{"id":"https://openalex.org/W7127064108","doi":"https://doi.org/10.3389/fnins.2026.1728473","title":"Microbial dysbiosis as a diagnostic marker in psychiatric disorders: a systematic review of gut\u2013brain axis disruptions","display_name":"Microbial dysbiosis as a diagnostic marker in psychiatric disorders: a systematic review of gut\u2013brain axis disruptions","publication_year":2026,"publication_date":"2026-02-03","ids":{"openalex":"https://openalex.org/W7127064108","doi":"https://doi.org/10.3389/fnins.2026.1728473","pmid":"https://pubmed.ncbi.nlm.nih.gov/41710156"},"language":"en","primary_location":{"id":"doi:10.3389/fnins.2026.1728473","doi":"https://doi.org/10.3389/fnins.2026.1728473","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2026.1728473","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2026.1728473/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://public-pages-files-2025.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2026.1728473/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5119783072","display_name":"Paula Espinosa Villagomez","orcid":"https://orcid.org/0009-0001-4561-6242","observed_orcids":["https://orcid.org/0009-0001-4561-6242"]},"institutions":[{"id":"https://openalex.org/I4210140740","display_name":"Universidad Internacional del Ecuador","ror":"https://ror.org/04xf2rc74","country_code":"EC","type":"education","lineage":["https://openalex.org/I4210140740"]}],"countries":["EC"],"is_corresponding":false,"raw_author_name":"Paula Espinosa","raw_affiliation_strings":["Escuela de Medicina, Universidad Internacional del Ecuador","NeurALL Research Group"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escuela de Medicina, Universidad Internacional del Ecuador","institution_ids":["https://openalex.org/I4210140740"]},{"raw_affiliation_string":"NeurALL Research Group","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117143608","display_name":"Mario S. Hinojosa-Figueroa","orcid":"https://orcid.org/0009-0005-4948-4768","observed_orcids":["https://orcid.org/0009-0005-4948-4768"]},"institutions":[{"id":"https://openalex.org/I4210140740","display_name":"Universidad Internacional del Ecuador","ror":"https://ror.org/04xf2rc74","country_code":"EC","type":"education","lineage":["https://openalex.org/I4210140740"]}],"countries":["EC"],"is_corresponding":false,"raw_author_name":"Mario S. Hinojosa-Figueroa","raw_affiliation_strings":["Escuela de Medicina, Universidad Internacional del Ecuador","NeurALL Research Group"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escuela de Medicina, Universidad Internacional del Ecuador","institution_ids":["https://openalex.org/I4210140740"]},{"raw_affiliation_string":"NeurALL Research Group","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Paula Vallejo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paula Vallejo","raw_affiliation_strings":["NeurALL Research Group"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NeurALL Research Group","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124780848","display_name":"Felipe P\u00e9rez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100770","display_name":"University of the Americas","ror":"https://ror.org/0166e9x11","country_code":"CL","type":"education","lineage":["https://openalex.org/I4210100770"]},{"id":"https://openalex.org/I4210102282","display_name":"Universidad de Las Am\u00e9ricas","ror":"https://ror.org/0198j4566","country_code":"EC","type":"education","lineage":["https://openalex.org/I4210102282"]},{"id":"https://openalex.org/I4210120382","display_name":"Universidad de las Am\u00e9ricas","ror":"https://ror.org/02j003371","country_code":"MX","type":"education","lineage":["https://openalex.org/I4210120382"]}],"countries":["CL","EC","MX"],"is_corresponding":false,"raw_author_name":"Felipe P\u00e9rez","raw_affiliation_strings":["Cerebro, Emoci\u00f3n, Conducta (CEC) Research Group, Escuela de Medicina, Universidad de las Am\u00e9ricas (UDLA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cerebro, Emoci\u00f3n, Conducta (CEC) Research Group, Escuela de Medicina, Universidad de las Am\u00e9ricas (UDLA)","institution_ids":["https://openalex.org/I4210100770","https://openalex.org/I4210102282","https://openalex.org/I4210120382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124812012","display_name":"Gabriela