{"id":"https://openalex.org/W7127068529","doi":"https://doi.org/10.1111/codi.70393","title":"Time to define the role of hyperthermic intraperitoneal chemotherapy (HIPEC) in T4 colon cancer","display_name":"Time to define the role of hyperthermic intraperitoneal chemotherapy (HIPEC) in T4 colon cancer","publication_year":2026,"publication_date":"2026-02-01","ids":{"openalex":"https://openalex.org/W7127068529","doi":"https://doi.org/10.1111/codi.70393","pmid":"https://pubmed.ncbi.nlm.nih.gov/41622968"},"language":"en","primary_location":{"id":"doi:10.1111/codi.70393","doi":"https://doi.org/10.1111/codi.70393","is_oa":true,"landing_page_url":"https://doi.org/10.1111/codi.70393","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/codi.70393","source":{"id":"https://openalex.org/S91064148","display_name":"Colorectal Disease","issn_l":"1462-8910","issn":["1462-8910","1463-1318"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Colorectal Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/codi.70393","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045051234","display_name":"Mina Sarofim","orcid":"https://orcid.org/0000-0003-3808-0774","observed_orcids":["https://orcid.org/0000-0003-3808-0774"]},"institutions":[{"id":"https://openalex.org/I2800849109","display_name":"Liverpool Hospital","ror":"https://ror.org/03zzzks34","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800849109"]},{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Mina Sarofim","raw_affiliation_strings":["Department of Colorectal Surgery Liverpool Hospital  New South Wales Australia","Innovation, Surgical Teaching and Research (iSTAR) Unit  Liverpool Hospital New South Wales Australia","School of Clinical Medicine University of New South Wales  New South Wales Australia"],"raw_orcid":"https://orcid.org/0000-0003-3808-0774","affiliations":[{"raw_affiliation_string":"Department of Colorectal Surgery Liverpool Hospital  New South Wales Australia","institution_ids":["https://openalex.org/I2800849109"]},{"raw_affiliation_string":"Innovation, Surgical Teaching and Research (iSTAR) Unit  Liverpool Hospital New South Wales Australia","institution_ids":["https://openalex.org/I2800849109"]},{"raw_affiliation_string":"School of Clinical Medicine University of New South Wales  New South Wales Australia","institution_ids":["https://openalex.org/I31746571"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5045051234"],"corresponding_institution_ids":["https://openalex.org/I2800849109","https://openalex.org/I31746571"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06556892,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"2","first_page":"e70393","last_page":"e70393"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperthermic-intraperitoneal-chemotherapy","display_name":"hyperthermic intraperitoneal chemotherapy","score":1.0},{"id":"https://openalex.org/keywords/t4-colon-cancer","display_name":"T4 colon cancer","score":0.9639999866485596},{"id":"https://openalex.org/keywords/peritoneal-metastases","display_name":"peritoneal carcinomatosis","score":0.7289999723434448},{"id":"https://openalex.org/keywords/cytoreductive-surgery","display_name":"cytoreductive surgery","score":0.9309999942779541},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.5899999737739563},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.5799999833106995},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.6510000228881836},{"id":"https://openalex.org/keywords/biomarker-driven-patient-selection","display_name":"biomarker-driven patient selection","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9546999931335449},{"id":"https://openalex.org/C2779458272","wikidata":"https://www.wikidata.org/wiki/Q612526","display_name":"Hyperthermic intraperitoneal chemotherapy","level":5,"score":0.949400007724762},{"id":"https://openalex.org/C2994223192","wikidata":"https://www.wikidata.org/wiki/Q96375802","display_name":"Cytoreductive surgery","level":4,"score":0.626800000667572},{"id":"https://openalex.org/C2776001837","wikidata":"https://www.wikidata.org/wiki/Q9629","display_name":"Peritoneum","level":2,"score":0.6026999950408936},{"id":"https://openalex.org/C3019901188","wikidata":"https://www.wikidata.org/wiki/Q612526","display_name":"Intraperitoneal chemotherapy","level":4,"score":0.5982999801635742},{"id":"https://openalex.org/C2778536324","wikidata":"https://www.wikidata.org/wiki/Q1030169","display_name":"Peritoneal