page_url":"https://doi.org/10.23736/s0392-9590.26.05497-0","pdf_url":null,"source":{"id":"https://openalex.org/S55497336","display_name":"International Angiology","issn_l":"0392-9590","issn":["0392-9590","1827-1839"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4320800528","host_organization_name":"Edizioni Minerva Medica","host_organization_lineage":["https://openalex.org/P4320800528"],"host_organization_lineage_names":["Edizioni Minerva Medica"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Angiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.6484031677246094,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W2011859830","https://openalex.org/W2093337494","https://openalex.org/W2167163646","https://openalex.org/W2170474739","https://openalex.org/W3007080699","https://openalex.org/W4206813711","https://openalex.org/W4213266173","https://openalex.org/W4232996309","https://openalex.org/W4250931707","https://openalex.org/W4317470293","https://openalex.org/W4384925641"],"related_works":[],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"1064":[2,49],"nm":[3,50],"Nd:YAG":[4,48],"transdermal":[5,74],"laser":[6,23,51,75,104],"is":[7],"commonly":[8],"used":[9],"in":[10],"the":[11,43,58,103,146],"ambulatory":[12,71],"treatment":[13],"of":[14,33,46,85,92,136,148,179],"lower":[15],"limb":[16],"reticular":[17,54],"veins":[18,55],"and":[19,27,87,105,115,117,129,139],"telangiectasias.":[20],"However,":[21],"optimal":[22],"parameters,":[24],"particularly":[25],"fluence":[26,86,161],"pulse":[28,88,134,164,168,177],"duration,":[29],"remain":[30],"a":[31],"subject":[32],"debate.":[34],"In":[35],"this":[36],"prospective":[37],"cohort":[38],"pilot":[39],"study,":[40],"we":[41],"evaluated":[42],"histopathological":[44],"effects":[45],"different":[47,83],"settings":[52],"on":[53],"to":[56,80],"identify":[57],"parameter":[59],"combinations":[60,84],"most":[61],"associated":[62,144],"with":[63,102,113,133,145,162,170,176],"vein":[64,94],"wall":[65,130],"damage.":[66],"METHODS:":[67],"Patients":[68],"scheduled":[69],"for":[70,124],"phlebectomy":[72],"received":[73],"therapy":[76],"24":[77],"hours":[78],"prior":[79],"surgery,":[81],"using":[82],"duration.":[89],"A":[90],"total":[91],"15":[93,137],"segments":[95],"were":[96,111,142,156],"collected":[97],"during":[98],"phlebectomy,":[99],"12":[100],"treated":[101],"3":[106],"untreated":[107],"controls.":[108],"All":[109],"samples":[110],"stained":[112],"hematoxylin":[114],"eosin":[116],"independently":[118],"analyzed":[119],"by":[120],"two":[121],"blinded":[122],"pathologists":[123],"neutrophilic":[125],"infiltration,":[126],"luminal":[127],"thrombosis,":[128],"fibrosis.":[131],"RESULTS:":[132],"durations":[135,165,178],"ms":[138,141],"30":[140],"significantly":[143],"presence":[147],"inflammatory":[149],"infiltrates":[150],"(P<0.05).":[151],"No":[152],"statistically":[153],"significant":[154],"differences":[155],"found":[157],"when":[158],"comparing":[159],"fixed":[160,167],"variable":[163,171],"or":[166],"duration":[169],"fluences":[172],"(P>0.05).":[173],"CONCLUSIONS:":[174],"combined":[175],"15-30":[180],"ms.":[181]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-02-03T00:00:00"}