Burneo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100770","display_name":"University of the Americas","ror":"https://ror.org/0166e9x11","country_code":"CL","type":"education","lineage":["https://openalex.org/I4210100770"]},{"id":"https://openalex.org/I4210102282","display_name":"Universidad de Las Am\u00e9ricas","ror":"https://ror.org/0198j4566","country_code":"EC","type":"education","lineage":["https://openalex.org/I4210102282"]},{"id":"https://openalex.org/I4210120382","display_name":"Universidad de las Am\u00e9ricas","ror":"https://ror.org/02j003371","country_code":"MX","type":"education","lineage":["https://openalex.org/I4210120382"]}],"countries":["CL","EC","MX"],"is_corresponding":false,"raw_author_name":"Gabriela Burneo","raw_affiliation_strings":["Cerebro, Emoci\u00f3n, Conducta (CEC) Research Group, Escuela de Medicina, Universidad de las Am\u00e9ricas (UDLA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cerebro, Emoci\u00f3n, Conducta (CEC) Research Group, Escuela de Medicina, Universidad de las Am\u00e9ricas (UDLA)","institution_ids":["https://openalex.org/I4210100770","https://openalex.org/I4210102282","https://openalex.org/I4210120382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124782679","display_name":"Coral\u00eda Villarreal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100770","display_name":"University of the Americas","ror":"https://ror.org/0166e9x11","country_code":"CL","type":"education","lineage":["https://openalex.org/I4210100770"]},{"id":"https://openalex.org/I4210102282","display_name":"Universidad de Las Am\u00e9ricas","ror":"https://ror.org/0198j4566","country_code":"EC","type":"education","lineage":["https://openalex.org/I4210102282"]},{"id":"https://openalex.org/I4210120382","display_name":"Universidad de las Am\u00e9ricas","ror":"https://ror.org/02j003371","country_code":"MX","type":"education","lineage":["https://openalex.org/I4210120382"]}],"countries":["CL","EC","MX"],"is_corresponding":false,"raw_author_name":"Coral\u00eda Villarreal","raw_affiliation_strings":["Cerebro, Emoci\u00f3n, Conducta (CEC) Research Group, Escuela de Medicina, Universidad de las Am\u00e9ricas (UDLA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cerebro, Emoci\u00f3n, Conducta (CEC) Research Group, Escuela de Medicina, Universidad de las Am\u00e9ricas (UDLA)","institution_ids":["https://openalex.org/I4210100770","https://openalex.org/I4210102282","https://openalex.org/I4210120382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054101301","display_name":"Jos\u00e9 Antonio Rodas","orcid":"https://orcid.org/0000-0001-8217-0238","observed_orcids":["https://orcid.org/0000-0001-8217-0238"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]},{"id":"https://openalex.org/I3132284232","display_name":"Universidad Esp\u00edritu Santo","ror":"https://ror.org/00b210x50","country_code":"EC","type":"education","lineage":["https://openalex.org/I3132284232"]}],"countries":["EC","IE"],"is_corresponding":false,"raw_author_name":"Jose A. Rodas","raw_affiliation_strings":["Escuela de Psicolog\u00eda, Universidad Esp\u00edritu Santo","School of Psychology, University College Dublin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escuela de Psicolog\u00eda, Universidad Esp\u00edritu Santo","institution_ids":["https://openalex.org/I3132284232"]},{"raw_affiliation_string":"School of Psychology, University College Dublin","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084316127","display_name":"Jos\u00e9 E. Le\u00f3n-Rojas","orcid":"https://orcid.org/0000-0002-8130-6460","observed_orcids":["https://orcid.org/0000-0002-8130-6460"]},"institutions":[{"id":"https://openalex.org/I4210100770","display_name":"University of the Americas","ror":"https://ror.org/0166e9x11","country_code":"CL","type":"education","lineage":["https://openalex.org/I4210100770"]},{"id":"https://openalex.org/I4210102282","display_name":"Universidad de Las Am\u00e9ricas","ror":"https://ror.org/0198j4566","country_code":"EC","type":"education","lineage":["https://openalex.org/I4210102282"]},{"id":"https://openalex.org/I4210120382","display_name":"Universidad de las Am\u00e9ricas","ror":"https://ror.org/02j003371","country_code":"MX","type":"education","lineage":["https://openalex.org/I4210120382"]}],"countries":["CL","EC","MX"],"is_corresponding":false,"raw_author_name":"Jose