cavity","level":2,"score":0.5940999984741211},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.5273000001907349},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5200999975204468},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5174999833106995},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4805999994277954},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4575999975204468},{"id":"https://openalex.org/C3018227240","wikidata":"https://www.wikidata.org/wiki/Q2481887","display_name":"Adjuvant chemotherapy","level":4,"score":0.444599986076355},{"id":"https://openalex.org/C520017518","wikidata":"https://www.wikidata.org/wiki/Q178934","display_name":"Occult","level":3,"score":0.4262000024318695},{"id":"https://openalex.org/C2779949491","wikidata":"https://www.wikidata.org/wiki/Q242165","display_name":"Hyperthermia","level":2,"score":0.39309999346733093},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.36250001192092896},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.33009999990463257},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32359999418258667},{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.31869998574256897},{"id":"https://openalex.org/C2908737533","wikidata":"https://www.wikidata.org/wiki/Q9629","display_name":"Peritoneal diseases","level":2,"score":0.3160000145435333},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.31279999017715454},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3093999922275543},{"id":"https://openalex.org/C2991818862","wikidata":"https://www.wikidata.org/wiki/Q2071182","display_name":"Peritoneal carcinomatosis","level":4,"score":0.290800005197525},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.2628999948501587},{"id":"https://openalex.org/C2993216161","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colonic cancer","level":4,"score":0.2533999979496002},{"id":"https://openalex.org/C2777982462","wikidata":"https://www.wikidata.org/wiki/Q2481887","display_name":"Adjuvant therapy","level":3,"score":0.2513999938964844}],"mesh":[{"descriptor_ui":"D000084262","descriptor_name":"Hyperthermic Intraperitoneal Chemotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000084262","descriptor_name":"Hyperthermic Intraperitoneal Chemotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000084262","descriptor_name":"Hyperthermic Intraperitoneal Chemotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000084262","descriptor_name":"Hyperthermic Intraperitoneal Chemotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000084262","descriptor_name":"Hyperthermic Intraperitoneal Chemotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000084262","descriptor_name":"Hyperthermic Intraperitoneal Chemotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000084262","descriptor_name":"Hyperthermic Intraperitoneal Chemotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000084262","descriptor_name":"Hyperthermic Intraperitoneal Chemotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006979","descriptor_name":"Hyperthermia, Induced","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006979","descriptor_name":"Hyperthermia, Induced","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006979","descriptor_name":"Hyperthermia, Induced","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006979","descriptor_name":"Hyperthermia, Induced","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006979","descriptor_name":"Hyperthermia, Induced","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010534","descriptor_name":"Peritoneal Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D010534","descriptor_name":"Peritoneal Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D010534","descriptor_name":"Peritoneal Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D010534","descriptor_name":"Peritoneal Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D010534","descriptor_name":"Peritoneal Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D010534","descriptor_name":"Peritoneal Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D010534","descriptor_name":"Peritoneal Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D010534","descriptor_name":"Peritoneal Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D010534","descriptor_name":"Peritoneal Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010534","descriptor_name":"Peritoneal Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