{"id":"https://openalex.org/W7127069849","doi":"https://doi.org/10.1002/ctm2.70575","title":"Beyond bacterial defences: the role of lysozyme in cancer","display_name":"Beyond bacterial defences: the role of lysozyme in cancer","publication_year":2026,"publication_date":"2026-02-01","ids":{"openalex":"https://openalex.org/W7127069849","doi":"https://doi.org/10.1002/ctm2.70575","pmid":"https://pubmed.ncbi.nlm.nih.gov/41622693"},"language":"en","primary_location":{"id":"doi:10.1002/ctm2.70575","doi":"https://doi.org/10.1002/ctm2.70575","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ctm2.70575","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ctm2.70575","source":{"id":"https://openalex.org/S2765071679","display_name":"Clinical and Translational Medicine","issn_l":"2001-1326","issn":["2001-1326"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ctm2.70575","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100349000","display_name":"Linlin Wang","orcid":"https://orcid.org/0000-0002-5897-4401","observed_orcids":["https://orcid.org/0000-0002-5897-4401","https://orcid.org/0000-0002-7014-2149","https://orcid.org/0000-0003-0048-5979","https://orcid.org/0000-0003-1105-8542","https://orcid.org/0000-0002-6999-5056"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I37796252","display_name":"Beijing University of Technology","ror":"https://ror.org/037b1pp87","country_code":"CN","type":"education","lineage":["https://openalex.org/I37796252"]},{"id":"https://openalex.org/I4210149540","display_name":"Beijing Proteome Research Center","ror":"https://ror.org/05pp5b412","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210149540"]},{"id":"https://openalex.org/I4391768116","display_name":"State Key Laboratory of Proteomics","ror":"https://ror.org/019bev041","country_code":null,"type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4391768116"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Wang","raw_affiliation_strings":["College of Chemistry and Life Science Beijing University of Technology  Beijing China","State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Research Unit of Proteomics\u2010Driven Cancer Precision Medicine (Chinese Academy of Medical Sciences) Beijing Institute of Lifeomics  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Life Science Beijing University of Technology  Beijing China","institution_ids":["https://openalex.org/I37796252"]},{"raw_affiliation_string":"State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Research Unit of Proteomics\u2010Driven Cancer Precision Medicine (Chinese Academy of Medical Sciences) Beijing Institute of Lifeomics  Beijing China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210149540","https://openalex.org/I4391768116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124766065","display_name":"Qian Dong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210149540","display_name":"Beijing Proteome Research Center","ror":"https://ror.org/05pp5b412","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210149540"]},{"id":"https://openalex.org/I4391768116","display_name":"State Key Laboratory of Proteomics","ror":"https://ror.org/019bev041","country_code":null,"type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4391768116"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Dong","raw_affiliation_strings":["State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Research Unit of Proteomics\u2010Driven Cancer Precision Medicine (Chinese Academy of Medical Sciences) Beijing Institute of Lifeomics  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Research Unit of Proteomics\u2010Driven Cancer Precision Medicine (Chinese Academy of Medical Sciences) Beijing Institute of Lifeomics  Beijing China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210149540","https://openalex.org/I4391768116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102988480","display_name":"Fuchu He","orcid":"https://orcid.org/0000-0002-1094-4019","observed_orcids":["https://orcid.org/0000-0002-1094-4019"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210149540","display_name":"Beijing Proteome Research Center","ror":"https://ror.org/05pp5b412","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210149540"]},{"id":"https://openalex.org/I4391768116","display_name":"State Key Laboratory of Proteomics","ror":"https://ror.org/019bev041","country_code":null,"type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4391768116"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fuchu He","raw_affiliation_strings":["State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Research Unit of Proteomics\u2010Driven Cancer Precision Medicine (Chinese Academy of Medical Sciences) Beijing Institute of Lifeomics  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Research Unit of Proteomics\u2010Driven Cancer Precision Medicine (Chinese Academy of Medical Sciences) Beijing Institute of Lifeomics  Beijing