{"id":"https://openalex.org/W7127064480","doi":"https://doi.org/10.3390/jcm15031134","title":"Cultivated Oral Mucosal Epithelial Transplantation for Limbal Stem Cell Deficiency: A Scoping Review of Indications, Platforms, Outcomes and Safety","display_name":"Cultivated Oral Mucosal Epithelial Transplantation for Limbal Stem Cell Deficiency: A Scoping Review of Indications, Platforms, Outcomes and Safety","publication_year":2026,"publication_date":"2026-02-01","ids":{"openalex":"https://openalex.org/W7127064480","doi":"https://doi.org/10.3390/jcm15031134","pmid":"https://pubmed.ncbi.nlm.nih.gov/41682815"},"language":"en","primary_location":{"id":"doi:10.3390/jcm15031134","doi":"https://doi.org/10.3390/jcm15031134","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm15031134","pdf_url":"https://www.mdpi.com/2077-0383/15/3/1134/pdf?version=1769943891","source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2077-0383/15/3/1134/pdf?version=1769943891","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101741230","display_name":"Konstantinos A. Papadopoulos","orcid":"https://orcid.org/0009-0004-5614-4668","observed_orcids":["https://orcid.org/0009-0004-5614-4668"]},"institutions":[{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Konstantinos Papadopoulos","raw_affiliation_strings":["Guy\u2019s and St Thomas\u2019 NHS Foundation Trust, London SE1 7EH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guy\u2019s and St Thomas\u2019 NHS Foundation Trust, London SE1 7EH, UK","institution_ids":["https://openalex.org/I200166805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077178210","display_name":"Mohamed Elalfy","orcid":"https://orcid.org/0000-0001-6796-9340","observed_orcids":["https://orcid.org/0000-0001-6796-9340"]},"institutions":[{"id":"https://openalex.org/I2802146118","display_name":"Queen Victoria Hospital","ror":"https://ror.org/01ywpxj09","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802146118","https://openalex.org/I4210138177"]},{"id":"https://openalex.org/I4210108806","display_name":"Research Institute of Ophthalmology","ror":"https://ror.org/01h0ca774","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210108806"]}],"countries":["EG","GB"],"is_corresponding":false,"raw_author_name":"Mohamed Elalfy","raw_affiliation_strings":["Corneoplastic Unit, Queen Victoria Hospital, East Grinstead RH19 3DZ, UK","The Research Institute of Ophthalmology, Cairo 3725102, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Corneoplastic Unit, Queen Victoria Hospital, East Grinstead RH19 3DZ, UK","institution_ids":["https://openalex.org/I2802146118"]},{"raw_affiliation_string":"The Research Institute of Ophthalmology, Cairo 3725102, Egypt","institution_ids":["https://openalex.org/I4210108806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079471756","display_name":"Hasan Naveed","orcid":"https://orcid.org/0000-0001-7668-3168","observed_orcids":["https://orcid.org/0000-0001-7668-3168"]},"institutions":[{"id":"https://openalex.org/I2802146118","display_name":"Queen Victoria Hospital","ror":"https://ror.org/01ywpxj09","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802146118","https://openalex.org/I4210138177"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hasan Naveed","raw_affiliation_strings":["Corneoplastic Unit, Queen Victoria Hospital, East Grinstead RH19 3DZ, UK"],"raw_orcid":"https://orcid.org/0000-0001-7668-3168","affiliations":[{"raw_affiliation_string":"Corneoplastic Unit, Queen Victoria Hospital, East Grinstead RH19 3DZ, UK","institution_ids":["https://openalex.org/I2802146118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075926089","display_name":"Sokratis Zormpas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153400","display_name":"King's College Hospital","ror":"https://ror.org/044nptt90","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210111135","https://openalex.org/I4210153400"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sokratis Zormpas","raw_affiliation_strings":["King\u2019s College Hospital, London SE5 9RS, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King\u2019s College Hospital, London SE5 9RS, UK","institution_ids":["https://openalex.org/I4210153400"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083009828","display_name":"Artemis Matsou","orcid":"https://orcid.org/0000-0002-4242-8983","observed_orcids":["https://orcid.org/0000-0002-4242-8983"]},"institutions":[{"id":"https://openalex.org/I2802146118","display_name":"Queen Victoria Hospital","ror":"https://ror.org/01ywpxj09","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802146118","https://openalex.org/I4210138177"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Artemis Matsou","raw_affiliation_strings":["Corneoplastic Unit, Queen Victoria Hospital, East Grinstead RH19 3DZ, UK"],"raw_orcid":"https://orcid.org/0000-0002-4242-8983","affiliations":[{"raw_affiliation_string":"Corneoplastic