E. Leon-Rojas","raw_affiliation_strings":["Cerebro, Emoci\u00f3n, Conducta (CEC) Research Group, Escuela de Medicina, Universidad de las Am\u00e9ricas (UDLA)","Grupo de Investigaci\u00f3n Bienestar, Salud y Sociedad, Escuela de Psicolog\u00eda y Educaci\u00f3n, Universidad de Las Am\u00e9rica"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cerebro, Emoci\u00f3n, Conducta (CEC) Research Group, Escuela de Medicina, Universidad de las Am\u00e9ricas (UDLA)","institution_ids":["https://openalex.org/I4210100770","https://openalex.org/I4210102282","https://openalex.org/I4210120382"]},{"raw_affiliation_string":"Grupo de Investigaci\u00f3n Bienestar, Salud y Sociedad, Escuela de Psicolog\u00eda y Educaci\u00f3n, Universidad de Las Am\u00e9rica","institution_ids":["https://openalex.org/I4210100770","https://openalex.org/I4210102282","https://openalex.org/I4210120382"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":2.6712,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.88262371,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"20","issue":null,"first_page":"1728473","last_page":"1728473"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dysbiosis","display_name":"dysbiosis","score":0.871999979019165},{"id":"https://openalex.org/keywords/gut-brain-axis","display_name":"gut-brain axis","score":0.8960000276565552},{"id":"https://openalex.org/keywords/mental-disorders","display_name":"mental illness","score":0.7820000052452087},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8420000076293945},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.9070000052452087},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.9430000185966492},{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mood-disorders","display_name":"mood disorders","score":0.9020000100135803},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.7730000019073486},{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":0.996999979019165},{"id":"https://openalex.org/keywords/anorexia-nervosa","display_name":"anorexia nervosa","score":0.8949999809265137},{"id":"https://openalex.org/keywords/binge-eating-disorder","display_name":"binge eating disorder","score":0.9909999966621399},{"id":"https://openalex.org/keywords/attention-deficit-hyperactivity-disorder","display_name":"attention deficit hyperactivity disorder","score":0.8920000195503235},{"id":"https://openalex.org/keywords/firmicutes-bacteroidetes-ratio","display_name":"Firmicutes/Bacteroidetes ratio","score":0.9160000085830688},{"id":"https://openalex.org/keywords/akkermansia","display_name":"Akkermansia","score":0.9649999737739563},{"id":"https://openalex.org/keywords/christensenellaceae","display_name":"Christensenellaceae","score":0.9430000185966492},{"id":"https://openalex.org/keywords/lachnospiraceae","display_name":"Lachnospiraceae","score":0.8460000157356262},{"id":"https://openalex.org/keywords/bifidobacteriaceae","display_name":"Bifidobacteriaceae","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7141000032424927},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.6409000158309937},{"id":"https://openalex.org/C177857423","wikidata":"https://www.wikidata.org/wiki/Q17077315","display_name":"Gut\u2013brain axis","level":3,"score":0.390500009059906},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3840000033378601},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3718000054359436},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3529999852180481},{"id":"https://openalex.org/C2994403141","wikidata":"https://www.wikidata.org/wiki/Q2976573","display_name":"Psychiatric diagnosis","level":3,"score":0.2906999886035919},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2872999906539917},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.273499995470047},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.272599995136261},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25440001487731934}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3389/fnins.2026.1728473","doi":"https://doi.org/10.3389/fnins.2026.1728473","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2026.1728473","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2026.1728473/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},{"id":"pmid:41710156","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