{"id":"https://openalex.org/W7127064932","doi":"https://doi.org/10.3389/fmed.2026.1758413","title":"Diagnostic challenges of giant cervical pilomatrixoma mimicking malignancy: case report and focused literature review","display_name":"Diagnostic challenges of giant cervical pilomatrixoma mimicking malignancy: case report and focused literature review","publication_year":2026,"publication_date":"2026-02-03","ids":{"openalex":"https://openalex.org/W7127064932","doi":"https://doi.org/10.3389/fmed.2026.1758413","pmid":"https://pubmed.ncbi.nlm.nih.gov/41709894"},"language":"en","primary_location":{"id":"doi:10.3389/fmed.2026.1758413","doi":"https://doi.org/10.3389/fmed.2026.1758413","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2026.1758413","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1758413/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://public-pages-files-2025.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1758413/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013008505","display_name":"Hora\u0163iu Constantin Urechescu","orcid":"https://orcid.org/0000-0001-9670-1079","observed_orcids":["https://orcid.org/0000-0001-9670-1079"]},"institutions":[{"id":"https://openalex.org/I4210088791","display_name":"Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara","ror":"https://ror.org/00afdp487","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210088791"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Horatiu Urechescu","raw_affiliation_strings":["Department of Oral and Maxillo-Facial Surgery, Victor Babes University of Medicine and Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillo-Facial Surgery, Victor Babes University of Medicine and Pharmacy","institution_ids":["https://openalex.org/I4210088791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030146015","display_name":"Marius Octavian Pricop","orcid":"https://orcid.org/0000-0001-5136-9615","observed_orcids":["https://orcid.org/0000-0001-5136-9615"]},"institutions":[{"id":"https://openalex.org/I4210088791","display_name":"Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara","ror":"https://ror.org/00afdp487","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210088791"]}],"countries":["RO"],"is_corresponding":true,"raw_author_name":"Marius Pricop","raw_affiliation_strings":["Department of Oral and Maxillo-Facial Surgery, Victor Babes University of Medicine and Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillo-Facial Surgery, Victor Babes University of Medicine and Pharmacy","institution_ids":["https://openalex.org/I4210088791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114348003","display_name":"Flavia Zar\u0103","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088791","display_name":"Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara","ror":"https://ror.org/00afdp487","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210088791"]}],"countries":["RO"],"is_corresponding":true,"raw_author_name":"Flavia Zara","raw_affiliation_strings":["Angiogenesis Research Center, Victor Babes University of Medicine and Pharmacy","Department of Microscopic Morphology, Victor Babes University of Medicine and Pharmacy","Service of Pathology, Emergency City Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Angiogenesis Research Center, Victor Babes University of Medicine and Pharmacy","institution_ids":["https://openalex.org/I4210088791"]},{"raw_affiliation_string":"Department of Microscopic Morphology, Victor Babes University of Medicine and Pharmacy","institution_ids":["https://openalex.org/I4210088791"]},{"raw_affiliation_string":"Service of Pathology, Emergency City Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092999433","display_name":"Raluca Maria Clo\u015fca","orcid":"https://orcid.org/0009-0001-1397-1864","observed_orcids":["https://orcid.org/0009-0001-1397-1864"]},"institutions":[{"id":"https://openalex.org/I4210088791","display_name":"Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara","ror":"https://ror.org/00afdp487","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210088791"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Raluca Maria Closca","raw_affiliation_strings":["Angiogenesis Research Center, Victor Babes University of Medicine and Pharmacy","Department of Microscopic Morphology, Victor Babes University of Medicine and Pharmacy","Service of Pathology, Emergency City Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Angiogenesis Research Center, Victor Babes University of Medicine and Pharmacy","institution_ids":["https://openalex.org/I4210088791"]},{"raw_affiliation_string":"Department of Microscopic Morphology, Victor Babes University of Medicine and Pharmacy","institution_ids":["https://openalex.org/I4210088791"]},{"raw_affiliation_string":"Service of Pathology, Emergency City Hospital","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078064999","display_name":"Felicia Streian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088791","display_name":"Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara","ror":"https://ror.org/00afdp487","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210088791"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Felicia Streian","raw_affiliation_strings":["Department of Oral and Maxillo-Facial Surgery, Victor Babes University of Medicine and Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillo-Facial Surgery, Victor Babes University of Medicine and Pharmacy","institution_ids":["https://openalex.org/I4210088791"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5030146015","https://openalex.org/A5114348003"],"corresponding_institution_ids":["https://openalex.org/I4210088791"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.057068,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":"1758413","last_page":"1758413"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11868","display_name":"Cancer and Skin Lesions","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11868","display_name":"Cancer and Skin Lesions","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13363","display_name":"Soft tissue tumors and treatment","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11787","display_name":"Oral and Maxillofacial Pathology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pilomatrixoma","display_name":"pilomatrixoma","score":0.9229999780654907},{"id":"https://openalex.org/keywords/cervical-mass","display_name":"cervical