Unit, Queen Victoria Hospital, East Grinstead RH19 3DZ, UK","institution_ids":["https://openalex.org/I2802146118"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5083009828"],"corresponding_institution_ids":["https://openalex.org/I2802146118"],"apc_list":{"value":2600,"currency":"CHF","value_usd":3137},"apc_paid":{"value":2600,"currency":"CHF","value_usd":3137},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06234212,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"3","first_page":"1134","last_page":"1134"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12989","display_name":"Ocular Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/limbal-stem-cell-deficiency","display_name":"limbal stem cell deficiency","score":0.9070000052452087},{"id":"https://openalex.org/keywords/ocular-surface-reconstruction","display_name":"ocular surface reconstruction","score":0.8339999914169312},{"id":"https://openalex.org/keywords/amniotic-membrane","display_name":"amniotic membrane","score":0.7870000004768372},{"id":"https://openalex.org/keywords/neovascularization","display_name":"neovascularization","score":0.7910000085830688},{"id":"https://openalex.org/keywords/symblepharon","display_name":"symblepharon","score":0.765999972820282},{"id":"https://openalex.org/keywords/burns","display_name":"burns","score":0.3160000145435333},{"id":"https://openalex.org/keywords/severe-burns","display_name":"severe burns","score":0.38100001215934753},{"id":"https://openalex.org/keywords/stevens-johnson-syndrome","display_name":"Stevens-Johnson syndrome","score":0.8349999785423279}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9370999932289124},{"id":"https://openalex.org/C94081185","wikidata":"https://www.wikidata.org/wiki/Q3559","display_name":"Comet","level":2,"score":0.6037999987602234},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5619999766349792},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.45190000534057617},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.4381999969482422},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.4262999892234802},{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.4169999957084656},{"id":"https://openalex.org/C2779257441","wikidata":"https://www.wikidata.org/wiki/Q2040445","display_name":"Corneal epithelium","level":3,"score":0.40290001034736633},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3901999890804291},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.3540000021457672},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3384999930858612},{"id":"https://openalex.org/C2780686511","wikidata":"https://www.wikidata.org/wiki/Q579361","display_name":"Corneal transplantation","level":3,"score":0.28870001435279846},{"id":"https://openalex.org/C2778155685","wikidata":"https://www.wikidata.org/wiki/Q5918496","display_name":"Limbal stem cell","level":4,"score":0.27889999747276306},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.27570000290870667},{"id":"https://openalex.org/C3019137385","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell survival","level":3,"score":0.2623000144958496},{"id":"https://openalex.org/C2781053140","wikidata":"https://www.wikidata.org/wiki/Q3501232","display_name":"Corneal topography","level":3,"score":0.25519999861717224}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/jcm15031134","doi":"https://doi.org/10.3390/jcm15031134","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm15031134","pdf_url":"https://www.mdpi.com/2077-0383/15/3/1134/pdf?version=1769943891","source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},{"id":"pmid:41682815","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41682815","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical medicine","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11704976","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12897836","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12897836","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12897836/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Clin Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/jcm15031134","doi":"https://doi.org/10.3390/jcm15031134","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm15031134","pdf_url":"https://www.mdpi.com/2077-0383/15/3/1134/pdf?version=1769943891","source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7127064480.pdf","grobid_xml":"https://content.openalex.org/works/W7127064480.