China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210149540","https://openalex.org/I4391768116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124836767","display_name":"Zhiwen Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhiwen Gu","raw_affiliation_strings":["Core Unit of National Clinical Research Center for Laboratory Medicine Peking University Third Hospital  Beijing China","Department of Laboratory Medicine Peking University Third Hospital  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Core Unit of National Clinical Research Center for Laboratory Medicine Peking University Third Hospital  Beijing China","institution_ids":["https://openalex.org/I4210141942"]},{"raw_affiliation_string":"Department of Laboratory Medicine Peking University Third Hospital  Beijing China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101662218","display_name":"Aihua Sun","orcid":"https://orcid.org/0000-0001-7931-6662","observed_orcids":["https://orcid.org/0000-0001-7931-6662"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210149540","display_name":"Beijing Proteome Research Center","ror":"https://ror.org/05pp5b412","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210149540"]},{"id":"https://openalex.org/I4391768116","display_name":"State Key Laboratory of Proteomics","ror":"https://ror.org/019bev041","country_code":null,"type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4391768116"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Aihua Sun","raw_affiliation_strings":["State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Research Unit of Proteomics\u2010Driven Cancer Precision Medicine (Chinese Academy of Medical Sciences) Beijing Institute of Lifeomics  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Research Unit of Proteomics\u2010Driven Cancer Precision Medicine (Chinese Academy of Medical Sciences) Beijing Institute of Lifeomics  Beijing China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210149540","https://openalex.org/I4391768116"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5101662218","https://openalex.org/A5124836767"],"corresponding_institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141942","https://openalex.org/I4210149540","https://openalex.org/I4391768116"],"apc_list":{"value":3470,"currency":"USD","value_usd":3470},"apc_paid":{"value":3470,"currency":"USD","value_usd":3470},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06184486,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"2","first_page":"e70575","last_page":"e70575"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.5199999809265137,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.5199999809265137,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0560000017285347,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.054099999368190765,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lysozyme","display_name":"lysozyme","score":0.996999979019165},{"id":"https://openalex.org/keywords/c-type-lysozyme","display_name":"c-type lysozyme","score":0.9079999923706055},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.824999988079071},{"id":"https://openalex.org/keywords/tumor-suppression","display_name":"tumor suppression","score":0.6940000057220459},{"id":"https://openalex.org/keywords/tumor-promotion","display_name":"tumor promotion","score":0.972000002861023},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.8769999742507935},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.6949999928474426},{"id":"https://openalex.org/keywords/antimicrobial-proteins","display_name":"antimicrobial proteins","score":0.5759999752044678},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.859000027179718},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.9210000038146973},{"id":"https://openalex.org/keywords/precision-oncology","display_name":"precision oncology","score":0.7749999761581421},{"id":"https://openalex.org/keywords/multi-omics-integration","display_name":"multi-omics integration","score":0.7599999904632568}],"concepts":[{"id":"https://openalex.org/C2776966407","wikidata":"https://www.wikidata.org/wiki/Q24779410","display_name":"Lysozyme","level":2,"score":0.7717999815940857},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.567799985408783},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.5110999941825867},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5105999708175659},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49939998984336853},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4659000039100647},{"id":"https://openalex.org/C540938839","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antimicrobial peptides","level":3,"score":0.41119998693466187},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40709999203681946},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.39750000834465027},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3959999978542328},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3889000117778778},{"id":"https://openalex.org/C3019440502","wikidata":"https://www.wikidata.org/wiki/Q500430","display_name":"Dual