mass","score":0.6970000267028809},{"id":"https://openalex.org/keywords/benign-skin-adnexal-tumor","display_name":"benign skin adnexal tumor","score":0.7760000228881836},{"id":"https://openalex.org/keywords/differential-diagnosis-of-malignancy","display_name":"differential diagnosis of malignancy","score":0.7990000247955322},{"id":"https://openalex.org/keywords/core-needle-biopsy","display_name":"core needle biopsy","score":0.9459999799728394},{"id":"https://openalex.org/keywords/surgical-excision","display_name":"surgical excision","score":0.8500000238418579},{"id":"https://openalex.org/keywords/histopathology","display_name":"histopathology","score":0.8830000162124634},{"id":"https://openalex.org/keywords/foreign-body-giant-cell-reaction","display_name":"foreign body giant cell reaction","score":0.8330000042915344}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9370999932289124},{"id":"https://openalex.org/C2909060831","wikidata":"https://www.wikidata.org/wiki/Q1704531","display_name":"Pilomatrixoma","level":2,"score":0.9221000075340271},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.7178999781608582},{"id":"https://openalex.org/C2780801072","wikidata":"https://www.wikidata.org/wiki/Q837512","display_name":"Differential diagnosis","level":2,"score":0.654699981212616},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.5776000022888184},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.544700026512146},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4496000111103058},{"id":"https://openalex.org/C3020547009","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathological examination","level":2,"score":0.36880001425743103},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.34610000252723694},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.34439998865127563},{"id":"https://openalex.org/C527108885","wikidata":"https://www.wikidata.org/wiki/Q835153","display_name":"Physical examination","level":2,"score":0.3156000077724457},{"id":"https://openalex.org/C2776170712","wikidata":"https://www.wikidata.org/wiki/Q180071","display_name":"Fine-needle aspiration","level":3,"score":0.3133000135421753},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.26739999651908875},{"id":"https://openalex.org/C2781289335","wikidata":"https://www.wikidata.org/wiki/Q1704531","display_name":"Pilomatricoma","level":2,"score":0.26080000400543213}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3389/fmed.2026.1758413","doi":"https://doi.org/10.3389/fmed.2026.1758413","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2026.1758413","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1758413/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},{"id":"pmid:41709894","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41709894","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in medicine","raw_type":"Case Reports"},{"id":"pmh:oai:pubmedcentral.nih.gov:12909184","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12909184/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Med (Lausanne)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3389/fmed.2026.1758413","doi":"https://doi.org/10.3389/fmed.2026.1758413","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2026.1758413","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1758413/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.48310065269470215,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7127064932.pdf","grobid_xml":"https://content.openalex.org/works/W7127064932.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W2069069366","https://openalex.org/W2090220580","https://openalex.org/W3200412172","https://openalex.org/W4221041855","https://openalex.org/W4319057915","https://openalex.org/W4394792360","https://openalex.org/W4400760517","https://openalex.org/W4401252204","https://openalex.org/W4405855884","https://openalex.org/W4407923199","https://openalex.org/W4410871227","https://openalex.org/W4412186392","https://openalex.org/W4415027288"],"related_works":[],"abstract_inverted_index":{"Pilomatrixoma":[0],"is":[1],"a":[2,34,40,43,48,75,90],"benign":[3],"skin":[4],"adnexal":[5],"tumor":[6],"arising":[7],"from":[8],"the":[9,24,56,121,133,140],"hair-follicle":[10],"matrix.":[11],"While":[12],"typically":[13],"small":[14],"and":[15,28,102,125],"slowly":[16],"growing,":[17],"rare":[18],"\"giant\"":[19],"variants":[20],"(>5":[21],"cm)-especially":[22],"in":[23,55,139],"cervical":[25,59,145],"region-may":[26],"clinically":[27],"radiologically":[29],"mimic":[30],"malignant":[31],"masses,":[32],"posing":[33],"significant":[35],"diagnostic":[36],"challenge.":[37],"We":[38],"report":[39],"case":[41,131],"of":[42,92,135,143],"29-year-old":[44],"male":[45],"presenting":[46],"with":[47,167],"solitary,":[49],"firm,":[50],"subcutaneous":[51,78],"mass":[52,95],"(~6":[53],"cm)":[54],"left":[57],"anterior":[58],"region,":[60],"which":[61],"enlarged":[62],"rapidly":[63],"over":[64],"6":[65],"months":[66],"without":[67,80],"pain":[68],"or":[69,82],"systemic":[70],"symptoms.":[71],"Contrast-enhanced":[72],"CT":[73],"revealed":[74],"well-defined,":[76],"heterogeneous":[77],"lesion":[79],"muscular":[81],"vascular":[83],"invasion.":[84],"Core":[85],"needle":[86],"biopsy":[87],"(CNB)":[88],"supported":[89],"diagnosis":[91,142],"pilomatrixoma.":[93],"The":[94],"was":[96,123,128],"completely":[97],"excised":[98],"under":[99],"IV":[100],"sedation":[101],"local":[103],"anesthesia.":[104],"Histopathology":[105],"confirmed":[106],"classic":[107],"pilomatrixoma":[108,138],"features":[109],"(basaloid":[110],"cells,":[111,113],"shadow":[112],"foreign-body":[114],"giant":[115,137],"cell":[116],"reaction).":[117],"At":[118],"one-year":[119],"follow-up":[120],"patient":[122],"disease-free,":[124],"scar":[126],"outcome":[127],"excellent.":[129],"This":[130],"underscores":[132],"importance":[134],"including":[136],"differential":[141],"large":[144],"soft-tissue":[146],"masses.":[147],"Histopathological":[148],"examination":[149],"remains":[150],"essential":[151],"for":[152,172],"definitive":[153],"diagnosis,":[154],"while":[155],"CNB":[156],"can":[157],"guide":[158],"preoperative":[159],"planning.":[160],"Complete":[161],"surgical":[162],"excision":[163],"yields":[164],"excellent":[165],"outcomes":[166],"minimal":[168],"morbidity,":[169],"avoiding":[170],"overtreatment":[171],"suspected":[173],"malignancy.":[174]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2026-02-03T00:00:00"}