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1843059029","https://openalex.org/W1970867604","https://openalex.org/W1975479312","https://openalex.org/W2004834618","https://openalex.org/W2021192940","https://openalex.org/W2030330654","https://openalex.org/W2039289514","https://openalex.org/W2042280852","https://openalex.org/W2051340239","https://openalex.org/W2145889217","https://openalex.org/W2154933631","https://openalex.org/W2165106854","https://openalex.org/W2515250052","https://openalex.org/W2776598089","https://openalex.org/W2910893554","https://openalex.org/W2937131334","https://openalex.org/W2965283627","https://openalex.org/W2989734157","https://openalex.org/W3014902820","https://openalex.org/W3037993292","https://openalex.org/W3041016292","https://openalex.org/W3044924369","https://openalex.org/W3075453774","https://openalex.org/W3161534223","https://openalex.org/W4289687707","https://openalex.org/W4362698526","https://openalex.org/W4377211784","https://openalex.org/W4378675797","https://openalex.org/W4388215866","https://openalex.org/W4390837350","https://openalex.org/W4404634262","https://openalex.org/W4406061373"],"related_works":[],"abstract_inverted_index":{"Background:":[0],"Cultivated":[1],"oral":[2],"mucosal":[3],"epithelial":[4,83],"transplantation":[5],"(COMET/CAOMECS)":[6],"is":[7],"an":[8],"autologous,":[9],"immunosuppression-sparing":[10,247],"option":[11],"for":[12],"ocular":[13],"surface":[14,148,224,252],"reconstruction":[15,248],"in":[16,95,156,186],"limbal":[17],"stem":[18],"cell":[19],"deficiency":[20],"(LSCD).":[21],"After":[22],"two":[23],"decades,":[24],"indications,":[25],"platforms":[26],"and":[27,31,57,65,97,110,125,160,198,226,254],"outcome":[28,73],"definitions":[29,96],"vary,":[30],"COMET\u2019s":[32,281],"position":[33],"relative":[34,283],"to":[35,176,279,284],"limbal-derived":[36,231,285],"epithelium":[37],"remains":[38],"uncertain.":[39],"Methods:":[40],"We":[41],"conducted":[42],"a":[43,146,206,262],"PRISMA-ScR":[44],"scoping":[45],"review":[46],"of":[47,236],"human":[48],"clinical":[49],"studies":[50,273],"(PubMed,":[51],"2000\u201330":[52],"December":[53],"2025)":[54],"with":[55,162,201,216,230,249,274],"hand-searching":[56],"regulatory":[58],"sources.":[59],"Eligible":[60],"reports":[61,114],"included":[62],"COMET/CAOMECS":[63],"series":[64],"comparative":[66,220,272],"cohorts":[67,221],"(CLET/ACLET,":[68],"SLET,":[69],"KLAL/CLAL).":[70],"The":[71],"primary":[72],"was":[74,153],"anatomical":[75,133],"success":[76,134],"(stable":[77],"epithelialised":[78],"cornea":[79],"without":[80],"recurrent":[81],"persistent":[82],"defect,":[84],"progressive":[85],"conjunctivalisation":[86],"or":[87,166],"uncontrolled":[88],"neovascularisation":[89,197],"at":[90,149,233],"last":[91,150],"assessment).":[92],"Given":[93],"heterogeneity":[94],"analytic":[98],"frames":[99],"(fixed-time":[100],"vs.":[101],"Kaplan\u2013Meier":[102],"[KM]),":[103],"results":[104],"were":[105,119,122],"synthesised":[106],"narratively":[107],"by":[108],"indication":[109],"platform.":[111],"Results:":[112],"Twenty-five":[113],"(893":[115],"eyes;":[116],"821":[117],"patients)":[118],"included.":[120],"Aetiologies":[121],"predominantly":[123],"burns":[124],"SJS/TEN.":[126],"Across":[127],"amniotic":[128],"membrane-based":[129],"mixed-aetiology":[130],"series,":[131],"12-month":[132,194],"clustered":[135],"around":[136],"55\u201370%.":[137],"Aggregated":[138],"descriptively":[139],"across":[140],"COMET":[141,245],"eyes,":[142],"211/467":[143],"(45%)":[144],"had":[145],"stable":[147],"follow-up.":[151],"Epithelialisation":[152],"generally":[154],"rapid":[155],"quiet":[157],"AM-based":[158],"reconstructions":[159],"slower":[161],"severe":[163],"adnexal":[164],"disease":[165],"carrier-free":[167],"platforms.":[168],"Mean":[169],"BCVA":[170,200],"improved":[171],"from":[172],"1.8":[173],"\u00b1":[174,178],"0.7":[175,179],"1.4":[177],"logMAR":[180],"(471":[181],"eyes);":[182],"\u22652-line":[183],"gains":[184,258],"occurred":[185],"308/471":[187],"(65.4%).":[188],"A":[189],"matched":[190],"comparison":[191],"suggested":[192,222],"better":[193,199],"survival,":[195],"less":[196],"substrate-free":[202,268],"versus":[203],"AM-carried":[204],"COMET;":[205],"biomaterial-/feeder-free":[207],"platform":[208],"reconstructed":[209],"most":[210],"eyes":[211],"but":[212],"failed":[213],"more":[214],"often":[215],"four-quadrant":[217],"symblepharon.":[218],"Observational":[219],"higher":[223],"survival":[225],"average":[227],"visual":[228,257],"gain":[229],"epithelium,":[232],"the":[234],"cost":[235],"systemic":[237],"immunosuppression.":[238],"Conclusions:":[239],"In":[240],"appropriately":[241],"selected":[242],"bilateral":[243],"LSCD,":[244],"offers":[246],"moderate,":[250],"durable":[251],"stability":[253],"clinically":[255],"meaningful":[256],"when":[259],"performed":[260],"on":[261],"quiet,":[263],"optimised":[264],"surface.":[265],"Platform":[266],"refinements\u2014particularly":[267],"constructs\u2014and":[269],"prospective,":[270],"indication-defined":[271],"harmonised":[275],"outcomes":[276],"are":[277],"needed":[278],"define":[280],"role":[282],"epithelium.":[286]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2026-02-03T00:00:00"}