role","level":2,"score":0.3758000135421753},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.3402000069618225},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3221000134944916},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3127000033855438},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.311599999666214},{"id":"https://openalex.org/C2780980858","wikidata":"https://www.wikidata.org/wiki/Q110022","display_name":"Dual (grammatical number)","level":2,"score":0.31029999256134033},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.3068000078201294},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.29580000042915344},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.28349998593330383},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.27549999952316284},{"id":"https://openalex.org/C2777002142","wikidata":"https://www.wikidata.org/wiki/Q5031432","display_name":"Cancer biomarkers","level":3,"score":0.2687000036239624},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.2671000063419342},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2648000121116638},{"id":"https://openalex.org/C2993175405","wikidata":"https://www.wikidata.org/wiki/Q8054","display_name":"Bacterial protein","level":3,"score":0.26249998807907104},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.2547000050544739}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/ctm2.70575","doi":"https://doi.org/10.1002/ctm2.70575","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ctm2.70575","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ctm2.70575","source":{"id":"https://openalex.org/S2765071679","display_name":"Clinical and Translational Medicine","issn_l":"2001-1326","issn":["2001-1326"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Medicine","raw_type":"journal-article"},{"id":"pmid:41622693","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41622693","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and translational medicine","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11669787","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12862186","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:dcd8ee0a18fd414d8642ee8e80fdfcec","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/dcd8ee0a18fd414d8642ee8e80fdfcec","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical and Translational Medicine, Vol 16, Iss 2, Pp n/a-n/a (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/ctm2.70575","doi":"https://doi.org/10.1002/ctm2.70575","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ctm2.70575","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ctm2.70575","source":{"id":"https://openalex.org/S2765071679","display_name":"Clinical and Translational Medicine","issn_l":"2001-1326","issn":["2001-1326"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2033724137","display_name":null,"funder_award_id":"82303197","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8912623653","display_name":null,"funder_award_id":"2021YFA1301604","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G987564722","display_name":null,"funder_award_id":"2019-I2M-5-063","funder_id":"https://openalex.org/F4320323137","funder_display_name":"Chinese Academy of Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323137","display_name":"Chinese Academy of Medical Sciences","ror":"https://ror.org/03cve4549"},{"id":"https://openalex.org/F4320324787","display_name":"Peking University","ror":"https://ror.org/02v51f717"},{"id":"https://openalex.org/F4320325739","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7127069849.pdf","grobid_xml":"https://content.openalex.org/works/W7127069849.grobid-xml"},"referenced_works_count":107,"referenced_works":["https://openalex.org/W65362011","https://openalex.org/W251784485","https://openalex.org/W1488903292","https://openalex.org/W1537844134","https://openalex.org/W1547533961","https://openalex.org/W1571775272","https://openalex.org/W1595293335","https://openalex.org/W1685928765","https://openalex.org/W1950514687","https://openalex.org/W1963896368","https://openalex.org/W1966312834","https://openalex.org/W1972052129","https://openalex.org/W1972881118","https://openalex.org/W1973268693","https://openalex.org/W1975597358","https://openalex.org/W1976392832","https://openalex.org/W1976794252","https://openalex.org/W1977653686","https://openalex.org/W1977802642","https://openalex.org/W1979165607","https://openalex.org/W1982377026","https://openalex.org/W1985421564","https://openalex.org/W2001166572","https://openalex.org/W2002169638","https://openalex.org/W2021577984","https://openalex.org/W2022978842","https://openalex.org/W2025552261","https://openalex.org/W2029389776","https://openalex.org/W2034357212","https://openalex.org/W2036133089","https://openalex.org/W2036470133","https://openalex.org/W2046879739","https://openalex.org/W2046981045","https://openalex.org/W2055450300","https://openalex.org/W2060399705","https://openalex.org/W2064358027","https://openalex.org/W2066463299","https://openalex.org/W2067585177","https://openalex.org/W2070380466","https://openalex.org/W2072673404","https://openalex.org/W2081363906","https://openalex.org/W2084999465","https://openalex.org/W2089940687","https://openalex.org/W2090572837","https://openalex.org/W2106304308","https://openalex.org/W2107321380","https://openalex.org/W2110713576","https://openalex.org/W2111141558","https://openalex.org/W2118027928","https://openalex.org/W2121971677","https://openalex.org/W2123087827","https://openalex.org/W2128878636","https://openalex.org/W2131856634","https://openalex.org/W2136817978","https://openalex.org/W2160611039","https://openalex.org/W2161193293","https://openalex.org/W2162352013","https://openalex.org/W2166576789","https://openalex.org/W2167898988","https://openalex.org/W2168639912","https://openalex.org/W2170130696","https://openalex.org/W2170848055","https://openalex.org/W2274225939","https://openalex.org/W2314220712","https://openalex.org/W2316368247","https://openalex.org/W2320945459","https://openalex.org/W2323984459","https://openalex.org/W2413230604","https://openalex.org/W2460289322","https://openalex.org/W2471468172","https://openalex.org/W2508251718","https://openalex.org/W2517327794","https://openalex.org/W2760465643","https://openalex.org/W2891800729","https://openalex.org/W2922343610","https://openalex.org/W2944459188","https://openalex.org/W3015375987","https://openalex.org/W3026836352","https://openalex.org/W3041116333","https://openalex.org/W3041219630","https://openalex.org/W3081768459","https://openalex.org/W3093532012","https://openalex.org/W3104755560","https://openalex.org/W3169828904","https://openalex.org/W3176288306","https://openalex.org/W3200585147","https://openalex.org/W4200174039","https://openalex.org/W4214843261","https://openalex.org/W4221057800","https://openalex.org/W4281612104","https://openalex.org/W4288716862","https://openalex.org/W4307969384","https://openalex.org/W4312129827","https://openalex.org/W4313260494","https://openalex.org/W4315436762","https://openalex.org/W4323665139","https://openalex.org/W4382403407","https://openalex.org/W4383753030","https://openalex.org/W4385556257","https://openalex.org/W4386503826","https://openalex.org/W4389614270","https://openalex.org/W4390579385","https://openalex.org/W4390617198","https://openalex.org/W4399321037","https://openalex.org/W4403853942","https://openalex.org/W4410489270","https://openalex.org/W4414281035"],"related_works":[],"abstract_inverted_index":{"Lysozyme":[0],"(LYZ)":[1],"is":[2,152,184],"a":[3,14,133,153,185],"naturally":[4],"occurring":[5],"antimicrobial":[6,21],"protein":[7],"first":[8],"discovered":[9],"in":[10,26,44,65,82,117,170,192],"the":[11,37,67,180],"1920s.":[12],"As":[13],"key":[15],"component":[16],"of":[17,50],"innate":[18],"immunity,":[19],"its":[20,41,114,128,167],"effects":[22,55],"and":[23,53,79,99,104,108,136,161,178,189],"immunomodulatory":[24,162],"functions":[25],"bacterial":[27],"defence":[28],"have":[29],"been":[30],"extensively":[31],"characterized.":[32],"However,":[33],"emerging":[34],"evidence":[35,165],"since":[36],"1950s":[38],"has":[39],"revealed":[40],"complex":[42,168],"involvement":[43],"tumour":[45,171,176],"progression,":[46],"with":[47,106],"conflicting":[48],"reports":[49],"both":[51,132,159],"tumour-suppressive":[52],"tumour-promoting":[54],"across":[56],"different":[57],"cancer":[58],"types.":[59],"A":[60],"critical":[61],"knowledge":[62],"gap":[63],"remains":[64],"understanding":[66],"mechanistic":[68,109],"basis":[69],"for":[70,146],"this":[71],"duality,":[72],"exacerbated":[73],"by":[74,173],"reliance":[75],"on":[76,88],"single-omics":[77],"approaches":[78],"small":[80],"cohorts":[81],"previous":[83],"studies.":[84],"This":[85],"review":[86],"focuses":[87],"mammalian":[89],"C-type":[90],"LYZ":[91,95,151,183],"(referred":[92],"to":[93,111,142],"as":[94,131],"hereafter":[96],"unless":[97],"specified)":[98],"integrates":[100],"multi-omics":[101,124],"data":[102],"(transcriptomics":[103],"proteomics)":[105],"clinical":[107],"research":[110],"systematically":[112],"dissect":[113],"dual":[115,129],"roles":[116],"cancer.":[118],"By":[119],"analysing":[120],"cross-cancer":[121],"heterogeneity":[122],"through":[123],"perspectives,":[125],"we":[126],"emphasize":[127],"promise":[130],"prognostic":[134],"biomarker":[135,188],"an":[137],"actionable":[138],"therapeutic":[139,190],"target,":[140],"aiming":[141],"provide":[143],"new":[144],"insights":[145],"precision":[147],"oncology.":[148],"KEY":[149],"POINTS:":[150],"multi-functional":[154],"secreted":[155],"factor":[156],"that":[157],"encompasses":[158],"antibacterial":[160],"functions.":[163],"Emerging":[164],"highlights":[166],"role":[169],"progression":[172],"directly":[174],"influencing":[175],"cells":[177],"modulating":[179],"immune":[181],"microenvironment.":[182],"promising":[186],"potential":[187],"target":[191],"some":[193],"cancers.":[194]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2026-02-03T00:00:00"}
