{"id":"https://openalex.org/W7127069213","doi":"https://doi.org/10.1051/bioconf/202518703003/pdf","title":"Identification and quantitation of Choline in food supplements using high performance liquid chromatography","display_name":"Identification and quantitation of Choline in food supplements using high performance liquid chromatography","publication_year":2025,"publication_date":"2025-09-09","ids":{"openalex":"https://openalex.org/W7127069213","doi":"https://doi.org/10.1051/bioconf/202518703003/pdf"},"language":"en","primary_location":{"id":"pmh:oai:edpsciences.org:dkey/10.1051/bioconf/202518703003","doi":"https://doi.org/10.1051/bioconf/202518703003/pdf","is_oa":false,"landing_page_url":"https://www.bio-conferences.org/10.1051/bioconf/202518703003/pdf","pdf_url":"https://www.bio-conferences.org/10.1051/bioconf/202518703003/pdf","source":{"id":"https://openalex.org/S4306400744","display_name":"Springer Link (Chiba Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8488066","host_organization_name":"Chiba Institute of Technology","host_organization_lineage":["https://openalex.org/I8488066"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://doi.org/10.1051/bioconf/202518703003","raw_type":"Text"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036599919","display_name":"Alexandrina Mateeva","orcid":"https://orcid.org/0000-0003-1905-7130","observed_orcids":["https://orcid.org/0000-0003-1905-7130"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexandrina Mateeva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070533424","display_name":"Rebeca Ruseva","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rebeca Ruseva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060064999","display_name":"Lily Peikova","orcid":"https://orcid.org/0000-0002-8030-3479","observed_orcids":["https://orcid.org/0000-0002-8030-3479"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lily Peikova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011166542","display_name":"Emilio Mateev","orcid":"https://orcid.org/0000-0002-5885-7213","observed_orcids":["https://orcid.org/0000-0002-5885-7213"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emilio Mateev","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020858809","display_name":"Alexander Zlatkov","orcid":"https://orcid.org/0000-0002-1695-8454","observed_orcids":["https://orcid.org/0000-0002-1695-8454"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander Zlatkov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5062420036","display_name":"Maya Georgieva","orcid":"https://orcid.org/0000-0002-4752-5002","observed_orcids":["https://orcid.org/0000-0002-4752-5002","https://orcid.org/0000-0001-7009-5744"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maya Georgieva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.39555815,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14127","display_name":"Food and Agricultural Sciences","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/choline","display_name":"choline","score":0.9940000176429749},{"id":"https://openalex.org/keywords/dietary-supplements","display_name":"dietary supplements","score":0.9919999837875366},{"id":"https://openalex.org/keywords/reversed-phase-hplc","display_name":"reversed-phase HPLC","score":0.7509999871253967},{"id":"https://openalex.org/keywords/method-validation","display_name":"method validation","score":0.8119999766349792},{"id":"https://openalex.org/keywords/ich-q2-guidelines","display_name":"ICH Q2 guidelines","score":0.7250000238418579},{"id":"https://openalex.org/keywords/supplement-quality-control","display_name":"supplement quality control","score":0.7689999938011169},{"id":"https://openalex.org/keywords/label-claim-verification","display_name":"label claim verification","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.8531000018119812},{"id":"https://openalex.org/C2781123555","wikidata":"https://www.wikidata.org/wiki/Q193166","display_name":"Choline","level":2,"score":0.7430999875068665},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.641700029373169},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.6087999939918518},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.6018000245094299},{"id":"https://openalex.org/C95986675","wikidata":"https://www.wikidata.org/wiki/Q185168","display_name":"Quantitative analysis (chemistry)","level":2,"score":0.46560001373291016},{"id":"https://openalex.org/C51989270","wikidata":"https://www.wikidata.org/wiki/Q623738","display_name":"Relative standard deviation","level":3,"score":0.29190000891685486},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.2718999981880188},{"id":"https://openalex.org/C2778576202","wikidata":"https://www.wikidata.org/wiki/Q2540164","display_name":"Sample preparation","level":2,"score":0.27079999446868896},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.26840001344680786},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.25200000405311584}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:edpsciences.org:dkey/10.1051/bioconf/202518703003","doi":"https://doi.org/10.1051/bioconf/202518703003/pdf","is_oa":false,"landing_page_url":"https://www.bio-conferences.org/10.1051/bioconf/202518703003/pdf","pdf_url":"https://www.bio-conferences.org/10.1051/bioconf/202518703003/pdf","source":{"id":"https://openalex.org/S4306400744","display_name":"Springer Link (Chiba Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8488066","host_organization_name":"Chiba Institute of Technology","host_organization_lineage":["https://openalex.org/I8488066"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://doi.org/10.1051/bioconf/202518703003","raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.4753110706806183,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"A":[0],"reversed-phase":[1],"high-performance":[2],"liquid":[3],"chromatography":[4],"(RP-HPLC)":[5],"method":[6,23,58,97,120,146],"was":[7,140],"developed":[8],"and":[9,14,33,55,76,82,90,102,135],"validated":[10],"for":[11,116,149],"the":[12,26,66,96,136],"separation":[13],"quantitative":[15],"determination":[16],"of":[17,28,68,80,95,124,153],"choline":[18,101,110,125,154],"in":[19,126,155],"dietary":[20,105,156],"supplements.":[21],"The":[22,57,78,119],"optimization":[24],"involved":[25],"selection":[27],"a":[29],"Purospher":[30],"C18":[31],"column":[32],"an":[34],"acetonitrile:water":[35],"(75:25,":[36],"v/v)":[37],"mobile":[38],"phase,":[39],"with":[40,71,128],"detection":[41,81],"at":[42],"205\u2013208":[43],"nm.":[44],"Validation":[45],"followed":[46],"ICH":[47],"Q2":[48],"guidelines,":[49],"assessing":[50],"specificity,":[51],"linearity,":[52],"accuracy,":[53],"precision,":[54],"sensitivity.":[56],"demonstrated":[59],"excellent":[60],"linearity":[61],"(R\u00b2":[62],">":[63],"0.9900)":[64],"over":[65],"range":[67],"50\u2013150":[69],"\u00b5g/mL,":[70,92],"recovery":[72],"rates":[73],"between":[74],"99.3%":[75],"101.0%.":[77],"limit":[79],"quantification":[83,123],"were":[84],"determined":[85],"to":[86,98,112],"be":[87],"4":[88],"\u00b5g/mL":[89],"12":[91],"respectively.":[93],"Application":[94],"both":[99],"pure":[100],"commercial":[103],"multicomponent":[104],"supplements":[106],"showed":[107],"that":[108],"drying":[109],"prior":[111],"analysis":[113],"is":[114,147],"necessary":[115],"reliable":[117],"results.":[118],"provided":[121],"consistent":[122],"supplements,":[127],"measured":[129],"amounts":[130],"closely":[131],"matching":[132],"label":[133],"claims,":[134],"largest":[137],"deviation":[138],"observed":[139],"approximately":[141],"7":[142],"milligrams.":[143],"This":[144],"RP-HPLC":[145],"suitable":[148],"routine":[150],"quality":[151],"control":[152],"supplement":[157],"formulations.":[158]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-02-03T00:00:00"}