010534","descriptor_name":"Peritoneal Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010534","descriptor_name":"Peritoneal Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010534","descriptor_name":"Peritoneal Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010534","descriptor_name":"Peritoneal Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010534","descriptor_name":"Peritoneal Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010534","descriptor_name":"Peritoneal Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/codi.70393","doi":"https://doi.org/10.1111/codi.70393","is_oa":true,"landing_page_url":"https://doi.org/10.1111/codi.70393","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/codi.70393","source":{"id":"https://openalex.org/S91064148","display_name":"Colorectal Disease","issn_l":"1462-8910","issn":["1462-8910","1463-1318"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Colorectal Disease","raw_type":"journal-article"},{"id":"pmid:41622968","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41622968","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/codi.70393","doi":"https://doi.org/10.1111/codi.70393","is_oa":true,"landing_page_url":"https://doi.org/10.1111/codi.70393","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/codi.70393","source":{"id":"https://openalex.org/S91064148","display_name":"Colorectal Disease","issn_l":"1462-8910","issn":["1462-8910","1463-1318"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Colorectal Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8214097023010254}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7127068529.pdf","grobid_xml":"https://content.openalex.org/works/W7127068529.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1934094702","https://openalex.org/W2530593780","https://openalex.org/W2964855288","https://openalex.org/W3044568447","https://openalex.org/W3100919445","https://openalex.org/W3126104714","https://openalex.org/W3161481554","https://openalex.org/W4221014254","https://openalex.org/W4367047719","https://openalex.org/W4387473993","https://openalex.org/W4388282629","https://openalex.org/W4390729404","https://openalex.org/W4394868873"],"related_works":[],"abstract_inverted_index":{"T4":[0,78,133,138],"colon":[1,139],"adenocarcinoma,":[2],"defined":[3],"by":[4,46,92],"tumour":[5,44,106],"penetration":[6,57],"of":[7,13,20,99,117],"the":[8,48,118],"visceral":[9],"peritoneum":[10],"or":[11,73],"invasion":[12],"adjacent":[14],"structures,":[15],"carries":[16],"a":[17,36,93],"15%-30%":[18],"risk":[19],"peritoneal":[21,49],"metastases":[22],"(PM)":[23],"despite":[24],"curative":[25],"resection":[26],"and":[27,58,86,108,114,127,146,161],"adjuvant":[28,74],"systemic":[29],"chemotherapy.":[30],"Hyperthermic":[31],"intraperitoneal":[32,43,100],"chemotherapy":[33],"(HIPEC)":[34],"offers":[35],"biologically":[37],"rational":[38],"strategy":[39],"to":[40,51,104],"eradicate":[41],"occult":[42],"cells":[45],"exposing":[47],"cavity":[50],"heated":[52],"cytotoxic":[53],"agents":[54],"with":[55,65],"enhanced":[56],"synergistic":[59],"thermal":[60],"cytotoxicity.":[61],"Although":[62],"widely":[63],"used":[64],"cytoreductive":[66],"surgery":[67],"for":[68,137],"established":[69,150],"PM,":[70],"its":[71,122],"prophylactic":[72],"role":[75],"in":[76,143],"non-metastatic":[77],"disease":[79],"remains":[80,141],"uncertain.":[81],"Randomized":[82],"evidence":[83],"is":[84],"conflicting":[85],"divergent":[87],"outcomes":[88],"may":[89,148],"be":[90,149],"explained":[91],"mechanistic":[94],"triad":[95],"encompassing:":[96],"(1)":[97],"timing":[98],"drug":[101],"exposure":[102],"relative":[103],"early":[105],"implantation":[107],"adhesion":[109],"formation;":[110],"(2)":[111],"pharmacological,":[112],"thermal,":[113],"dosing":[115],"characteristics":[116],"HIPEC":[119,136],"regimen,":[120],"including":[121],"most":[123],"often":[124],"single":[125],"administration;":[126],"(3)":[128],"underlying":[129],"biological":[130],"heterogeneity":[131],"within":[132],"tumours.":[134],"Thus,":[135],"cancer":[140],"promising":[142],"selected":[144],"patients,":[145],"it":[147],"as":[151],"routine":[152],"if":[153],"ongoing":[154],"studies":[155],"rigorously":[156],"define":[157],"timing,":[158],"agent":[159],"selection":[160],"biomarker-driven":[162],"patient":[163],"stratification.":[164]},"counts_by_year":[],"updated_date":"2026-08-22T07:34:49.880490","created_date":"2026-02-03T00:00:00"}