41710156","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12909529","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12909529/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Neurosci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3389/fnins.2026.1728473","doi":"https://doi.org/10.3389/fnins.2026.1728473","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2026.1728473","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2026.1728473/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities","score":0.45286351442337036}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7127064108.pdf","grobid_xml":"https://content.openalex.org/works/W7127064108.grobid-xml"},"referenced_works_count":105,"referenced_works":["https://openalex.org/W1832427420","https://openalex.org/W1860290282","https://openalex.org/W1977804070","https://openalex.org/W2005365566","https://openalex.org/W2011914193","https://openalex.org/W2031441917","https://openalex.org/W2037701117","https://openalex.org/W2058716454","https://openalex.org/W2080528636","https://openalex.org/W2125826054","https://openalex.org/W2136417551","https://openalex.org/W2144133378","https://openalex.org/W2148546434","https://openalex.org/W2149756110","https://openalex.org/W2205656408","https://openalex.org/W2292048640","https://openalex.org/W2311311994","https://openalex.org/W2337492846","https://openalex.org/W2400938511","https://openalex.org/W2415812427","https://openalex.org/W2516846297","https://openalex.org/W2529737593","https://openalex.org/W2547912129","https://openalex.org/W2559803799","https://openalex.org/W2560780914","https://openalex.org/W2572551054","https://openalex.org/W2581406049","https://openalex.org/W2589381355","https://openalex.org/W2589674438","https://openalex.org/W2687532560","https://openalex.org/W2730563215","https://openalex.org/W2734898627","https://openalex.org/W2751205196","https://openalex.org/W2757638882","https://openalex.org/W2781422490","https://openalex.org/W2783481349","https://openalex.org/W2789794205","https://openalex.org/W2791219314","https://openalex.org/W2793340652","https://openalex.org/W2805264232","https://openalex.org/W2837018377","https://openalex.org/W2883458662","https://openalex.org/W2884283422","https://openalex.org/W2887688374","https://openalex.org/W2891956880","https://openalex.org/W2892517180","https://openalex.org/W2894431477","https://openalex.org/W2897792087","https://openalex.org/W2898118387","https://openalex.org/W2898802841","https://openalex.org/W2902315967","https://openalex.org/W2909668868","https://openalex.org/W2910042249","https://openalex.org/W2911322073","https://openalex.org/W2914809023","https://openalex.org/W2914854965","https://openalex.org/W2921695936","https://openalex.org/W2924027400","https://openalex.org/W2924578805","https://openalex.org/W2936474142","https://openalex.org/W2938142558","https://openalex.org/W2940981270","https://openalex.org/W2945279282","https://openalex.org/W2948003108","https://openalex.org/W2953864347","https://openalex.org/W2960526082","https://openalex.org/W2961458645","https://openalex.org/W2968316112","https://openalex.org/W2971621396","https://openalex.org/W2974084948","https://openalex.org/W2977720542","https://openalex.org/W2982323348","https://openalex.org/W2990566193","https://openalex.org/W2991599102","https://openalex.org/W2997678137","https://openalex.org/W3004003872","https://openalex.org/W3005342594","https://openalex.org/W3005957319","https://openalex.org/W3008987915","https://openalex.org/W3014052079","https://openalex.org/W3027618338","https://openalex.org/W3027958678","https://openalex.org/W3036274992","https://openalex.org/W3037343749","https://openalex.org/W3044870576","https://openalex.org/W3045895528","https://openalex.org/W3082222079","https://openalex.org/W3084436257","https://openalex.org/W3087712817","https://openalex.org/W3088258341","https://openalex.org/W3094081273","https://openalex.org/W3094487801","https://openalex.org/W3113071498","https://openalex.org/W3123584887","https://openalex.org/W3127826052","https://openalex.org/W3134197607","https://openalex.org/W3135540293","https://openalex.org/W4210653451","https://openalex.org/W4213219820","https://openalex.org/W4297236086","https://openalex.org/W4297502289","https://openalex.org/W4383533530","https://openalex.org/W4391385014","https://openalex.org/W4391968374","https://openalex.org/W4400772569"],"related_works":[],"abstract_inverted_index":{"Background/objectives":[0],"Mental":[1],"health":[2,8],"disorders":[3],"represent":[4,278],"a":[5,51,59,245,292],"major":[6,186],"global":[7],"burden.":[9],"Recent":[10],"interest":[11],"has":[12,289],"surged":[13],"in":[14,28,140,207,218],"the":[15,88,131,150],"microbiome\u2013gut\u2013brain":[16],"axis,":[17],"which":[18],"may":[19,277],"influence":[20],"psychiatric":[21,36,76,296],"pathophysiology.":[22],"This":[23],"systematic":[24,60],"review":[25,61,321],"evaluates":[26],"alterations":[27,102,255],"intestinal":[29,83],"microbiome":[30],"(IM)":[31],"composition":[32],"between":[33],"individuals":[34],"with":[35,50,164],"disorders\u2014such":[37],"as":[38,149,291],"schizophrenia,":[39],"autism":[40],"spectrum":[41,159],"disorder":[42,160,188,229],"(ASD),":[43],"mood":[44],"and":[45,66,82,91,96,105,109,145,169,173,179,189,197,212,216,220,226,237,263,282,303,316],"eating":[46,228],"disorders\u2014and":[47],"healthy":[48],"controls,":[49],"focus":[52],"on":[53],"diagnostic":[54,285,318],"relevance.":[55],"Methods":[56],"We":[57],"conducted":[58],"across":[62],"PubMed,":[63],"Scopus,":[64],"CENTRAL,":[65],"PsycINFO,":[67],"following":[68],"PRISMA":[69],"2020":[70],"guidelines.":[71],"Studies":[72],"were":[73,78,99,103,138],"included":[74],"if":[75],"diagnoses":[77],"made":[79],"using":[80,116,306],"DSM-V":[81],"dysbiosis":[84,275],"was":[85,114,162,203],"characterised":[86],"at":[87],"phylum,":[89],"family,":[90],"genus":[92],"levels.":[93],"Only":[94],"observational":[95],"interventional":[97],"studies":[98,126,305],"considered.":[100],"Microbial":[101],"extracted":[104],"analysed":[106],"both":[107,261],"qualitatively":[108],"quantitatively.":[110],"Risk":[111],"of":[112,124,152,240,272],"bias":[113],"assessed":[115],"NIH":[117],"Quality":[118],"Assessment":[119],"Tools.":[120],"Results":[121],"A":[122],"total":[123],"80":[125],"involving":[127],"2,691":[128],"participants":[129],"met":[130],"inclusion":[132],"criteria.":[133],"Across":[134],"disorders,":[135,184],"consistent":[136],"disruptions":[137],"observed":[139],"Firmicutes":[141,166,246],",":[142,144,209,211,324],"Bacteroidetes":[143,170,248],"Actinobacteria":[146],"phyla":[147],"presented":[148],"percentage":[151],"affected":[153],"patients":[154],"within":[155],"each":[156],"disorder.":[157],"Autism":[158],"(ASD)":[161],"associated":[163],"decreased":[165,198],"(\u2193":[167,171,200,222],"4.79%)":[168],"3.29%)":[172],"increased":[174,193],"Bifidobacteria":[175],"ceae":[176],"(\u2191":[177,181,195,214,250],"5.86%)":[178],"Eggerthellaceae":[180],"5.50%).":[182],"Mood":[183],"including":[185,233],"depressive":[187],"bipolar":[190],"disorder,":[191],"showed":[192,244],"Christensenellaceae":[194,210],"18.1%)":[196],"Ruminococcaceae":[199],"2.0%).":[201],"Schizophrenia":[202],"marked":[204],"by":[205],"elevations":[206],"Lachnospiraceae":[208],"Enterobacteriaceae":[213],"11\u201328%)":[215],"reductions":[217],"Akkermansia":[219,241],"Turicibacteraceae":[221],"9\u201328%).":[223],"Anorexia":[224],"nervosa":[225],"binge":[227],"displayed":[230],"profound":[231],"dysbiosis,":[232],"\u2193":[234,252],"Lactobacillus":[235],"(48.5%)":[236],"complete":[238],"loss":[239],"(100%).":[242],"ADHD":[243],"/":[247],"imbalance":[249],"49.8%,":[251],"56.6%).":[253],"These":[254],"suggest":[256],"microbial":[257,274,280,314],"signatures":[258,315],"that":[259,276],"are":[260,309],"disorder-specific":[262],"partially":[264],"overlapping.":[265],"Conclusion":[266],"Our":[267],"findings":[268],"highlight":[269],"reproducible":[270],"patterns":[271],"gut":[273],"candidate":[279],"biomarkers":[281],"inform":[283],"future":[284],"research.":[286],"Microbiome":[287],"profiling":[288],"potential":[290],"non-invasive":[293],"adjunct":[294],"to":[295,311],"diagnosis,":[297],"warranting":[298],"further":[299],"exploration.":[300],"Future":[301],"longitudinal":[302],"mechanistic":[304],"standardised":[307],"methods":[308],"essential":[310],"validate":[312],"these":[313],"their":[317],"utility.":[319],"Systematic":[320],"registration":[322],"https://www.crd.york.ac.uk/PROSPERO/view/CRD42021254293":[323],"CRD42021254293.":[325]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2026-02-03T00:00:00"}
